-
1
-
-
79952232216
-
Global cancer statistics
-
Jemal, A. et al. Global cancer statistics. CA Cancer J. Clin. 61, 69-90 (2011
-
(2011)
CA Cancer J. Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
-
2
-
-
84872967522
-
Cancer statistics 2013
-
Siegel, R., Naishadham, D. & Jemal, A. Cancer statistics, 2013. CA Cancer J. Clin. 63, 11-30 (2013
-
(2013)
CA Cancer J. Clin
, vol.63
, pp. 11-30
-
-
Siegel, R.1
Naishadham, D.2
Jemal, A.3
-
3
-
-
84879329196
-
Non-small cell lung cancer version 2.2013
-
Ettinger, D. S. et al. Non-Small Cell Lung Cancer, Version 2.2013. J. Natl Compr. Canc. Netw. 11, 645-653 (2013
-
(2013)
J. Natl Compr. Canc. Netw
, vol.11
, pp. 645-653
-
-
Ettinger, D.S.1
-
4
-
-
84898736387
-
The pivotal role of pathology in the management of lung cancer
-
Davidson, M. R., Gazdar, A. F. & Clarke, B. E. The pivotal role of pathology in the management of lung cancer. J. Thorac. Dis. 5, S463-S478 (2013
-
(2013)
J. Thorac. Dis
, vol.5
-
-
Davidson, M.R.1
Gazdar, A.F.2
Clarke, B.E.3
-
5
-
-
79951862254
-
The evolving role of histology in the management of advanced non-small-cell lung cancer
-
Langer, C. J., Besse, B., Gualberto, A., Brambilla, E. & Soria, J. C. The evolving role of histology in the management of advanced non-small-cell lung cancer. J. Clin. Oncol. 28, 5311-5320 (2010
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 5311-5320
-
-
Langer, C.J.1
Besse, B.2
Gualberto, A.3
Brambilla, E.4
Soria, J.C.5
-
6
-
-
77956538031
-
Airway basal stem cells: A perspective on their roles in epithelial homeostasis and remodeling
-
Rock, J. R., Randell, S. H. & Hogan, B. L. M. Airway basal stem cells: A perspective on their roles in epithelial homeostasis and remodeling. Dis. Model. Mech. 3, 545-556 (2010
-
(2010)
Dis. Model. Mech
, vol.3
, pp. 545-556
-
-
Rock, J.R.1
Randell, S.H.2
Hogan, B.L.M.3
-
7
-
-
77956224492
-
Evidence that Sox2 overexpression is oncogenic in the lung
-
Lu, Y. et al. Evidence that Sox2 overexpression is oncogenic in the lung. PLoS ONE 5, http://dx.doi. org/10.1371/journal.pone.0011022 (2010
-
(2010)
PLoS ONE
, vol.5
-
-
Lu, Y.1
-
8
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
DOI 10.1038/nature00766
-
Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature 417, 949-954 (2002 (Pubitemid 34716871)
-
(2002)
Nature
, vol.417
, Issue.6892
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
Davis, N.11
Dicks, E.12
Ewing, R.13
Floyd, Y.14
Gray, K.15
Hall, S.16
Hawes, R.17
Hughes, J.18
Kosmidou, V.19
Menzies, A.20
Mould, C.21
Parker, A.22
Stevens, C.23
Watt, S.24
Hooper, S.25
Wilson, R.26
Jayatilake, H.27
Gusterson, B.A.28
Cooper, C.29
Shipley, J.30
Hargrave, D.31
Pritchard-Jones, K.32
Maitland, N.33
Chenevix-Trench, G.34
Riggins, G.J.35
Bigner, D.D.36
Palmleri, G.37
Cossu, A.38
Flanagan, A.39
Nicholson, A.40
Ho, J.W.C.41
Leung, S.Y.42
Yuen, S.T.43
Weber, B.L.44
Seigler, H.F.45
Darrow, T.L.46
Paterson, H.47
Marais, R.48
Marshall, C.J.49
Wooster, R.50
Stratton, M.R.51
Futreal, P.A.52
more..
-
9
-
-
0021362206
-
Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient
-
Santos, E. et al. Malignant activation of a K ras oncogene in lung carcinoma but not in normal tissue of the same patient. Science 223, 661-664 (1984 (Pubitemid 14186799)
-
(1984)
Science
, vol.223
, Issue.4637
, pp. 661-664
-
-
Santos, E.1
Martin Zanca, D.2
Reddy, E.P.3
-
10
-
-
2342471392
-
Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non-Small-Cell Lung Cancer to Gefitinib
-
DOI 10.1056/NEJMoa040938
-
Lynch, T. J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129-2139 (2004 (Pubitemid 38637993)
-
(2004)
New England Journal of Medicine
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
Louis, D.N.11
Christiani, D.C.12
Settleman, J.13
Haber, D.A.14
-
11
-
-
2342624080
-
EGFR mutations in lung, cancer: Correlation with clinical response to gefitinib therapy
-
DOI 10.1126/science.1099314
-
Paez, J. G. et al. EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 304, 1497-1500 (2004 (Pubitemid 38720929)
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
Naoki, K.11
Sasaki, H.12
Fujii, Y.13
Eck, M.J.14
Sellers, W.R.15
Johnson, B.E.16
Meyerson, M.17
-
12
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
DOI 10.1073/pnas.0405220101
-
Pao, W. et al. EGF receptor gene mutations are common in lung cancers from never smokers and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc. Natl Acad. Sci. USA 101, 13306-13311 (2004 (Pubitemid 39209661)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.36
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
Doherty, J.4
Politi, K.5
Sarkaria, I.6
Singh, B.7
Heelan, R.8
Rusch, V.9
Fulton, L.10
Mardis, E.11
Kupfer, D.12
Wilson, R.13
Kris, M.14
Varmus, H.15
-
13
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
DOI 10.1056/NEJMoa050753
-
Shepherd, F. A. et al. Erlotinib in previously treated non-small-cell lung cancer. N. Engl. J. Med. 353, 123-132 (2005 (Pubitemid 41058344)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.2
, pp. 123-132
-
-
Shepherd, F.A.1
Pereira, J.R.2
Ciuleanu, T.3
Eng, H.T.4
Hirsh, V.5
Thongprasert, S.6
Campos, D.7
Maoleekoonpiroj, S.8
Smylie, M.9
Martins, R.10
Van Kooten, M.11
Dediu, M.12
Findlay, B.13
Tu, D.14
Johnston, D.15
Bezjak, A.16
Clark, G.17
Santabarbara, P.18
Seymour, L.19
-
14
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
DOI 10.1126/science.1141478
-
Engelman, J. A. et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316, 1039-1043 (2007 (Pubitemid 46799492)
-
(2007)
Science
, vol.316
, Issue.5827
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Joon, O.P.6
Lindeman, N.7
Gale, C.-M.8
Zhao, X.9
Christensen, J.10
Kosaka, T.11
Holmes, A.J.12
Rogers, A.M.13
Cappuzzo, F.14
Mok, T.15
Lee, C.16
Johnson, B.E.17
Cantley, L.C.18
Janne, P.A.19
-
15
-
-
84897942860
-
CD74 NRG1 fusions in lung adenocarcinoma
-
Fernandez-Cuesta, L. et al. CD74 NRG1 fusions in lung adenocarcinoma. Cancer Discov. 4, 415-422 (2014
-
(2014)
Cancer Discov
, vol.4
, pp. 415-422
-
-
Fernandez-Cuesta, L.1
-
16
-
-
84857929267
-
KIF5B RET fusions in lung adenocarcinoma
-
Kohno, T. et al. KIF5B RET fusions in lung adenocarcinoma. Nature Med. 18, 375-377 (2012
-
(2012)
Nature Med
, vol.18
, pp. 375-377
-
-
Kohno, T.1
-
17
-
-
36849065315
-
Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer
-
DOI 10.1016/j.cell.2007.11.025, PII S009286740701522X
-
Rikova, K. et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131, 1190-1203 (2007 (Pubitemid 350235027)
-
(2007)
Cell
, vol.131
, Issue.6
, pp. 1190-1203
-
-
Rikova, K.1
Guo, A.2
Zeng, Q.3
Possemato, A.4
Yu, J.5
Haack, H.6
Nardone, J.7
Lee, K.8
Reeves, C.9
Li, Y.10
Hu, Y.11
Tan, Z.12
Stokes, M.13
Sullivan, L.14
Mitchell, J.15
Wetzel, R.16
MacNeill, J.17
Ren, J.M.18
Yuan, J.19
Bakalarski, C.E.20
Villen, J.21
Kornhauser, J.M.22
Smith, B.23
Li, D.24
Zhou, X.25
Gygi, S.P.26
Gu, T.-L.27
Polakiewicz, R.D.28
Rush, J.29
Comb, M.J.30
more..
