Multiple cells-of-origin of mutant K-Ras-induced mouse lung adenocarcinoma

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 13, 2014, Pages 4952-4957

  Sutherland, Kate D ^a,d   Song, Ji Ying ^b   Kwon, Min Chul ^a   Proost, Natalie ^a   Zevenhoven, John ^a   Berns, Anton ^a,c  

^a Department of Molecular Genetics   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c SKOLKOVO INSTITUTE OF SCIENCE AND TECHNOLOGY   (Russian Federation)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

BASCs; Bronchioalveolar stem cells; Non small cell lung cancer; NSCLC

Indexed keywords

ADENOVIRUS VECTOR; CRE RECOMBINASE; K RAS PROTEIN; MUTANT PROTEIN; PROTEIN P53; SURFACTANT PROTEIN C;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL EXPANSION; CLARA CELL; CONTROLLED STUDY; EPITHELIUM CELL; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG ALVEOLUS CELL TYPE 2; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SUPPRESSOR GENE;

BASCS; BRONCHIOALVEOLAR STEM CELLS; NON SMALL CELL LUNG CANCER; NSCLC;

ADENOCARCINOMA; ADENOVIRIDAE; ANIMALS; CELL PROLIFERATION; CLONE CELLS; DISEASE PROGRESSION; GENETIC VECTORS; IMMUNOHISTOCHEMISTRY; INTEGRASES; LUNG NEOPLASMS; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MUTANT PROTEINS; MUTATION; PRECANCEROUS CONDITIONS; PROTO-ONCOGENE PROTEINS P21(RAS); RECOMBINATION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; UTEROGLOBIN;

EID: 84897563108     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1319963111     Document Type: Article

References (20)

1. Mao C, et al. (2010) KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: A meta-analysis of 22 studies. Lung Cancer 69(3): 272-278.
2. Giangreco A, Reynolds SD, Stripp BR (2002) Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. Am J Pathol 161(1):173-182.
3. Dovey JS, Zacharek SJ, Kim CF, Lees JA (2008) Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion. Procatl Acad Sci USA 105(33):11857-11862.
4. Kim CF, et al. (2005) Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121(6):823-835.
5. Ventura JJ, et al. (2007) p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation Nat Genet 39(6):750-758.
6. Yang Y, et al. (2008) Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer. PLoS ONE 3(5):e2220.
7. Besson A, et al. (2007) Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev 21(14):1731-1746.
8. Ynagi S, et al. (2007) Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest 117(10):2929-2940.
9. Jackson EL, et al. (2001) Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev 15(24):3243-3248.
10. Xu X, et al. (2012) Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. Procatl Acad Sci USA 109(13):4910-4915.
11. Berquam-Vrieze KE, et al. (2011) Cell of origin strongly influences genetic selection in a mouse model of T-ALL. Blood 118(17):4646-4656.
12. Jackson EL, et al. (2005) The differential effects of mutant p53 alleles on advanced murine lung cancer. Cancer Res 65(22):10280-10288.
13. Sutherland KD, et al. (2011) Cell of origin of small cell lung cancer: Inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung. Cancer Cell 19(6):754-764.
14. Jonkers J, et al. (2001) Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer Nat Genet 29(4):418-425.
15. Visvader JE (2011) Cells of origin in cancer.Nature 469(7330):314-322.
16. Winslow MM, et al. (2011) Suppression of lung adenocarcinoma progression bykx2-1. NNature 473(7345):101-104.
17. Snippert HJ, et al. (2010) Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell 143(1):134-144.
18. Guerra C, et al. (2003) Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell 4(2):111-120.
19. Rawlins EL, et al. (2009) The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell Stem Cell 4(6): 525-534.
20. Yin L, et al. (2013) Spatiotemporal quantification of cell dynamics in the lung following influenza virus infection. J Biomed Opt 18(4):046001.