Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells

Experimental Eye Research

Volumn 113, Issue , 2013, Pages 66-73

  Thomasy, Sara M ^a   Morgan, Joshua T ^a   Wood, Joshua A ^a   Murphy, Christopher J ^a,b   Russell, Paul ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biophysical cues; Extracellular matrix; Glaucoma; Mechanotransduction; Substratum compliance; Trabecular meshwork

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; DIMETHYL SULFOXIDE; LATRUNCULIN B; MESSENGER RNA; PDZ PROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYSTYRENE; PROTEIN; PROTEIN 14 3 3; SCLEROPROTEIN; UNCLASSIFIED DRUG; YES ASSOCIATED PROTEIN; CTGF PROTEIN, HUMAN; EXONUCLEASE; FUSED HETEROCYCLIC RINGS; PHOSPHOPROTEIN; SERPINE1 PROTEIN, HUMAN; SFN PROTEIN, HUMAN; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; THIAZOLIDINE DERIVATIVE; TUMOR MARKER; WWTR1 PROTEIN, HUMAN; YAP1 (YES ASSOCIATED) PROTEIN, HUMAN; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GLAUCOMA; HUMAN; HUMAN CELL; HYDROGEL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RIGIDITY; SUBSTRATUM STIFFNESS; TISSUE CULTURE; TRABECULAR MESHWORK; UPREGULATION; BIOPHYSICAL CUES; DRUG EFFECT; EXTRACELLULAR MATRIX; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; MECHANOTRANSDUCTION; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBSTRATUM COMPLIANCE; UVEA;

BIOPHYSICAL CUES; EXTRACELLULAR MATRIX; GLAUCOMA; MECHANOTRANSDUCTION; SUBSTRATUM COMPLIANCE; TRABECULAR MESHWORK;

14-3-3 PROTEINS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BICYCLO COMPOUNDS, HETEROCYCLIC; CELLS, CULTURED; CONNECTIVE TISSUE GROWTH FACTOR; DOWN-REGULATION; EXONUCLEASES; EXTRACELLULAR MATRIX; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; GLAUCOMA; HUMANS; IMMUNOBLOTTING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHOSPHOPROTEINS; PHOSPHORYLATION; PLASMINOGEN ACTIVATOR INHIBITOR 1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THIAZOLIDINES; TRABECULAR MESHWORK; TUMOR MARKERS, BIOLOGICAL; UVEA;

EID: 84879442105     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2013.05.014     Document Type: Article

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