-
18
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
DOI 10.1038/nature05945, PII NATURE05945
-
Soda, M. et al. Identification of the transforming EML4 ALK fusion gene in non-small-cell lung cancer. Nature 448, 561-566 (2007 (Pubitemid 47206930)
-
(2007)
Nature
, vol.448
, Issue.7153
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
Takada, S.4
Yamashita, Y.5
Ishikawa, S.6
Fujiwara, S.-I.7
Watanabe, H.8
Kurashina, K.9
Hatanaka, H.10
Bando, M.11
Ohno, S.12
Ishikawa, Y.13
Aburatani, H.14
Niki, T.15
Sohara, Y.16
Sugiyama, Y.17
Mano, H.18
-
19
-
-
4944232647
-
Lung cancer: Intragenic ERBB2 kinase mutations in tumours
-
Stephens, P. et al. Lung cancer: Intragenic ERBB2 kinase mutations in tumours. Nature 431, 525-526 (2004
-
(2004)
Nature
, vol.431
, pp. 525-526
-
-
Stephens, P.1
-
20
-
-
84866894408
-
Comprehensive genomic characterization of squamous cell lung cancers
-
The Cancer Genome Atlas Research Network (TCGA
-
The Cancer Genome Atlas Research Network (TCGA). Comprehensive genomic characterization of squamous cell lung cancers. Nature 489, 519-525 (2012
-
(2012)
Nature
, vol.489
, pp. 519-525
-
-
-
21
-
-
84887445619
-
Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer
-
Vaishnavi, A. et al. Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer. Nature Med. 19, 1469-1472 (2013
-
(2013)
Nature Med
, vol.19
, pp. 1469-1472
-
-
Vaishnavi, A.1
-
22
-
-
78650451788
-
Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
-
62ra93
-
Weiss, J. et al. Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci Transl. Med. 2, 62ra93 (2010
-
(2010)
Sci Transl. Med
, vol.2
-
-
Weiss, J.1
-
23
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
Ding, L. et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455, 1069-1075 (2008
-
(2008)
Nature
, vol.455
, pp. 1069-1075
-
-
Ding, L.1
-
24
-
-
84866410479
-
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing
-
Imielinski, M. et al. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 150, 1107-1120 (2012
-
(2012)
Cell
, vol.150
, pp. 1107-1120
-
-
Imielinski, M.1
-
25
-
-
84858590519
-
Snapshot: Non-small cell lung cancer
-
Heist, R. S. & Engelman, J. A. Snapshot: Non-small cell lung cancer. Cancer Cell 21, 448-448.e2 (2012
-
(2012)
Cancer Cell
, vol.21
-
-
Heist, R.S.1
Engelman, J.A.2
-
26
-
-
84871491773
-
FGFR genetic alterations predict for sensitivity to NVP BGJ398, a selective pan-FGFR inhibitor
-
Guagnano, V. et al. FGFR genetic alterations predict for sensitivity to NVP BGJ398, a selective pan-FGFR inhibitor. Cancer Discov. 2, 1118-1133 (2012
-
(2012)
Cancer Discov
, vol.2
, pp. 1118-1133
-
-
Guagnano, V.1
-
27
-
-
84866709500
-
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer
-
Hammerman, P. S. et al. Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov. 1, 78-89 (2011
-
(2011)
Cancer Discov
, vol.1
, pp. 78-89
-
-
Hammerman, P.S.1
-
28
-
-
84885735554
-
Mutational landscape and significance across 12 major cancer types
-
Kandoth, C. et al. Mutational landscape and significance across 12 major cancer types. Nature 502, 333-339 (2013
-
(2013)
Nature
, vol.502
, pp. 333-339
-
-
Kandoth, C.1
-
29
-
-
84905029258
-
Comprehensive molecular profiling of lung adenocarcinoma
-
The Cancer Genome Atlas Research Network (TCGA
-
The Cancer Genome Atlas Research Network (TCGA). Comprehensive molecular profiling of lung adenocarcinoma. Nature http://dx.doi.org/10.1038/ nature13385 (2014
-
(2014)
Nature
-
-
-
30
-
-
84892833777
-
Discovery and saturation analysis of cancer genes across 21 tumour types
-
Lawrence, M. S. et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 505, 495-501 (2014
-
(2014)
Nature
, vol.505
, pp. 495-501
-
-
Lawrence, M.S.1
-
31
-
-
84866434919
-
Genomic landscape of non-small cell lung cancer in smokers and never-smokers
-
Govindan, R. et al. Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell 150, 1121-1134 (2012
-
(2012)
Cell
, vol.150
, pp. 1121-1134
-
-
Govindan, R.1
-
32
-
-
70449091786
-
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
-
Barbie, D. A. et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 462, 108-112 (2009
-
(2009)
Nature
, vol.462
, pp. 108-112
-
-
Barbie, D.A.1
-
33
-
-
84884548352
-
Isocitrate dehydrogenase 1 is a novel plasma biomarker for the diagnosis of non-small cell lung cancer
-
Sun, N. et al. Isocitrate dehydrogenase 1 is a novel plasma biomarker for the diagnosis of non-small cell lung cancer. Clin. Cancer Res. 19, 5136-5145 (2013
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 5136-5145
-
-
Sun, N.1
-
34
-
-
84863053122
-
Identification of isocitrate dehydrogenase 1 as a potential diagnostic and prognostic biomarker for non-small cell lung cancer by proteomic analysis
-
M111.008821
-
Tan, F. et al. Identification of isocitrate dehydrogenase 1 as a potential diagnostic and prognostic biomarker for non-small cell lung cancer by proteomic analysis. Mol. Cell Proteomics 11, M111.008821 (2012
-
(2012)
Mol. Cell Proteomics
, vol.11
-
-
Tan, F.1
-
35
-
-
84887444879
-
Microenvironmental regulation of tumor progression and metastasis
-
Quail, D. F. & Joyce, J. A. Microenvironmental regulation of tumor progression and metastasis. Nature Med. 19, 1423-1437 (2013
-
(2013)
Nature Med
, vol.19
, pp. 1423-1437
-
-
Quail, D.F.1
Joyce, J.A.2
-
36
-
-
78651451436
-
Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression
-
DuPage, M. et al. Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression. Cancer Cell 19, 72-85 (2011
-
(2011)
Cancer Cell
, vol.19
, pp. 72-85
-
-
Dupage, M.1
-
37
-
-
47949090079
-
The role of myeloid cells in the promotion of tumour angiogenesis
-
Murdoch, C., Muthana, M., Coffelt, S. B. & Lewis, C. E. The role of myeloid cells in the promotion of tumour angiogenesis. Nature Rev. Cancer 8, 618-631 (2008
-
(2008)
Nature Rev. Cancer
, vol.8
, pp. 618-631
-
-
Murdoch, C.1
Muthana, M.2
Coffelt, S.B.3
Lewis, C.E.4
-
38
-
-
84876355029
-
The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas
-
Xiao, Z. et al. The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas. Cancer Cell 23, 527-540 (2013
-
(2013)
Cancer Cell
, vol.23
, pp. 527-540
-
-
Xiao, Z.1
-
39
-
-
0028046042
-
The role of platelet-derived growth factor production by tumor-Associated macrophages in tumor stroma formation in lung cancer
-
Vignaud, J. M. et al. The role of platelet-derived growth factor production by tumor-Associated macrophages in tumor stroma formation in lung cancer. Cancer Res. 54, 5455-5463 (1994
-
(1994)
Cancer Res
, vol.54
, pp. 5455-5463
-
-
Vignaud, J.M.1
-
40
-
-
82755192210
-
A critical role for macrophages in promotion of urethane-induced lung carcinogenesis
-
Zaynagetdinov, R. et al. A critical role for macrophages in promotion of urethane-induced lung carcinogenesis. J. Immunol. 187, 5703-5711 (2011
-
(2011)
J. Immunol
, vol.187
, pp. 5703-5711
-
-
Zaynagetdinov, R.1
-
41
-
-
0031975315
-
Neutrophil alveolitis in bronchioloalveolar carcinoma: Induction by tumor-derived interleukin-8 and relation to clinical outcome
-
Bellocq, A. et al. Neutrophil alveolitis in bronchioloalveolar carcinoma: Induction by tumor-derived interleukin 8 and relation to clinical outcome. Am. J. Pathol. 152, 83-92 (1998 (Pubitemid 28028049)
-
(1998)
American Journal of Pathology
, vol.152
, Issue.1
, pp. 83-92
-
-
Bellocq, A.1
Antoine, M.2
Flahault, A.3
Philippe, C.4
Crestani, B.5
Bernaudin, J.-F.6
Mayaud, C.7
Milleron, B.8
Baud, L.9
Cadranel, J.10
-
42
-
-
76249101753
-
Neutrophil elastase-mediated degradation of IRS 1 accelerates lung tumor growth
-
Houghton, A. M. et al. Neutrophil elastase-mediated degradation of IRS 1 accelerates lung tumor growth. Nature Med. 16, 219-223 (2010
-
(2010)
Nature Med
, vol.16
, pp. 219-223
-
-
Houghton, A.M.1
-
43
-
-
79960829290
-
