Walking through trabecular meshwork biology: Toward engineering design of outflow physiology

Biotechnology Advances

Volumn 32, Issue 5, 2014, Pages 971-983

  Dautriche, Cula N ^a   Xie, Yubing ^a   Sharfstein, Susan T ^a  

^a SUNY POLYTECHNIC INSTITUTE   (United States)

Author keywords

Extracellular matrix; Glaucoma; Hydrogel; Intraocular pressure; Outflow; Tissue engineering; Trabecular meshwork

Indexed keywords

ANIMALS; BIOLOGICAL MATERIALS; EYE PROTECTION; HYDROGELS; OPHTHALMOLOGY; TISSUE ENGINEERING;

EXTRACELLULAR MATRICES; GLAUCOMA; INTRA OCULAR PRESSURE; OUTFLOW; TRABECULAR MESHWORKS;

SCAFFOLDS (BIOLOGY);

ANIMALIA;

ANIMAL; DISEASE MODEL; GLAUCOMA; HUMAN; NANOTECHNOLOGY; PATHOLOGY; PHYSIOLOGY; PROCEDURES; TISSUE ENGINEERING; TRABECULAR MESHWORK; ULTRASTRUCTURE;

ANIMALS; DISEASE MODELS, ANIMAL; GLAUCOMA; HUMANS; NANOTECHNOLOGY; TISSUE ENGINEERING; TRABECULAR MESHWORK;

EID: 84904753443     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2014.04.012     Document Type: Review

References (175)

