Cerebellar atrophy in Alzheimer's disease - Clinicopathological correlations

Brain Research

Volumn 818, Issue 1, 1999, Pages 41-50

  Wegiel, Jerzy ^a   Wisniewski, Henryk M ^a   Dziewiatkowski, Jerzy ^b   Badmajew, Eulalia ^a   Tarnawski, Michal ^a   Reisberg, Barry ^c   Mlodzik, Bogdan ^c   De Leon, Mony J ^c   Miller, Douglas C ^c  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

^c NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; Atrophy; Cerebellum; Clinicopathological correlation; Morphometry; Neuronal loss

Indexed keywords

AMYLOID BETA PROTEIN;

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN SIZE; CELL LOSS; CEREBELLUM ATROPHY; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DEMENTIA; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; GRANULE CELL; HUMAN; HUMAN TISSUE; MALE; MORPHOMETRICS; NEUROFILAMENT; PATHOGENESIS; PRIORITY JOURNAL; PURKINJE CELL; VASCULAR AMYLOIDOSIS;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ATROPHY; CASE-CONTROL STUDIES; CEREBELLUM; CEREBRAL AMYLOID ANGIOPATHY; CEREBRAL CORTEX; FEMALE; HUMANS; MALE; MENINGES; NEURONS; PURKINJE CELLS;

EID: 0033528253     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)01279-7     Document Type: Article

References (73)