Neutrophils in the activation and regulation of innate and adaptive immunity
-
Mantovani, A., Cassatella, M. A., Costantini, C. & Jaillon, S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nature Rev. Immunol. 11, 519-531 (2011
-
(2011)
Nature Rev. Immunol
, vol.11
, pp. 519-531
-
-
Mantovani, A.1
Cassatella, M.A.2
Costantini, C.3
Jaillon, S.4
-
44
-
-
84862903106
-
Safety and activity of anti PD L1 antibody in patients with advanced cancer
-
Brahmer, J. R. et al. Safety and activity of anti PD L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366, 2455-2465 (2012
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
-
45
-
-
84862859820
-
Safety, activity, and immune correlates of anti PD 1 antibody in cancer
-
Topalian, S. L. et al. Safety, activity, and immune correlates of anti PD 1 antibody in cancer. N. Engl. J. Med. 366, 2443-2454 (2012
-
(2012)
N. Engl. J. Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
-
46
-
-
42649125225
-
PD 1 and its ligands in tolerance and immunity
-
Keir, M. E., Butte, M. J., Freeman, G. J. & Sharpe, A. H. PD 1 and its ligands in tolerance and immunity. Annu. Rev. Immunol. 26, 677-704 (2008
-
(2008)
Annu. Rev. Immunol
, vol.26
, pp. 677-704
-
-
Keir, M.E.1
Butte, M.J.2
Freeman, G.J.3
Sharpe, A.H.4
-
47
-
-
84895812969
-
New strategies in lung cancer: Translating immunotherapy into clinical practice
-
Forde, P. M., Kelly, R. J. & Brahmer, J. R. New strategies in lung cancer: Translating immunotherapy into clinical practice. Clin. Cancer Res. 20, 1067-1073 (2014
-
(2014)
Clin. Cancer Res
, vol.20
, pp. 1067-1073
-
-
Forde, P.M.1
Kelly, R.J.2
Brahmer, J.R.3
-
48
-
-
84890020587
-
Activation of the PD 1 pathway contributes to immune escape in EGFR-driven lung tumors
-
Akbay, E. A. et al. Activation of the PD 1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov. 3, 1355-1363 (2013
-
(2013)
Cancer Discov
, vol.3
, pp. 1355-1363
-
-
Akbay, E.A.1
-
49
-
-
84900393562
-
Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD L1 expression
-
Xu, C. et al. Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD L1 expression. Cancer Cell 25, 590-604 (2014
-
(2014)
Cancer Cell
, vol.25
, pp. 590-604
-
-
Xu, C.1
-
50
-
-
34447506658
-
Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis
-
DOI 10.1101/gad.1549407
-
Ancrile, B., Lim, K. H. & Counter, C. M. Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Genes Dev. 21, 1714-1719 (2007 (Pubitemid 47076470)
-
(2007)
Genes and Development
, vol.21
, Issue.14
, pp. 1714-1719
-
-
Ancrile, B.1
Lim, K.-H.2
Counter, C.M.3
-
51
-
-
36849012237
-
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
-
DOI 10.1172/JCI31871
-
Gao, S. P. et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL 6 production in human lung adenocarcinomas. J. Clin. Invest. 117, 3846-3856 (2007 (Pubitemid 350224094)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.12
, pp. 3846-3856
-
-
Gao, S.P.1
Mark, K.G.2
Leslie, K.3
Pao, W.4
Motoi, N.5
Gerald, W.L.6
Travis, W.D.7
Bornmann, W.8
Veach, D.9
Clarkson, B.10
Bromberg, J.F.11
-
52
-
-
78751676408
-
Cells of origin in cancer
-
Visvader, J. E. Cells of origin in cancer. Nature 469, 314-322 (2011
-
(2011)
Nature
, vol.469
, pp. 314-322
-
-
Visvader, J.E.1
-
53
-
-
84887619426
-
Dedifferentiation of committed epithelial cells into stem cells in vivo
-
Tata, P. R. et al. Dedifferentiation of committed epithelial cells into stem cells in vivo. Nature 503, 218-223 (2013
-
(2013)
Nature
, vol.503
, pp. 218-223
-
-
Tata, P.R.1
-
54
-
-
79956351015
-
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
-
Chaffer, C. L. et al. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc. Natl Acad. Sci. 108, 7950-7955 (2011
-
(2011)
Proc. Natl Acad. Sci
, vol.108
, pp. 7950-7955
-
-
Chaffer, C.L.1
-
55
-
-
84875813017
-
Mouse models for lung cancer
-
Kwon, M. & Berns, A. Mouse models for lung cancer. Mol. Oncol. 7, 165-177 (2013
-
(2013)
Mol. Oncol
, vol.7
, pp. 165-177
-
-
Kwon, M.1
Berns, A.2
-
56
-
-
20444397431
-
Identification of bronchioalveolar stem cells in normal lung and lung cancer
-
DOI 10.1016/j.cell.2005.03.032, PII S0092867405003429
-
Kim, C. et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121, 823-835 (2005 (Pubitemid 40806415)
-
(2005)
Cell
, vol.121
, Issue.6
, pp. 823-835
-
-
Bender Kim, C.F.1
Jackson, E.L.2
Woolfenden, A.E.3
Lawrence, S.4
Babar, I.5
Vogel, S.6
Crowley, D.7
Bronson, R.T.8
Jacks, T.9
-
57
-
-
70349861927
-
Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury
-
Tiozzo, C. et al. Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury. Am. J. Respir. Crit. Care Med. 180, 701-712 (2009
-
(2009)
Am. J. Respir. Crit. Care Med
, vol.180
, pp. 701-712
-
-
Tiozzo, C.1
-
58
-
-
34249807348
-
P38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
-
DOI 10.1038/ng2037, PII NG2037
-
Ventura, J. J. et al. p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nature Genet. 39, 750-758 (2007 (Pubitemid 46848588)
-
(2007)
Nature Genetics
, vol.39
, Issue.6
, pp. 750-758
-
-
Ventura, J.J.1
Tenbaum, S.2
Perdiguero, E.3
Huth, M.4
Guerra, C.5
Barbacid, M.6
Pasparakis, M.7
Nebreda, A.R.8
-
59
-
-
84859476198
-
Evidence for type II cells as cells of origin of K Ras-induced distal lung adenocarcinoma
-
Xu, X. et al. Evidence for type II cells as cells of origin of K Ras-induced distal lung adenocarcinoma. Proc. Natl Acad. Sci. USA109, 4910-4915 (2012
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 4910-4915
-
-
Xu, X.1
-
60
-
-
84896319764
-
Alveolar progenitor and stem cells in lung development, renewal and cancer
-
Desai, T. J., Brownfield, D. G. & Krasnow, M. A. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature 507, 190-194 (2014
-
(2014)
Nature
, vol.507
, pp. 190-194
-
-
Desai, T.J.1
Brownfield, D.G.2
Krasnow, M.A.3
-
61
-
-
84891904882
-
Identification of cancer initiating cells in K Ras driven lung adenocarcinoma
-
Mainardi, S. et al. Identification of cancer initiating cells in K Ras driven lung adenocarcinoma. Proc. Natl Acad. Sci. USA 111, 255-260 (2014
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 255-260
-
-
Mainardi, S.1
-
62
-
-
84897488955
-
Diverse cells at the origin of lung adenocarcinoma
-
Rowbotham, S. P. & Kim, C. F. Diverse cells at the origin of lung adenocarcinoma. Proc. Natl Acad. Sci. USA 111, 4745-4746 (2014
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 4745-4746
-
-
Rowbotham, S.P.1
Kim, C.F.2
-
63
-
-
84897563108
-
Multiple cells of origin of mutant K Ras-induced mouse lung adenocarcinoma
-
Sutherland, K. D. et al. Multiple cells of origin of mutant K Ras-induced mouse lung adenocarcinoma. Proc. Natl Acad. Sci. USA 111, 4952-4957 (2014
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 4952-4957
-
-
Sutherland, K.D.1
-
64
-
-
84856692365
-
β Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial- mesenchymal transition
-
Giangreco, A. et al. β Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition. J. Pathol. 226, 575-587 (2012
-
(2012)
J. Pathol
, vol.226
, pp. 575-587
-
-
Giangreco, A.1
-
65
-
-
34547926839
-
LKB1 modulates lung cancer differentiation and metastasis
-
DOI 10.1038/nature06030, PII NATURE06030
-
Ji, H. et al. LKB1 modulates lung cancer differentiation and metastasis. Nature 448, 807-810 (2007 (Pubitemid 47266337)
-
(2007)
Nature
, vol.448
, Issue.7155
, pp. 807-810
-
-
Ji, H.1
Ramsey, M.R.2
Hayes, D.N.3
Fan, C.4
McNamara, K.5
Kozlowski, P.6
Torrice, C.7
Wu, M.C.8
Shimamura, T.9
Perera, S.A.10
Liang, M.-C.11
Cai, D.12
Naumov, G.N.13
Bao, L.14
Contreras, C.M.15
Li, D.16
Chen, L.17
Krishnamurthy, J.18
Koivunen, J.19
Chirieac, L.R.20
Padera, R.F.21
Bronson, R.T.22
Lindeman, N.I.23
Christiani, D.C.24
Lin, X.25
Shapiro, G.I.26
Janne, P.A.27
Johnson, B.E.28
Meyerson, M.29
Kwiatkowski, D.J.30
Castrillon, D.H.31
Bardeesy, N.32
Sharpless, N.E.33
Wong, K.-K.34
more..
