Extracellular matrix in the trabecular meshwork

Experimental Eye Research

Volumn 86, Issue 4, 2008, Pages 543-561

  Acott, Ted S ^a   Kelley, Mary J ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

aqueous humor outflow resistance; extracellular matrix proteins; extracellular matrix turnover; proteoglycans

Indexed keywords

CD31 ANTIGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 4; COLLAGEN TYPE 5; COLLAGEN TYPE 6; CYTOKINE; DEXAMETHASONE; ELASTIN; FIBRONECTIN; GLUCOCORTICOID; GLYCOSAMINOGLYCAN; INTERLEUKIN 1; MESSENGER RNA; MYOCILIN; OSTEOPONTIN; PROTEOGLYCAN; SCLEROPROTEIN; SYNDECAN 1; SYNDECAN 2; SYNDECAN 3; SYNDECAN 4; TENASCIN; THROMBOSPONDIN 1; THROMBOSPONDIN 2; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; VASCULAR CELL ADHESION MOLECULE 1; VITRONECTIN;

AQUEOUS HUMOR FLOW; BASEMENT MEMBRANE; CELL ADHESION; CELL SURFACE; DRUG MECHANISM; EXTRACELLULAR MATRIX; FIBER; GENE EXPRESSION; HUMAN; INTRAOCULAR PRESSURE; NONHUMAN; OPEN ANGLE GLAUCOMA; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; REGULATORY MECHANISM; REVIEW; RNA SPLICING; SCHLEMM CANAL; TRABECULAR MESHWORK;

AQUEOUS HUMOR; EXTRACELLULAR MATRIX; EYE PROTEINS; GLAUCOMA; GLYCOSAMINOGLYCANS; HUMANS; INTRAOCULAR PRESSURE; PROTEOGLYCANS; TRABECULAR MESHWORK;

EID: 41049089213     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2008.01.013     Document Type: Review

References (274)

1. Abu-Lail N.I., Ohashi T., et al. Understanding the elasticity of fibronectin fibrils: unfolding strengths of FN-III and GFP domains measured by single molecule force spectroscopy. Matrix Biol. 25 (2006) 175-184
2. Acott T.S. Trabecular extracellular matrix regulation. In: Drance S.M., Van Buskirk E.M., and Neufeld A.H. (Eds). Pharmacology of Glaucoma (1992), Williams & Wilkins, Baltimore, MD 125-157
3. Acott T.S. Biochemistry of aqueous humor outflow. In: Kaufman P.L., and Mittag T.W. (Eds). Textbook of Ophthalmology 7 (1994), Mosby, London 1.47-1.78
4. Acott T.S. Receptor biology and glaucoma - integrins in the eye. In: Anderson D.R., and Drance S.M. (Eds). Encounters in Glaucoma Research 1: Receptor Biology and Glaucoma (1994), Foglizza Editore, Milan 97-135
5. Acott T.S., and Wirtz M.K. Biochemistry of aqueous outflow. In: Ritch R., Shields M.B., and Krupin T. (Eds). The Glaucomas (1996), I. Mosby, St Louis, MO 281-305
6. Acott T.S., Westcott M., et al. Trabecular meshwork glycosaminoglycans in human and cynomolgus monkey eye. Invest. Ophthalmol. Vis. Sci. 26 (1985) 1320-1329
7. Acott T.S., Kingsley P.D., et al. Human trabecular meshwork organ culture: morphology and glycosaminoglycan synthesis. Invest. Ophthalmol. Vis. Sci. 29 (1988) 90-100
8. Alexander J.P., Samples J.R., et al. Growth factor and cytokine modulation of trabecular meshwork matrix metalloproteinase and TIMP expression. Curr. Eye Res. 17 (1998) 276-285
9. Aspberg A., Adam S., et al. Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican. J. Biol. Chem. 274 (1999) 20444-20449
10. Bachmann B., Birke M., et al. Ultrastructural and biochemical evaluation of the porcine anterior chamber perfusion model. Invest. Ophthalmol. Vis. Sci. 47 (2006) 2011-2020
11. Bahler C.K., Hann C.R., et al. Pharmacologic disruption of Schlemm's canal cells and outflow facility in anterior segments of human eyes. Invest. Ophthalmol. Vis. Sci. 45 (2004) 2246-2254
12. Baldock C., Sherratt M.J., et al. The supramolecular organization of collagen VI microfibrils. J. Mol. Biol. 330 (2003) 297-307
13. Ball S.G., Baldock C., et al. The role of the C1 and C2 a-domains in type VI collagen assembly. J. Biol. Chem. 276 (2001) 7422-7430
14. Ball S., Bella J., et al. Structural basis of type VI collagen dimer formation. J. Biol. Chem. 278 (2003) 15326-15332
15. Baneyx G., Baugh L., et al. Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension. Proc. Natl. Acad. Sci. USA 99 (2002) 5139-5143
16. Bárány E. In vitro studies of the resistance to flow through the angle of the anterior chamber. Acta Soc. Med. Uppsala 59 (1953) 260-276
17. Bárány E.H., and Scotchbrook S. Influence of testicular hyaluronidase on the resistance to flow through the angle of the anterior chamber. Acta Physiol. Scand. 30 (1954) 240-248
18. Bárány E.H., and Woodin A.M. Hyaluronic acid and hyaluronidase in the aqueous humour and the angle of the anterior chamber. Acta Physiol. Scand 33 (1954) 257-290
19. Bhatt K., Gong H., et al. Freeze-fracture studies of interendothelial junctions in the angle of the human eye. Invest. Ophthalmol. Vis. Sci. 36 (1995) 1379-1389
20. Bill A., and Maepea O. Mechanisms and routes of aqueous humor drainage. In: Albert D.M., and Jakotiec F.A. (Eds). Principles and Practices of Ophthalmology (1994), WB Saunders, Philadelphia, PA 206-226
21. Bornstein P., and Sage E.H. Matricellular proteins: extracellular modulators of cell function. Curr. Opin. Cell Biol. 14 (2002) 608-616
22. Borras T. Gene expression in the trabecular meshwork and the influence of intraocular pressure. Prog. Retin. Eye Res. 22 (2003) 435-463
23. Borras T., Rowlette L.L., et al. Effects of elevated intraocular pressure on outflow facility and TIGR/MYOC expression in perfused human anterior segments. Invest. Ophthalmol. Vis. Sci. 43 (2002) 33-40
24. Bradley J.M.B., Vranka J.A., et al. Effects of matrix metalloproteinase activity on outflow in perfused human organ culture. Invest. Ophthalmol. Vis. Sci. 39 (1998) 2649-2658
25. Bradley J.M.B., Anderssohn A.M., et al. Mediation of laser trabeculoplasty-induced matrix metalloproteinase expression by IL-1β and TNFα Invest. Ophthalmol. Vis. Sci. 41 (2000) 422-430
26. Bradley J.M.B., Kelley M.J., et al. Effects of mechanical stretching on trabecular matrix metalloproteinases. Invest. Ophthalmol. Vis. Sci. 42 (2001) 1505-1513
