The role of the actomyosin system in regulating trabecular fluid outflow

Experimental Eye Research

Volumn 88, Issue 4, 2009, Pages 713-717

  Tian, Baohe ^a   Gabelt, B'Ann T ^a   Geiger, Benjamin ^b   Kaufman, Paul L ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

actomyosin; cytoskeleton; glaucoma; intraocular pressure; outflow facility; trabecular meshwork

Indexed keywords

1 (5 IODO 1 NAPHTHALENESULFONYL)HEXAHYDRO 1H 1,4 DIAZEPINE; 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALDESMON; CARBONATE DEHYDRATASE INHIBITOR; CHELERYTHRINE; CHOLINERGIC RECEPTOR STIMULATING AGENT; ETACRYNIC ACID; EXOENZYME C3; FASUDIL; H 1152; INS 117548; LATRUNCULIN A; LATRUNCULIN B; MICROTUBULE PROTEIN; MYOSIN ADENOSINE TRIPHOSPHATASE; MYOSIN LIGHT CHAIN KINASE; PROSTAGLANDIN DERIVATIVE; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; RHO KINASE; STAUROSPORINE; UNCLASSIFIED DRUG; Y 39983;

AQUEOUS HUMOR OUTFLOW; CORNEA DISEASE; CYTOSKELETON; DRUG MECHANISM; EXTRACELLULAR MATRIX; GLAUCOMA; HUMAN; HYPOTENSION; INTRAOCULAR PRESSURE; NONHUMAN; OPEN ANGLE GLAUCOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW; SCHLEMM CANAL; TRABECULAR MESHWORK; TRANSMISSION ELECTRON MICROSCOPY; UNSPECIFIED SIDE EFFECT;

ACTOMYOSIN; ANIMALS; CALMODULIN-BINDING PROTEINS; GLAUCOMA, OPEN-ANGLE; HUMANS; INTRAOCULAR PRESSURE; PROTEIN KINASE INHIBITORS; TRABECULAR MESHWORK; TUBULIN MODULATORS;

EID: 64249129112     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2008.08.008     Document Type: Review

References (53)