1. Acott T.S., Kelley M.J. Extracellular matrix in the trabecular meshwork. Exp Eye Res 2008, 86:543-561.
2. Acott T.S., Samples J.R., Bradley J.M., Bacon D.R., Bylsma S.S., Van Buskirk E.M. Trabecular repopulation by anterior trabecular meshwork cells after laser trabeculoplasty. Am J Ophthalmol 1989, 107:1-6.
3. Allen D.D., Caviedes R., Cárdenas A.M., Shimahara T., Segura-Aguilar J., Caviedes P.A. Cell lines as in vitro models for drug screening and toxicity studies. Drug Dev Ind Pharm 2005, 31:757-768.
4. Allingham R.R., Liu Y., Rhee D.J. The genetics of primary open-angle glaucoma: a review. Exp Eye Res 2009, 88:837-844.
5. Alvarado J.A., Wood I., Polansky J.R. Human trabecular cells. II. Growth pattern and ultrastructural characteristics. Invest Ophthalmol Vis Sci 1982, 23:464-478.
6. Alvarado J.A., Murphy C.G., Franse-Carman L., Chen J., Underwood J.L. Effect of beta-adrenergic agonists on paracellular width and fluid flow across outflow pathway cells. Invest Ophthalmol Vis Sci 1998, 39:1813-1822.
7. Alvarado J.A., Yeh R.F., Franse-Carman L., Marcellino G., Brownstein M.J. Interactions between endothelia of the trabecular meshwork and of Schlemm's canal: a new insight into the regulation of aqueous outflow in the eye. Trans Am Ophthalmol Soc 2005, 103:148-162. [discussion 62-3].
8. Atala A., Kasper F.K., Mikos A.G. Engineering complex tissues. Sci Transl Med 2012, 4:160rv12.
9. Baker B.M., Chen C.S. Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues. J Cell Sci 2012, 125:3015-3024.
10. Barany E.H. In vitro studies of the resistance to flow through the angle of the anterior chamber. Acta Soc Med Ups 1954, 59:260-276.
11. Barany E.H., Scotchbrook S. Influence of testicular hyaluronidase on the resistance to flow through the angle of the anterior chamber. Acta Physiol Scand 1954, 30:240-248.
12. Betancourt T., Brannon-Peppas L. Micro- and nanofabrication methods in nanotechnological medical and pharmaceutical devices. Int J Nanomedicine 2006, 1:483-495.
13. Bianco P., Robey P.G. Stem cells in tissue engineering. Nature 2001, 414:118-121.
14. Bill A. Some aspects of aqueous humour drainage. Eye (Lond) 1993, 7(Pt 1):14-19.
15. Boland E.D., Matthews J.A., Pawlowski K.J., Simpson D.G., Wnek G.E., Bowlin G.L. Electrospinning collagen and elastin: preliminary vascular tissue engineering. Front Biosci 2004, 9:1422-1432.
16. Borras T. Gene expression in the trabecular meshwork and the influence of intraocular pressure. Prog Retin Eye Res 2003, 22:435-463.
17. Bouhenni R.A., Dunmire J., Sewell A., Edward D.P. Animal models of glaucoma. J Biomed Biotechnol 2012, 2012:692609.
18. Bradley J.M., Vranka J., Colvis C.M., Conger D.M., Alexander J.P., Fisk A.S., et al. Effect of matrix metalloproteinases activity on outflow in perfused human organ culture. Invest Ophthalmol Vis Sci 1998, 39:2649-2658.
19. Brahatheeswaran Dhandayuthapani Y.Y., Maekawa Toru, Sakthi Kumar D. Polymeric scaffolds in tissue engineering application: a review. Int J Polym Sci 2011, 2011.
20. Caballero M., Liton P.B., Epstein D.L., Gonzalez P. Proteasome inhibition by chronic oxidative stress in human trabecular meshwork cells. Biochem Biophys Res Commun 2003, 308:346-352.
21. Chen G., Sato T., Ushida T., Ochiai N., Tateishi T. Tissue engineering of cartilage using a hybrid scaffold of synthetic polymer and collagen. Tissue Eng 2004, 10:323-330.
22. Chi Z.L., Akahori M., Obazawa M., Minami M., Noda T., Nakaya N., et al. Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice. Hum Mol Genet 2010, 19:2606-2615.
23. Chrysostomou V., Rezania F., Trounce I.A., Crowston J.G. Oxidative stress and mitochondrial dysfunction in glaucoma. Curr Opin Pharmacol 2013, 13:12-15.
24. Chung I.M., Enemchukwu N.O., Khaja S.D., Murthy N., Mantalaris A., Garcia A.J. Bioadhesive hydrogel microenvironments to modulate epithelial morphogenesis. Biomaterials 2008, 29:2637-2645.
25. Cukierman E., Pankov R., Stevens D.R., Yamada K.M. Taking cell-matrix adhesions to the third dimension. Science 2001, 294:1708-1712.
