Helicobacter pylori CagA upregulation of CIP2A is dependent on the Src and MEK/ERK pathways

Journal of Medical Microbiology

Volumn 59, Issue 3, 2010, Pages 259-265

  Zhao, Dapeng ^a   Liu, Zhifang ^a   Ding, Jian ^a   Li, Wenjuan ^a   Sun, Yundong ^a   Yu, Han ^a   Zhou, Yabin ^a   Zeng, Jiping ^a   Chen, Chunyan ^a   Jia, Jihui ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CAGA PROTEIN; CIP2A PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MYC PROTEIN; ONCOPROTEIN; PROTEIN TYROSINE KINASE; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; ATTENUATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; UPREGULATION;

ANTIGENS, BACTERIAL; AUTOANTIGENS; BACTERIAL PROTEINS; CELL LINE; EPITHELIAL CELLS; HELICOBACTER PYLORI; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOBLOTTING; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 76649101395     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.014704-0     Document Type: Article

References (36)

1. Akopyants, N. S., Clifton, S. W., Kersulyte, D., Crabtree, J. E., Youree, B. E., Reece, C. A., Bukanov, N. O., Drazek, E. S., Roe, B. A. & Berg, D. E. (1998). Analyses of the cag pathogenicity island of Helicobacter pylori. Mol Microbiol 28, 37-53.
2. Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T. & Saltiel, A. R. (1995). PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270, 27489-27494.
3. Azuma, T., Yamazaki, S., Yamakawa, A., Ohtani, M., Muramatsu, A., Suto, H., Ito, Y., Dojo, M., Yamazaki, Y. & other authors (2004). Association between diversity in the Src homology 2 domain-containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer. J Infect Dis 189, 820-827.
4. Backert, S. & Meyer, T. F. (2006). Type IV secretion systems and their effectors in bacterial pathogenesis. Curr Opin Microbiol 9, 207-217.
5. Backert, S. & Selbach, M. (2008). Role of type IV secretion in Helicobacter pylori pathogenesis. Cell Microbiol 10, 1573-1581.
6. Chang, Y. J., Wu, M. S., Lin, J. T., Pestell, R. G., Blaser, M. J. & Chen, C. C. (2006). Mechanisms for H. pylori CagA-induced cyclin D1 expression that affect cell cycle. Cell Microbiol 8, 1740-1752.
7. Franco, A. T., Israel, D. A., Washington, M. K., Krishna, U., Fox, J. G., Rogers, A. B., Neish, A. S., Collier-Hyams, L., Perez-Perez, G. I. & other authors (2005). Activation of β-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A 102, 10646-10651.
8. Hanahan, D. & Weinberg, R. A. (2000). The hallmarks of cancer. Cell 100, 57-70.
9. Handa, O., Naito, Y. & Yoshikawa, T. (2007). CagA protein of Helicobacter pylori: a hijacker of gastric epithelial cell signaling. Biochem Pharmacol 73, 1697-1702.
10. Hanke, J. H., Gardner, J. P., Dow, R. L., Changelian, P. S., Brissette, W. H., Weringer, E. J., Pollok, B. A. & Connelly, P. A. (1996). Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem 271, 695-701.
11. Hatakeyama, M. (2003). Helicobacter pylori CagA - a potential bacterial oncoprotein that functionally mimics the mammalian Gab family of adaptor proteins. Microbes Infect 5, 143-150.
12. Hatakeyama, M. (2004). Oncogenic mechanisms of the Helicobacter pylori CagA protein. Nat Rev Cancer 4, 688-694.
13. Houghton, J. & Wang, T. C. (2005). Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers. Gastroenterology 128, 1567-1578.
14. Junttila, M. R., Puustinen, P., Niemelä, M., Ahola, R., Arnold, H., Böttzauw, T., Alaaho, R., Nielsen, C., Ivaska, J. & other authors (2007). CIP2A inhibits PP2A in human malignancies. Cell 130, 51-62.
15. Khanna, A., Böckelman, C., Hemmes, A., Junttila, M. R., Wiksten, J. P., Lundin, M., Junnila, S., Murphy, D. J., Evan, G. I. & other authors (2009). MYC-dependent regulation and prognostic role of CIP2A in gastric cancer. J Natl Cancer Inst 101, 793-805.
16. Kim, S. Y., Lee, Y. C., Kim, H. K. & Blaser, M. J. (2006). Helicobacter pylori CagA transfection of gastric epithelial cells induces interleukin-8. Cell Microbiol 8, 97-106.