-
66
-
-
84908311796
-
Role of PTEN in basal cell derived lung carcinogenesis
-
Malkoski, S. P. et al. Role of PTEN in basal cell derived lung carcinogenesis. Mol. Carcinog. http://dx.doi. org/10.1002/mc.22030 (2013
-
(2013)
Mol. Carcinog
-
-
Malkoski, S.P.1
-
67
-
-
84884558125
-
Unravelling cancer stem cell potential
-
Beck, B. & Blanpain, C. Unravelling cancer stem cell potential. Nature Rev. Cancer 13, 727-738 (2013
-
(2013)
Nature Rev. Cancer
, vol.13
, pp. 727-738
-
-
Beck, B.1
Blanpain, C.2
-
68
-
-
33846239456
-
Beyond tumorigenesis: Cancer stem cells in metastasis
-
DOI 10.1038/sj.cr.7310118, PII 7310118
-
Li, F., Tiede, B., Massague, J. & Kang, Y. Beyond tumorigenesis: Cancer stem cells in metastasis. Cell Res. 17, 3-14 (2007 (Pubitemid 46096419)
-
(2007)
Cell Research
, vol.17
, Issue.1
, pp. 3-14
-
-
Li, F.1
Tiede, B.2
Massague, J.3
Kang, Y.4
-
69
-
-
62549152644
-
Aldehyde dehydrogenase 1 is a tumor stem cell-Associated marker in lung cancer
-
Jiang, F. et al. Aldehyde dehydrogenase 1 is a tumor stem cell-Associated marker in lung cancer. Mol. Cancer Res. 7, 330-338 (2009
-
(2009)
Mol. Cancer Res
, vol.7
, pp. 330-338
-
-
Jiang, F.1
-
70
-
-
84898640056
-
Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis
-
Lau, A. N. et al. Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis. EMBO J. 33, 468-481 (2014
-
(2014)
EMBO J.
, vol.33
, pp. 468-481
-
-
Lau, A.N.1
-
71
-
-
84886743503
-
Lung cancer tumorigenicity and drug resistance are maintained through ALDHhiCD44hi tumor initiating cells
-
Liu, J. et al. Lung cancer tumorigenicity and drug resistance are maintained through ALDHhiCD44hi tumor initiating cells. Oncotarget 4, 1698-1711 (2013
-
(2013)
Oncotarget
, vol.4
, pp. 1698-1711
-
-
Liu, J.1
-
72
-
-
78649960144
-
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on Notch signaling
-
Sullivan, J. P. et al. Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on Notch signaling. Cancer Res. 70, 9937-9948 (2010
-
(2010)
Cancer Res
, vol.70
, pp. 9937-9948
-
-
Sullivan, J.P.1
-
73
-
-
84880023918
-
A rare population of CD24+ITGB4+Notchhi cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal
-
Zheng, Y. et al. A rare population of CD24+ITGB4+Notchhi cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal. Cancer Cell 24, 59-74 (2013
-
(2013)
Cancer Cell
, vol.24
, pp. 59-74
-
-
Zheng, Y.1
-
74
-
-
77957676330
-
Primary tumor genotype is an important determinant in identification of lung cancer propagating cells
-
Curtis, S. J. et al. Primary tumor genotype is an important determinant in identification of lung cancer propagating cells. Cell Stem Cell 7, 127-133 (2010
-
(2010)
Cell Stem Cell
, vol.7
, pp. 127-133
-
-
Curtis, S.J.1
-
75
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
75ra26
-
Sequist, L. V. et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci. Transl. Med. 3, 75ra26 (2011
-
(2011)
Sci. Transl. Med
, vol.3
-
-
Sequist, L.V.1
-
76
-
-
84867912495
-
Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis
-
Song, H. et al. Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis. Proc. Natl Acad. Sci. USA 109, 17531-17536 (2012
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 17531-17536
-
-
Song, H.1
-
77
-
-
80051725013
-
Characterization of the cell of origin for small cell lung cancer
-
Park, K. S. et al. Characterization of the cell of origin for small cell lung cancer. Cell Cycle 10, 2806-2815 (2011
-
(2011)
Cell Cycle
, vol.10
, pp. 2806-2815
-
-
Park, K.S.1
-
78
-
-
79958761641
-
Cell of origin of small cell lung cancer: Inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung
-
Sutherland, K. D. et al. Cell of origin of small cell lung cancer: Inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung. Cancer Cell 19, 754-764 (2011
-
(2011)
Cancer Cell
, vol.19
, pp. 754-764
-
-
Sutherland, K.D.1
-
79
-
-
77956570532
-
Lung cancer cell lines as tools for biomedical discovery and research
-
Gazdar, A. F., Girard, L., Lockwood, W. W., Lam, W. L. & Minna, J. D. Lung cancer cell lines as tools for biomedical discovery and research. J. Natl Cancer Inst. 102, 1310-1321 (2010
-
(2010)
J. Natl Cancer Inst
, vol.102
, pp. 1310-1321
-
-
Gazdar, A.F.1
Girard, L.2
Lockwood, W.W.3
Lam, W.L.4
Minna, J.D.5
-
80
-
-
84858397489
-
Life in the fast lane: Mammalian disease models in the genomics era
-
Dow, L. E. & Lowe, S. W. Life in the fast lane: Mammalian disease models in the genomics era. Cell 148, 1099-1109 (2012
-
(2012)
Cell
, vol.148
, pp. 1099-1109
-
-
Dow, L.E.1
Lowe, S.W.2
-
81
-
-
84868331240
-
Translating genomic information into clinical medicine: Lung cancer as a paradigm
-
Levy, M. A., Lovly, C. M. & Pao, W. Translating genomic information into clinical medicine: Lung cancer as a paradigm. Genome Res. 22, 2101-2108 (2012
-
(2012)
Genome Res
, vol.22
, pp. 2101-2108
-
-
Levy, M.A.1
Lovly, C.M.2
Pao, W.3
-
82
-
-
84888646015
-
Tyrosine kinase gene rearrangements in epithelial malignancies
-
Shaw, A. T., Hsu, P. P., Awad, M. M. & Engelman, J. A. Tyrosine kinase gene rearrangements in epithelial malignancies. Nature Rev. Cancer 13, 772-787 (2013
-
(2013)
Nature Rev. Cancer
, vol.13
, pp. 772-787
-
-
Shaw, A.T.1
Hsu, P.P.2
Awad, M.M.3
Engelman, J.A.4
-
83
-
-
84866934606
-
Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: Updated results from a phase 1 study
-
Camidge, D. R. et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: Updated results from a phase 1 study. Lancet Oncol. 13, 1011-1019 (2012
-
(2012)
Lancet Oncol
, vol.13
, pp. 1011-1019
-
-
Camidge, D.R.1
-
84
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok, T. S. et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N. Engl. J. Med. 361, 947-957 (2009
-
(2009)
N. Engl. J. Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
-
85
-
-
80053386829
-
Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: A retrospective analysis
-
Shaw, A. T. et al. Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: A retrospective analysis. Lancet Oncol. 12, 1004-1012 (2011
-
(2011)
Lancet Oncol
, vol.12
, pp. 1004-1012
-
-
Shaw, A.T.1
-
86
-
-
84904913414
-
Phase i study of BGJ398, a selective pan-FGFR inhibitor in genetically preselected advanced solid tumors
-
Sequist, L. V. et al. Phase I study of BGJ398, a selective pan-FGFR inhibitor in genetically preselected advanced solid tumors. AACR Meet. [Abstr] CT326 (2014
-
(2014)
AACR Meet. [Abstr]
, vol.CT326
-
-
Sequist, L.V.1
-
87