27. Bradley J.M., Kelley M.J., et al. Signaling pathways used in trabecular matrix metalloproteinase response to mechanical stretch. Invest. Ophthalmol. Vis. Sci. 44 (2003) 5174-5181
28. Brilakis H.S., Hann C.R., et al. A comparison of different embedding media on the ultrastructure of the trabecular meshwork. Curr. Eye Res. 22 (2001) 235-244
29. Brubaker R.F. The measurement of pseudofacility and true facility by constant pressure perfusion in the normal rhesus monkey eye. Invest. Ophthalmol. 9 (1970) 42-52
30. Brubaker R.F. Flow of aqueous humor in humans. Invest. Ophthalmol. Vis. Sci. 32 (1991) 3145-3166
31. Bruns R.R., Press W., et al. Type VI collagen in extracellular, 100-nm periodic filaments and fibrils: identification by immunoelectron microscopy. J. Cell Biol. 103 (1986) 393-404
32. Buller C., and Johnson D. Segmental variability of the trabecular meshwork in normal and glaucomatous eyes. Invest. Ophthalmol. Vis. Sci. 35 (1994) 3841-3851
33. Chen Y., Kelley M.J., et al. DNA microarray analysis of gene expression in trabecular meshwork cells in response to TNFα and IL-1α. Invest. Ophthalmol. Vis. Sci. 46 (2005) (Abstract #1349)
34. Chiquet-Ehrismann R. Tenascins. Int. J. Biochem. Cell Biol. 36 (2004) 986-990
35. Chiquet-Ehrismann R., and Chiquet M. Tenascins: regulation and putative functions during pathological stress. J. Pathol. 200 (2003) 488-499
36. Chiquet-Ehrismann R., Kalla P., et al. Tenascin interferes with fibronectin action. Cell 53 (1988) 383-390
37. Choi J., Miller A.M., et al. Soluble CD44 is cytotoxic to trabecular meshwork and retinal ganglion cells in vitro. Invest. Ophthalmol. Vis. Sci. 46 (2005) 214-222
38. Chu M.L., Pan T.C., et al. Sequence analysis of alpha 1(VI) and alpha 2(VI) chains of human type VI collagen reveals internal triplication of globular domains similar to the A domains of von Willebrand factor and two alpha 2(VI) chain variants that differ in the carboxy terminus. EMBO J. 8 (1989) 1939-1946
39. Chung C.Y., Zardi L., et al. Binding of tenascin-C to soluble fibronectin and matrix fibrils. J. Biol. Chem. 270 (1995) 29012-29017
40. Clark A.F., Wilson K., et al. Glucocorticoid-induced formation of cross-linked actin networks in cultured human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 35 (1994) 281-294
41. Clark A.F., Miggans S.T., et al. Cytoskeletal changes in cultured human glaucoma trabecular meshwork cells. J. Glaucoma 4 (1995) 183-188
42. Clark A.F., Wilson K., et al. Dexamethasone-induced ocular hypertension in perfusion-cultured human eyes. Invest. Ophthalmol. Vis. Sci. 36 (1995) 478-489
43. Clark A.F., Brotchie D., et al. Dexamethasone alters F-actin architecture and promotes cross-linked actin network formation in human trabecular meshwork tissue. Cell Motil. Cytoskeleton 60 (2005) 83-95
44. Couchman J.R. Syndecans: proteoglycan regulators of cell-surface microdomains?. Nat. Rev. Mol. Cell Biol. 4 (2003) 926-937
45. Couchman J.R., and Woods A. Syndecan-4 and integrins: combinatorial signaling in cell adhesion. J. Cell Sci. 112 Pt. 20 (1999) 3415-3420
46. Couchman J.R., Chen L., et al. Syndecans and cell adhesion. Int. Rev. Cytol. 207 (2001) 113-150
47. Crawford S.E., Stellmach V., et al. Thrombospondin-1 is a major activator of TGF-beta1 in vivo. Cell 93 (1998) 1159-1170
48. De Cat B., and David G. Developmental roles of the glypicans. Semin. Cell Dev. Biol. 12 (2001) 117-125
49. Denhardt D.T., and Guo X. Osteopontin: a protein with diverse functions. FASEB J. 7 (1993) 1475-1482
50. Diskin S., Kumar J., et al. Detection of differentially expressed glycogenes in trabecular meshwork of eyes with primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 47 (2006) 1491-1499
51. Ellingsen B.A., and Grant W.M. Trabeculotomy and sinusotomy in enucleated human eyes. Invest. Ophthalmol. 11 (1972) 21-28
52. Engvall E., Hessle H., et al. Molecular assembly, secretion, and matrix deposition of type VI collagen. J. Cell Biol. 102 (1986) 703-710
53. Epstein D., and Anderson P. The biochemistry of outflow mechanisms. In: Drance S. (Ed). Glaucoma: Applied Pharmacology in Medical Treatment (1984), Grune & Stratton, New York 135-150
54. Epstein D.L., and Rohen J.W. Morphology of the trabecular meshwork and inner-wall endothelium after cationized ferritin perfusion in the monkey eye. Invest. Ophthalmol. Vis. Sci. 32 (1991) 160-171
55. Epstein D.L., Hashimoto J.M., et al. Effect of iodoacetamide perfusion on outflow facility and metabolism of the trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 20 (1981) 625-631
56. Epstein D., Rowlette L.-L., et al. Acto-myosin drug effects and aqueous outflow function. Invest. Ophthalmol. Vis. Sci. 40 (1999) 74-81
57. Ethier C.R. The inner wall of Schlemm's canal. Exp. Eye Res. 74 (2002) 161-172
58. Ethier C.R., and Chan D.-H. Cationic ferritin changes outflow facility in human eyes whereas anionic ferritin does not. Invest. Ophthalmol. Vis. Sci. 42 (2001) 1795-1802
59. Ethier C.R., Kamm R.D., et al. Calculations of flow resistance in the juxtacanalicular meshwork. Invest. Ophthalmol. Vis. Sci. 27 (1986) 1741-1750
60. Ethier C.R., Read A.T., et al. Biomechanics of Schlemm's canal endothelial cells: influence on F-actin architecture. Biophys. J. 87 (2004) 2828-2837
61. Fautsch M.P., and Johnson D.H. Aqueous humor outflow: what do we know? Where will it lead us?. Invest. Ophthalmol. Vis. Sci. 47 (2006) 4181-4187
62. Fautsch M.P., Bahler C.K., et al. Perfusion of his-tagged eukaryotic myocilin increases outflow resistance in human anterior segments in the presence of aqueous humor. Invest. Ophthalmol. Vis. Sci. 47 (2006) 213-221
63. Filla M.S., Liu X., et al. In vitro localization of TIGR/MYOC in trabecular meshwork extracellular matrix and binding to fibronectin. Invest. Ophthalmol. Vis. Sci. 43 (2002) 151-161
