Mitochondria-targeted catalase reverts the neurotoxicity of hSOD1 G93A astrocytes without extending the survival of ALS-linked mutant hSOD1 mice

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Pehar, Mariana ^a   Beeson, Gyda ^a   Beeson, Craig C ^a   Johnson, Jeffrey A ^b   Vargas, Marcelo R ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; SUPEROXIDE DISMUTASE; COPPER ZINC SUPEROXIDE DISMUTASE; REACTIVE OXYGEN METABOLITE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ASSAY; ARTICLE; ASTROCYTE; CELL CULTURE; CELL DEATH; CELL ISOLATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DETOXIFICATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; GAIN OF FUNCTION MUTATION; GENE OVEREXPRESSION; MITOCHONDRION; MOLECULAR MECHANICS; MOUSE; NERVE CELL; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; ANIMAL; C57BL MOUSE; CYTOLOGY; GENETICS; HUMAN; METABOLISM; MUTATION; PATHOLOGY; UPREGULATION;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ASTROCYTES; CATALASE; CELLS, CULTURED; HUMANS; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MUTATION; NEURONS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; UP-REGULATION;

EID: 84904648362     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0103438     Document Type: Article

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