-
-
84856999699
-
Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers
-
120ra17
-
Katayama, R. et al. Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers. Sci. Transl. Med. 4, 120ra17 (2012
-
(2012)
Sci. Transl. Med
, vol.4
-
-
Katayama, R.1
-
88
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
DOI 10.1056/NEJMoa044238
-
Kobayashi, S. et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 352, 786-792 (2005 (Pubitemid 40271173)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.8
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
Janne, P.A.4
Kocher, O.5
Meyerson, M.6
Johnson, B.E.7
Eck, M.J.8
Tenen, D.G.9
Halmos, B.10
-
89
-
-
84896957081
-
Ceritinib in ALK-rearranged non-small-cell lung cancer
-
Shaw, A. T. et al. Ceritinib in ALK-rearranged non-small-cell lung cancer. N. Engl. J. Med. 370, 1189-1197 (2014
-
(2014)
N. Engl. J. Med
, vol.370
, pp. 1189-1197
-
-
Shaw, A.T.1
-
90
-
-
84887977876
-
Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M mediated resistance in NSCLC
-
Walter, A. O. et al. Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M mediated resistance in NSCLC. Cancer Discov. 3, 1404-1415 (2013
-
(2013)
Cancer Discov
, vol.3
, pp. 1404-1415
-
-
Walter, A.O.1
-
91
-
-
84904898065
-
AZD9291, an irreversible EGFR TKI, overcomes T790M mediated resistance to EGFR inhibitors in lung cancer
-
Cross, D. A. et al. AZD9291, an irreversible EGFR TKI, overcomes T790M mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. http://dx.doi. org/10.1158/2159-8290.CD-14-0337 (2014
-
(2014)
Cancer Discov
-
-
Cross, D.A.1
-
92
-
-
80052591747
-
Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab
-
99ra86
-
Yonesaka, K. et al. Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab. Sci. Transl. Med. 3, 99ra86 (2011
-
(2011)
Sci. Transl. Med
, vol.3
-
-
Yonesaka, K.1
-
93
-
-
84864402225
-
Activation of the AXL kinase causes resistance to EGFR-Targeted therapy in lung cancer
-
Zhang, Z. et al. Activation of the AXL kinase causes resistance to EGFR-Targeted therapy in lung cancer. Nature Genet. 44, 852-860 (2012
-
(2012)
Nature Genet
, vol.44
, pp. 852-860
-
-
Zhang, Z.1
-
94
-
-
84868010326
-
Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors
-
Ercan, D. et al. Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors. Cancer Discov. 2, 934-947 (2012
-
(2012)
Cancer Discov
, vol.2
, pp. 934-947
-
-
Ercan, D.1
-
95
-
-
84871992219
-
Mechanisms of resistance to epidermal growth factor receptor inhibitors and novel therapeutic strategies to overcome resistance in NSCLC patients
-
Lin, L. & Bivona, T. G. Mechanisms of resistance to epidermal growth factor receptor inhibitors and novel therapeutic strategies to overcome resistance in NSCLC patients. Chemother. Res. Pract. 2012, 817297 (2012
-
(2012)
Chemother. Res. Pract
, vol.2012
, pp. 817297
-
-
Lin, L.1
Bivona, T.G.2
-
96
-
-
79953046542
-
FAS and NF κb signalling modulate dependence of lung cancers on mutant EGFR
-
Bivona, T. G. et al. FAS and NF κB signalling modulate dependence of lung cancers on mutant EGFR. Nature 471, 523-526 (2011
-
(2011)
Nature
, vol.471
, pp. 523-526
-
-
Bivona, T.G.1
-
97
-
-
84871052080
-
Ezh2 oncogenic activity in castration-resistant prostate cancer cells is polycomb-independent
-
Xu, K. et al. EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent. Science 338, 1465-1469 (2012
-
(2012)
Science
, vol.338
, pp. 1465-1469
-
-
Xu, K.1
-
98
-
-
84862777541
-
A murine lung cancer co clinical trial identifies genetic modifiers of therapeutic response
-
Chen, Z. et al. A murine lung cancer co clinical trial identifies genetic modifiers of therapeutic response. Nature 483, 613-617 (2012
-
(2012)
Nature
, vol.483
, pp. 613-617
-
-
Chen, Z.1
-
99
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
Engelman, J. A. et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nature Med. 14, 1351-1356 (2008
-
(2008)
Nature Med
, vol.14
, pp. 1351-1356
-
-
Engelman, J.A.1
-
100
-
-
84871720411
-
Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: A randomised, multicentre, placebo-controlled, phase 2 study
-
Janne, P. A. et al. Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: A randomised, multicentre, placebo-controlled, phase 2 study. Lancet Oncol. 14, 38-47 (2013
-
(2013)
Lancet Oncol
, vol.14
, pp. 38-47
-
-
Janne, P.A.1
-
101
-
-
84890947640
-
Therapeutic targeting of oncogenic K Ras by a covalent catalytic site inhibitor
-
Lim, S. M. et al. Therapeutic targeting of oncogenic K Ras by a covalent catalytic site inhibitor. Angew. Chem. Int. Ed Engl. 53, 199-204 (2014
-
(2014)
Angew. Chem. Int. Ed Engl
, vol.53
, pp. 199-204
-
-
Lim, S.M.1
-
102
-
-
84888639050
-
K RasG12C inhibitors allosterically control GTP affinity and effector interactions
-
Ostrem, J. M., Peters, U., Sos, M. L., Wells, J. A. & Shokat, K. M. K RasG12C inhibitors allosterically control GTP affinity and effector interactions. Nature 503, 548-551 (2013
-
(2013)
Nature
, vol.503
, pp. 548-551
-
-
Ostrem, J.M.1
Peters, U.2
Sos, M.L.3
Wells, J.A.4
Shokat, K.M.5
-
103
-
-
70350641014
-
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas
-
Bass, A. J. et al. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nature Genet. 41, 1238-1242 (2009
-
(2009)
Nature Genet
, vol.41
, pp. 1238-1242
-
-
Bass, A.J.1
-
104
-
-
79952732654
-
MYC amplification as a prognostic marker of early-stage lung adenocarcinoma identified by whole genome copy number analysis
-
Iwakawa, R. et al. MYC amplification as a prognostic marker of early-stage lung adenocarcinoma identified by whole genome copy number analysis. Clin. Cancer Res. 17, 1481-1489 (2011
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 1481-1489
-
-
Iwakawa, R.1
-
105
-
-
84867021989
-
Transcriptional amplification in tumor cells with elevated c Myc
-
Lin, C. Y. et al. Transcriptional amplification in tumor cells with elevated c Myc. Cell 151, 56-67 (2012
-
(2012)
Cell
, vol.151
, pp. 56-67
-
-
Lin, C.Y.1
-
106
-
-
49649127657
-
Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
-
Engelman, J. A. & Janne, P. A. Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Clin. Cancer Res. 14, 2895-2899 (2008
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 2895-2899
-
-
Engelman, J.A.1
Janne, P.A.2
-
107
-
-
84873129546
-
CTLA 4 blockade in tumor models: An overview of preclinical and translational research
-