64. Filla M.S., David G., et al. Distribution of syndecans 1-4 within the anterior segment of the human eye: expression of a variant syndecan-3 and matrix-associated syndecan-2. Exp. Eye Res. 79 (2004) 61-74
65. Filla M.S., Woods A., et al. Beta1 and beta3 integrins cooperate to induce syndecan-4-containing cross-linked actin networks in human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 47 (2006) 1956-1967
66. Filmus J., and Selleck S.B. Glypicans: proteoglycans with a surprise. J. Clin. Invest. 108 (2001) 497-501
67. Fitzgerald J., Morgelin M., et al. The N-terminal N5 subdomain of the alpha 3(VI) chain is important for collagen VI microfibril formation. J. Biol. Chem. 276 (2001) 187-193
68. Fleenor D.L., Shepard A.R., et al. TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressure. Invest. Ophthalmol. Vis. Sci. 47 (2006) 226-234
69. Floyd B.B., Cleveland P.H., et al. Fibronectin in human trabecular drainage channels. Invest. Ophthalmol. Vis. Sci. 26 (1985) 797-804
70. Flugel-Koch C., Ohlmann A., et al. Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-beta1 and dexamethasone in vitro. Exp. Eye Res. 79 (2004) 649-663
71. Francois J. The importance of the mucopolysaccharides in intraocular pressure regulation. Invest. Ophthalmol. 14 (1975) 173-176
72. Friedman J.S., Ducharme R., et al. Isolation of a novel iris-specific and leucine-rich repeat protein (oculoglycan) using differential selection. Invest. Ophthalmol. Vis. Sci. 41 (2000) 2059-2066
73. Friedman J.S., Faucher M., et al. Protein localization in the human eye and genetic screen of opticin. Hum. Mol. Genet. 11 (2002) 1333-1342
74. Fuchshofer R., Welge-Lussen U., et al. Biochemical and morphological analysis of basement membrane component expression in corneoscleral and cribriform human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 47 (2006) 794-801
75. Fuchshofer R., Yu A.H., et al. Bone morphogenetic protein-7 is an antagonist of transforming growth factor-beta2 in human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 48 (2007) 715-726
76. Funderburgh J.L. Keratan sulfate biosynthesis. IUBMB Life 54 (2002) 187-194
77. Geiger B., and Bershadsky A. Assembly and mechanosensory function of focal contacts. Curr. Opin. Cell Biol. 13 (2001) 584-592
78. Geiger B., Bershadsky A., et al. Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk. Nat. Rev. Mol. Cell Biol. 2 (2001) 793-805
79. Gersdorff N., Otto S., et al. The absence of one or both nidogens does not alter basement membrane composition in adult murine kidney. Histol. Histopathol. 22 (2007) 1077-1084
80. Ghert M.A., Qi W.N., et al. Tenascin-C splice variant adhesive/anti-adhesive effects on chondrosarcoma cell attachment to fibronectin. Cell Struct. Funct. 26 (2001) 179-187
81. Gillan L., Matei D., et al. Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility. Cancer Res. 62 (2002) 5358-5364
82. Goldwich A., Ethier C.R., et al. Perfusion with the olfactomedin domain of myocilin does not affect outflow facility. Invest. Ophthalmol. Vis. Sci. 44 (2003) 1953-1961
83. Gong H., Trinkaus-Randall V., et al. Ultrastructural immunocytochemical localization of elastin in normal human trabecular meshwork. Curr. Eye Res. 8 (1989) 1071-1082
84. Gong H., Freddo T.F., et al. Age-related changes of sulfated proteoglycans in the normal human trabecular meshwork. Exp. Eye Res. 55 (1992) 691-709
85. Gong H., Overby D., et al. Human outflow pathway viewed by quick freeze deep etch. Invest. Ophthalmol. Vis. Sci. 42 (2001) S749
86. Gong H., Ruberti J., et al. A new view of the human trabecular meshwork using quick-freeze, deep-etch electron microscopy. Exp. Eye Res. 75 (2002) 347-358
87. Gonzalez P., Epstein D.L., et al. Genes upregulated in the human trabecular meshwork in response to elevated intraocular pressure. Invest. Ophthalmol. Vis. Sci. 41 (2000) 352-361
88. Gottanka J., Johnson D.H., et al. Beta-adrenergic blocker therapy and the trabecular meshwork. Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol. 239 (2001) 138-144
89. Gottanka J., Chan D., et al. Effects of TGF-beta2 in perfused human eyes. Invest. Ophthalmol. Vis. Sci. 45 (2004) 153-158
90. Grant S.M. Further studies on facility of flow through the trabecular meshwork. Arch. Ophthalmol. 60 (1958) 523-533
91. Grant W.M. Facility of flow through the trabecular meshwork. Arch. Ophthalmol. 54 (1956) 245-248
92. Grant W.M. Experimental aqueous perfusion in enucleated human eyes. Arch. Ophthalmol. 69 (1963) 783-801
93. Gregory K., Kelley M.J., et al. Alternative splicing of extracellular matrix genes by trabecular meshwork cells subjected to mechanical stretch. Invest. Ophthalmol. Vis. Sci. 46 (2005) 1341
94. Grierson I., and Calthorpe C.M. Characteristics of meshwork cells and age changes in the outflow system of the eye: their relevance to primary open-angle glaucoma. In: Mills K.B. (Ed). Glaucoma. Proceedings of the Fourth International Symposium of the Northern Eye Institute (1989), Pergamon Press, Oxford 12-31
95. Grierson I., and Lee W.R. Junctions between the cells of the trabecular meshwork. Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol. 192 (1974) 89-104
96. Grierson I., and Lee W.R. Acid mucopolysaccharides in the outflow apparatus. Exp. Eye Res. 21 (1975) 417-431
97. Grierson I., Lee W.R., et al. Associations between the cells of the walls of Schlemm's canal. Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol. 208 (1978) 33-47
98. Hann C.R., and Johnson D.H. Trabecular meshwork pigmentation and collector channels - areas of higher flow?. Invest. Ophthalmol. Vis. Sci. (2007) ARVO e-Abstracts, #2053
99. Hann C.R., Bahler C.K., et al. Cationic ferritin and segmental flow through the trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 46 (2005) 1-7
