Changes in gene expression by trabecular meshwork cells in response to mechanical stretching

Investigative Ophthalmology and Visual Science

Volumn 46, Issue 8, 2005, Pages 2857-2868

  Vittal, Vasavi ^a   Rose, Anastasia ^a   Gregory, Kate E ^a   Kelley, Mary J ^a   Acott, Ted S ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX METALLOPROTEINASE; MESSENGER RNA; PROTEOGLYCAN; EYE PROTEIN; RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; EXTRACELLULAR MATRIX; GENE EXPRESSION; INTRAOCULAR PRESSURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE; TRABECULAR MESHWORK; UNINDEXED SEQUENCE; UPREGULATION; WESTERN BLOTTING; ANIMAL; CULTURE TECHNIQUE; CYTOLOGY; DNA MICROARRAY; GENETICS; ISOLATION AND PURIFICATION; MECHANICAL STRESS; METABOLISM; PHYSIOLOGY; TIME;

ANIMALS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; EYE PROTEINS; GENE EXPRESSION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER; STRESS, MECHANICAL; SWINE; TIME FACTORS; TRABECULAR MESHWORK; UP-REGULATION;

EID: 24644436988     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.05-0075     Document Type: Article

References (92)

1. Quigley HA. Open-angle glaucoma. N Engl J Med. 1993;328:1097-1106.
2. Quigley HA. Number of people with glaucoma worldwide. Br J Ophthalmol. 1996;80:389-393.
3. Acott TS, Wirtz MK. Biochemistry of aqueous outflow. In: Ritch R, Shields MB, Krupin T, eds. The Glaucomas. Vol. 1. St. Louis: Mosby; 1996:281-305.
4. Acott TS. Biochemistry of aqueous humor outflow. In: Kaufman PL, Mittag TW, eds. Textbook of Ophthalmology. Vol. 7. London: Mosby; 1994:1.47-41.78.
5. Alexander JP, Samples JR, Van Buskirk EM, Acott TS. Expression of matrix metalloproteinases and inhibitor by human trabecular meshwork. Invest Ophthalmol Vis Sci. 1991;32:172-180.
6. Acott TS. Trabecular extracellular matrix regulation. In: Drance SM, Van Buskirk EM, Neufeld AH, eds. Pharmacology of Glaucoma. Baltimore: Williams & Wilkins; 1992:125-157.
7. Bradley JMB, Vranka JA, Colvis CM, et al. Effects of matrix metalloproteinase activity on outflow in perfused human organ culture. Invest Ophthalmol Vis Sci. 1998;39:2649-2658.
8. Parshley DE, Bradley JMB, Fisk A, et al. Laser trabeculoplasty induces stromelysin expression by trabecular juxtacanalicular cells. Invest Ophthalmol Vis Sci. 1996;37:795-804.
9. Parshley DE, Bradley JMB, Samples JR, Van Buskirk EM, Acott TS. Early changes in matrix metalloproteinases and inhibitors after in vivo laser treatment to the trabecular meshwork. Cur Eye Res. 1995;14:537-544.
10. Bradley JMB, Anderssohn AM, Colvis CM, et al. Mediation of laser trabeculoplasty-induced matrix metalloproteinase expression by IL-1β and TNFα. Invest Ophthalmol Vis Sci. 2000;41:422-430.
11. Bill A, Maepea O. Mechanisms and routes of aqueous humor drainage. In: Albert DM, Jakotiec FA, eds. Principles and Practices of Ophthalmology. Philadelphia: WB Saunders; 1994:206-226.
12. Acott TS. Receptor biology and glaucoma: integrins in the eye. In: Anderson DR, Drance SM, eds. Encounters in Glaucoma Research 1: Receptor Biology and Glaucoma. Milan, Italy: Foglizza Editore; 1994:97-135.
13. Zhou LL, Zhang S-R, Yue BYJT. Adhesion of human trabecular meshwork cells to extracellular matrix proteins: roles and distribution of integrin receptors. Invest Ophthalmol Vis Sci. 1996;37:104-113.
14. Bradley JMB, Kelley MJ, Zhu XH, Anderssohn AM, Alexander JP, Acott TS. Effects of mechanical stretching on trabecular matrix metalloproteinases. Invest Ophthalmol Vis Sci. 2001;42:1505-1513.
15. Tumminia SJ, Mitton KP, Arora J, Zelenka P, Epstein PL, Russell P. Mechanical stretch alters the actin cytoskeletal network and signal transduction in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 1998;39:1361-1371.
16. WuDunn D. The effect of mechanical strain on matrix metalloproteinase production by bovine trabecular meshwork cells. Curr Eye Res. 2001;22:394-397.
17. Okada Y, Matsuo T, Ohtsukl H. Bovine trabecular cells produce TIMP-1 and MMP-2 in response to mechanical stretching. Jpn J Ophthalmol. 1998;42:90-94.
