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Volumn 8, Issue 1, 2013, Pages

The Prognostic Value of Epigenetic Silencing of p16 Gene in NSCLC Patients: A Systematic Review and Meta-Analysis

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P16;

EID: 84872838573     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054970     Document Type: Article
Times cited : (52)

References (49)
  • 1
    • 79952232216 scopus 로고    scopus 로고
    • Global cancer statistics
    • Center MM, Ferlay J, Ward E, et al
    • Jemal A, Bray F, (2011) Center MM, Ferlay J, Ward E, et al (2011) Global cancer statistics. CA Cancer J Clin 61: 69-90.
    • (2011) CA Cancer J Clin , vol.61 , pp. 69-90
    • Jemal, A.1    Bray, F.2
  • 2
    • 84860462123 scopus 로고    scopus 로고
    • Clinical potential of DNA methylation in gastric cancer: a meta-analysis
    • Sapari NS, Loh M, Vaithilingam A, Soong R, (2012) Clinical potential of DNA methylation in gastric cancer: a meta-analysis. PLoS One 7: e36275.
    • (2012) PLoS One , vol.7
    • Sapari, N.S.1    Loh, M.2    Vaithilingam, A.3    Soong, R.4
  • 3
    • 83255181725 scopus 로고    scopus 로고
    • Cigarette smoking and p16INK4alpha gene promoter hypermethylation in non-small cell lung carcinoma patients: a meta-analysis
    • Zhang B, Zhu W, Yang P, Liu T, Jiang M, et al. (2011) Cigarette smoking and p16INK4alpha gene promoter hypermethylation in non-small cell lung carcinoma patients: a meta-analysis. PLoS One 6: e28882.
    • (2011) PLoS One , vol.6
    • Zhang, B.1    Zhu, W.2    Yang, P.3    Liu, T.4    Jiang, M.5
  • 4
    • 80054111424 scopus 로고    scopus 로고
    • DNA methylation and nonsmall cell lung cancer
    • Lu F, Zhang HT, (2011) DNA methylation and nonsmall cell lung cancer. Anat Rec (Hoboken) 294: 1787-1795.
    • (2011) Anat Rec (Hoboken) , vol.294 , pp. 1787-1795
    • Lu, F.1    Zhang, H.T.2
  • 5
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M, Hannon GJ, Beach D, (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366: 704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 6
    • 0142258073 scopus 로고    scopus 로고
    • The tumor-suppressive functions of the human INK4A locus
    • Voorhoeve PM, Agami R, (2003) The tumor-suppressive functions of the human INK4A locus. Cancer Cell 4: 311-319.
    • (2003) Cancer Cell , vol.4 , pp. 311-319
    • Voorhoeve, P.M.1    Agami, R.2
  • 7
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, et al. (1995) 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1: 686-692.
    • (1995) Nat Med , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5
  • 8
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M, (2008) Epigenetics in cancer. N Engl J Med 358: 1148-1159.
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 9
    • 84859546456 scopus 로고    scopus 로고
    • Quantitative analysis of multiple gene promoter methylation in Korean non-small cell lung cancer patients and its association study with cancer risk factor and survival
    • Kang HJ, Kim EJ, Lee KM, Roh MS, Kwak JY, et al. (2012) Quantitative analysis of multiple gene promoter methylation in Korean non-small cell lung cancer patients and its association study with cancer risk factor and survival. Molecular and Cellular Toxicology 8: 25-34.
    • (2012) Molecular and Cellular Toxicology , vol.8 , pp. 25-34
    • Kang, H.J.1    Kim, E.J.2    Lee, K.M.3    Roh, M.S.4    Kwak, J.Y.5
  • 10
    • 80052960976 scopus 로고    scopus 로고
    • A comprehensive analysis of p16 expression, gene status, and promoter hypermethylation in surgically resected non-small cell lung carcinomas
    • Sterlacci W, Tzankov A, Veits L, Zelger B, Bihl MP, et al. (2011) A comprehensive analysis of p16 expression, gene status, and promoter hypermethylation in surgically resected non-small cell lung carcinomas. Journal of Thoracic Oncology 6: 1649-1657.
    • (2011) Journal of Thoracic Oncology , vol.6 , pp. 1649-1657
    • Sterlacci, W.1    Tzankov, A.2    Veits, L.3    Zelger, B.4    Bihl, M.P.5
  • 11
    • 77955723898 scopus 로고    scopus 로고
    • Methylation of the DLEC1 gene correlates with poor prognosis in Japanese lung cancer patients
    • Sasaki H, Hikosaka Y, Kawan O, Moiyama S, Yan M, et al. (2010) Methylation of the DLEC1 gene correlates with poor prognosis in Japanese lung cancer patients. Oncology Letters 1: 283-287.