100. Hartwig S., Hu M.C., et al. Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo. Mech. Dev. 122 (2005) 928-938
101. Heimark R.L., Kaochar S., et al. Human Schlemm's canal cells express the endothelial adherens proteins, VE-cadherin and PECAM-1. Curr. Eye Res. 25 (2002) 299-308
102. Hernandez M.R., and Gong H. Extracellular Matrix of the Trabecular Meshwork and Optic Nerve Head (1996), Mosby-Year Book, Inc., St. Louis, MO
103. Hessle H., and Engvall E. Type VI collagen. Studies on its localization, structure, and biosynthetic form with monoclonal antibodies. J. Biol. Chem. 259 (1984) 3955-3961
104. Hogan M.J., Alvarado J.A., et al. Histology of the Human Eye. An Atlas and Textbook (1971), W.B. Saunders Company, Philadelphia, PA
105. Hubbard W., Johnson M., et al. Intraocular pressure and outflow facility are unchanged following acute and chronic intracameral chondroitinase ABC and hyaluronidase in monkeys. Exp. Eye Res. 65 (1997) 177-190
106. Inomata H., Bill A., et al. Aqueous humor pathways through the trabecular meshwork and into Schlemm's canal in the cynomolgus monkey (Macaca irus): an electron microscopic study. Am. J. Ophthalmol. 73 (1972) 760
107. Ishibashi T., Takagi Y., et al. cDNA microarray analysis of gene expression changes induced by dexamethasone in cultured human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 43 (2002) 3691-3697
108. Isogai Z., Aspberg A., et al. Versican interacts with fibrillin-1 and links extracellular microfibrils to other connective tissue networks. J. Biol. Chem. 277 (2002) 4565-4572
109. Itano N., and Kimata K. Mammalian hyaluronan synthases. IUBMB Life 54 (2002) 195-199
110. Johnson D. The effect of cytochalasin D on outflow facility and the trabecular meshwork of the human eye in perfusion organ culture. Invest. Ophthalmol. Vis. Sci. 38 (1997) 2790-2799
111. Johnson D., and Bahler C. Heparitinase increases outflow facility in the human eye. Invest. Ophthalmol. Vis. Sci. 40 (1999) (Abstract S504)
112. Johnson D., Gottanka J., et al. Ultrastructural changes in the trabecular meshwork of human eyes treated with corticosteroids. Arch. Ophthalmol. 115 (1997) 375-383
113. Johnson M. What controls aqueous humour outflow resistance?. Exp. Eye Res. 82 (2006) 545-557
114. Johnson M., and Erickson K. Mechanisms and routes of aqueous humor drainage. In: Albert D., and Jakobie F. (Eds). Principles and Practice of Ophthalmology (2000), W.B. Saunders Company, Philadelphia, PA 2577-2595
115. Johnson M., Shapiro A., et al. Modulation of outflow resistance by the pores of the inner wall endothelium. Invest. Ophthalmol. Vis. Sci. 33 (1992) 1670-1675
116. Johnstone M.A. The aqueous outflow system as a mechanical pump: evidence from examination of tissue and aqueous movement in human and non-human primates. J. Glaucoma 13 (2004) 421-438
117. Jumper M.D., Stern R., et al. Expression of CD44 isoforms in cultured human trabecular meshwork cells. Ophthalmic Res. 30 (1998) 314-320
118. Kania A.M., Reichenberger E., et al. Structural variation of type XII collagen at its carboxyl-terminal NC1 domain generated by tissue-specific alternative splicing. J. Biol. Chem. 274 (1999) 22053-22059
119. Kaufman P.L., and Erickson K.A. Cytochalasin B and D dose-outflow facility response relationships in the cynomolgus monkey. Invest. Ophthalmol. Vis. Sci. 23 (1982) 646-650
120. Keller, K.E., Bradley, J.M., et al. Effects of modifiers of glycosaminoglycan biosynthesis on outflow facility in perfusion culture. Invest. Ophthalmol. Vis. Sci., in press.
121. Keller K.E., Bradley J.M., et al. Effect of modifiers of glycosaminoglycan biosynthesis on outflow facility in perfusion culture. Invest. Ophthalmol. Vis. Sci. 48 (2007) (e-Abstract #2052)
122. Keller K.E., Kelley M.J., et al. Extracellular matrix gene alternative splicing by trabecular meshwork cells in response to mechanical stretching. Invest. Ophthalmol. Vis. Sci. 48 (2007) 1164-1172
123. Kelley M.J., Radecki M.I., et al. Changes in beta3-integrin levels and protein associations following trabecular cell mechanical stretching. Invest. Ophthalmol. Vis. Sci 41 (2000) S505
124. Kelley M.J., Rose A.Y., et al. Synergism of TNF and IL-1 in the induction of matrix metalloproteinase-3 in trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 48 (2007) 2634-2643
125. Kenagy R.D., Plaas A.H., et al. Versican degradation and vascular disease. Trends Cardiovasc. Med. 16 (2006) 209-215
126. Kielty C.M., Cummings C., et al. Isolation and ultrastructural analysis of microfibrillar structures from foetal bovine elastic tissues. Relative abundance and supramolecular architecture of type VI collagen assemblies and fibrillin. J. Cell Sci. 99 Pt. 4 (1991) 797-807
127. Kielty C.M., Whittaker S.P., et al. Attachment of human vascular smooth muscles cells to intact microfibrillar assemblies of collagen VI and fibrillin. J. Cell Sci. 103 Pt. 2 (1992) 445-451
128. Kielty C.M., Whittaker S.P., et al. Type VI collagen microfibrils: evidence for a structural association with hyaluronan. J. Cell Biol. 118 (1992) 979-990
129. Kielty C.M., Baldock C., et al. Fibrillin: from microfibril assembly to biomechanical function. Phil. Trans. R. Soc. Lond. B Biol. Sci. 357 (2002) 207-217
130. Kielty C.M., Wess T.J., et al. Fibrillin-rich microfibrils: elastic biopolymers of the extracellular matrix. J. Muscle Res. Cell Motil. 23 (2002) 581-596
131. Kielty C.M., Sherratt M.J., et al. Fibrillin microfibrils. Adv. Protein Chem. 70 (2005) 405-436
132. Kii I., Amizuka N., et al. Periostin is an extracellular matrix protein required for eruption of incisors in mice. Biochem. Biophys. Res. Commun. 342 (2006) 766-772
133. Knepper P.A., Farbman A.I., et al. Aqueous outflow pathway glycosaminoglycans. Exp. Eye Res. 32 (1981) 265-277