1. Bahler C.K., Hann C.R., Fautsch M.P., and Johnson D.H. Pharmacologic disruption of Schlemm's canal cells and outflow facility in anterior segments of human eyes. Invest. Ophthalmol. Vis. Sci. 45 (2004) 2246-2254
2. Bershadsky A., Chausovsky A., Becker E., Lyubimova A., and Geiger B. Involvement of microtubules in the control of adhesion-dependent signal transduction. Curr. Biol. 6 (1996) 1279-1289
3. Cai S., Liu X., Glasser A., Volberg T., Filla M., Geiger B., and Kaufman P.L. Effect of latrunculin-A on morphology and actin-associated adhesions of cultured human trabecular meshwork cells. Mol. Vis. 6 (2000) 132-143.
4. Chen C.S., and Ingber D.E. Tensegrity and mechanoregulation: from skeleton to cytoskeleton. Osteoarthr. Cartil. 7 (1999) 81-94
5. Epstein D.L., Freddo T.F., Bassett-Chu S., Chung M., and Karageuzian L. Influence of ethacrynic acid on outflow facility in the monkey and calf eye. Invest. Ophthalmol. Vis. Sci. 28 (1987) 2067-2075
6. Epstein D.L., Rowlette L.L., and Roberts B.C. Acto-myosin drug effects and aqueous outflow function. Invest. Ophthalmol. Vis. Sci. 40 (1999) 74-81
7. Erickson-Lamy K., Schroeder A., and Epstein D.L. Ethacrynic acid induces reversible shape and cytoskeletal changes in cultured cells. Invest. Ophthalmol. Vis. Sci. 33 (1992) 2631-2640
8. Ethier C.R., Read A.T., and Chan D.W. Effects of latrunculin-B on outflow facility and trabecular meshwork structure in human eyes. Invest. Ophthalmol. Vis. Sci. 47 (2006) 1991-1998
9. Gabelt B.T., Hu Y., Vittitow J.L., Rasmussen C.R., Grosheva I., Bershadsky A.D., Geiger B., Borrás T., and Kaufman P.L. Caldesmon transgene expression disrupts focal adhesions in HTM cells and increases outflow facility in organ-cultured human and monkey anterior segments. Exp. Eye Res. 82 (2006) 935-944
10. Geiger B., Yehuda-Levenberg S., and Bershadsky A.D. Molecular interactions in the submembrane plaque of cell-cell and cell-matrix adhesions. Acta Anat. (Basel) 154 (1995) 46-62
11. Grosheva I., Vittitow J.L., Goichberg P., Gabelt B.T., Kaufman P.L., Borrás T., Geiger B., and Bershadsky A.D. Caldesmon effects on the actin cytoskeleton and cell adhesion in cultured HTM cells. Exp. Eye Res. 82 (2006) 945-958
12. Honjo M., Inatani M., Kido N., Sawamura T., Yue B.Y., Honda Y., and Tanihara H. Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes. Arch. Ophthalmol. 119 (2001) 1171-1178
13. Honjo M., Tanihara H., Inatani M., Kido N., Sawamura T., Yue B.Y.J.T., Shuh N., and Honda Y. Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility. Invest. Ophthalmol. Vis. Sci. 42 (2001) 137-144
14. Hu Y., Gabelt B.T., and Kaufman P.L. Monkey organ-cultured anterior segments: technique and response to H-7. Exp. Eye Res. 82 (2006) 1100-1108
15. Johnson M. What controls aqueous humour outflow resistance?. Exp. Eye Res. 82 (2006) 545-557
16. Khurana R.N., Deng P.F., Epstein D.L., and Rao P.V. The role of protein kinase C in modulation of aqueous humor outflow facility. Exp. Eye Res. 76 (2003) 39-47
17. Liang L.L., Epstein D.L., de Kater A.W., Shahsafaei A., and Erickson-Lamy K.A. Ethacrynic acid increases facility of outflow in the human eye in vitro. Arch. Ophthalmol. 110 (1992) 106-109
18. Liu X., Cai S., Glasser A., Volberg T., Polansky J.R., Fauss D.J., Brandt C.R., Geiger B., and Kaufman P.L. Effects of H-7 on cultured human trabecular meshwork cells. Mol. Vis. 7 (2001) 145-153.
19. Liu X., Hu Y., Filla M.S., Gabelt B.T., Peters D.M., Brandt C.R., and Kaufman P.L. The effect of C3 transgene expression on actin and cellular adhesions in cultured human trabecular meshwork cells and on outflow facility in organ cultured monkey eyes. Mol. Vis. 11 (2005) 1112-1121
20. Lu Z., Overby D.R., Scott P.A., Freddo T.F., and Gong H. The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes. Exp. Eye Res. 86 (2008) 271-281
21. Lütjen-Drecoll E., Futa R., and Rohen J.W. Ultrahistochemical studies on tangential sections of the trabecular meshwork in normal and glaucomatous eyes. Invest. Ophthalmol. Vis. Sci. 21 (1981) 563-573
22. Melamed S., Kotas-Neumann R., Barak A., and Epstein D.L. The effect of intracamerally injected ethacrynic acid on intraocular pressure in patients with glaucoma. Am. J. Ophthalmol. 113 (1992) 508-512
23. O'Brien E.T., Kinch M., Harding T.W., and Epstein D.L. A mechanism for trabecular meshwork cell retraction: ethacrynic acid initiates the dephosphorylation of focal adhesion proteins. Exp. Eye Res. 65 (1997) 471-483
24. Okka M., Tian B., and Kaufman P.L. Effect of low-dose latrunculin B on anterior segment physiologic features in the monkey eye. Arch. Ophthalmol. 122 (2004) 1482-1488
25. Peterson J.A., Tian B., Bershadsky A.D., Volberg T., Gangnon R.E., Spector I., Geiger B., and Kaufman P.L. Latrunculin-A increases outflow facility in the monkey. Invest. Ophthalmol. Vis. Sci. 40 (1999) 931-941
26. Peterson J.A., Tian B., Geiger B., and Kaufman P.L. Effect of latrunculin-B on outflow facility in monkeys. Exp. Eye Res. 70 (2000) 307-313
27. Peterson W.M., Lampe J., Navratil T., Paran Y., Zvi K., Hennes E.A., Gabelt B.T., Geiger B., Kaufman P.L., and Vittitow J.L. Topical administration of a novel and potent Rho kinase (ROK) inhibitor INS117548 alters the actin cytoskeleton, effectively lowers IOP, and is well tolerated on the ocular surface. Invest. Ophthalmol. Vis. Sci. 49 (2008). E-abstract 3816
