메뉴 건너뛰기




Volumn 73, Issue 22, 2013, Pages 6548-6553

Cancerous inhibitor of protein phosphatase 2A, an emerging human oncoprotein and a potential cancer therapy target

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BORTEZOMIB; CANCEROUS INHIBITOR OF PROTEIN PHOSPHATASE 2A; CHECKPOINT KINASE 1; DEATH ASSOCIATED PROTEIN KINASE; IMATINIB; MYC PROTEIN; ONCOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN KINASE B; PROTEIN UNC5H2; RECEPTOR PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

EID: 84888337350     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-1994     Document Type: Review
Times cited : (131)

References (31)
  • 1
    • 84864326095 scopus 로고    scopus 로고
    • From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets
    • Eifert C, Powers RS. From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets. Nat Rev Cancer 2012;12:572-8.
    • (2012) Nat Rev Cancer , vol.12 , pp. 572-578
    • Eifert, C.1    Powers, R.S.2
  • 2
    • 84876990097 scopus 로고    scopus 로고
    • Protein phosphatase 2A: A target for anticancer therapy
    • Perrotti D, Neviani P. Protein phosphatase 2A: a target for anticancer therapy. Lancet Oncol 2013;14:e229-38.
    • (2013) Lancet Oncol , vol.14
    • Perrotti, D.1    Neviani, P.2
  • 3
    • 41549090369 scopus 로고    scopus 로고
    • Multiple pathways regulated by the tumor suppressor PP2A in transformation
    • Westermarck J, Hahn WC. Multiple pathways regulated by the tumor suppressor PP2A in transformation. Trends Mol Med 2008;14:152-60.
    • (2008) Trends Mol Med , vol.14 , pp. 152-160
    • Westermarck, J.1    Hahn, W.C.2
  • 5
    • 0037173724 scopus 로고    scopus 로고
    • Cloning and characterization of a novel 90 kDa 'companion' auto-antigen of p62 overexpressed in cancer
    • Soo Hoo L, Zhang JY, Chan EK. Cloning and characterization of a novel 90 kDa 'companion' auto-antigen of p62 overexpressed in cancer. Oncogene 2002;21:5006-15.
    • (2002) Oncogene , vol.21 , pp. 5006-5015
    • Soo Hoo, L.1    Zhang, J.Y.2    Chan, E.K.3
  • 6
    • 78649511007 scopus 로고    scopus 로고
    • CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells
    • Chen KF, Liu CY, Lin YC, Yu HC, Liu TH, Hou DR, et al. CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells. Oncogene 2010;29:6257-66.
    • (2010) Oncogene , vol.29 , pp. 6257-6266
    • Chen, K.F.1    Liu, C.Y.2    Lin, Y.C.3    Yu, H.C.4    Liu, T.H.5    Hou, D.R.6
  • 7
    • 79952925941 scopus 로고    scopus 로고
    • CIP2A is over-expressed in acute myeloid leukaemia and associated with HL60 cells proliferation and differentiation
    • [Epub ahead of print]
    • Wang J, Li W, Li L, Yu X, Jia J, Chen C. CIP2A is over-expressed in acute myeloid leukaemia and associated with HL60 cells proliferation and differentiation. Int J Lab Hematol 2011. [Epub ahead of print]
    • (2011) Int J Lab Hematol
    • Wang, J.1    Li, W.2    Li, L.3    Yu, X.4    Jia, J.5    Chen, C.6
  • 8
    • 84867039610 scopus 로고    scopus 로고
    • CIP2A signature reveals the MYC dependency of CIP2A-regulated phenotypes and its clinical association with breast cancer subtypes
    • Niemela M, Kauko O, Sihto H, Mpindi JP, Nicorici D, Pernila P, et al. CIP2A signature reveals the MYC dependency of CIP2A-regulated phenotypes and its clinical association with breast cancer subtypes. Oncogene 2012;31:4266-78.
