Impairments of long-term depression induction and motor coordination precede Aβ accumulation in the cerebellum of APPswe/PS1dE9 double transgenic mice

Journal of Neurochemistry

Volumn 130, Issue 3, 2014, Pages 432-443

  Kuwabara, Yuki ^a   Ishizeki, Masato ^a   Watamura, Naoto ^a   Toba, Junya ^a   Yoshii, Aya ^a   Inoue, Takafumi ^a   Ohshima, Toshio ^a,b  

^a WASEDA UNIVERSITY   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Alzheimer's disease; amyloid beta; amyloid precursor protein; cerebellum; long term depression; treatment

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; OLIGOMER;

AGE; AGED; ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BALANCE IMPAIRMENT; BIOACCUMULATION; BRAIN CORTEX; BRAIN LEVEL; BRAIN SLICE; CEREBELLUM; CONTROLLED STUDY; EXPERIMENTAL LOCOMOTOR ACTIVITY TEST; FEMALE; GLIA CELL; HIPPOCAMPUS; HISTOPATHOLOGY; LONG TERM DEPRESSION; MALE; MOTOR COORDINATION; MOTOR DYSFUNCTION; MOUSE; MOUSE MUTANT; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PURKINJE CELL; SYNAPSE; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE; WILD TYPE;

MUS; MUS MUSCULUS;

ALZHEIMER'S DISEASE; AMYLOID BETA; AMYLOID PRECURSOR PROTEIN; CEREBELLUM; LONG-TERM DEPRESSION; TREATMENT;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOTTING, WESTERN; CEREBELLUM; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; NEURONAL PLASTICITY; PEPTIDE FRAGMENTS; PRESENILIN-1; PSYCHOMOTOR PERFORMANCE; REFLEX; SYNAPSES;

EID: 84904642233     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12728     Document Type: Article

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