1. Aikawa H., Suzuki K., Iwasaki Y., Iizuka R. Atypical Alzheimer's disease with spastic paresis and ataxia. Ann. Neurol. 17:1985;297-300.
2. Akshomoff N., Courchesne E. A new role for the cerebellum in cognitive operations. Behav. Neurosci. 106:1992;731-738.
3. Alzheimer A. Ueber eigenartige Krankheitsfaelle des spaeteren Alters. Z. Ges. Neurol. Psych. 4:1911;356-385.
4. Appollonio I.M., Grafman J., Schwartz V., Massaquoi S., Hallett M. Memory in patients with cerebellar degeneration. Neurology. 43:1993;1536-1544.
5. Azzarelli B., Muller J., Ghetti B., Dyken M., Conneally P.M. Cerebellar plaques in familial Alzheimer's disease (Gerstmann-Straussler-Scheinker variant?). Acta Neuropathol. 65:1985;235-246.
6. Bancher C., Brunner C., Lassmann H., Budka H., Jellinger K., Wiche G., Seitelberger F., Grundke-Iqbal I., Iqbal K., Wisniewski H.M. Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease. Brain Res. 477:1989;90-99.
7. Bobinski M., Wegiel J., Wisniewski H.M., Tarnawski M., Bobinski M., Reisberg B., de Leon J.M., Miller D.C. Neurofibrillary pathology - correlation with hippocampal formation atrophy in Alzheimer disease. Neurobiol. Aging. 17:1996;909-919.
8. Botez M. The neuropsychology of the cerebellum: an emerging concept. Arch. Neurol. 49:1992;1229-1230.
9. Braak H., Braak E., Bohl J., Lang W. Alzheimer's disease: amyloid plaques in the cerebellum. J. Neurol. Sci. 93:1989;277-287.
10. H. Braak, E. Braak, Pathology of Alzheimer's disease, in: D.B. Calne (Ed.), Neurodegenerative Diseases. W.B. Saunders, Philadelphia, 1994, pp. 585-613.
11. Bracke-Tolkmitt R., Linden A., Canavan A.G.M., Rockstroh B., Scholz E., Wessel K., Diener H.C. The cerebellum contributes to mental skills. Behav. Neurosci. 103:1989;442-446.
12. Braitenberg V., Atwood R. Morphological observations on the cerebellar cortex. J. Comp. Neurol. 109:1958;1-34.
13. Campbell S.K., Switzer R.C., Martin T.L. Alzheimer's plaques and tangles: a controlled and enhanced silver staining method. Soc. Neurosci. Abstr. 13:1987;678.
14. Cork L.C., Masters C., Beyreuther K., Price D.L. Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits. Am. J. Pathol. 137:1990;1383-1392.
15. Critchley M. The nature and significance of senile plaques. J. Neurol. Psychopathol. 10:1929;124-139.
16. R.T. De Hoff, Sampling of material and statistical analysis in quantitative stereology, in: H. Elias (Ed.), Stereology: Proceedings of the Second International Congress of Stereology. Springer-Verlag, New York, 1967, 119.
17. De Vito J.L., Graham J., Sackett G.P. Volumetric growth of the major brain divisions in fetal Macaca nemestrina. J. Hirnforsch. 30:1989;479-487.
18. Dickson D.W., Wertkin A., Mattiace L.A., Fier E., Kress Y., Davies P., Yen S.-H. Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease. Acta Neuropathol. 79:1990;486-493.
19. Floderus S. Untersuchungen uber den Bau der menschlichen Hypophyse mit Besonderer Berucksichtigung der quantitativen mikromorphologishen Verhaltnisse. Acta Pathol. Microbiol. Scand. 53:1944;1-176.
20. J. Frackowiak, B. Mazur-Kolecka, J. Wegiel, K.S. Kim, H.M. Wisniewski, Culture of canine vascular myocytes as a model to study production and accumulation of β-protein by cells involved in amyloidogenesis, in: K. Iqbal, J.A. Mortimer, B. Winblad, H.M. Wisniewski (Eds.), Research Advances in Alzheimer's Disease and Related Disorders, Wiley, Chichester, 1995, pp. 747-754.
21. Franssen E.H., Reisberg B., Kluger A., Sinaiko E., Boja C. Cognition independent neurologic symptomatology in normal aging and probable Alzheimer's disease. Arch. Neurol. 48:1991;148-154.
22. Franssen E.H., Kluger A., Torrossian C.L., Reisberg B. The neurologic syndrome of severe Alzheimer's disease: relationship to functional decline. Arch. Neurol. 50:1993;1029-1039.
23. Grafman J., Litvan I., Massaquoi S., Stewart M., Sirigu A., Hallett M. Cognitive planning deficit in patients with cerebellar atrophy. Neurology. 42:1992;1493-1496.
24. Greenberg S.M., Vonsattel J.P.G., Stakes J.W., Gruber M., Finklestein S.P. The clinical spectrum of cerebral amyloid angiopathy: presentations without lobar hemorrhage. Neurology. 43:1993;2073-2079.
25. Gutzman H., Kuhl K.P. Emotion control and cerebellar atrophy in senile dementia. Arch. Gerontol. Geriatr. 6:1987;61-71.
26. Haug H. Stereological methods in the analysis of neuronal parameters in the central nervous system. J. Microsc. 95:1971;165-180.