    • (2012) Oncogene , vol.31 , pp. 4266-4278
    • Niemela, M.1    Kauko, O.2    Sihto, H.3    Mpindi, J.P.4    Nicorici, D.5    Pernila, P.6
  • 9
    • 84855913352 scopus 로고    scopus 로고
    • Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation
    • Mathiasen DP, Egebjerg C, Andersen SH, Rafn B, Puustinen P, Khanna A, et al. Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation. Oncogene 2012;31:390-401.
    • (2012) Oncogene , vol.31 , pp. 390-401
    • Mathiasen, D.P.1    Egebjerg, C.2    Andersen, S.H.3    Rafn, B.4    Puustinen, P.5    Khanna, A.6
  • 12
    • 79955739210 scopus 로고    scopus 로고
    • CIP2A is overexpressed in non-small cell lung cancer and correlates with poor prognosis
    • Dong QZ, Wang Y, Dong XJ, Li ZX, Tang ZP, Cui QZ, et al. CIP2A is overexpressed in non-small cell lung cancer and correlates with poor prognosis. Ann Surg Oncol 2011;18:857-65.
    • (2011) Ann Surg Oncol , vol.18 , pp. 857-865
    • Dong, Q.Z.1    Wang, Y.2    Dong, X.J.3    Li, Z.X.4    Tang, Z.P.5    Cui, Q.Z.6
  • 14
    • 79959252521 scopus 로고    scopus 로고
    • Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression
    • Lucas CM, Harris RJ, Giannoudis A, Copland M, Slupsky JR, Clark RE. Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression. Blood 2011;117:6660-8.
    • (2011) Blood , vol.117 , pp. 6660-6668
    • Lucas, C.M.1    Harris, R.J.2    Giannoudis, A.3    Copland, M.4    Slupsky, J.R.5    Clark, R.E.6
  • 15
    • 84871567858 scopus 로고    scopus 로고
    • CIP2A is a predictor of survival and a novel therapeutic target in bladder urothelial cell carcinoma
    • Xue YJ, Wu GQ, Wang XN, Zou XF, Zhang GX, Xiao RH, et al. CIP2A is a predictor of survival and a novel therapeutic target in bladder urothelial cell carcinoma. Med Oncol 2013;30:406.
    • (2013) Med Oncol , vol.30 , pp. 406
    • Xue, Y.J.1    Wu, G.Q.2    Wang, X.N.3    Zou, X.F.4    Zhang, G.X.5    Xiao, R.H.6
  • 16
    • 84873908988 scopus 로고    scopus 로고
    • Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1
    • Laine A, Sihto H, Come C, Rosenfeldt MT, Zwolinska A, Niemela M, et al. Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discov 2013;3:182-97.
    • (2013) Cancer Discov , vol.3 , pp. 182-197
    • Laine, A.1    Sihto, H.2    Come, C.3    Rosenfeldt, M.T.4    Zwolinska, A.5    Niemela, M.6
  • 19
    • 84858858444 scopus 로고    scopus 로고
    • CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice
    • Ventela S, Come C, Makela JA, Hobbs RM, Mannermaa L, Kallajoki M, et al. CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice. PLoS ONE 2012;7:e33209.
    • (2012) PLoS ONE , vol.7
    • Ventela, S.1    Come, C.2    Makela, J.A.3    Hobbs, R.M.4    Mannermaa, L.5    Kallajoki, M.6
  • 20
    • 84888380323 scopus 로고    scopus 로고
    • CIP2A modulates cell cycle progression in human cancer cells by regulating the stability and activity of PLK1
    • Kim JS, Kim EJ, Oh JS, Park IC, Hwang SG. CIP2A modulates cell cycle progression in human cancer cells by regulating the stability and activity of PLK1. Cancer Res 2013;73:6667-6678.
    • (2013) Cancer Res , vol.73 , pp. 6667-6678
    • Kim, J.S.1    Kim, E.J.2    Oh, J.S.3    Park, I.C.4    Hwang, S.G.5
  • 21
    • 33845919326 scopus 로고    scopus 로고
    • The ins and outs of MYC regulation by posttranslational mechanisms
    • DOI 10.1074/jbc.R600017200