134. Knepper P.A., Farbman A.I., et al. Exogenous hyaluronidases and degradation of hyaluronic acid in the rabbit eye. Invest. Ophthalmol. Vis. Sci. 25 (1984) 286-293
135. Knepper P.A., Goossens W., et al. Glycosaminoglycans of the human trabecular meshwork in primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 37 (1996) 1360-1367
136. Knepper P.A., Goossens W., et al. Glycosaminoglycan stratification of the juxtacanalicular tissue in normal and primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 37 (1996) 2414-2425
137. Knepper P., Goossens W., et al. CD44H localization in primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 39 (1998) 673-680
138. Knepper P.A., Mayanil C.S., et al. Aqueous humor in primary open-angle glaucoma contains an increased level of CD44S. Invest. Ophthalmol. Vis. Sci. 43 (2002) 133-139
139. Knepper P.A., Miller A.M., et al. Hypophosphorylation of aqueous humor sCD44 and primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 46 (2005) 2829-2837
140. Knupp C., Pinali C., et al. Structural correlation between collagen VI microfibrils and collagen VI banded aggregates. J. Struct. Biol. 154 (2006) 312-326
141. In: Kreis T., and Vale R. (Eds). Guidebook to the Extracellular Matrix, Anchor, and Adhesion Proteins (1999), Oxford University Press, Oxford
142. Lerner L.E., Polansky J.R., et al. Hyaluronan in the human trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 38 (1997) 1222-1228
143. Li J., Tripathi B.J., et al. Modulation of pre-mRNA splicing and protein production of fibronectin by TGF-beta2 in porcine trabecular cells. Invest. Ophthalmol. Vis. Sci. 41 (2000) 3437-3443
144. Linsenmayer T.F. Collagen. In: Hay E.D. (Ed). Cell Biology of Extracellular Matrix (1991), Plenum Press, New York 7-44
145. Liton P.B., Luna C., et al. Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue. Mol. Vis. 12 (2006) 774-790
146. Litvin J., Selim A.H., et al. Expression and function of periostin-isoforms in bone. J. Cell Biochem. 92 (2004) 1044-1061
147. Liu X., Wu Z., et al. Low dose latrunculin-A inhibits dexamethasone-induced changes in the actin cytoskeleton and alters extracellular matrix protein expression in cultured human trabecular meshwork cells. Exp. Eye Res. 77 (2003) 181-188
148. Lo W.R., Rowlette L.L., et al. Tissue differential microarray analysis of dexamethasone induction reveals potential mechanisms of steroid glaucoma. Invest. Ophthalmol. Vis. Sci. 44 (2003) 473-485
149. Lütjen-Drecoll E. Functional morphology of the trabecular meshwork in primate eyes. Prog. Retin. Eye Res. 18 (1999) 91-119
150. Lütjen-Drecoll E., and Rohen J.W. Anatomy of aqueous humor formation and drainage. In: Podos S.M., and Yanoff M. (Eds). Textbook of Ophthalmology 7 (1994), Mosby, London 1.1-1.16
151. Lütjen-Drecoll E., and Rohen J.W. Morphology of aqueous outflow pathways in normal and glaucomatous eyes. In: Ritch R., Shields M.B., and Krupin T. (Eds). The Glaucomas (1996), I. Mosby-Year Book, Inc., St. Louis, MO 89-124
152. Lütjen-Drecoll E., and Rohen J.W. Functional morphology of the trabecular meshwork. In: Tasman W., and Jaeger E.A. (Eds). Duane's Foundations of Clinical Ophthalmology (2001), J.B. Lippincott Company, Philadelphia, PA 1-30
153. Differences in the amount of 'plaque-material' in the outflow system of eyes with chronic simple and exfoliation glaucoma. In: Lütjen-Drecoll E., and Tamm E. (Eds). Glaucoma Update III (1987), Springer-Verlag, Berlin, Heidelberg
154. Lütjen-Drecoll E., Futa R., et al. Ultrahistochemical studies on tangential sections of the trabecular meshwork in normal and glaucomatous eyes. Invest. Ophthalmol. Vis. Sci. 21 (1981) 563-573
155. Lütjen-Drecoll E., Shimizu T., et al. Quantitative analysis of "plaque material" in the inner- and outer wall of Schlemm's canal in normal and glaucomatous eyes. Exp. Eye Res. 42 (1986) 443-455
156. Lütjen-Drecoll E., Rittig M., et al. Immunomicroscopical study of type VI collagen in the trabecular meshwork of normal and glaucomatous eyes. Exp. Eye Res. 48 (1989) 139-147
157. Lütjen-Drecoll E., Schenholm M., et al. Visualization of hyaluronic acid in the anterior segment of rabbit and monkey eyes. Exp. Eye Res. 51 (1990) 55-63
158. Maepea O., and Bill A. Pressures in the juxtacanalicular tissue and Schlemm's canal in monkeys. Exp. Eye Res. 54 (1992) 879-883
159. Mao Y., and Schwarzbauer J.E. Fibronectin fibrillogenesis, a cell-mediated matrix assembly process. Matrix Biol. 24 (2005) 389-399
160. Marshall G.E., Konstas A.G., et al. Immunogold localization of type IV collagen and laminin in the aging human outflow system. Exp. Eye Res. 51 (1990) 691-699
161. Marshall G.E., Konstas A.G.P., et al. Immunogold ultrastructural localization of collagens in the aged human outflow system. Ophthalmology 98 (1991) 692-700
162. McEwen W.K. Application of Poiseuille's law to aqueous outflow. Arch. Ophthalmol. 60 (1958) 290-294
163. Morrison J.C., and Acott T.S. Anatomy and physiology of aqueous humor outflow. In: Morrison J.C., and Pollack I.P. (Eds). Glaucoma: Science and Practice (2003), Thieme, New York 34-41
164. Murphy C.G., Yun A.J., et al. Localization of extracellular proteins of the human trabecular meshwork by indirect immunofluorescence. Am. J. Ophthalmol. 104 (1987) 33-43
165. O'Regan A., and Berman S. Osteopontin: a key cytokine in cell-mediated and granulomatous inflammation. Int. J. Exp. Pathol. 81 (2000) 373-390
166. Olin A.I., Morgelin M., et al. The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding. J. Biol. Chem. 276 (2001) 1253-1261
167. Overby D., Gong H., et al. The mechanism of increasing outflow facility during washout in the bovine eye. Invest. Ophthalmol. Vis. Sci. 43 (2002) 3455-3464