28. Rao P.V., Deng P., Maddala R., Epstein D.L., Li C.Y., and Shimokawa H. Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow. Mol. Vis. 11 (2005) 288-297
29. Rao P.V., Deng P., Sasaki Y., and Epstein D.L. Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility. Exp. Eye Res. 80 (2005) 197-206
30. Rao P.V., Deng P.F., Kumar J., and Epstein D.L. Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. Invest. Ophthalmol. Vis. Sci. 42 (2001) 1029-1037 Erratum in: Invest. Ophthalmol. Vis. Sci. 2001; 42:1690
31. Rao P.V., Shimazaki A., Ichikawa M., Alvarado J.A., and Epstein D.L. Effects of novel ethacrynic acid derivatives on human trabecular meshwork cell shape, actin cytoskeletal organization, and transcellular fluid flow. Biol. Pharm. Bull. 28 (2005) 2189-2196
32. Renieri G., Choritz L., Rosenthal R., Meissner S., Pfeiffer N., and Thieme H. Effects of endothelin-1 on calcium-independent contraction of bovine trabecular meshwork. Graefes Arch. Clin. Exp. Ophthalmol. (2008) [Epub ahead of print]
33. Rohen J.W., Futa R., and Lütjen-Drecoll E. The fine structure of the cribriform meshwork in normal and glaucomatous eyes as seen in tangential sections. Invest. Ophthalmol. Vis. Sci. 21 (1981) 574-585
34. Rosenthal R., Choritz L., Schlott S., Bechrakis N.E., Jaroszewski J., Wiederholt M., and Thieme H. Effects of ML-7 and Y-27632 on carbachol- and endothelin-1-induced contraction of bovine trabecular meshwork. Exp. Eye Res. 80 (2005) 837-845
35. Sabanay I., Gabelt B.T., Tian B., Kaufman P.L., and Geiger B. H-7 effects on the structure and fluid conductance of monkey trabecular meshwork. Arch. Ophthalmol. 118 (2000) 955-962
36. Sabanay I., Tian B., Gabelt B.T., Geiger B., and Kaufman P.L. Functional and structural reversibility of H-7 effects on the conventional aqueous outflow pathway in monkeys. Exp. Eye Res. 78 (2004) 137-150
37. Sabanay I., Tian B., Gabelt B.T., Geiger B., and Kaufman P.L. Latrunculin B effects on trabecular meshwork and corneal endothelial morphology in monkeys. Exp. Eye Res. 82 (2006) 236-246
38. Shimazaki A., Ichikawa M., Rao P.V., Kirihara T., Konomi K., Epstein D.L., and Hara H. Effects of the new ethacrynic acid derivative SA9000 on intraocular pressure in cats and monkeys. Biol. Pharm. Bull. 27 (2004) 1019-1024
39. Shimazaki A., Kirihara T., Rao P.V., Tajima H., Matsugi T., and Epstein D.L. Effects of the new ethacrynic acid oxime derivative SA12590 on intraocular pressure in cats and monkeys. Biol. Pharm. Bull. 30 (2007) 1445-1449
40. Thieme H., Nass J.U., Nuskovski M., Bechrakis N.E., Stumpff F., Strauss O., and Wiederholt M. The effects of protein kinase C on trabecular meshwork and ciliary muscle contractility. Invest. Ophthalmol. Vis. Sci. 40 (1999) 3254-3261
41. Thieme H., Nuskovski M., Nass J.U., Pleyer U., Strauss O., and Wiederholt M. Mediation of calcium-independent contraction in trabecular meshwork through protein kinase C and rho-A. Invest. Ophthalmol. Vis. Sci. 41 (2000) 4240-4246
42. Tian B., Brumback L.C., and Kaufman P.L. ML-7, chelerythrine and phorbol ester increase outflow facility in the monkey eye. Exp. Eye Res. 71 (2000) 551-566
43. Tian B., Gabelt B.T., and Kaufman P.L. Effect of staurosporine on outflow facility in monkeys Invest. Ophthalmol. Vis. Sci. 40 (1999) 1009-1011
44. Tian B., Gabelt B.T., Peterson J.A., Kiland J.A., and Kaufman P.L. H-7 increases trabecular facility and facility after ciliary muscle disinsertion in monkeys. Invest. Ophthalmol. Vis. Sci. 67 (1999) 293-295
45. Tian B., and Kaufman P.L. Effects of the rho kinase inhibitor Y-27632 and the phosphatase inhibitor calyculin A on outflow facility in monkeys. Exp. Eye Res. 80 (2005) 215-225
46. Tian B., Kaufman P.L., Volberg T., Gabelt B.T., and Geiger B. H-7 disrupts the actin cytoskeleton and increases outflow facility. Arch. Ophthalmol. 116 (1998) 633-643
47. Tian B., Sabanay I., Peterson J.A., Hubbard W.C., Geiger B., and Kaufman P.L. Acute effects of H-7 on ciliary epithelium and corneal endothelium in monkey eyes. Curr. Eye Res. 22 (2001) 109-120
48. Tian B., Wang R.-F., Podos S.M., and Kaufman P.L. Effects of topical H-7 on outflow facility, intraocular pressure and corneal thickness in monkeys. Arch. Ophthalmol. 122 (2004) 1171-1177
49. Tokushige H., Inatani M., Nemoto S., Sakaki H., Katayama K., Uehata M., and Tanihara H. Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. Invest. Ophthalmol. Vis. Sci. 48 (2007) 3216-3222
50. Volberg T., Geiger B., Citi S., and Bershadsky A.D. Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system. Cell. Motil. Cytoskel. 29 (1994) 321-338
51. Waki M., Yoshida Y., Oka T., and Azuma M. Reduction of intraocular pressure by topical administration of an inhibitor of the rho-associated protein kinase. Curr. Eye Res. 22 (2001) 470-474
52. Wettschureck N., and Offermanns S. Rho/Rho-kinase mediated signaling in physiology and pathophysiology. J. Mol. Med. 80 (2002) 629-638
53. Wiederholt M., Thieme H., and Stumpff F. The regulation of trabecular meshwork and ciliary muscle contractility. Prog. Retin. Eye Res. 19 (2000) 271-295