    • Vervoorts J, Luscher-Firzlaff J, Luscher B. The ins and outs of MYC regulation by posttranslational mechanisms. J Biol Chem 2006;281:34725-9. (Pubitemid 46036511)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.46 , pp. 34725-34729
    • Vervoorts, J.1    Luscher-Firzlaff, J.2    Luscher, B.3
  • 22
    • 79952916409 scopus 로고    scopus 로고
    • ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells
    • Khanna A, Okkeri J, Bilgen T, Tiirikka T, Vihinen M, Visakorpi T, et al. ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells. PLoS One 2011;6:e17979.
    • (2011) PLoS One , vol.6
    • Khanna, A.1    Okkeri, J.2    Bilgen, T.3    Tiirikka, T.4    Vihinen, M.5    Visakorpi, T.6
  • 23
    • 84865727989 scopus 로고    scopus 로고
    • CIP2A is highly expressed in hepatocellular carcinoma and predicts poor prognosis
    • He H, Wu G, Li W, Cao Y, Liu Y. CIP2A is highly expressed in hepatocellular carcinoma and predicts poor prognosis. Diagn Mol Pathol 2012;21:143-9.
    • (2012) Diagn Mol Pathol , vol.21 , pp. 143-149
    • He, H.1    Wu, G.2    Li, W.3    Cao, Y.4    Liu, Y.5
  • 24
    • 84885053768 scopus 로고    scopus 로고
    • CIP2A influences survival in colon cancer and is critical in maintaining Myc expression
    • (Epub ahead of print)
    • Wiegering A, Pfann C, Uthe FW, Otto C, Rycak L, Mäder U, et al. CIP2A influences survival in colon cancer and is critical in maintaining Myc expression. PLoS One 2013;8:e75292 (Epub ahead of print).
    • (2013) PLoS One , vol.8
    • Wiegering, A.1    Pfann, C.2    Uthe, F.W.3    Otto, C.4    Rycak, L.5    Mäder, U.6
  • 27
  • 28
    • 78650251694 scopus 로고    scopus 로고
    • The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase
    • Guenebeaud C, Goldschneider D, Castets M, Guix C, Chazot G, Delloye-Bourgeois C, et al. The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Mol Cell 2010;40:863-76.
    • (2010) Mol Cell , vol.40 , pp. 863-876
    • Guenebeaud, C.1    Goldschneider, D.2    Castets, M.3    Guix, C.4    Chazot, G.5    Delloye-Bourgeois, C.6
  • 29
    • 84877120847 scopus 로고    scopus 로고
    • First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement
    • Tabernero J, Shapiro GI, Lorusso PM, Cervantes A, Schwartz GK, Weiss GJ, et al. First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement. Cancer Discov 2013;3:406-17.
    • (2013) Cancer Discov , vol.3 , pp. 406-417
    • Tabernero, J.1    Shapiro, G.I.2    Lorusso, P.M.3    Cervantes, A.4    Schwartz, G.K.5    Weiss, G.J.6
  • 30
    • 84855347756 scopus 로고    scopus 로고
    • Interfacial inhibitors: Targeting macromolecular complexes
    • Pommier Y, Marchand C. Interfacial inhibitors: targeting macromolecular complexes. Nat Rev Drug Discov 2012;11:25-36.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 25-36
    • Pommier, Y.1    Marchand, C.2
  • 31
    • 84888360794 scopus 로고    scopus 로고
    • Regulation of Cancerous inhibitor of PP2A (CIP2A) by small molecule inhibitor for c-Jun NH2-Terminal Kinases (JNKs), SP600125, in Human Fibrosarcoma (HT1080) cells
    • Khanna A. Regulation of Cancerous inhibitor of PP2A (CIP2A) by small molecule inhibitor for c-Jun NH2-Terminal Kinases (JNKs), SP600125, in Human Fibrosarcoma (HT1080) cells. F1000Research 2013;2:174.
    • (2013) F1000Research , vol.2 , pp. 174
    • Khanna, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.