18. Sato Y, Matouo T, Ohtsuki H. A novel gene (oculomedin) induced by mechanical stretching of human trabecular cells of the eye. Biochem Biophys Res Commun. 1999;259:349-351.
19. Stamer WD, Roberts BC, Epstein DL. Hydraulic pressure stimulates adenosine 3′, 5′-cyclic monophosphate accumulation in endothelial cells from Schlemm's canal. Invest Ophthalmol Vis Sci. 1999; 40:1983-1988.
20. Mitton KP, Tumminia SJ, Arora J, Zelenka P, Epstein DL, Russell P. Transient loss of α-crystallin: an early cellular response to mechanical stretch. Biochem Biophys Res Commun. 1997;235:69-73.
21. Tamm ER, Russell P, Epstein DL, Johnson DH, Piatigorsky J. Modulation of myocillin: TIGR expression in human trabecular meshwork. Invest Ophthalmol Vis Sci. 1999;40:2577-2582.
22. Gonzalez P, Epstein DL, Borras T. Genes upregulated in the human trabecular meshwork in response to elevated intraocular pressure. Invest Ophthalmol Vis Sci. 2000;41:352-361.
23. Borras T, Rowlette LL, Tamm ER, Gottanka J, Epstein DL. Effects of elevated intraocular pressure on outflow facility and TIGR/MYOC expression in perfused human anterior segments. Invest Ophthalmol Vis Sci. 2002;43:33-40.
24. Borras T. Gene expression in the trabecular meshwork and the influence of intraocular pressure. Prog Retin Eye Res. 2003;22:435-463.
25. Polansky JR, Wood IS, Maglio MT, Alvarado JA. Trabecular meshwork cell culture in glaucoma research: evaluation of biological activity and structural properties of human trabecular cells in vitro. Ophthalmology. 1984;91:580-595.
26. Polansky JR, Weinreb R, Alvarado JA. Studies on human trabecular cells propagated in vitro. Vision Res. 1981;21:155-160.
27. Stamer WD, Seftor RE, Williams SK, Samaha HA, Snyder RW. Isolation and culture of human trabecular meshwork cells by extracellular matrix digestion. Curr Eye Res. 1995;14:611-617.
28. Bradley JM, Kelley MJ, Rose A, Acott TS. Signaling pathways used in trabecular matrix metalloproteinase response to mechanical stretch. Invest Ophthalmol Vis Sci. 2003;44:5174-5181.
29. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1989.
30. Harlow E, Lane D. Antibodies: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1988.
31. Alexander JP, Acott TS. Involvement of protein kinase C in TNFα regulation of trabecular matrix metalloproteinases and TIMPs. Invest Ophthalmol Vis Sci. 2001;42:2831-2838.
32. Lennon G, Auffray C, Polymeropoulos M, Soares MB. The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics. 1996;33:151-152.
33. Quackenbush J. Microarray data normalization and transformation. Nat Genet. 2002;32(suppl 2):496-501.
34. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA. 2001:98:5116-5121.
35. Rasmussen R. Quantification on the LightCycler. In: Meuer S, Wittwer C, Nakagawara K-I, eds. Rapid Cycle Real-Time PCR: Methods and Applications. New York: Springer; 2001:21-34.
36. Alexander JP, Bradley JMB, Gabourel JD, Acott TS. Expression of matrix metalloproteinases and inhibitor by human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1990;31:2520-2528.
37. Samples JR, Alexander JP, Acott TS. Regulation of the levels of human trabecular matrix metalloproteinases and inhibitor by interleukin-1 and dexamethasone. Invest Ophthalmol Vis Sci. 1993; 34:3386-3395.
38. Stone EM, Fingert JH, Alward WLM, et al. Identification of a gene that causes primary open angle glaucoma. Science. 1997;275:668-670.
39. Rezaie T, Child A, Hitchings R, et al. Adult-onset primary open-angle glaucoma caused by mutations in optineurin. Science. 2002; 295:1077-1079.
40. Monemi S, Spaeth G, Dasilva A, et al. Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1. Hum Mol Genet. 2005;14:725-733.
41. Stoilova D, Child A, Trifan OC, Crick RP, Coakes RL, Sarfarazi M. Localization of a locus (GLC1B) for adult-onset primary open angle glaucoma to the 2cen-q13 region. Genomics. 1996;36:142-150.