Grosso, J. F. & Jure-Kunkel, M. N. CTLA 4 blockade in tumor models: An overview of preclinical and translational research. Cancer Immun. 13, 5 (2013
-
(2013)
Cancer Immun
, vol.13
, pp. 5
-
-
Grosso, J.F.1
Jure-Kunkel, M.N.2
-
108
-
-
84861122295
-
The future is now: Chimeric antigen receptors as new targeted therapies for childhood cancer
-
Lee, D. W., Barrett, D. M., Mackall, C., Orentas, R. & Grupp, S. A. The future is now: Chimeric antigen receptors as new targeted therapies for childhood cancer. Clin. Cancer Res. 18, 2780-2790 (2012
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 2780-2790
-
-
Lee, D.W.1
Barrett, D.M.2
MacKall, C.3
Orentas, R.4
Grupp, S.A.5
-
109
-
-
84879733796
-
Anti CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T cell response
-
Tseng, D. et al. Anti CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T cell response. Proc. Natl Acad. Sci. USA 110, 11103-11108 (2013
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 11103-11108
-
-
Tseng, D.1
-
110
-
-
77955750932
-
CD73: A novel target for cancer immunotherapy
-
Zhang, B. CD73: A novel target for cancer immunotherapy. Cancer Res. 70, 6407-6411 (2010
-
(2010)
Cancer Res
, vol.70
, pp. 6407-6411
-
-
Zhang, B.1
-
111
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
DOI 10.1056/NEJMoa061884
-
Sandler, A. et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N. Engl. J. Med. 355, 2542-2550 (2006 (Pubitemid 44917502)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
Lilenbaum, R.7
Johnson, D.H.8
-
112
-
-
78650385895
-
Active immunotherapy induces antibody responses that target tumor angiogenesis
-
Schoenfeld, J. et al. Active immunotherapy induces antibody responses that target tumor angiogenesis. Cancer Res. 70, 10150-10160 (2010
-
(2010)
Cancer Res
, vol.70
, pp. 10150-10160
-
-
Schoenfeld, J.1
-
113
-
-
84996525854
-
Pretreatment serum VEGF is associated with clinical response and overall survival in advanced melanoma patients treated with ipilimumab
-
Yuan, J. et al. Pretreatment serum VEGF is associated with clinical response and overall survival in advanced melanoma patients treated with ipilimumab. Cancer Immunol. Res. 2, 127-132 (2014
-
(2014)
Cancer Immunol. Res
, vol.2
, pp. 127-132
-
-
Yuan, J.1
-
114
-
-
84893436164
-
Lung stem cell differentiation in mice directed by endothelial cells via a BMP4 NFATc1 thrombospondin 1 axis
-
Lee, J. H. et al. Lung stem cell differentiation in mice directed by endothelial cells via a BMP4 NFATc1 thrombospondin 1 axis. Cell 156, 440-455 (2014
-
(2014)
Cell
, vol.156
, pp. 440-455
-
-
Lee, J.H.1
-
115
-
-
84864285794
-
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
-
Straussman, R. et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature 487, 500-504 (2012
-
(2012)
Nature
, vol.487
, pp. 500-504
-
-
Straussman, R.1
-
116
-
-
78650847770
-
Selective inhibition of BET bromodomains
-
Filippakopoulos, P. et al. Selective inhibition of BET bromodomains. Nature 468, 1067-1073 (2010
-
(2010)
Nature
, vol.468
, pp. 1067-1073
-
-
Filippakopoulos, P.1
-
117
-
-
84888106365
-
Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer
-
Shimamura, T. et al. Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer. Clin. Cancer Res. 19, 6183-6192 (2013
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 6183-6192
-
-
Shimamura, T.1
-
118
-
-
84881508779
-
Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1 mutant lung cancer
-
Liu, Y. et al. Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1 mutant lung cancer. Cancer Discov. 3, 870-879 (2013
-
(2013)
Cancer Discov
, vol.3
, pp. 870-879
-
-
Liu, Y.1
-
119
-
-
84877630250
-
Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer
-
Molina-Arcas, M., Hancock, D. C., Sheridan, C., Kumar, M. S. & Downward, J. Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer. Cancer Discov. 3, 548-563 (2013
-
(2013)
Cancer Discov
, vol.3
, pp. 548-563
-
-
Molina-Arcas, M.1
Hancock, D.C.2
Sheridan, C.3
Kumar, M.S.4
Downward, J.5
-
120
-
-
37249017959
-
Selective inhibition of fatty acid synthase for lung cancer treatment
-
DOI 10.1158/1078-0432.CCR-07-1186
-
Orita, H. et al. Selective inhibition of fatty acid synthase for lung cancer treatment. Clin. Cancer Res. 13, 7139-7145 (2007 (Pubitemid 350276900)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.23
, pp. 7139-7145
-
-
Orita, H.1
Coulter, J.2
Lemmon, C.3
Tully, E.4
Vadlamudi, A.5
Medghalchi, S.M.6
Kuhajda, F.P.7
Gabrielson, E.8
-
121
-
-
84873584845
-
LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin
-
Shackelford, D. B. et al. LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell 23, 143-158 (2013
-
(2013)
Cancer Cell
, vol.23
, pp. 143-158
-
-
Shackelford, D.B.1
-
122
-
-
84885049499
-
The CpG island methylator phenotype: Whats in a name?
-
Hughes, L. A. et al. The CpG island methylator phenotype: Whats in a name?. Cancer Res. 73, 5858-5868 (2013
-
(2013)
Cancer Res
, vol.73
, pp. 5858-5868
-
-
Hughes, L.A.1
-
123
-
-
84876889621
-
What a difference a hydroxyl makes: Mutant IDH (R)-2 hydroxyglutarate and cancer
-
Losman, J. A. & Kaelin, W. G. Jr. What a difference a hydroxyl makes: Mutant IDH, (R)-2 hydroxyglutarate, and cancer. Genes Dev. 27, 836-852 (2013
-
(2013)
Genes Dev
, vol.27
, pp. 836-852
-
-
Losman, J.A.1
Kaelin Jr., W.G.2
-
124
-
-
84865160485
-
Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma
-
Shinjo, K. et al. Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma. Carcinogenesis 33, 1277-1285 (2012
-
(2012)
Carcinogenesis
, vol.33
, pp. 1277-1285
-
-
Shinjo, K.1
-
125
-
-
78649973178
-
Inhibition of ALK PI3K/MEK and HSP90 in murine lung adenocarcinoma induced by EML4 ALK fusion oncogene
-
Chen, Z. et al. Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4 ALK fusion oncogene. Cancer Res. 70, 9827-9836 (2010
-
(2010)
Cancer Res
, vol.70
, pp. 9827-9836
-
-
Chen, Z.1
-
126
-
-
33744788136
-
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies
-
DOI 10.1016/j.ccr.2006.04.022, PII S1535610806001462
-
Ji, H. et al. The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-Targeted therapies. Cancer Cell 9, 485-495 (2006 (Pubitemid 43832191)
-
(2006)
Cancer Cell
, vol.9
, Issue.6
, pp. 485-495
-
-
Ji, H.1
Li, D.2
Chen, L.3
Shimamura, T.4
Kobayashi, S.5
McNamara, K.6
Mahmood, U.7
Mitchell, A.8
Sun, Y.9
Al-Hashem, R.10
Chirieac, L.R.11
Padera, R.12
Bronson, R.T.13
Kim, W.14
Janne, P.A.15
Shapiro, G.I.16
Tenen, D.17
Johnson, B.E.18
Weissleder, R.19
Sharpless, N.E.20
Wong, K.-K.21
more..