26. Dahlin R.L., Kasper F.K., Mikos A.G. Polymeric nanofibers in tissue engineering. Tissue Eng Part B Rev 2011, 17:349-364.
27. Dai W., Li M. Experimental study of growth of trabecular cells on the filters and hydraulic conductivity. Chin Med J (Engl) 1999, 112:207-210.
28. Demetriades A.M. Gene therapy for glaucoma. Curr Opin Ophthalmol 2011, 22:73-77.
29. DeVolder R., Kong H.J. Hydrogels for in vivo-like three-dimensional cellular studies. Wiley Interdiscip Rev Syst Biol Med 2012, 4:351-365.
30. Dietlein T.S., Jacobi P.C., Luke C., Krieglstein G.K. Morphological variability of the trabecular meshwork in glaucoma patients: implications for non-perforating glaucoma surgery. Br J Ophthalmol 2000, 84:1354-1359.
31. Discher D.E., Mooney D.J., Zandstra P.W. Growth factors, matrices, and forces combine and control stem cells. Science 2009, 324:1673-1677.
32. Du Y., Roh D.S., Mann M.M., Funderburgh M.L., Funderburgh J.L., Schuman J.S. Multipotent stem cells from trabecular meshwork become phagocytic TM cells. Invest Ophthalmol Vis Sci 2012, 53:1566-1575.
33. Du Y., Yun H., Yang E., Schuman J.S. Stem cells from trabecular meshwork home to TM tissue in vivo. Invest Ophthalmol Vis Sci 2013, 54:1450-1459.
34. Dvir T., Timko B.P., Kohane D.S., Langer R. Nanotechnological strategies for engineering complex tissues. Nat Nanotechnol 2011, 6:13-22.
35. Edgington S.M. 3-D biotech: tissue engineering. Nat Biotechnol 1992, 10:855-860.
36. Engler A.J., Sen S., Sweeney H.L., Discher D.E. Matrix elasticity directs stem cell lineage specification. Cell 2006, 126:677-689.
37. Engler A.J., Humbert P.O., Wehrle-Haller B., Weaver V.M. Multiscale modeling of form and function. Science 2009, 324:208-212.
38. Epstein D.L., Patterson M.M., Rivers S.C., Anderson P.J. N-ethylmaleimide increases the facility of aqueous outflow of excised monkey and calf eyes. Invest Ophthalmol Vis Sci 1982, 22:752-756.
39. Erickson-Lamy K., Schroeder A.M., Bassett-Chu S., Epstein D.L. Absence of time-dependent facility increase ("washout") in the perfused enucleated human eye. Invest Ophthalmol Vis Sci 1990, 31:2384-2388.
40. Fan B.J., Wiggs J.L. Glaucoma: genes, phenotypes, and new directions for therapy. J Clin Invest 2010, 120:3064-3072.
41. Filla M.S., David G., Weinreb R.N., Kaufman P.L., Peters D.M. Distribution of syndecans 1-4 within the anterior segment of the human eye: expression of a variant syndecan-3 and matrix-associated syndecan-2. Exp Eye Res 2004, 79:61-74.
42. Fingert J.H. Primary open-angle glaucoma genes. Eye (Lond) 2011, 25:587-595.
43. Fingert J.H., Stone E.M., Sheffield V.C., Alward W.L.M. Myocilin glaucoma. Surv Ophthalmol 2002, 47:547-561.
44. Forgacs G., Sun W. Biofabrication: micro- and nano-fabrication, printing, patterning and assemblies 2013, Elsevier Science.
45. Francois J. The importance of the mucopolysaccharides in intraocular pressure regulation. Invest Ophthalmol 1975, 14:173-176.
46. Freed L.E., Vunjak-Novakovic G. Tissue engineering bioreactors 2000, Academic Press, San Diego, CA. 2nd ed.
47. Fuchshofer R., Welge-Lussen U., Lutjen-Drecoll E., Birke M. Biochemical and morphological analysis of basement membrane component expression in corneoscleral and cribriform human trabecular meshwork cells. Invest Ophthalmol Vis Sci 2006, 47:794-801.
48. Gaasterland D., Kupfer C. Experimental glaucoma in the rhesus monkey. Invest Ophthalmol 1974, 13:455-457.
49. Gaasterland D.E., Pederson J.E., MacLellan H.M., Reddy V.N. Rhesus monkey aqueous humor composition and a primate ocular perfusate. Invest Ophthalmol Vis Sci 1979, 18:1139-1150.
50. Gabelt B.A.T., Kaufman P.L. Changes in aqueous humor dynamics with age and glaucoma. Prog Retin Eye Res 2005, 24:612-637.
51. Gasiorowski J.Z., Russell P. Biological properties of trabecular meshwork cells. Exp Eye Res 2009, 88:671-675.
52. Gauvin R., Parenteau-Bareil R., Dokmeci M.R., Merryman W.D., Khademhosseini A. Hydrogels and microtechnologies for engineering the cellular microenvironment. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2012, 4:235-246.
