Myocilin gene expression in the trabecular meshwork of rats in a steroid-induced ocular hypertension model

Ophthalmic Research

Volumn 37, Issue 5, 2005, Pages 235-242

  Sawaguchi, Keiko ^a   Nakamura, Yoshimi ^a   Nakamura, Yuko ^a   Sakai, Hiroshi ^a   Sawaguchi, Shoichi ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

Immunohistochemistry; In situ hybridization; Myocilin; Rat steroid induced ocular hypertension model; Steroid induced ocular hypertension

Indexed keywords

DEXAMETHASONE; MESSENGER RNA; MYOCILIN; PROTEIN; STEROID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPUTER ANALYSIS; COMPUTER PROGRAM; CONTROLLED STUDY; ELECTRON; ENDOTHELIUM; ENDOTHELIUM CELL; EVALUATION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE; MONITORING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; SCHLEMM CANAL; STAINING; TRABECULAR MESHWORK;

ANIMALS; CYTOSKELETAL PROTEINS; DEXAMETHASONE; DISEASE MODELS, ANIMAL; EYE PROTEINS; GENE EXPRESSION; GLUCOCORTICOIDS; GLYCOPROTEINS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION; INTRAOCULAR PRESSURE; OCULAR HYPERTENSION; RATS; RATS, WISTAR; RNA, MESSENGER; TONOMETRY, OCULAR; TRABECULAR MESHWORK;

EID: 24744463538     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000086946     Document Type: Article

References (47)

