CIP2A is overexpressed in gastric cancer and its depletion leads to impaired clonogenicity, senescence, or differentiation of tumor cells

Clinical Cancer Research

Volumn 14, Issue 12, 2008, Pages 3722-3728

  Li, Wenjuan ^a,c   Ge, Zheng ^c   Liu, Cheng ^c   Liu, Zhifang ^b   Björkholm, Magnus ^c   Jia, Jihui ^a,b   Xu, Dawei ^c  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b SHANDONG UNIVERSITY   (China)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CANCEROUS INHIBITOR OF PROTEIN PHOSPHATASE 2A; MESSENGER RNA; MYC PROTEIN; ONCOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN P53; RETINOBLASTOMA PROTEIN; SMALL INTERFERING RNA; TUMOR MARKER; UNCLASSIFIED DRUG; AUTOANTIGEN; KIAA1524 PROTEIN, HUMAN; MEMBRANE PROTEIN;

ADULT; AGED; ARTICLE; CANCER INHIBITION; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL TRANSFORMATION; CLINICAL ARTICLE; CLONOGENESIS; CONTROLLED STUDY; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SENESCENCE; STOMACH CANCER; TUMOR CELL LINE; CELL AGING; CELL STRAIN HCT116; CELL STRAIN HL 60; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; HELA CELL; MIDDLE AGED; STOMACH TUMOR; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; AUTOANTIGENS; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HELA CELLS; HL-60 CELLS; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; RNA, SMALL INTERFERING; STOMACH NEOPLASMS; TUMOR STEM CELL ASSAY; UP-REGULATION;

EID: 52449121851     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-07-4137     Document Type: Article

References (32)

1. Vogiatzi P.Vindigni C, Roviello F, Renieri A, Giordano A. Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis. J Cell Physiol 2007;211:287-95.
2. Di Mario F, Cavallaro LG. Cavestro GM, Franze A Are there useful biomarkers for gastric cancer? Dig Liver Dis 2006;38:308-9.
3. Correa P, Houghton J. Carcinogenesis of Helicobacter pylori Gastroenterology 2007;133:659-72.
4. Knekt P, Teppo L, Aromaa A, Rissanen H, Kosunen TU. Helicobacter pylori IgA and IgG antibodies, serum pepsinogen I and the risk of gastric cancer: changes in the risk with extended follow-up period. Int J Cancer 2006;119:702-5.
5. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
6. Junttila MR. Puustinen P. Niemela M, et al. CIP2A inhibits PP2A in human malignancies Cell 2007;130:51-62.
7. 2 arrest after DNA damage Science 1998;282:1497-501.
8. Lou F, Chen X, Jalink M, et al. The opposing effect of hypoxia-inducible factor-2a on expression of telomer-ase reverse transcriptase. Mol Cancer Res 2007;5:793-800.
9. Li W, Li L, Liu Z, et al. Expression of the full-length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues. Cancer Lett 2008;260:28-36.
10. Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 1995;92:9363-7.
11. Lindvall C, Hou M, Komurasaki T, et al Molecular characterization of human telomerase reverse tran-scriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene. Cancer Res 2003;63:1743-7.
12. Xu D, Popov N, Hou M, et al. Switch from Myc/Max to Mad1/Max binding and decrease in histone acetyla-tion at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Proc Natl Acad Sci U S A 2001;98:3826-31.
13. Jiang XH, Wong BC, Lin MC, et al. Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kB activation in gastric cancer cells. Oncogene 2002;20:8009-18.
14. Goodwin EC, DiMaio D. Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways. Proc Natl Acad Sci U S A 2000;97:12513-8.
15. Mattioli E, Vogiatzi P, Sun A, et al. Immunohisto-chemical analysis of pRb2/p130, VEGF, EZH2, p53, p16(INK4A). p27(KIP1), p21 (WAF1), Ki-67 expression patterns in gastric cancer. J Cell Physiol 2007;210:183-91.
16. Shi SL.Wang YY, Liang Y, Li QF. Effects of tachyple-sin and N-sodium butyrate on proliferation and gene expression of human gastric adenocarcinoma cell line BGC-823. World J Gastroenterol 2006;12:1694-8.
17. Fang JY, Yang L, Zhu HY, et al. 5-Aza-2-deoxycity-dine induces demethylation and up-regulates transcription of p16INK4A gene in human gastric cancer cell lines. Chin Med J (Engl) 2004;117:99-103.
18. d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, et al A DNA damage checkpoint response in telo-mere-initiated senescence. Nature 2003;426:194-8.
19. Kim WY Sharpless NE. The regulation of INK4/ARF in cancer and aging. Cell 2006;127:265-75.
20. Shay JW, Roninson IB. Hallmarks of senescence in carcinogenesis and cancer therapy Oncogene 2004;23:2919-33
21. Phipps SM. Berletch JB, Andrews LG.Tollefsbol TO Aging cell culture: methods and observations. Methods Mol Biol 2007;371:9-19.
22. Xu D, Gruber A, Peterson C, Pisa P. Suppression of telomerase activity in HL60 cells after treatment with differentiating agents. Leukemia 1996;10:1354-7.
23. Zhao JJ. Gjoerup OV, Subramanian RR. et al Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase Cancer Cell 2003;3:483-95
24. Arroyo JD, Hahn WC. Involvement of PP2A in viral and cellular transformation Oncogene 2005;24:7746-55.
25. Lowe SW, Cepero E, Evan G Intrinsic tumour suppression. Nature 2004;432:307-15
26. Braig M, Lee S, Loddenkemper C. et al Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 2005;436:660-5.
27. Chen Z.Trotman LC. Shaffer D, et al Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis Nature 2005;436:725-30
28. Crescenzi E, Palumbo G, de Boer J, Brady HJM Ataxia telangectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy. Clin Cancer Res 2008;14:1877-87
29. XueW. Zender L. Miething C, et al Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007;445:656-60
30. Guney I.Wu S, Sedivy JM. Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a). Proc Natl Acad Sci USA 2006:103:3645-50
31. Wu CH, van Riggelen J. Yetil A, Fan AC, Bachireddy P, Felsher DW. Cellular senescence is an important mechanism of tumor regression upon c-Myc inactiva- tion. Proc Natl Acad Sci U S A 2007;104:13028-33
32. Eckhardt SG, Dai A, Davidson KK. Forseth BJ. Wahl GM. Von Hoff DD. Induction of differentiation in HL60 cells by the reduction of extrachromosomally amplified c-myc. Proc Natl Acad Sci U S A 1994;91:6674-8.