53. Geckil H., Xu F., Zhang X., Moon S., Demirci U. Engineering hydrogels as extracellular matrix mimics. Nanomedicine (Lond) 2010, 5:469-484.
54. Gong H., Freddo T.F., Johnson M. Age-related changes of sulfated proteoglycans in the normal human trabecular meshwork. Exp Eye Res 1992, 55:691-709.
55. Gong H., Ruberti J., Overby D., Johnson M., Freddo T.F. A new view of the human trabecular meshwork using quick-freeze, deep-etch electron microscopy. Exp Eye Res 2002, 75:347-358.
56. Gong G., Kosoko-Lasaki O., Haynatzki G.R., Wilson M.R. Genetic dissection of myocilin glaucoma. Hum Mol Genet 2004, 13(1):R91-102.
57. Gonzalez P., Epstein D.L., Luna C., Liton P.B. Characterization of free-floating spheres from human trabecular meshwork (HTM) cell culture in vitro. Exp Eye Res 2006, 82:959-967.
58. Gottanka J., Johnson D.H., Martus P., Lütjen-Drecoll E. Severity of optic nerve damage in eyes with POAG is correlated with changes in the trabecular meshwork. J Glaucoma 1997, 6:123-132.
59. Grant W.M. Further studies on facility of flow through the trabecular meshwork. AMA Arch Ophthalmol 1958, 60:523-533.
60. Grierson I., Rahi A. Microfilaments in the cells of the human trabecular meshwork. Br J Ophthalmol 1979, 63:3-8.
61. Griffith L.G., Naughton G. Tissue engineering-current challenges and expanding opportunities. Science 2002, 295:1009-1014.
62. Griffith L.G., Swartz M.A. Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 2006, 7:211-224.
63. Griffith M., Jackson W.B., Lagali N., Merrett K., Li F., Fagerholm P. Artificial corneas: a regenerative medicine approach. Eye (Lond) 2009, 23:1985-1989.
64. Haddadin R.I., Oh D.J., Kang M.H., Filippopoulos T., Gupta M., Hart L., et al. SPARC-null mice exhibit lower intraocular pressures. Invest Ophthalmol Vis Sci 2009, 50:3771-3777.
65. Hashimoto J.M., Epstein D.L. Influence of intraocular pressure on aqueous outflow facility in enucleated eyes of different mammals. Invest Ophthalmol Vis Sci 1980, 19:1483-1489.
66. Hong H., McCullough C.M., Stegemann J.P. The role of ERK signaling in protein hydrogel remodeling by vascular smooth muscle cells. Biomaterials 2007, 28:3824-3833.
67. Hubbell J.A. Biomaterials in tissue engineering. Nat Biotechnol 1995, 13:565-576.
68. Huebsch N., Mooney D.J. Inspiration and application in the evolution of biomaterials. Nature 2009, 462:426-432.
69. Hynd M.R., Frampton J.P., Dowell-Mesfin N., Turner J.N., Shain W. Directed cell growth on protein-functionalized hydrogel surfaces. J Neurosci Methods 2007, 162:255-263.
70. Jacobson N., Andrews M., Shepard A.R., Nishimura D., Searby C., Fingert J.H., et al. Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor. Hum Mol Genet 2001, 10:117-125.
71. Joe M.K., Sohn S., Hur W., Moon Y., Choi Y.R., Kee C. Accumulation of mutant myocilins in ER leads to ER stress and potential cytotoxicity in human trabecular meshwork cells. Biochem Biophys Res Commun 2003, 312:592-600.
72. Johnson M., Gong H., Freddo T.F., Ritter N., Kamm R. Serum proteins and aqueous outflow resistance in bovine eyes. Invest Ophthalmol Vis Sci 1993, 34:3549-3557.
73. Johnstone M.A. Intraocular pressure regulation: findings of pulse-dependent trabecular meshwork motion lead to unifying concepts of intraocular pressure homeostasis. J Ocul Pharmacol Ther 2013, 30(2-3):88-93.
74. Kaplan D.L., Moon R.T., Vunjak-Novakovic G. It takes a village to grow a tissue. Nat Biotechnol 2005, 23:1237-1239.
75. Kaufman P.L., True-Gabelt B., Erickson-Lamy K.A. Time-dependence of perfusion outflow facility in the cynomolgus monkey. Curr Eye Res 1988, 7:721-726.
76. Kelleher C.M., Vacanti J.P. Engineering extracellular matrix through nanotechnology. J R Soc Interface 2010, 7(Suppl. 6):S717-S729.
77. Kelley M.J., Rose A.Y., Keller K.E., Hessle H., Samples J.R., Acott T.S. Stem cells in the trabecular meshwork: present and future promises. Exp Eye Res 2009, 88:747-751.
78. Kim B.S., Baez C.E., Atala A. Biomaterials for tissue engineering. World J Urol 2000, 18:2-9.