1. Armaly MF: Effect of corticosteroids on intraocular pressure and fluid dynamics. Arch Ophthalmol 1963;70:482-491.
2. Kass MA, Johnson T: Corticosteroid-induced glaucoma. The Glaucomas, St Louis, Mosby, 1989, vol 2, pp 1161-1168.
3. Bernstein HN, Schwartz B: Effects of long-term systemic steroids on ocular pressure and tonographic values. Arch Ophthalmol 1962;68:742-753.
4. Johnson D, Gottanka J, Flugel C, Hoffman F, Futa R, Lutjen-Drecoll E: Ultrastructural changes in the trabecular meshwork of human eyes treated with corticosteroids. Arch Ophthalmol 1997;115:375-383.
5. Rohen JW, Linner E, Witmer R: Electron microscopic studies on the trabecular meshwork in two cases of corticosteroid-glaucoma. Exp Eye Res 1973;17:19-31.
6. Toriyama K: An electron microscopic study on the TM in corticosteroid-glaucoma. Folia Ophthalmol Jpn 1979;30:1583-1589.
7. Segawa K: Ultrastructural changes of the trabecular tissue in primary open angle glaucoma. Jpn J Ophthalmol 1975;19:317-338.
8. Rohen JW: Why is intraocular pressure elevated in chronic simple glaucoma? Anatomical considerations. Ophthalmology 1983;90:758-765.
9. Alvarado JA, Yun AJ, Murphy CG: Juxtacanalicular tissue in primary open angle glaucoma and in nonglaucomatous normals. Arch Ophthalmol 1986;104:1517-1528.
10. Sheffield VC, Stone EM, Alward WL, Drack AV, Johnson AT, Streb LM, Nichols BE: Genetic linkage of familial open angle glaucoma to chromosome 1q21-q31. Nat Genet 1993;4:47-50.
11. Stone EM, Fingert JH, Alward WL, Nguyen TD, Polansky JR, Sunden SL, Nishimura D, Clark AF, Nystuen A, Nichols BE, Mackey DA, Ritch R, Kalenak JW, Craven ER, Sheffield VC: Identification of a gene that causes primary open angle glaucoma. Science 1997;275:668-670.
12. Alward WL, Fingert JH, Coote MA, Johnson AT, Lerner SF, Junqua D, Durcan FJ, McCartney PJ, Mackey DA, Sheffield VC, Stone EM: Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A). N Engl J Med 1998;338:1022-1027.
13. Partridge CA, Weinstein BI, Southren AL, Gerritsen ME: Dexamethasone induces specific proteins in human trabecular meshwork cells. Invest Ophthalmol Vis Sci 1989;30:1843-1847.
14. Polansky JR, Fauss DJ, Chen P, Chen H, Lutjen-Drecoll E, Johnson D, Kurtz RM, Ma ZD, Bloom E, Nguyen TD: Cellular pharmacology and molecular biology of the trabecular meshwork inducible glucocorticoid response gene product. Ophthalmologica 1997;211:126-139.
15. Wang X, Johnson DH: mRNA in situ hybridization of TIGR/MYOC in human trabecular meshwork. Invest Ophthalmol Vis Sci 2000;41:1724-1729.
16. Clark AF, Steely HT, Dickerson JE Jr, English-Wright S, Stropki K, McCartney MD, Jacobson N, Shepard AR, Clark JI, Matsushima H, Peskind ER, Leverenz JB, Wilkinson CW, Swiderski RE, Fingert JH, Sheffield VC, Stone EM: Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues. Invest Ophthalmol Vis Sci 2001;42:1769-1780.
17. Taguchi M, Kanno H, Kubota R, Miwa S, Shishiba Y, Ozawa Y: Molecular cloning and expression profile of rat myocilin. Mol Genet Metab 2000;70:75-80.
18. Ahmed F, Torrado M, Johnson E, Morrison J, Tomarev SI: Changes in mRNA levels of the Myoc/Tigr gene in the rat eye after experimental elevation of intraocular pressure or optic nerve transection. Invest Ophthalmol Vis Sci 2001;42:3165-3172.
19. Sakai M, Sakai H, Nakamura Y, Fukuchi T, Sawaguchi S: Immunolocalization of heat shock proteins in the retina of normal monkey eyes and monkey eyes with laser-induced glaucoma. Jpn J Ophthalmol 2003;47:42-52.
20. Ueda J, Wentz-Hunter KK, Cheng EL, Fukuchi T, Abe H, Yue BY: Ultrastructural localization of myocilin in human trabecular meshwork cells and tissues. J Histochem Cytochem 2000;48:1321-1330.
21. Ueda J, Wentz-Hunter K, Yue BY: Distribution of myocilin and extracellular matrix components in the juxtacanalicular tissue of human eyes. Invest Ophthalmol Vis Sci 2002;43:1068-1076.
22. Wentz-Hunter K, Ueda J, Shimizu N, Yue BY: Myocilin is associated with mitochondria in human trabecular meshwork cells. J Cell Physiol 2002;190:46-53.
23. Bill A: The drainage of aqueous humor. Invest Ophthalmol Vis Sci 1975;14:1-3.
24. Russell P, Tamm ER, Grehn FJ, Picht G, Johnson M: The presence and properties of myocilin in the aqueous humor. Invest Ophthalmol Vis Sci 2001;42:983-986.