    • (2010) Oncology Letters , vol.1 , pp. 283-287
    • Sasaki, H.1    Hikosaka, Y.2    Kawan, O.3    Moiyama, S.4    Yan, M.5
  • 12
    • 77449124527 scopus 로고    scopus 로고
    • PTEN, RASSF1 and DAPK site-specific hypermethylation and outcome in surgically treated stage I and II nonsmall cell lung cancer patients
    • Buckingham L, Penfield Faber L, Kim A, Liptay M, Barger C, et al. (2010) PTEN, RASSF1 and DAPK site-specific hypermethylation and outcome in surgically treated stage I and II nonsmall cell lung cancer patients. Int J Cancer 126: 1630-1639.
    • (2010) Int J Cancer , vol.126 , pp. 1630-1639
    • Buckingham, L.1    Penfield Faber, L.2    Kim, A.3    Liptay, M.4    Barger, C.5
  • 13
    • 70449592216 scopus 로고    scopus 로고
    • Promoter hypermethylation of the p16 and Wif-1 genes as an independent prognostic marker in stage IA non-small cell lung cancers
    • Yoshino M, Suzuki M, Tian L, Moriya Y, Hoshino H, et al. (2009) Promoter hypermethylation of the p16 and Wif-1 genes as an independent prognostic marker in stage IA non-small cell lung cancers. International Journal of Oncology 35: 1201-1209.
    • (2009) International Journal of Oncology , vol.35 , pp. 1201-1209
    • Yoshino, M.1    Suzuki, M.2    Tian, L.3    Moriya, Y.4    Hoshino, H.5
  • 14
    • 33847704518 scopus 로고    scopus 로고
    • Prognostic significance of RASSF1A promoter methylation on survival of non-small cell lung cancer patients treated with gemcitabine
    • Fischer JR, Ohnmacht U, Rieger N, Zemaitis M, Stoffregen C, et al. (2007) Prognostic significance of RASSF1A promoter methylation on survival of non-small cell lung cancer patients treated with gemcitabine. Lung Cancer 56: 115-123.
    • (2007) Lung Cancer , vol.56 , pp. 115-123
    • Fischer, J.R.1    Ohnmacht, U.2    Rieger, N.3    Zemaitis, M.4    Stoffregen, C.5
  • 15
    • 33750724417 scopus 로고    scopus 로고
    • Prognostic significance of p16INK4a hypermethylation in non-small cell lung cancer is evident by quantitative DNA methylation analysis
    • Ota N, Kawakami K, Okuda T, Takehara A, Hiranuma C, et al. (2006) Prognostic significance of p16INK4a hypermethylation in non-small cell lung cancer is evident by quantitative DNA methylation analysis. Anticancer Research 26: 3729-3732.
    • (2006) Anticancer Research , vol.26 , pp. 3729-3732
    • Ota, N.1    Kawakami, K.2    Okuda, T.3    Takehara, A.4    Hiranuma, C.5
  • 16
    • 85058200933 scopus 로고    scopus 로고
    • Prognostic implication of aberrant promoter hypermethylation of CpG islands in adenocarcinoma of the lung
    • Kim YT, Park SJ, Lee SH, Kang HJ, Hahn S, et al. (2005) Prognostic implication of aberrant promoter hypermethylation of CpG islands in adenocarcinoma of the lung. J Thorac Cardiovasc Surg 130: 1378.
    • (2005) J Thorac Cardiovasc Surg , vol.130 , pp. 1378
    • Kim, Y.T.1    Park, S.J.2    Lee, S.H.3    Kang, H.J.4    Hahn, S.5
  • 18
    • 16544395214 scopus 로고    scopus 로고
    • Value of p16INK4a and RASSF1A promoter hypermethylation in prognosis of patients with resectable non-small cell lung cancer
    • Wang J, Lee JJ, Wang L, Liu DD, Lu C, et al. (2004) Value of p16INK4a and RASSF1A promoter hypermethylation in prognosis of patients with resectable non-small cell lung cancer. Clinical Cancer Research 10: 6119-6125.