79. Kim B., Grzybowski D.M., Weber P., Roberts C.J., Zhao Y. Electrospun micro/nanofiber assisted in vitro construction of trabecular meshwork for glaucoma investigation. Proceeding of the 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS'09) 2009.
80. Kwon I.K., Kidoaki S., Matsuda T. Electrospun nano- to microfiber fabrics made of biodegradable copolyesters: structural characteristics, mechanical properties and cell adhesion potential. Biomaterials 2005, 26:3929-3939.
81. Kwon Y.H., Fingert J.H., Kuehn M.H., Alward W.L. Primary open-angle glaucoma. N Engl J Med 2009, 360:1113-1124.
82. Kwon Y.H., Fingert J.H., Kuehn M.H., Alward W.L.M. Primary open-angle glaucoma. N Engl J Med 2009, 360:1113-1124.
83. Langer R., Tirrell D.A. Designing materials for biology and medicine. Nature 2004, 428:487-492.
84. Langer R., Vacanti J.P. Tissue engineering. Science 1993, 260:920-926.
85. Lee K., Silva E.A., Mooney D.J. Growth factor delivery-based tissue engineering: general approaches and a review of recent developments. J R Soc Interface 2011, 8:153-170.
86. Lepple-Wienhues A., Stahl F., Wiederholt M. Differential smooth muscle-like contractile properties of trabecular meshwork and ciliary muscle. Exp Eye Res 1991, 53:33-38.
87. Lerner L.E., Polansky J.R., Howes E.L., Stern R. Hyaluronan in the human trabecular meshwork. Invest Ophthalmol Vis Sci 1997, 38:1222-1228.
88. Liton P.B., Liu X., Challa P., Epstein D.L., Gonzalez P. Induction of TGF-beta1 in the trabecular meshwork under cyclic mechanical stress. J Cell Physiol 2005, 205:364-371.
89. Liu Y., Vollrath D. Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma. Hum Mol Genet 2004, 13:1193-1204.
90. Lutjen-Drecoll E. Functional morphology of the trabecular meshwork in primate eyes. Prog Retin Eye Res 1999, 18:91-119.
91. Lutjen-Drecoll E. Morphological changes in glaucomatous eyes and the role of TGFbeta2 for the pathogenesis of the disease. Exp Eye Res 2005, 81:1-4.
92. Lutjen-Drecoll E., Futa R., Rohen J.W. Ultrahistochemical studies on tangential sections of the trabecular meshwork in normal and glaucomatous eyes. Invest Ophthalmol Vis Sci 1981, 21:563-573.
93. Lutjen-Drecoll E., Shimizu T., Rohrbach M., Rohen J.W. Quantitative analysis of 'plaque material' in the inner- and outer wall of Schlemm's canal in normal- and glaucomatous eyes. Exp Eye Res 1986, 42:443-455.
94. Lutjen-Drecoll E., Schenholm M., Tamm E., Tengblad A. Visualization of hyaluronic acid in the anterior segment of rabbit and monkey eyes. Exp Eye Res 1990, 51:55-63.
95. Marshall G.E., Konstas A.G., Lee W.R. Immunogold localization of type IV collagen and laminin in the aging human outflow system. Exp Eye Res 1990, 51:691-699.
96. Marshall G.E., Konstas A.G., Lee W.R. Immunogold ultrastructural localization of collagens in the aged human outflow system. Ophthalmology 1991, 98:692-700.
97. Matsumoto Y., Johnson D.H. Dexamethasone decreases phagocytosis by human trabecular meshwork cells in situ. Invest Ophthalmol Vis Sci 1997, 38:1902-1907.
98. Matthews J.A., Wnek G.E., Simpson D.G., Bowlin G.L. Electrospinning of collagen nanofibers. Biomacromolecules 2002, 3:232-238.
99. Mauney J.R., Sjostorm S., Blumberg J., Horan R., O'Leary J.P., Vunjak-Novakovic G., et al. Mechanical stimulation promotes osteogenic differentiation of human bone marrow stromal cells on 3-D partially demineralized bone scaffolds in vitro. Calcif Tissue Int 2004, 74:458-468.
100. Mc E.W. Application of Poiseuille's law to aqueous outflow. AMA Arch Ophthalmol 1958, 60:290-294.
101. McEwen W. Application of Poiseuille's law to aqueous outflow. AMA Arch Ophthalmol 1958, 60:290-294.
102. McGowan S.L., Edelhauser H.F., Pfister R.R., Whikehart D.R. Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. Mol Vis 2007, 13:1984-2000.
103. McKee C.T., Wood J.A., Shah N.M., Fischer M.E., Reilly C.M., Murphy C.J., et al. The effect of biophysical attributes of the ocular trabecular meshwork associated with glaucoma on the cell response to therapeutic agents. Biomaterials 2011, 32:2417-2423.