42. Wirtz MK, Samples JR, Kramer PL, et al. Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q. Am J Hum Genet. 1997;60:296-304.
43. Trifan OC, Traboulsi EI, Stoilova D, et al. A third locus (GLC1D) for adult-onset primary open-angle glaucoma maps to the 8q23 region. Am J Ophthalmol. 1998;126:17-28.
44. Wirtz MK, Samples JR, Rust K, et al. GLC1F, a new primary open-angle glaucoma locus, maps to 7q35-q36. Arch Ophthalmol. 1999;117:237-24l.
45. Wiggs J, Allingham R, Hossain A, et al. Genome-wide scan for adult onset primary open angle glaucoma. Hum Mol Genet. 2000;9:1109-1117.
46. Nemesure B, Jiao X, He Q, et al. A genome-wide scan for primary open-angle glaucoma (POAG): the Barbados Family Study of Open-Angle Glaucoma. Hum Genet. 2003;112:600-609.
47. Wiggs JL, Lynch S, Ynagi G, et al. A genomewide scan identifies novel early-onset primary open-angle glaucoma loci on 9q22 and 2pl2. Am J Hum Genet. 2004;74:1314-1320.
48. Gonzalez P, Zigler JS Jr, Epstein DL, Borras T. Identification and isolation of differentially expressed genes from very small tissue samples. BioTecbniques. 1999;26:884-886, 888-892.
49. Kuroda S, Oyasu M, Kawakami M, et al. Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2. Biochem Biophys Res Commun. 1999; 265:79-86.
50. Ghert MA, Qi WN, Erickson HP, Block JA, Scully SP. Tenascin-C splice variant adhesive/anti-adhesive effects on chondrosarcoma cell attachment to fibronectin. Cell Struct Funct. 2001;26:179-187.
51. Joester A, Faissner A. The structure and function of tenascins in the nervous system. Matrix Biol. 2001;20:13-22.
52. Yan Q, Sage EH. SPARC, a matricellular glycoprotein with important biological functions. J Histochem Cytochem. 1999;47:1495-1506.
53. Rhee DJ, Fariss RN, Brekken R, Sage EH, Russell P. The matricellular protein SPARC is expressed in human trabecular meshwork. Exp Eye Res. 2003;77:601-607.
54. Bornstein P, Sage EH. Matricellular proteins: extracellular modulators of cell function. Curr Opin Cell Biol. 2002;14:608-616.
55. Hohenester E, Engel J. Domain structure and organisation in extracellular matrix proteins. Matrix Biol. 2002;21:115-128.
56. Santas AJ, Peterson JA, Halbleib JL, Craig SE, Humphries MJ, Peters DM. Alternative splicing of the inCS domain in fibronectin governs the role of the heparin II domain in fibrillogenesis and cell spreading. J Biol Chem. 2002;277:13650-13658.
57. Santas AJ, Bahler C, Peterson JA, et al. Effect of heparin II domain of fibronectin on aqueous outflow in cultured anterior segments of human eyes. Invest Ophthalmol Vis Sci. 2003;44:4796-4804.
58. Ekblom P, Lonai P, Talts JF. Expression and biological role of laminin-1. Matrix Biol. 2003;22:35-47.
59. Ehnis T, Dieterich W, Bauer M, Lampe B, Schuppan D. A chondroitin/dermatan sulfate form of CD44 is a receptor for collagen XTV (undulin). Exp Cell Res. 1996;229:388-397.
60. Gerecke DR, Foley JW, Castagnola P, et al. Tpe XIV collagen is encoded by alternative transcripts with distinct 5′ regions and is a multidomain protein with homologies to von Willebrand's factor, fibronectin, and other matrix proteins. J Biol Chem. 1993;268:12177-12184.
61. Yue BYJT. The extracellular matrix and its modulation in the trabecular meshwork. Surv Ophthalmol. 1996;40:379-390.
62. Mostafavi-Pour Z, Askari JA, Whittard JD, Humphries MJ. Identification of a novel heparin-binding site in the alternatively spliced IIICS region of fibronectin: roles of integrins and proteoglycans in cell adhesion to fibronectin splice variants. Matrix Biol. 2001;20:63-73.
63. Yamada KM. Fibronectin and other cell interactive glycoproteins. In: Hay ED, ed. Cell Biology of Extracellular Matrix. New York: Plenum: 1991;111-146.
64. Li J, Tripathi BJ, Tripathi RC. Modulation of pre-mRNA splicing and protein production of fibronectin by TGF-beta2 in porcine trabecular cells. Invest Ophthalmol Vis Sci. 2000;41:3437-3443.
65. Sasaki T, Fassler R, Hohenester E. Laminin: the crux of basement membrane assembly. J Cell Biol. 2004;164:959-963.