    • (2004) Clinical Cancer Research , vol.10 , pp. 6119-6125
    • Wang, J.1    Lee, J.J.2    Wang, L.3    Liu, D.D.4    Lu, C.5
  • 19
    • 1642400575 scopus 로고    scopus 로고
    • Hypermethylation of FHIT as a Prognostic Marker in Nonsmall Cell Lung Carcinoma
    • Maruyama R, Sugio K, Yoshino I, Maehara Y, Gazdar AF, (2004) Hypermethylation of FHIT as a Prognostic Marker in Nonsmall Cell Lung Carcinoma. Cancer 100: 1472-1477.
    • (2004) Cancer , vol.100 , pp. 1472-1477
    • Maruyama, R.1    Sugio, K.2    Yoshino, I.3    Maehara, Y.4    Gazdar, A.F.5
  • 20
  • 21
    • 0035132145 scopus 로고    scopus 로고
    • Aberrant promoter methylation of multiple genes in non-small cell lung cancers
    • Zochbauer-Muller S, Fong KM, Virmani AK, Geradts J, Gazdar AF, et al. (2001) Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res 61: 249-255.
    • (2001) Cancer Res , vol.61 , pp. 249-255
    • Zochbauer-Muller, S.1    Fong, K.M.2    Virmani, A.K.3    Geradts, J.4    Gazdar, A.F.5
  • 22
    • 0035870282 scopus 로고    scopus 로고
    • p16INK4a and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer
    • Kim DH, Nelson HH, Wiencke JK, Zheng S, Christiani DC, et al. (2001) p16INK4a and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer. Cancer Research 61: 3419-3424.
    • (2001) Cancer Research , vol.61 , pp. 3419-3424
    • Kim, D.H.1    Nelson, H.H.2    Wiencke, J.K.3    Zheng, S.4    Christiani, D.C.5
  • 23
    • 34547450763 scopus 로고    scopus 로고
    • Practical methods for incorporating summary time-to-event data into meta-analysis
    • Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR, (2007) Practical methods for incorporating summary time-to-event data into meta-analysis. Trials 8: 16.
    • (2007) Trials , vol.8 , pp. 16
    • Tierney, J.F.1    Stewart, L.A.2    Ghersi, D.3    Burdett, S.4    Sydes, M.R.5
  • 24
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • Higgins JP, Thompson SG, (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21: 1539-1558.
    • (2002) Stat Med , vol.21 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 26
    • 84959801619 scopus 로고
    • Statistical aspects of the analysis of data from retrospective studies of disease
    • Mantel N, Haenszel W, (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22: 719-748.
    • (1959) J Natl Cancer Inst , vol.22 , pp. 719-748
    • Mantel, N.1    Haenszel, W.2
  • 27
    • 0030693603 scopus 로고    scopus 로고
    • Quantitative synthesis in systematic reviews
    • Lau J, Ioannidis JP, Schmid CH, (1997) Quantitative synthesis in systematic reviews. Ann Intern Med 127: 820-826.
    • (1997) Ann Intern Med , vol.127 , pp. 820-826
    • Lau, J.1    Ioannidis, J.P.2    Schmid, C.H.3
  • 28
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M, Minder C, (1997) Bias in meta-analysis detected by a simple, graphical test. Bmj 315: 629-634.
    • (1997) Bmj , vol.315 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 29
    • 4344596649 scopus 로고    scopus 로고
    • The relationship between aberrant methylation and survival in non-small-cell lung cancers
    • Toyooka S, Suzuki M, Maruyama R, Toyooka KO, Tsukuda K, et al. (2004) The relationship between aberrant methylation and survival in non-small-cell lung cancers. British Journal of Cancer 91: 771-774.
    • (2004) British Journal of Cancer , vol.91 , pp. 771-774
    • Toyooka, S.1    Suzuki, M.2    Maruyama, R.3    Toyooka, K.O.4    Tsukuda, K.5
  • 30
    • 15944374764 scopus 로고    scopus 로고
    • Can aberrant promoter hypermethylation of CpG islands predict the clinical outcome of non-small cell lung cancer after curative resection?
    • Kim YT, Lee SH, Sung SW, Kim JH, (2005) Can aberrant promoter hypermethylation of CpG islands predict the clinical outcome of non-small cell lung cancer after curative resection? Annals of Thoracic Surgery 79: 1180-1188.