104. Millon L.E., Padavan D.T., Hamilton A.M., Boughner D.R., Wan W. Exploring cell compatibility of a fibronectin-functionalized physically crosslinked poly(vinyl alcohol) hydrogel. J Biomed Mater Res B Appl Biomater 2012, 100:1-10.
105. Murphy C.G., Yun A.J., Newsome D.A., Alvarado J.A. Localization of extracellular proteins of the human trabecular meshwork by indirect immunofluorescence. Am J Ophthalmol 1987, 104:33-43.
106. Nemeno-Guanzon J.G., Lee S., Berg J.R., Jo Y.H., Yeo J.E., Nam B.M., et al. Trends in tissue engineering for blood vessels. J Biomed Biotechnol 2012, 2012:956345.
107. Nichol J.W., Khademhosseini A. Modular tissue engineering: engineering biological tissues from the bottom up. Soft Matter 2009, 5:1312-1319.
108. Nilsson S.F. The uveoscleral outflow routes. Eye (Lond) 1997, 11(Pt 2):149-154.
109. Overby D.R., Stamer W.D., Johnson M. The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium. Exp Eye Res 2009, 88:656-670.
110. Pang I.H., Shade D.L., Clark A.F., Steely H.T., DeSantis L. Preliminary characterization of a transformed cell strain derived from human trabecular meshwork. Curr Eye Res 1994, 13:51-63.
111. Peck Y., Wang D.A. Three-dimensionally engineered biomimetic tissue models for in vitro drug evaluation: delivery, efficacy and toxicity. Expert Opin Drug Deliv 2013, 10:369-383.
112. Peppas N.A., Langer R. New challenges in biomaterials. Science 1994, 263:1715-1720.
113. Perkins T.W., Alvarado J.A., Polansky J.R., Stilwell L., Maglio M., Juster R. Trabecular meshwork cells grown on filters. Conductivity and cytochalasin effects. Invest Ophthalmol Vis Sci 1988, 29:1836-1846.
114. Peterson W.S., Jocson V.L. Hyaluronidase effects on aqueous outflow resistance. Quantitative and localizing studies in the rhesus monkey eye. Am J Ophthalmol 1974, 77:573-577.
115. Polansky J.R., Weinreb R.N., Baxter J.D., Alvarado J. Human trabecular cells. I. Establishment in tissue culture and growth characteristics. Invest Ophthalmol Vis Sci 1979, 18:1043-1049.
116. Polansky J.R., Wood I.S., Maglio M.T., Alvarado J.A. Trabecular meshwork cell culture in glaucoma research: evaluation of biological activity and structural properties of human trabecular cells in vitro. Ophthalmology 1984, 91:580-595.
117. Polansky J.R., Fauss D.J., Zimmerman C.C. Regulation of TIGR/MYOC gene expression in human trabecular meshwork cells. Eye 2000, 14:503-514.
118. Quigley H.A., Broman A.T. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol 2006, 90:262-267.
119. Ravi S., Chaikof E.L. Biomaterials for vascular tissue engineering. Regen Med 2010, 5:107-120.
120. Raviola G. Schwalbe line's cells: a new cell type in the trabecular meshwork of Macaca mulatta. Invest Ophthalmol Vis Sci 1982, 22:45-56.
121. Rhee D.J., Tamm E.R., Russell P. Donor corneoscleral buttons: a new source of trabecular meshwork for research. Exp Eye Res 2003, 77:749-756.
122. Richardson T.M. Distribution of glycosaminoglycans in the aqueous outflow system of the cat. Invest Ophthalmol Vis Sci 1982, 22:319-329.
123. Ryder M.I., Weinreb R.N., Alvarado J., Polansky J. The cytoskeleton of the cultured human trabecular cell. Characterization and drug responses. Invest Ophthalmol Vis Sci 1988, 29:251-260.
124. Sarfarazi M., Rezaie T. Optineurin in primary open angle glaucoma. Ophthalmol Clin North Am 2003, 16:529-541.
125. Sawaguchi K., Nakamura Y., Sakai H., Sawaguchi S. Myocilin gene expression in the trabecular meshwork of rats in a steroid-induced ocular hypertension model. Ophthalmic Res 2005, 37:235-242.
126. Schlunck G., Han H., Wecker T., Kampik D., Meyer-ter-Vehn T., Grehn F. Substrate rigidity modulates cell matrix interactions and protein expression in human trabecular meshwork cells. Invest Ophthalmol Vis Sci 2008, 49:262-269.
127. Schwinn M.K., Gonzalez J.M., Gabelt B.T., Sheibani N., Kaufman P.L., Peters D.M. Heparin II domain of fibronectin mediates contractility through an alpha4beta1 co-signaling pathway. Exp Cell Res 2010, 316:1500-1512.