-
127
-
-
84895817152
-
Co clinical trials demonstrate superiority of crizotinib to chemotherapy in ALK-rearranged non-small cell lung cancer and predict strategies to overcome resistance
-
Chen, Z. et al. Co clinical trials demonstrate superiority of crizotinib to chemotherapy in ALK-rearranged non-small cell lung cancer and predict strategies to overcome resistance. Clin. Cancer Res. 20, 1204-1211 (2014
-
(2014)
Clin. Cancer Res
, vol.20
, pp. 1204-1211
-
-
Chen, Z.1
-
128
-
-
28544432790
-
The differential effects of mutant p53 alleles on advanced murine lung cancer
-
DOI 10.1158/0008-5472.CAN-05-2193
-
Jackson, E. L. et al. The Differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Res. 65, 10280-10288 (2005 (Pubitemid 41743720)
-
(2005)
Cancer Research
, vol.65
, Issue.22
, pp. 10280-10288
-
-
Jackson, E.L.1
Olive, K.P.2
Tuveson, D.A.3
Bronson, R.4
Crowley, D.5
Brown, M.6
Jacks, T.7
-
129
-
-
77950923924
-
Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer
-
Oliver, T. G. et al. Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes Dev. 24, 837-852 (2010
-
(2010)
Genes Dev
, vol.24
, pp. 837-852
-
-
Oliver, T.G.1
-
130
-
-
79955980366
-
C Raf, but not B Raf, is essential for development of K Ras oncogene-driven non-small cell lung carcinoma
-
Blasco, R. B. et al. c Raf, but not B Raf, is essential for development of K Ras oncogene-driven non-small cell lung carcinoma. Cancer Cell 19, 652-663 (2011
-
(2011)
Cancer Cell
, vol.19
, pp. 652-663
-
-
Blasco, R.B.1
-
131
-
-
77954279920
-
A synthetic lethal interaction between K Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma
-
Puyol, M. et al. A synthetic lethal interaction between K Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell 18, 63-73 (2010
-
(2010)
Cancer Cell
, vol.18
, pp. 63-73
-
-
Puyol, M.1
-
132
-
-
79960623998
-
The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy
-
Savino, M. et al. The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy. PLoS ONE 6, e22284 (2011
-
(2011)
PLoS ONE
, vol.6
-
-
Savino, M.1
-
133
-
-
53349103292
-
Modelling Myc inhibition as a cancer therapy
-
Soucek, L. et al. Modelling Myc inhibition as a cancer therapy. Nature 455, 679-683 (2008
-
(2008)
Nature
, vol.455
, pp. 679-683
-
-
Soucek, L.1
-
134
-
-
84874835799
-
Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice
-
Soucek, L. et al. Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice. Genes Dev. 27, 504-513 (2013
-
(2013)
Genes Dev
, vol.27
, pp. 504-513
-
-
Soucek, L.1
-
135
-
-
84856087055
-
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis
-
Zhang, W. C. et al. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 148, 259-272 (2012
-
(2012)
Cell
, vol.148
, pp. 259-272
-
-
Zhang, W.C.1
-
136
-
-
69149106207
-
Basal cells as stem cells of the mouse trachea and human airway epithelium
-
Rock, J. R. et al. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc. Natl Acad. Sci. USA 106, 12771-12775 (2009
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 12771-12775
-
-
Rock, J.R.1
-
137
-
-
79960858341
-
Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential
-
Hegab, A. E. et al. Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential. Stem Cells 29, 1283-1293 (2011
-
(2011)
Stem Cells
, vol.29
, pp. 1283-1293
-
-
Hegab, A.E.1
-
138
-
-
80054030182
-
Epithelial progenitor cells in lung development, maintenance, repair, and disease
-
Rock, J. R. & Hogan, B. L. M. Epithelial progenitor cells in lung development, maintenance, repair, and disease. Annu. Rev. Cell Dev. Biol. 27, 493-512 (2011
-
(2011)
Annu. Rev. Cell Dev. Biol
, vol.27
, pp. 493-512
-
-
Rock, J.R.1
Hogan, B.L.M.2
-
139
-
-
66049083441
-
The role of Scgb1a1+ Clara cells in the long-Term maintenance and repair of lung airway, but not alveolar, epithelium
-
Rawlins, E. L. et al. The role of Scgb1a1+ Clara cells in the long-Term maintenance and repair of lung airway, but not alveolar, epithelium. Cell Stem Cell 4, 525-534 (2009
-
(2009)
Cell Stem Cell
, vol.4
, pp. 525-534
-
-
Rawlins, E.L.1
-
140
-
-
84886257050
-
Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors
-
Teixeira, V. H. et al. Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors. eLife 2, http://dx.doi.org/ 10.7554/eLife.00966#sthash.XxrCqaIk.dpuf (2013
-
(2013)
Elife
, vol.2
-
-
Teixeira, V.H.1
-
141
-
-
65249098332
-
Prospective isolation of bronchiolar stem cells based upon immunophenotypic and autofluorescence characteristics
-
Teisanu, R. M., Lagasse, E., Whitesides, J. F. & Stripp, B. R. Prospective Isolation of Bronchiolar Stem Cells Based Upon Immunophenotypic and Autofluorescence Characteristics. Stem Cells 27, 612-622 (2009
-
(2009)
Stem Cells
, vol.27
, pp. 612-622
-
-
Teisanu, R.M.1
Lagasse, E.2
Whitesides, J.F.3
Stripp, B.R.4
-
142
-
-
84879640376
-
Type 2 alveolar cells are stem cells in adult lung
-
Barkauskas, C. E. et al. Type 2 alveolar cells are stem cells in adult lung. J. Clin. Invest. 123, 3025-3036 (2013
-
(2013)
J. Clin. Invest
, vol.123
, pp. 3025-3036
-
-
Barkauskas, C.E.1
-
143
-
-
79959946669
-
Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice
-
Chapman, H. A. et al. Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice. J. Clin. Invest. 121, 2855-2862 (2011
-
(2011)
J. Clin. Invest
, vol.121
, pp. 2855-2862
-
-
Chapman, H.A.1
-
144
-
-
84860511591
-
Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia
-
Tropea, K. A. et al. Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. Am. J. Physiol. Lung Cell. Mol. Physiol. 302, L829-L837 (2012
-
(2012)
Am. J. Physiol. Lung Cell. Mol. Physiol
, vol.302
-
-
Tropea, K.A.1
-
145
-
-
80052289137
-
Lung stem cell self-renewal relies on BMI1 dependent control of expression at imprinted loci
-
Zacharek, S. J. et al. Lung stem cell self-renewal relies on BMI1 dependent control of expression at imprinted loci. Cell Stem Cell 9, 272-281 (2010
-
(2010)
Cell Stem Cell
, vol.9
, pp. 272-281
-
-
Zacharek, S.J.1
-
146
-
-
84855511323
-
Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
-
Rock, J. R. et al. Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc. Natl Acad. Sci. USA 108, E1475-E1483 (2011
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
-
-
Rock, J.R.1
-
147
-
-
76549126430
-
Evidence of an epithelial stem/ progenitor cell hierarchy in the adult mouse lung
-
McQualter, J. L., Yuen, K., Williams, B. & Bertoncello, I. Evidence of an epithelial stem/ progenitor cell hierarchy in the adult mouse lung. Proc. Natl Acad. Sci. USA 107, 1414-1419 (2010
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 1414-1419
-
-
McQualter, J.L.1
Yuen, K.2
Williams, B.3
Bertoncello, I.4
-
148
-
-
84875536082
-
Isolation and in vitro characterization of basal and submucosal gland duct stem/progenitor cells from human proximal airways
-
Hegab, A. E. et al. Isolation and in vitro characterization of basal and submucosal gland duct stem/progenitor cells from human proximal airways. Stem Cells Translat. Med. 1, 719-724 (2012
-
(2012)
Stem Cells Translat. Med
, vol.1
, pp. 719-724
-
-
Hegab, A.E.1
-
149
-
-
79955924124
-
Evidence for human lung stem cells
-
Kajstura, J. et al. Evidence for human lung stem cells. New Engl. J. Med. 364, 1795-1806 (2011
-
(2011)
New Engl. J. Med
, vol.364
, pp. 1795-1806
-
-
Kajstura, J.1
-
150
-
-
58849122812
-
Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells
-
Marek, L. et al. Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells. Mol. Pharmacol. 75, 196-207 (2009
-
(2009)
Mol. Pharmacol
, vol.75
, pp. 196-207
-
-
Marek, L.1
-
151
-
-
84882709305
-
Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma
-
Liao, R. G. et al. Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma. Cancer Res. 73, 5195-5205 (2013
-
(2013)
Cancer Res
, vol.73
, pp. 5195-5205
-
-
Liao, R.G.1
-
152
-
-
84863600752
-
Combined EGFR/MET or EGFR/HSP90 inhibition is effective in the treatment of lung cancers codriven by mutant EGFR containing T790M and MET
-
Xu, L. et al. Combined EGFR/MET or EGFR/HSP90 inhibition is effective in the treatment of lung cancers codriven by mutant EGFR containing T790M and MET. Cancer Res. 72, 3302-3311 (2012
-
(2012)
Cancer Res
, vol.72
, pp. 3302-3311
-
-
Xu, L.1
-
153
-
-
84865441368
-
Identifying and targeting ROS1 gene fusions in non-small cell lung cancer
-
