Expression and biological role of CIP2A in human astrocytoma

Molecular Medicine Reports

Volumn 7, Issue 5, 2013, Pages 1376-1380

  Yi, Fuxin ^a   Ni, Weimin ^a   Liu, Weixian ^a   Bai, Jinyang ^a   Li, Wenbin ^a  

^a JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Astrocytoma; CIP2A; Proliferation

Indexed keywords

CANCEROUS INHIBITOR OF PROTEIN PHOSPHATASE 2A; CASPASE 3; MYC PROTEIN; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADULT; ANCHORAGE INDEPENDENT GROWTH; APOPTOSIS; ARTICLE; ASTROCYTOMA; ASTROCYTOMA CELL; CANCER GRADING; CELL GROWTH; CELL PROLIFERATION; CORRELATION ANALYSIS; DOWN REGULATION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ADULT; APOPTOSIS; ASTROCYTOMA; AUTOANTIGENS; BRAIN NEOPLASMS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; RNA, SMALL INTERFERING;

EID: 84876003305     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1357     Document Type: Article

References (23)

1. Bondy ML, Scheurer ME, Malmer B, et al: Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer 113: 1953-1968, 2008.
2. Soo Hoo L, Zhang JY and Chan EK: Cloning and characterization of a novel 90 kDa 'companion' auto-antigen of p62 overexpressed in cancer. Oncogene 21: 5006-5015, 2002.
3. Junttila MR, Puustinen P, Niemela M, et al: CIP2A inhibits PP2A in human malignancies. Cell 130: 51-62, 2007.
4. Chen KF, Liu CY, Lin YC, et al: CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells. Oncogene 29: 6257-6266, 2010.
5. Lin YC, Chen KC, Chen CC, Cheng AL and Chen KF: CIP2A-mediated Akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cells. Oral Oncol 48: 585-593, 2012.
6. Come C, Laine A, Chanrion M, et al: CIP2A is associated with human breast cancer aggressivity. Clin Cancer Res 15: 5092-5100, 2009.
7. Basile JR and Czerninski R: The role of CIP2A in oral squamous cell carcinoma. Cancer Biol Ther 10: 700-702, 2010.
8. Bockelman C, Koskensalo S, Hagstrom J, Lundin M, Ristimaki A and Haglund C: CIP2A overexpression is associated with c-Myc expression in colorectal cancer. Cancer Biol Ther 13: 289-295, 2012.
9. Bockelman C, Lassus H, Hemmes A, et al: Prognostic role of CIP2A expression in serous ovarian cancer. Br J Cancer 105: 989-995, 2011.
10. Dong QZ, Wang Y, Dong XJ, et al: CIP2A is overexpressed in non-small cell lung cancer and correlates with poor prognosis. Ann Surg Oncol 18: 857-865, 2011.
11. Huang LP, Adelson ME, Mordechai E and Trama JP: CIP2A expression is elevated in cervical cancer. Cancer Biomark 8: 309-317, 2010-2011.
12. Katz J, Jakymiw A, Ducksworth MK, et al: CIP2A expression and localization in oral carcinoma and dysplasia. Cancer Biol Ther 10: 694-699, 2010.
13. Qu W, Li W, Wei L, Xing L, Wang X and Yu J: CIP2A is overexpressed in esophageal squamous cell carcinoma. Med Oncol 29: 113-118, 2012.
14. Ren J, Li W, Yan L, et al: Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients' survival. Br J Cancer 105: 1905-1911, 2011.
15. Teng HW, Yang SH, Lin JK, et al: CIP2A is a predictor of poor prognosis in colon cancer. J Gastrointest Surg 16: 1037-1047, 2012.
16. Vaarala MH, Vaisanen MR and Ristimaki A: CIP2A expression is increased in prostate cancer. J Exp Clin Cancer Res 29: 136, 2010.
17. Li W, Ge Z, Liu C, et al: CIP2A is overexpressed in gastric cancer and its depletion leads to impaired clonogenicity, senescence, or differentiation of tumor cells. Clin Cancer Res 14: 3722-3728, 2008.
18. Kerosuo L, Fox H, Perala N, et al: CIP2A increases self-renewal and is linked to Myc in neural progenitor cells. Differentiation 80: 68-77, 2010.
19. Chow LM, Endersby R, Zhu X, et al: Cooperativity within and among Pten, p53 and Rb pathways induces high-grade astrocytoma in adult brain. Cancer Cell 19: 305-316, 2011.
20. Gordan JD, Thompson CB and Simon MC: HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell 12: 108-113, 2007.
21. Mateyak MK, Obaya AJ and Sedivy JM: c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points. Mol Cell Biol 19: 4672-4683, 1999.
22. D'Amelio M, Cavallucci V and Cecconi F: Neuronal caspase-3 signaling: not only cell death. Cell Death Differ 17: 1104-1114, 2010.
23. Pugazhenthi S, Nesterova A, Sable C, et al: Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem 275: 10761-10766, 2000.