128. Scott P.A., Overby D.R., Freddo T.F., Gong H. Comparative studies between species that do and do not exhibit the washout effect. Exp Eye Res 2007, 84:435-443.
129. Seftor R.E., Stamer W.D., Seftor E.A., Snyder R.W. Dexamethasone decreases tissue plasminogen activator activity in trabecular meshwork organ and cell cultures. J Glaucoma 1994, 3:323-328.
130. Senatorov V., Malyukova I., Fariss R., Wawrousek E.F., Swaminathan S., Sharan S.K., et al. Expression of mutated mouse myocilin induces open-angle glaucoma in transgenic mice. J Neurosci 2006, 26:11903-11914.
131. Stamer W.D., Roberts B.C., Howell D.N., Epstein D.L. Isolation, culture, and characterization of endothelial cells from Schlemm's canal. Invest Ophthalmol Vis Sci 1998, 39:1804-1812.
132. Stamer D.W., Roberts B.C., Epstein D.L., Allingham R.R. Isolation of primary open-angle glaucomatous trabecular meshwork cells from whole eye tissue. Curr Eye Res 2000, 20:347-350.
133. Subramanian A., Krishnan U.M., Sethuraman S. Development of biomaterial scaffold for nerve tissue engineering: biomaterial mediated neural regeneration. J Biomed Sci 2009, 16:108.
134. Szentivanyi A.L., Zernetsch H., Menzel H., Glasmacher B. A review of developments in electrospinning technology: new opportunities for the design of artificial tissue structures. Int J Artif Organs 2011, 34:986-997.
135. Tamm E.R. Myocilin and glaucoma: facts and ideas. Prog Retin Eye Res 2002, 21:395-428.
136. Tamm E.R. The trabecular meshwork outflow pathways: structural and functional aspects. Exp Eye Res 2009, 88:648-655.
137. Tamm E.R., Fuchshofer R. What increases outflow resistance in primary open-angle glaucoma?. Surv Ophthalmol 2007, 52:S101-S104.
138. Tamm E.R., Siegner A., Baur A., Lutjen-Drecoll E. Transforming growth factor-beta 1 induces alpha-smooth muscle-actin expression in cultured human and monkey trabecular meshwork. Exp Eye Res 1996, 62:389-397.
139. Tanihara H., Ohira A., Takahashi M., Honda Y., Suzuki S. Localization and possible gene expression of proteoglycan decorin in the trabecular meshwork. Curr Eye Res 1995, 14:727-730.
140. Tawara A., Varner H.H., Hollyfield J.G. Distribution and characterization of sulfated proteoglycans in the human trabecular tissue. Invest Ophthalmol Vis Sci 1989, 30:2215-2231.
141. Tektas O.Y., Lutjen-Drecoll E. Structural changes of the trabecular meshwork in different kinds of glaucoma. Exp Eye Res 2009, 88:769-775.
142. Thomasy S.M., Morgan J.T., Wood J.A., Murphy C.J., Russell P. Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells. Exp Eye Res 2013, 113:66-73.
143. Tian B., Geiger B., Epstein D.L., Kaufman P.L. Cytoskeletal involvement in the regulation of aqueous humor outflow. Invest Ophthalmol Vis Sci 2000, 41:619-623.
144. Tian B., Gabelt B.T., Geiger B., Kaufman P.L. The role of the actomyosin system in regulating trabecular fluid outflow. Exp Eye Res 2009, 88:713-717.
145. Tibbitt M.W., Anseth K.S. Dynamic microenvironments: the fourth dimension. Sci Transl Med 2012, 4:160ps24.
146. Tomarev S.I., Wistow G., Raymond V., Dubois S., Malyukova I. Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. Invest Ophthalmol Vis Sci 2003, 44:2588-2596.
147. Torrejon K.Y., Pu D., Bergkvist M., Danias J., Sharfstein S.T., Xie Y. Recreating a human trabecular meshwork outflow system on microfabricated porous structures. Biotechnol Bioeng 2013, 110:3205-3218.
148. Tripathi R. Tracing the bulk outflow route of cerebrospinal fluid by transmission and scanning electron microscopy. Brain Res 1974, 80:503-506.
149. Tripathi R.C., Tripathi B.J. Human trabecular endothelium, corneal endothelium, keratocytes, and scleral fibroblasts in primary cell culture. A comparative study of growth characteristics, morphology, and phagocytic activity by light and scanning electron microscopy. Exp Eye Res 1982, 35:611-624.
150. Ueda J., Wentz-Hunter K., Yue B.Y. Distribution of myocilin and extracellular matrix components in the juxtacanalicular tissue of human eyes. Invest Ophthalmol Vis Sci 2002, 43:1068-1076.