Davies, K. D. et al. Identifying and targeting ROS1 gene fusions in non-small cell lung cancer. Clin. Cancer Res. 18, 4570-4579 (2012
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 4570-4579
-
-
Davies, K.D.1
-
154
-
-
84857985225
-
RET ROS1 and ALK fusions in lung cancer
-
Takeuchi, K. et al. RET, ROS1 and ALK fusions in lung cancer. Nature Med. 18, 378-381 (2012
-
(2012)
Nature Med
, vol.18
, pp. 378-381
-
-
Takeuchi, K.1
-
155
-
-
33745727112
-
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
-
Wang, S. E. et al. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell 10, 25-38 (2006
-
(2006)
Cancer Cell
, vol.10
, pp. 25-38
-
-
Wang, S.E.1
-
156
-
-
65949104526
-
Ligand-dependent platelet-derived growth factor receptor (PDGFR)-α activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors
-
McDermott, U. et al. Ligand-dependent platelet-derived growth factor receptor (PDGFR)-α activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors. Cancer Res. 69, 3937-3946 (2009
-
(2009)
Cancer Res
, vol.69
, pp. 3937-3946
-
-
McDermott, U.1
-
157
-
-
0035893252
-
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
-
DOI 10.1101/gad.943001
-
Jackson, E. L. et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K ras. Genes Dev. 15, 3243-3248 (2001 (Pubitemid 34008190)
-
(2001)
Genes and Development
, vol.15
, Issue.24
, pp. 3243-3248
-
-
Jackson, E.L.1
Willis, N.2
Mercer, K.3
Bronson, R.T.4
Crowley, D.5
Montoya, R.6
Jacks, T.7
Tuveson, D.A.8
-
158
-
-
19944430434
-
The role of RAS oncogene in survival of patients with lung cancer: A systematic review of the literature with meta-analysis
-
DOI 10.1038/sj.bjc.6602258
-
Mascaux, C. et al. The role of RAS oncogene in survival of patients with lung cancer: A systematic review of the literature with meta-Analysis. Br. J. Cancer 92, 131-139 (2005 (Pubitemid 40188446)
-
(2005)
British Journal of Cancer
, vol.92
, Issue.1
, pp. 131-139
-
-
Mascaux, C.1
Iannino, N.2
Martin, B.3
Paesmans, M.4
Berghmans, T.5
Dusart, M.6
Haller, A.7
Lothaire, P.8
Meert, A.-P.9
Noel, S.10
Lafitte, J.-J.11
Sculier, J.-P.12
-
159
-
-
80052557069
-
Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors
-
De Raedt, T. et al. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell 20, 400-413 (2011
-
(2011)
Cancer Cell
, vol.20
, pp. 400-413
-
-
De Raedt, T.1
-
160
-
-
79956316170
-
Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations
-
Paik, P. K. et al. Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J. Clin. Oncol. 29, 2046-2051 (2011
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 2046-2051
-
-
Paik, P.K.1
-
161
-
-
33751084640
-
PIK3CA mutation status in Japanese lung cancer patients
-
DOI 10.1016/j.lungcan.2006.07.006, PII S0169500206003576
-
Kawano, O. et al. PIK3CA mutation status in Japanese lung cancer patients. Lung Cancer 54, 209-215 (2006 (Pubitemid 44764916)
-
(2006)
Lung Cancer
, vol.54
, Issue.2
, pp. 209-215
-
-
Kawano, O.1
Sasaki, H.2
Endo, K.3
Suzuki, E.4
Haneda, H.5
Yukiue, H.6
Kobayashi, Y.7
Yano, M.8
Fujii, Y.9
-
162
-
-
48649107410
-
Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma
-
Marks, J. L. et al. Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma. Cancer Res. 68, 5524-5528 (2008
-
(2008)
Cancer Res
, vol.68
, pp. 5524-5528
-
-
Marks, J.L.1
-
163
-
-
84885081283
-
Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53
-
Licciulli, S. et al. Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53. Cancer Res. 73, 5974-5984 (2013
-
(2013)
Cancer Res
, vol.73
, pp. 5974-5984
-
-
Licciulli, S.1
-
164
-
-
76049110053
-
Alterations of the Notch pathway in lung cancer
-
Westhoff, B. et al. Alterations of the Notch pathway in lung cancer. Proc. Natl Acad. Sci. USA 106, 22293-22298 (2009
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 22293-22298
-
-
Westhoff, B.1
-
165
-
-
33847219608
-
Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth
-
Issaeva, I. et al. Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol. Cell. Biol. 27, 1889-1903 (2007
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 1889-1903
-
-
Issaeva, I.1
-
166
-
-
79959267832
-
Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker
-
Takawa, M. et al. Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker. Cancer Sci. 102, 1298-1305 (2011
-
(2011)
Cancer Sci
, vol.102
, pp. 1298-1305
-
-
Takawa, M.1
-
167
-
-
84873411803
-
Tumor development is associated with decrease of TET gene expression and 5 methylcytosine hydroxylation
-
Yang, H. et al. Tumor development is associated with decrease of TET gene expression and 5 methylcytosine hydroxylation. Oncogene 32, 663-669 (2013
-
(2013)
Oncogene
, vol.32
, pp. 663-669
-
-
Yang, H.1
-
168
-
-
81055130253
-
Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression
-
Gao, Q. et al. Deletion of the De novo DNA methyltransferase Dnmt3a promotes lung tumor progression. Proc. Natl Acad. Sci. USA 108, 18061-18066 (2011
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 18061-18066
-
-
Gao, Q.1
-
169
-
-
40449107193
-
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
-
DOI 10.1158/0008-5472.CAN-07-5003
-
Ohta, T. et al. Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res. 68, 1303-1309 (2008 (Pubitemid 351346836)
-
(2008)
Cancer Research
, vol.68
, Issue.5
, pp. 1303-1309
-
-
Ohta, T.1
Iijima, K.2
Miyamoto, M.3
Nakahara, I.4
Tanaka, H.5
Ohtsuji, M.6
Suzuki, T.7
Kobayashi, A.8
Yokota, J.9
Sakiyama, T.10
Shibata, T.11
Yamamoto, M.12
Hirohashi, S.13
-
170
-
-
33750885385
-
Dysfunctional KEAP1 NRF2 interaction in non-small-cell lung cancer
-
Singh, A. et al. Dysfunctional KEAP1 NRF2 interaction in non-small-cell lung cancer. PLoS Med. 3, e420 (2006
-
(2006)
PLoS Med
, vol.3
-
-
Singh, A.1
-
171
-
-
0042090506
-
Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: Differential chemopreventive effect of budesonide in wild-type and mutant A/J mice
-
Wang, Y., Zhang, Z., Kastens, E., Lubet, R. A. & You, M. Mice with alterations in both p53 and Ink4a/ Arf display a striking increase in lung tumor multiplicity and progression: Differential chemopreventive effect of budesonide in wild-Type and mutant A/J mice. Cancer Res. 63, 4389-4395 (2003 (Pubitemid 36951008)
-
(2003)
Cancer Research
, vol.63
, Issue.15
, pp. 4389-4395
-
-
Wang, Y.1
Zhang, Z.2
Kastens, E.3
Lubet, R.A.4
You, M.5
-
172
-
-
84872838573
-
The prognostic value of epigenetic silencing of p16 gene in NSCLC patients: A systematic review and meta-Analysis
-
Lou-Qian, Z. et al. The prognostic value of epigenetic silencing of p16 gene in NSCLC patients: A systematic review and meta-Analysis. PLoS ONE 8, e54970 (2013
-
(2013)
PLoS ONE
, vol.8
-
-
Lou-Qian, Z.1
-
173
-
-
0033765491
-
Prognostic significance of p53 alterations in patients with non-small cell lung cancer: A meta-Analysis
-
Mitsudomi, T., Hamajima, N., Ogawa, M. & Takahashi, T. Prognostic significance of p53 alterations in patients with non-small cell lung cancer: A meta-Analysis. Clin. Cancer Res. 6, 4055-4063 (2000
-
(2000)
Clin. Cancer Res
, vol.6
, pp. 4055-4063
-
-
Mitsudomi, T.1
Hamajima, N.2
Ogawa, M.3
Takahashi, T.4
-
174
-
-
0036645286
-
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
-
Sanchez-Cespedes, M. et al. Inactivation of LKB1/ STK11 is a common event in adenocarcinomas of the lung. Cancer Res. 62, 3659-3662 (2002 (Pubitemid 34728843)
-
(2002)
Cancer Research
, vol.62
, Issue.13
, pp. 3659-3662
-
-
Sanchez-Cespedes, M.1
Parrella, P.2
Esteller, M.3
Nomoto, S.4
Trink, B.5
Engles, J.M.6
Westra, W.H.7
Herman, J.G.8
Sidransky, D.9
-
175
-
-
39449134253
-
Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer
-
DOI 10.1158/0008-5472.CAN-07-3117
-
Iwanaga, K. et al. Pten inactivation accelerates oncogenic K ras-initiated tumorigenesis in a mouse model of lung cancer. Cancer Res. 68, 1119-1127 (2008 (Pubitemid 351272230)
-
(2008)
Cancer Research
, vol.68
, Issue.4
, pp. 1119-1127
-
-
Iwanaga, K.1
Yang, Y.2
Raso, M.G.3
Ma, L.4
Hanna, A.E.5
Thilaganathan, N.6
Moghaddam, S.7
Evans, C.M.8
Li, H.9
Cai, W.-W.10
Sato, M.11
Minna, J.D.12
Wu, H.13
Creighton, C.J.14
Demayo, F.J.15
Wistuba, I.I.16
Kurie, J.M.17
-
176
-
-
0036094196
-
Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation
-
Soria, J. C. et al. Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation. Clin. Cancer Res. 8, 1178-1184 (2002
-
(2002)
Clin. Cancer Res
, vol.8
, pp. 1178-1184
-
-
Soria, J.C.1
|