25. Fautsch MP, Bahler CK, Jewison DJ, Johnson DH: Recombinant TIGR/MYOC increases outflow resistance in the human anterior segment. Invest Ophthalmol Vis Sci 2000;41:4163-4168.
26. Caballero M, Rowlette LL, Borras T: Altered secretion of a TIGR/MYOC mutant lacking the olfactomedin domain. Biochim Biophys Acta 2000;1502:447-460.
27. Goldwich A, Ethier CR, Chan DW, Tamm ER: Perfusion with the olfactomedin domain of myocilin does not affect outflow facility. Invest Ophthalmol Vis Sci 2003;44:1953-1961.
28. McMenamin PG, Al-Shakarchi MJ: The effects of various levels of intraocular pressure on the rat aqueous outflow system. J Anat 1989;162:67-82.
29. Van der Zypen E: Experimental morphological study on structure and function of the filtration angle of the rat eye. Ophthalmologica 1977;174:285-298.
30. Stokes J, Noble J, Brett L, Phillips C, Seckl JR, O'Brien C, Andrew R: Distribution of glucocorticoid and mineralocorticoid receptors and 11β-hydroxysteroid dehydrogenases in human and rat ocular tissues. Invest Ophthalmol Vis Sci 2000;41:1629-1638.
31. Gonzalez P, Epstein DL, Borras T: Genes upregulated in the human trabecular meshwork in response to elevated intraocular pressure. Invest Ophthalmol Vis Sci 2000;41:352-361.
32. Knaupp C, Flugel-Koch C, Goldwich A, Ohlmann A, Tamm ER: The expression of myocilin during murine eye development. Graefes Arch Clin Exp Ophthalmol 2004;242:339-345.
33. Clark AF, Brotchie D, Read AT, Hellberg P, English-Wright S, Pang IH, Ethier CR, Grierson I: Dexamethasone alters F-actin architecture and promotes cross-linked actin network formation in human trabecular meshwork tissue. Cell Motil Cytoskeleton 2005;60:83-95.
34. Tripathi BJ, Tripathi RC, Swift HH: Hydrocortisone-induced DNA endoreplication in human trabecular cells in vitro. Exp Eye Res 1989;49:259-270.
35. Steely HT, Browder SL, Julian MB, Miggans ST, Wilson KL, Clark AF: The effects of dexamethasone on fibronectin expression in cultured human trabecular meshwork cells. Invest Ophthalmol Vis Sci 1992;33:2242-2250.
36. Yun AJ, Murphy CG, Polansky JR, Newsome DA, Alvarado JA: Proteins secreted by human trabecular cells. Glucocorticoid and other effects. Invest Ophthalmol Vis Sci 1989;30:2012-2022.
37. Hernandez MR, Weinstein BI, Dunn MW, Gordon GG, Southren AL: The effect of dexamethasone on the synthesis of collagen in normal human trabecular meshwork explants. Invest Ophthalmol Vis Sci 1985;26:1784-1788.
38. Johnson DH, Bradley JM, Acott TS: The effect of dexamethasone on glycosaminoglycans of human trabecular meshwork in perfusion organ culture. Invest Ophthalmol Vis Sci 1990;31:2568-2571.
39. Zhou L, Li Y, Yue BY: Glucocorticoid effects on extracellular matrix proteins and integrins in bovine trabecular meshwork cells in relation to glaucoma. Int J Mol Med 1998;1:339-346.
40. Engelbrecht-Schnur S, Siegner A, Prehm P, Lutjen-Drecoll E: Dexamethasone treatment decreases hyaluronan formation by primate trabecular meshwork cells in vitro. Exp Eye Res 1997;64:539-543.
41. Snyder RW, Stamer WD, Kramer TR, Seftor RE: Corticosteroid treatment and trabecular meshwork proteases in cell and organ culture supernatants. Exp Eye Res 1993;57:461-468.
42. Samples JR, Alexander JP, Acott TS: Regulation of the levels of human trabecular meshwork matrix metalloproteinases and inhibitor by interleukin-1 and dexamethasone. Invest Ophthalmol Vis Sci 1993;34:3386-3395.
43. Underwood JL, Murphy CG, Chen J, Franse-Carman L, Wood I, Epstein DL, Alvarado JA: Glucocorticoids regulate transendothelial fluid flow resistance and formation of intercellular junctions. Am J Physiol 1999;277:C330-C342.
44. Shirato S, Bloom E, Polansky JR, Alvarado JA, Stilwell L: Phagocytic properties of confluent cultured human trabecular meshwork cells. Invest Ophthalmol Vis Sci 1988;29(suppl):125.
45. Matsumoto Y, Johnson DH: Dexamethasone decreases phagocytosis by human trabecular meshwork cells in situ. Invest Ophthalmol Vis Sci 1997;38:1902-1907.
46. Putney LK, Brandt JD, O'Donnell ME: Effects of dexamethasone on sodium-potassium-chloride cotransport in trabecular meshwork cells. Invest Ophthalmol Vis Sci 1997;38:1229-1240.
47. Gould DB, Miceli-Libby L, Savinova OV, Torrado M, Tomarev SI, Smith RS, John SW: Genetically increasing Myoc expression supports a necessary pathologic role of abnormal proteins in glaucoma. Mol Cell Biol 2004;24:9019-9025.