17. Kwok, T., Zabler, D., Urman, S., Rohde, M., Hartig, R., Wessler, S., Misselwitz, R., Berger, J., Sewald, N. & other authors (2007). Helicobacter exploits integrin for type IV secretion and kinase activation. Nature 449, 862-866.
18. Li, W., Ge, Z., Liu, C., Liu, Z., Björkholm, M., Jia, J. & Xu, D. (2008). CIP2A is overexpressed in gastric cancer and its depletion leads to impaired clonogenicity, senescence, or differentiation of tumor cells. Clin Cancer Res 14, 3722-3728.
19. Li, Q., Liu, N., Shen, B., Zhou, L., Wang, Y., Wang, Y., Sun, J., Fan, Z. & Liu, R. H. (2009). Helicobacter pylori enhances cyclooxygenase 2 expression via p38MAPK/ATF-2 signaling pathway in MKN45 cells. Cancer Lett 278, 97-103.
20. Nakajima, N., Ito, Y., Yokoyama, K., Uno, A., Kinukawa, N., Nemoto, N. & Moriyama, M. (2009). The expression of murine double minute 2 (MDM2) on Helicobacter pylori-infected intestinal metaplasia and gastric cancer. J Clin Biochem Nutr 44, 196-202.
21. Nguyen, L. T., Uchida, T., Murakami, K., Fujioka, T. & Moriyama, M. (2008). Helicobacter pylori virulence and the diversity of gastric cancer in Asia. J Med Microbiol 57, 1445-1453.
22. Odenbreit, S., Puls, J., Sedlmaier, B., Gerland, E., Fischer, W. & Haas, R. (2000). Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 287, 1497-1500.
23. Peek, R. M. J. & Blaser, M. J. (2002). Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer 2, 28-37.
24. Pierce, J. W., Schoenleber, R., Jesmok, G., Best, J., Moore, S. A., Collins, T. & Gerritsen, M. E. (1997). Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem 272, 21096-21103.
25. Seo, J. H., Kim, K. H. & Kim, H. (2007). Role of proteinase-activated receptor-2 on cyclooxygenase-2 expression in H. pylori-infected gastric epithelial cells. Ann N Y Acad Sci 1096, 29-36.
26. Stein, M., Rappuoli, R. & Covacci, A. (2000). Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation. Proc Natl Acad Sci U S A 97, 1263-1268.
27. Stein, M., Bagnoli, F., Halenbeck, R., Rappuoli, R., Fantl, W. J. & Covacci, A. (2002). c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol Microbiol 43, 971-980.
28. Tomimori, K., Uema, E., Teruya, H., Ishikawa, C., Okudaira, T., Senba, M., Yamamoto, K., Matsuyama, T., Kinjo, F. & other authors (2007). Helicobacter pylori induces CCL20 expression. Infect Immun 75, 5223-5232.
29. Yang, Y., Deng, C. S., Peng, J. Z., Wong, B. C., Lam, S. K. & Xia, H. H. (2003). Effect of Helicobacter pylori on apoptosis and apoptosis related genes in gastric cancer cells. Mol Pathol 56, 19-24.
30. Yeh, E., Cunningham, M., Arnold, H., Chasse, D.,Monteith, T., Ivaldi, G., Hahn, W. C., Stukenberg, P. T., Shenolikar, S. & other authors (2004). A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol 6, 308-318.
31. Yokoyama, K., Higashi, H., Ishikawa, S., Fujii, Y., Kondo, S., Kato, H., Azuma, T., Wada, A., Hirayama, T. & other authors (2005). Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells. Proc Natl Acad Sci U S A 102, 9661-9666.
32. Young, P. R., McLaughlin, M. M., Kumar, S., Kassis, S., Doyle, M. L., McNulty, D., Gallagher, T. F., Fisher, S., McDonnell, P. C. & other authors (1997). Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J Biol Chem 272, 12116-12121.
33. Zhu, Y. L., Zheng, S., Qian, K. D. & Fang, P. C. (2004). Biological activity of the virulence factor cagA of Helicobacter pylori Chin Med J (Engl) 117, 1330-1333.
34. Zhu, Y. L., Zheng, S., Du, Q., Qian, K. D. & Fang, P. C. (2005). Characterization of CagA variable region of Helicobacter pylori isolates from Chinese patients. World J Gastroenterol 11, 880-884.
35. Zhu, Y., Wang, C., Huang, J., Ge, Z., Dong, Q., Zhong, X., Su, Y. & Zheng, S. (2007). The Helicobacter pylori virulence factor CagA promotes Erk1/2-mediated Bad phosphorylation in lymphocytes: a mechanism of CagA-inhibited lymphocyte apoptosis. Cell Microbiol 9, 952-961.
36. Zhu, Y., Shu, X., Chen, J., Xie, Y., Xu, P., Huang, D. Q. & Lu, N. H. (2008). Effect of Helicobacter pylori eradication on oncogenes and cell proliferation. Eur J Clin Invest 38, 628-633.