    • (2005) Annals of Thoracic Surgery , vol.79 , pp. 1180-1188
    • Kim, Y.T.1    Lee, S.H.2    Sung, S.W.3    Kim, J.H.4
  • 31
    • 20444443120 scopus 로고    scopus 로고
    • Methylation profiling of archived non-small cell lung cancer: a promising prognostic system
    • Safar AM, Spencer H, 3rd, Su X, Coffey M, Cooney CA, et al (2005) Methylation profiling of archived non-small cell lung cancer: a promising prognostic system. Clin Cancer Res 11: 4400-4405.
    • (2005) Clin Cancer Res , vol.11 , pp. 4400-4405
    • Safar, A.M.1    Spencer 3rd, H.2    Su, X.3    Coffey, M.4    Cooney, C.A.5
  • 32
    • 12744280715 scopus 로고    scopus 로고
    • Loss of function of p16 gene and prognosis of pulmonary adenocarcinoma
    • Tanaka R, Wang D, Morishita Y, Inadome Y, Minami Y, et al. (2005) Loss of function of p16 gene and prognosis of pulmonary adenocarcinoma. Cancer 103: 608-615.
    • (2005) Cancer , vol.103 , pp. 608-615
    • Tanaka, R.1    Wang, D.2    Morishita, Y.3    Inadome, Y.4    Minami, Y.5
  • 33
    • 33846187641 scopus 로고    scopus 로고
    • Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer
    • Gu J, Berman D, Lu C, Wistuba II, Roth JA, et al. (2006) Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer. Clinical Cancer Research 12: 7329-7338.
    • (2006) Clinical Cancer Research , vol.12 , pp. 7329-7338
    • Gu, J.1    Berman, D.2    Lu, C.3    Wistuba, I.I.4    Roth, J.A.5
  • 34
    • 33646343483 scopus 로고    scopus 로고
    • The methylation status and protein expression of CDH1, p16INK4A, and fragile histidine triad in nonsmall cell lung carcinoma: Epigenetic silencing, clinical features, and prognostic significance
    • Sugio K, (2006) The methylation status and protein expression of CDH1, p16INK4A, and fragile histidine triad in nonsmall cell lung carcinoma: Epigenetic silencing, clinical features, and prognostic significance. Cancer 106: 2190-2199.
    • (2006) Cancer , vol.106 , pp. 2190-2199
    • Sugio, K.1
  • 35
    • 34548513807 scopus 로고    scopus 로고
    • Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers
    • Yanagawa N, Tamura G, Oizumi H, Kanauchi N, Endoh M, et al. (2007) Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers. Lung Cancer 58: 131-138.
    • (2007) Lung Cancer , vol.58 , pp. 131-138
    • Yanagawa, N.1    Tamura, G.2    Oizumi, H.3    Kanauchi, N.4    Endoh, M.5
  • 36
    • 40849124009 scopus 로고    scopus 로고
    • DNA methylation markers and early recurrence in stage I lung cancer
    • Brock MV, Hooker CM, Ota-Machida E, Han Y, Guo M, et al. (2008) DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med 358: 1118-1128.
    • (2008) N Engl J Med , vol.358 , pp. 1118-1128
    • Brock, M.V.1    Hooker, C.M.2    Ota-Machida, E.3    Han, Y.4    Guo, M.5
  • 37
    • 64549101212 scopus 로고    scopus 로고
    • Prostaglandin E2 receptor 2 overexpression in squamous cell carcinoma of the lung correlates with p16INK4A methylation and an unfavorable prognosis
    • Alaa M, Suzuki M, Yoshino M, Tian L, Suzuki H, et al. (2009) Prostaglandin E2 receptor 2 overexpression in squamous cell carcinoma of the lung correlates with p16INK4A methylation and an unfavorable prognosis. International Journal of Oncology 34: 805-812.
    • (2009) International Journal of Oncology , vol.34 , pp. 805-812
    • Alaa, M.1    Suzuki, M.2    Yoshino, M.3    Tian, L.4    Suzuki, H.5
  • 38
    • 33646230046 scopus 로고    scopus 로고
    • Cohypermethylation of p16 and FHIT promoters as a prognostic factor of recurrence in surgically resected stage I non-small cell lung cancer
    • Kim JS, Kim JW, Han J, Shim YM, Park J, et al. (2006) Cohypermethylation of p16 and FHIT promoters as a prognostic factor of recurrence in surgically resected stage I non-small cell lung cancer. Cancer Res 66: 4049-4054.