151. Uematsu K., Hattori K., Ishimoto Y., Yamauchi J., Habata T., Takakura Y., et al. Cartilage regeneration using mesenchymal stem cells and a three-dimensional poly-lactic-glycolic acid (PLGA) scaffold. Biomaterials 2005, 26:4273-4279.
152. Urciuolo F., Imparato G., Guaccio A., Mele B., Netti P.A. Novel strategies to engineering biological tissue in vitro. Methods Mol Biol 2012, 811:223-244.
153. Vacanti J.P., Langer R. Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation. Lancet 1999, 354:S32-S34.
154. Vittal V., Rose A., Gregory K.E., Kelley M.J., Acott T.S. Changes in gene expression by trabecular meshwork cells in response to mechanical stretching. Invest Ophthalmol Vis Sci 2005, 46:2857-2868.
155. Wang N., Chintala S.K., Fini M.E., Schuman J.S. Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype. Nat Med 2001, 7:304-309.
156. Wang X., He J., Wang Y., Cui F.Z. Hyaluronic acid-based scaffold for central neural tissue engineering. Interface Focus 2012, 2:278-291.
157. Welge-Lussen U., May C.A., Eichhorn M., Bloemendal H., Lutjen-Drecoll E. AlphaB-crystallin in the trabecular meshwork is inducible by transforming growth factor-beta. Invest Ophthalmol Vis Sci 1999, 40:2235-2241.
158. Welge-Lussen U., May C.A., Lutjen-Drecoll E. Induction of tissue transglutaminase in the trabecular meshwork by TGF-beta1 and TGF-beta2. Invest Ophthalmol Vis Sci 2000, 41:2229-2238.
159. Wiederholt M., Thieme H., Stumpff F. The regulation of trabecular meshwork and ciliary muscle contractility. Prog Retin Eye Res 2000, 19:271-295.
160. Williams D. Revisiting the definition of biocompatibility. Med Device Technol 2003, 14:10-13.
161. Wirtz M.K., Bradley J.M., Xu H., Domreis J., Nobis C.A., Truesdale A.T., et al. Proteoglycan expression by human trabecular meshworks. Curr Eye Res 1997, 16:412-421.
162. Wolffe A.P., Tata J.R. Primary culture, cellular stress and differentiated function. FEBS Lett 1984, 176:8-15.
163. WuDunn D. Mechanobiology of trabecular meshwork cells. Exp Eye Res 2009, 88:718-723.
164. Xue W., Wallin R., Olmsted-Davis E.A., Borras T. Matrix GLA protein function in human trabecular meshwork cells: inhibition of BMP2-induced calcification process. Invest Ophthalmol Vis Sci 2006, 47:997-1007.
165. Yoo H.S., Kim T.G., Park T.G. Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery. Adv Drug Deliv Rev 2009, 61:1033-1042.
166. Yu W.Y., Sheridan C., Grierson I., Mason S., Kearns V., Lo A.C., et al. Progenitors for the corneal endothelium and trabecular meshwork: a potential source for personalized stem cell therapy in corneal endothelial diseases and glaucoma. J Biomed Biotechnol 2011, 2011. [412743].
167. Yue B.Y. The extracellular matrix and its modulation in the trabecular meshwork. Surv Ophthalmol 1996, 40:379-390.
168. Zhang S. Fabrication of novel biomaterials through molecular self-assembly. Nat Biotechnol 2003, 21:1171-1178.
169. Zhang M., Maddala R., Rao P.V. Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork. Am J Physiol Cell Physiol 2008, 295:C1057-C1070.
170. Zhang K., Zhang L., Weinreb R.N. Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma. Nat Rev Drug Discov 2012, 11:541-559.
171. Zhou L., Fukuchi T., Kawa J.E., Higginbotham E.J., Yue B.Y. Loss of cell-matrix cohesiveness after phagocytosis by trabecular meshwork cells. Invest Ophthalmol Vis Sci 1995, 36:787-795.
172. Zhou L., Zhang S.R., Yue B.Y. Adhesion of human trabecular meshwork cells to extracellular matrix proteins. Roles and distribution of integrin receptors. Invest Ophthalmol Vis Sci 1996, 37:104-113.
173. Zhou L., Higginbotham E.J., Yue B.Y. Effects of ascorbic acid on levels of fibronectin, laminin and collagen type 1 in bovine trabecular meshwork in organ culture. Curr Eye Res 1998, 17:211-217.
174. Zhou Y., Grinchuk O., Tomarev S.I. Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma. Invest Ophthalmol Vis Sci 2008, 49:1932-1939.
175. Zhu J. Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering. Biomaterials 2010, 31:4639-4656.