168. Parc C., Johnson D., et al. Giant vacuoles are found preferentially near collector channels. Invest. Ophthalmol. Vis. Sci. 41 (2000) 2984-2990
169. In: Parks W., and Mecham R. (Eds). Matrix Metalloproteinases (1998), Academic Press, San Diego, CA
170. Parshley D.E., Bradley J.M.B., et al. Early changes in matrix metalloproteinases and inhibitors after in vivo laser treatment to the trabecular meshwork. Curr. Eye Res. 14 (1995) 537-544
171. Parshley D.E., Bradley J.M.B., et al. Laser trabeculoplasty induces stromelysin expression by trabecular juxtacanalicular cells. Invest. Ophthalmol. Vis. Sci. 37 (1996) 795-804
172. Pedler C. The relationship of hyaluronidase to aqueous outflow resistance. Trans. Ophthalmol. Soc. UK 76 (1956) 51-63
173. Peterson W.S., and Jocson V.L. Hyaluronidase effects on aqueous outflow resistance. Quantitative and localizing studies in the rhesus monkey eye. Am. J. Ophthalmol. 77 (1974) 573-577
174. Peterson J.A., Tian B., et al. In cynomolgus monkeys Latrunculin (LAT)-A, LAT-B increase outflow facility, LQT-A decreased intraocular pressure and initially increases aqueous humor formation. Invest. Ophthalmol. Vis. Sci. 38 Suppl. (1997) S243
175. Peterson J.A., Sheibani N., et al. Heparin II domain of fibronectin uses alpha4beta1 integrin to control focal adhesion and stress fiber formation, independent of syndecan-4. J. Biol. Chem. 280 (2005) 6915-6922
176. Polansky J.R., and Nguyen T.D. The TIGR gene, pathogenic mechanisms, and other recent advances in glaucoma genetics. Curr. Opin. Ophthalmol. 9 (1998) 15-23
177. Polansky J.R., Fauss D.J., et al. Cellular pharmacology and molecular biology of the trabecular meshwork inducible glucocorticoid response gene product. Ophthalmologica 211 (1997) 126-139
178. Polansky J.R., Fauss D.J., et al. Regulation of TIGR/MYOC gene expression in human trabecular meshwork cells. Eye 14 Pt. 3B (2000) 503-514
179. Quigley H.A. Open-angle glaucoma. N. Engl. J. Med. 328 (1993) 1097-1106
180. Quigley H.A. Number of people with glaucoma worldwide. Br. J. Ophthalmol. 80 (1996) 389-393
181. Quigley H.A., and Vitale S. Models of open-angle glaucoma prevalence and incidence in the United States. Invest. Ophthalmol. Vis. Sci. 38 (1997) 83-91
182. Rao P., Deng P.-F., et al. Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. Invest. Ophthalmol. Vis. Sci. 42 (2001) 1029-1037
183. Rao P.V., Deng P., et al. Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow. Mol. Vis. 11 (2005) 288-297
184. Raviola G., and Raviola E. Paracellular route of aqueous outflow in the trabecular meshwork and canal of Schlemm. A freeze-fracture study of the endothelial junctions in the sclerocorneal angel of the macaque monkey eye. Invest. Ophthalmol. Vis. Sci. 21 (1981) 52-72
185. Reale E., Groos S., et al. In the mammalian eye type VI collagen tetramers form three morphologically different aggregates. Matrix Biol. 20 (2001) 37-51
186. Rhee D.J., Fariss R.N., et al. The matricellular protein SPARC is expressed in human trabecular meshwork. Exp. Eye Res. 77 (2003) 601-607
187. Richardson T.M. Distribution of glycosaminoglycans in the aqueous outflow system of the cat. Invest. Ophthalmol. Vis. Sci. 22 (1982) 319-329
188. Rohen J.W. Why is intraocular pressure elevated in chronic simple glaucoma?. Ophthalmology 90 (1983) 758-765
189. Rohen J.W., and Lutjen-Drecoll E. Ageing- and Non-ageing Processes within the Connective Tissues of the Anterior Segment of the Eye (1981), Steiner Verlag, Weisbaden
190. Rohen J.W., and Lütjen-Drecoll E. Biology of the Trabecular Meshwork (1982), F.K. Schattauer Verlag, Stuttgart
191. Rohen J.W., Futa R., et al. The fine structure of the cribriform meshwork in normal and glaucomatous eyes as seen in tangential sections. Invest. Ophthalmol. Vis. Sci. 21 (1981) 574-585
192. Rohen J.W., Schachtschabel D.O., et al. Histoautoradiographic and biochemical studies on human and monkey trabecular meshwork and ciliary body in short-term explant culture. Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol. 221 (1984) 199-206
193. Rohen J.W., Lütjen-Drecoll E., et al. Ultrastructure of the trabecular meshwork in untreated cases of primary open-angle glaucoma (POAG). Exp. Eye Res. 56 (1993) 683-692
194. Rose A.Y., Bradley J.M., et al. Integrin responses to mechanical stretching in trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 43 (2002) 1021
195. Rosenquist R., Epstein D., et al. Outflow resistance of enucleated human eyes at two different perfusion pressures and different extents of trabeculotomy. Curr. Eye Res. 8 (1989) 1233-1240
196. Sabanay I., Gabelt B., et al. H-7 effects on the structure and fluid conductance of monkey trabecular meshwork. Arch. Ophthalmol. 118 (2000) 955-962
197. Sakai L.Y., Keene D.R., et al. Purification and partial characterization of fibrillin, a cysteine-rich structural component of connective tissue microfibrils. J. Biol. Chem. 266 (1991) 14763-14770
198. Samples J.R., Alexander J.P., et al. Regulation of the levels of human trabecular matrix metalloproteinases and inhibitor by interleukin-1 and dexamethasone. Invest. Ophthalmol. Vis. Sci. 34 (1993) 3386-3395
199. Sanka K., Maddala R., et al. Influence of actin cytoskeletal integrity on matrix metalloproteinase-2 activation in cultured human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 48 (2007) 2105-2114
200. Santas A.J., Peterson J.A., et al. Alternative splicing of the IIICS domain in fibronectin governs the role of the heparin II domain in fibrillogenesis and cell spreading. J. Biol. Chem. 277 (2002) 13650-13658
201. Santas A.J., Bahler C., et al. Effect of heparin II domain of fibronectin on aqueous outflow in cultured anterior segments of human eyes. Invest. Ophthalmol. Vis. Sci. 44 (2003) 4796-4804
202. Sawaguchi S., Yue B., et al. Effects of intracameral injection of chondroitinase ABC in vivo. Arch. Ophthalmol. 110 (1992) 110-117