    • (2006) Cancer Res , vol.66 , pp. 4049-4054
    • Kim, J.S.1    Kim, J.W.2    Han, J.3    Shim, Y.M.4    Park, J.5
  • 39
    • 84885869597 scopus 로고    scopus 로고
    • Age-related CDKN2A (p16) promoter methylation and outcome in surgically treated stage I-II non-small cell lung cancer patients
    • Bradly DP, Buckingham L, Coon J, Liptay M, Bonomi P, et al. (2010) Age-related CDKN2A (p16) promoter methylation and outcome in surgically treated stage I-II non-small cell lung cancer patients. Laboratory Investigation 90: 399A.
    • (2010) Laboratory Investigation , vol.90
    • Bradly, D.P.1    Buckingham, L.2    Coon, J.3    Liptay, M.4    Bonomi, P.5
  • 40
    • 15044346933 scopus 로고    scopus 로고
    • Hypermethylation of E-cadherin gene is frequent and independent of p16INK4A methylation in non-small cell lung cancer: potential prognostic implication
    • Shimamoto T, Ohyashiki JH, Hirano T, Kato H, Ohyashiki K, (2004) Hypermethylation of E-cadherin gene is frequent and independent of p16INK4A methylation in non-small cell lung cancer: potential prognostic implication. Oncol Rep 12: 389-395.
    • (2004) Oncol Rep , vol.12 , pp. 389-395
    • Shimamoto, T.1    Ohyashiki, J.H.2    Hirano, T.3    Kato, H.4    Ohyashiki, K.5
  • 41
    • 21244438390 scopus 로고    scopus 로고
    • Abnormality of p16 gene and its clinicopathological significance in non-small cell lung cancer
    • Fu J, Zhang J, Zhang HW, (2003) Abnormality of p16 gene and its clinicopathological significance in non-small cell lung cancer. Zhonghua bing li xue za zhi Chinese journal of pathology 32: 133-136.
    • (2003) Zhonghua Bing Li Xue Za Zhi Chinese Journal of Pathology , vol.32 , pp. 133-136
    • Fu, J.1    Zhang, J.2    Zhang, H.W.3
  • 44
    • 32044438696 scopus 로고    scopus 로고
    • Aberrant DNA methylation of E-cadherin and p16 genes in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine
    • Kato A, Shimizu K, Shimoichi Y, Fujii H, Honoki K, et al. (2006) Aberrant DNA methylation of E-cadherin and p16 genes in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine. Mol Carcinog 45: 106-111.
    • (2006) Mol Carcinog , vol.45 , pp. 106-111
    • Kato, A.1    Shimizu, K.2    Shimoichi, Y.3    Fujii, H.4    Honoki, K.5
  • 45
    • 0347357849 scopus 로고    scopus 로고
    • Expression of the p16INK4a gene and methylation pattern of CpG sites in the promoter region in rat tumor cell lines
    • Honoki K, Tsujiuchi T, Mori T, Yoshitani K, Tsutsumi M, et al. (2004) Expression of the p16INK4a gene and methylation pattern of CpG sites in the promoter region in rat tumor cell lines. Mol Carcinog 39: 10-14.
    • (2004) Mol Carcinog , vol.39 , pp. 10-14
    • Honoki, K.1    Tsujiuchi, T.2    Mori, T.3    Yoshitani, K.4    Tsutsumi, M.5
  • 46
    • 0033851603 scopus 로고    scopus 로고
    • Hypermethylation of the p16 (Ink4a) promoter in B6C3F1 mouse primary lung adenocarcinomas and mouse lung cell lines
    • Patel AC, Anna CH, Foley JF, Stockton PS, Tyson FL, et al. (2000) Hypermethylation of the p16 (Ink4a) promoter in B6C3F1 mouse primary lung adenocarcinomas and mouse lung cell lines. Carcinogenesis 21: 1691-1700.
    • (2000) Carcinogenesis , vol.21 , pp. 1691-1700
    • Patel, A.C.1    Anna, C.H.2    Foley, J.F.3    Stockton, P.S.4    Tyson, F.L.5
  • 47
    • 0037068312 scopus 로고    scopus 로고
    • CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future
    • Esteller M, (2002) CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene 21: 5427-5440.
    • (2002) Oncogene , vol.21 , pp. 5427-5440
    • Esteller, M.1
  • 49
    • 0027478423 scopus 로고
    • Meta-analysis of the literature or of individual patient data: is there a difference?
    • Stewart LA, Parmar MK, (1993) Meta-analysis of the literature or of individual patient data: is there a difference? Lancet 341: 418-422.
    • (1993) Lancet , vol.341 , pp. 418-422
    • Stewart, L.A.1    Parmar, M.K.2


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