66. Kadoya Y, Salmivirta K, Talts JF, et al. Importance of nidogen binding to laminin gamma 1 for branching epithelial morphogenesis of the submandibular gland. Development. 1997;124:683-691.
67. Kuratomi Y, Nomizu M, Tanaka K, et al. Laminin gamma 1 chain peptide, C-16 (KAFDITYVRLKF), promotes migration, MMP-9 secretion, and pulmonary metastasis of B16-F10 mouse melanoma cells. Br J Cancer. 2002;86:1169-1173.
68. Nomizu M, Kuratomi Y, Song SY, et al. Identification of cell binding sequences in mouse laminin gamma 1 chain by systematic peptide screening. J Biol Chem. 1997;272:32198-32205.
69. Ponce ML, Nomizu M, Delgado MC, et al. Identification of endothelial cell binding sites on the laminin gamma 1 chain. Circ Res. 1999;84:688-694.
70. Knepper PA, Farbman AI, Telser AG. Exogenous hyaluronidases and degradation of hyaluronic acid in the rabbit eye. Invest Ophthalmol Vis Sci. 1984;25:286-293.
71. Knepper PA, Mayanil CS, Goossens W, et al. Aqueous humor in primary open-angle glaucoma contains an increased level of CD44S. Invest Ophthalmol Vis Sci. 2002;43:133-139.
72. Knepper PA, Goossens W, Mayanil CS. CD44H localization in primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 1998; 39:673-680.
73. Isacke CM, Yarwood H. The hyaluronan receptor, CD44. Int J Biochem Cell Biol. 2002;34:718-721.
74. Harigaya K. Role of CD44 and MT1-MMP in colorectal cancer invasion and metastasis [in Japanese]. Nippon Rinsho. 2003; 61(suppl 7):111-115.
75. Seiki M, Mori H, Kajita M, Uekita T, Itoh Y. Membrane-type 1 matrix metalloproteinase and cell migration. Biochem Soc Symp. 2003;70:253-262.
76. Couchman JR, Chen L, Woods A. Syndecans and cell adhesion. Int Rev Cytol. 2001;207:113-150.
77. Couchman JR. Syndecans: proteoglycan regulators of cell-surface microdomains? Nat Rev Mol Cell Biol. 2003;4:926-937.
78. Yoneda A, Couchman JR. Regulation of cytoskeletal organization by syndecan transmembrane proteoglycans. Matrix Biol. 2003;22:25-33.
79. Granes F, Berndt C, Roy C, Mangeat P, Reina M, Vilaro S. Identification of a novel ezrin-binding site in syndecan-2 cytoplasmic domain. FEBS Lett. 2003;547:212-216.
80. Ponta H, Sherman L Herrlich PA. CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol. 2003;4:33-45.
81. Ponta H, Wainwright D, Herrlich P. The CD44 protein family. Int J Biochem Cell Biol. 1998;30:299-305.
82. Hirao M, Sato N, Kondo T, et al. Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J Cell Biol. 1996;135:37-51.
83. Yonemura S, Hirao M, Doi Y, et al. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. J Cell Biol. 1998;140:885-895.
84. Chang L, Goldman RD. Intermediate filaments mediate cytoskeletal crosstalk. Nat Rev Mol Cell Biol. 2004;5:601-613.
85. Sabanay I, Tian B, Gabelt BT, Geiger B, Kaufman PL. Functional and structural reversibility of H-7 effects on the conventional aqueous outflow pathway in monkeys. Exp Eye Res. 2004;78:137-150.
86. Rao P, Deng P-F, Kumar J, Epstein D. Modulation of aqueous humor outflow facility by the Rho kinase-specinc inhibitor Y-27632. Invest Ophthalmol Vis Sci. 2001;42:1029-1037.
87. Vittitow JL, Garg R, Rowlette LL, Epstein DL, O'Brien ET, Borras T. Gene transfer of dominant-negative RhoA increases outflow facility in perfused human anterior segment cultures. Mol Vis. 2002;8:32-44.
88. Epstein D, Rowlette L-L, Roberts B. Acto-myosin drug effects and aqueous outflow function. Invest Ophthalmol Vis Sci. 1999;40:74-81.
89. Clark AF, Brotchie D, Read AT, et al. Dexamethasone alters F-actin architecture and promotes cross-linked actin network formation in human trabecular meshwork tissue. Cell Motil Cytoskeleton. 2005; 60:83-95.
90. Burdette SC, Lippard SJ. Meeting of the minds: metalloneurochemistry. Proc Natl Acad Sci USA. 2003;100:3605-3610.
91. Vasak M, Hasler DW. Metallothioneins: new functional and struc insights. Curr Opin Chem Biol. 2000;4:177-183.
92. Lu H, Hunt DM, Ganti R, et al. Metallothionein protects retinal pigment epithelial cells against apoptosis and oxidative stress. Exp Eye Res. 2002;74:83-92.