203. Sawaguchi S., Lam T.T., et al. Effects of glycosaminoglycan-degrading enzymes on bovine trabecular meshwork in organ culture. J. Glaucoma 2 (1993) 80-86
204. Schachtschabel D.O., Bigalke B., et al. Production of glycosaminoglycans by cell cultures of the trabecular meshwork of the primate eye. Exp. Eye Res. 24 (1977) 71-80
205. Schachtschabel D.O., Rohen J.W., et al. Synthesis and composition of glycosaminoglycans by cultured human trabecular meshwork cells. Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol. 218 (1982) 113-117
206. Schachtschabel U., Lindsey J.D., et al. The mechanism of action of prostaglandins on uveoscleral outflow. Curr. Opin. Ophthalmol. 11 (2000) 112-115
207. Scheele S., Nystrom A., et al. Laminin isoforms in development and disease. J. Mol. Med. 85 (2007) 825-836
208. Segade F., Trask B.C., et al. Identification of a matrix-binding domain in MAGP1 and MAGP2 and intracellular localization of alternative splice forms. J. Biol. Chem. 277 (2002) 11050-11057
209. Segawa K. Electron microscopic changes of the trabecular tissue in primary open-angle glaucoma. Ann. Ophthalmol. 11 (1979) 49-54
210. Si Z., Palkama A., et al. Distribution of thrombospondin-4 in the bovine eye. Curr. Eye Res. 27 (2003) 165-173
211. Silbert J.E., and Sugumaran G. Biosynthesis of chondroitin/dermatan sulfate. IUBMB Life 54 (2002) 177-186
212. Sodek J., Ganss B., et al. Osteopontin. Crit. Rev. Oral Biol. Med. 11 (2000) 279-303
213. Song H.H., and Filmus J. The role of glypicans in mammalian development. Biochim. Biophys. Acta 1573 (2002) 241-246
214. Song H.H., Shi W., et al. The loss of glypican-3 induces alterations in Wnt signaling. J. Biol. Chem. 280 (2005) 2116-2125
215. Specks U., Mayer U., et al. Structure of recombinant N-terminal globule of type VI collagen alpha 3 chain and its binding to heparin and hyaluronan. EMBO J. 11 (1992) 4281-4290
216. Steely H.T., Browder S.L., et al. The effects of dexamethasone on fibronectin expression in cultured human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 33 (1992) 2242-2250
217. Stone E.M., Fingert J.H., et al. Identification of a gene that causes primary open angle glaucoma. Science 275 (1997) 668-670
218. Sugahara K., and Kitagawa H. Heparin and heparan sulfate biosynthesis. IUBMB Life 54 (2002) 163-175
219. Suzuki R., and Anderson P. A temperature dependent action of fluoride on aqueous outflow facility of the calf eye. Curr. Eye Res. 12 (1993) 1-7
220. Tamm E., Flugel C., et al. Contractile cells in the human scleral spur. Exp. Eye Res. 54 (1992) 531-543
221. Tamm E., Flugel C., et al. Immunocytochemical and ultrastructural studies of human scleral spur. Characterization of a contractile cell population. Ophthalmologe 90 (1993) 66-72
222. Tanihara H., Ohira A., et al. Localization and possible gene expression of proteoglycan decorin in the trabecular meshwork. Curr. Eye Res. 14 (1995) 727-730
223. Tawara A., and Inomata H. Distribution and characterization of sulfated proteoglycans in the trabecular tissue of goniodysgenetic glaucoma. Am. J. Ophthalmol. 117 (1994) 741-755
224. Tawara A., Varner H.H., et al. Distribution and characterization of sulfated proteoglycans in the human trabecular tissue. Invest. Ophthalmol. Vis. Sci. 30 (1989) 2215-2231
225. Tian B., Kaufman P.L., et al. H-7 disrupts the actin cytoskeleton and increases outflow facility. Arch. Ophthalmol. 116 (1998) 633-643
226. Timpl R., Sasaki T., et al. Fibulins: a versatile family of extracellular matrix proteins. Nat. Rev. Mol. Cell Biol. 4 (2003) 479-489
227. Trask B.C., Trask T.M., et al. The microfibrillar proteins MAGP-1 and fibrillin-1 form a ternary complex with the chondroitin sulfate proteoglycan decorin. Mol. Biol. Cell 11 (2000) 1499-1507
228. Trask T.M., Ritty T.M., et al. N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly. Biochem. J. 340 Pt. 3 (1999) 693-701
229. Tripathi R.C. Mechanism of the aqueous outflow across the trabecular wall of Schlemm's canal. Exp. Eye Res. 11 (1971) 116-121
230. Tripathi R.C. The functional morphology of the outflow systems of ocular and cerebrospinal fluids. Exp. Eye Res. 25 Suppl. (1977) 65-116
231. Tripathi B.J., Tripathi R.C., et al. Synthesis of a thrombospondin-like cytoadhesion molecule by cells of the trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 32 (1991) 181-188
232. Tripathi B.J., Hansen M., et al. Identification of type VI collagen in the trabecular meshwork and expression of its mRNA by trabecular cells. Exp. Eye Res. 58 (1994) 181-187
233. Tripathi R.C., Li J., et al. Aqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2. Exp. Eye Res. 59 (1994) 723-727
234. Tschumper R.C., Johnson D.H., et al. Glycosaminoglycans of human trabecular meshwork in perfusion organ culture. Curr. Eye Res. 9 (1990) 363-369
235. Tumminia S.J., Mitton K.P., et al. Mechanical stretch alters the actin cytoskeletal network and signal transduction in human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 39 (1998) 1361-1371
236. Tumova S., Woods A., et al. Heparan sulfate chains from glypican and syndecans bind the Hep II domain of fibronectin similarly despite minor structural differences. J. Biol. Chem. 275 (2000) 9410-9417
237. Ueda J., and Yue B.Y. Distribution of myocilin and extracellular matrix components in the corneoscleral meshwork of human eyes. Invest. Ophthalmol. Vis. Sci. 44 (2003) 4772-4779
238. Ueda J., Wentz-Hunter K., et al. Distribution of myocilin and extracellular matrix components in the juxtacanalicular tissue of human eyes. Invest. Ophthalmol. Vis. Sci. 43 (2002) 1068-1076
239. Umihira J., Nagata S., et al. Localization of elastin in the normal and glaucomatous human trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 35 (1994) 486-494
240. Vainio S., Jalkanen M., et al. Syndecan and tenascin expression is induced by epithelial-mesenchymal interactions in embryonic tooth mesenchyme. J. Cell Biol. 108 (1989) 1945-1953
241. Van Buskirk E.M., and Brant W.M. Influence of temperature and the question of involvement of cellular metabolism in aqueous outflow. Am. J. Ophthalmol. 77 (1974) 565-572
242. Van Buskirk E.M., and Brett J. The canine eye: in vitro dissolution of the barriers to aqueous outflow. Invest. Ophthalmol. Vis. Sci. 17 (1978) 258-271
243. Vittal V., Rose A., et al. Changes in gene expression by trabecular meshwork cells in response to mechanical stretching. Invest. Ophthalmol. Vis. Sci. 46 (2005) 2857-2868
244. Vittitow J., and Borras T. Genes expressed in the human trabecular meshwork during pressure-induced homeostatic response. J. Cell Physiol. 201 (2004) 126-137
245. Vittitow J.L., Garg R., et al. Gene transfer of dominant-negative RhoA increases outflow facility in perfused human anterior segment cultures. Mol. Vis. 8 (2002) 32-44
246. Vogel V., and Sheetz M. Local force and geometry sensing regulate cell functions. Nat. Rev. Mol. Cell Biol. 7 (2006) 265-275
247. Wang N., Chintala S.K., et al. Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype. Nat. Med. 7 (2001) 304-309
248. Weinreb R.N. Uveoscleral outflow: the other outflow pathway. J. Glaucoma 9 (2000) 343-345
249. Weinreb R.N., Toris C.B., et al. Effects of prostaglandins on the aqueous humor outflow pathways. Surv. Ophthalmol. 47 Suppl. 1 (2002) S53-S64
250. Welge-Lussen U., May C.A., et al. AlphaB-crystallin in the trabecular meshwork is inducible by transforming growth factor-beta. Invest. Ophthalmol. Vis. Sci. 40 (1999) 2235-2241
251. Welge-Lussen U., May C.A., et al. Induction of tissue transglutaminase in the trabecular meshwork by TGF-beta1 and TGF-beta2. Invest. Ophthalmol. Vis. Sci. 41 (2000) 2229-2238
252. Wiberg C., Hedbom E., et al. Biglycan and decorin bind close to the n-terminal region of the collagen VI triple helix. J. Biol. Chem. 276 (2001) 18947-18952
253. Wiberg C., Heinegard D., et al. Biglycan organizes collagen VI into hexagonal-like networks resembling tissue structures. J. Biol. Chem. 277 (2002) 49120-49126
254. Wiberg C., Klatt A.R., et al. Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan. J. Biol. Chem. 278 (2003) 37698-37704
255. Wight T.N. Versican: a versatile extracellular matrix proteoglycan in cell biology. Curr. Opin. Cell Biol. 14 (2002) 617-623
256. Wirtz M.K., Bradley J.M.B., et al. Proteoglycan expression by human trabecular meshworks. Curr. Eye Res. 16 (1997) 412-421
257. Wordinger R.J., Fleenor D.L., et al. Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma. Invest. Ophthalmol. Vis. Sci. 48 (2007) 1191-1200
258. Wu Y.J., La Pierre D.P., et al. The interaction of versican with its binding partners. Cell Res. 15 (2005) 483-494
259. Xue W., Wallin R., et al. Matrix GLA protein function in human trabecular meshwork cells: inhibition of BMP2-induced calcification process. Invest. Ophthalmol. Vis. Sci. 47 (2006) 997-1007
260. Xue W., Comes N., et al. Presence of an established calcification marker in trabecular meshwork tissue of glaucoma donors. Invest. Ophthalmol. Vis. Sci. 48 (2007) 3184-3194
261. Yoneda A., and Couchman J.R. Regulation of cytoskeletal organization by syndecan transmembrane proteoglycans. Matrix Biol. 22 (2003) 25-33
262. Yue B.Y.J.T. The extracellular matrix and its modulation in the trabecular meshwork. Surv. Ophthalmol. 40 (1996) 379-390
263. Yue B.Y.J.T., and Elvart J.L. Biosynthesis of glycosaminoglycans by trabecular meshwork cells in vitro. Curr. Eye Res. 6 (1987) 959-967
264. Zanussi S., Doliana R., et al. The human type VI collagen gene. mRNA and protein variants of the alpha 3 chain generated by alternative splicing of an additional 5-end exon. J. Biol. Chem. 267 (1992) 24082-24089
265. Zhao X., and Russell P. Versican splice variants in human trabecular meshwork and ciliary muscle. Mol. Vis. 11 (2005) 603-608
266. Zhao X., Ramsey K.E., et al. Gene and protein expression changes in human trabecular meshwork cells treated with transforming growth factor-beta. Invest. Ophthalmol. Vis. Sci. 45 (2004) 4023-4034
267. Zhou L.L., Zhang S.-R., et al. Adhesion of human trabecular meshwork cells to extracellular matrix proteins: roles and distribution of integrin receptors. Invest. Ophthalmol. Vis. Sci. 37 (1996) 104-113
268. Zhou L., Higginbotham E.J., et al. Effects of ascorbic acid on levels of fibronectin, laminin and collagen type 1 in bovine trabecular meshwork in organ culture. Curr. Eye Res. 17 (1998) 211-217
269. Zhou L., Li Y., et al. Glucocorticoid effects on extracellular matrix proteins and integrins in bovine trabecular meshwork cells in relation to glaucoma. Int. J. Mol. Med. 1 (1998) 339-346
270. Zhou L., Li Y., et al. Alteration of cytoskeletal structure, integrin distribution, and migratory activity by phagocytic challenge in cells from an ocular tissue - the trabecular meshwork. In Vitro Cell Dev. Biol. Anim. 35 (1999) 144-149
271. Zhou L., Li Y., et al. Oxidative stress affects cytoskeletal structure and cell-matrix interactions in cells from an ocular tissue: the trabecular meshwork. J. Cell Physiol. 180 (1999) 182-189
272. Zhou L., Maruyama I., et al. Expression of integrin receptors in the human trabecular meshwork. Curr. Eye Res. 19 (1999) 395-402
273. Zhou L., Cheng E.L., et al. Signal transduction mediated by adhesion of human trabecular meshwork cells to extracellular matrix. Exp. Eye Res. 70 (2000) 457-465
274. Zillig M., Wurm A., et al. Overexpression and properties of wild-type and Tyr437His mutated myocilin in the eyes of transgenic mice. Invest. Ophthalmol. Vis. Sci. 46 (2005) 223-234