27. Ikeda S.L., Allsop D., Glenner G.G. The morphology and distribution of plaque and related deposits in the brain of Alzheimer's disease and control cases: an immunohistochemical study using amyloid beta-protein antibody. Lab. Invest. 60:1989;113-122.
28. Ishino H., Higashi S., Chuta M., Ohta H. Juvenile Alzheimer's disease with myoclonus: amyloid plaques and grumose alterations in the cerebellum. Clin. Neuropathol. 3:1984;193-198.
29. Ivry R., Baldo J. Is the cerebellum involved in learning and cognition? Curr. Opin. Neurobiol. 2:1992;212-216.
30. Jellinger K. Cerebrovascular amyloidosis with cerebral hemorrhage. J. Neurol. 214:1977;195-206.
31. Joachim C.L., Morris J.H., Selkoe D.J. Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am. J. Pathol. 135:1989;309-319.
32. Kim K.S., Miller D.L., Sapienza V.J., Cheng C.-M.J., Bai C., Grundke-Iqbal I., Currie J.R., Wisniewski H.M. Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci. Res. Commun. 2:1988;121-130.
33. Kitamoto T., Ogomori K., Tateishi J., Prusiner S.B. Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloidosis. Lab. Invest. 57:1987;230-236.
34. Kyriakides T., Silbert P.L., Kakulas B.A. Cerebral amyloid angiopathy and intracerebral hemorrhage with special reference to the pons. Clin. Neuropathol. 13:1994;71-76.
35. Kluger A., Gianutsos J., de Leon M.J., George A., Ferris S.H., Golomb J., Van Olden C., Densmore C., Franssen E., McRae T., Reisberg B. Motor impairment in mild cognitive decline and early Alzheimer's disease. Gerontol. 1(33):1993;20-21. Special Issue.
36. Lee S.S., Stemmermann G.N. Congophilic angiopathy and cerebral hemorrhage. Arch. Pathol. Lab. Med. 102:1978;317-321.
37. Leiner H.C., Leiner A.L., Dow R.S. Cerebro-cerebellar learning loops in apes and humans. Ital. J. Neurol. Sci. 8:1987;425-436.
38. Leiner H.C., Leiner A.L., Dow R.S. Reappraising the cerebellum: what does the hindbrain contribute to the forebrain? Behav. Neurosci. 103:1989;998-1008.
39. Leiner H.C., Leiner A.L., Dow R.S. The human cerebrocerebellar system: its computing, cognitive, and language skills. Behav. Brain Res. 44:1991;113-128.
40. Li Y.-T., Woodruff-Pak D., Trojanowski J. Amyloid plaques in cerebellar cortex and the integrity of Purkinje cell dendrites. Neurobiol. Aging. 15:1994;1-9.
41. Mann D.M.A., Jones D., Prinja D., Purkiss M.S. The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's syndrome and Alzheimer's disease. Acta Neuropathol. 80:1990;318-327.
42. Mattiace L.A., Davies P., Yen S.-H., Dickson D.W. Microglia in cerebellar plaques in Alzheimer's disease. Acta Neuropathol. 80:1990;493-498.
43. Mirra S.S., Hart M.N., Terry R.D. Making the diagnosis of Alzheimer's disease. Arch. Pathol. Lab. Med. 117:1993;132-144.
44. Ogomori K., Kitamoto T., Tateishi J., Sato Y., Suetsugu M., Abe M. β-protein amyloid is widely distributed in the central nervous system of patients with Alzheimer's disease. Am. J. Pathol. 134:1989;243-251.
45. Pappolla M.A., Omar R.A., Vinters H.V. Image analysis microspectroscopy shows that neurons participate in the genesis of a subset of early primitive (diffuse) senile plaques. Am. J. Pathol. 139:1991;599-607.
46. Petersen S.E., Fiez J.A. The processing of single words studied with positron emission tomography. Annu. Rev. Neurosci. 16:1993;509-530.
47. Pro J., Smith C., Sumi M. Presenile Alzheimer disease: amyloid plaques in the cerebellum. Neurology. 30:1980;820-825.
48. Reisberg B., Ferris S.H., de Leon M.J., Crook T. The Global Deterioration Scale for assessment of primary degenerative dementia. Am. J. Psychiatry. 139:1982;1136-1139.
49. Reisberg B., London E., Ferris S.H., Borenstein J., Scheier L., de Leon M.J. The Brief Cognitive Rating Scale: language, motoric and mood concomitants in primary degenerative dementia. Psychopharmacol. Bull. 19:1983;702-708.
50. Reisberg B. Functional Assessment Staging (FAST). Psychopharmacol. Bull. 24:1988;653-659.
51. Reisberg B., Ferris S.H., de Leon M.J., Kluger A., Franssen E., Borenstein J., Alba R.C. The stage specific temporal course of Alzheimer's disease: functional and behavioral concomitants based upon cross-sectional and longitudinal observation. Prog. Clin. Biol. Res. 317:1989;23-41.
52. Roland P.E. Metabolic measurements of the working frontal cortex in man. Trends Neurosci. 7:1984;430-435.
53. 99mTc-HMPAO. Cogn. Brain. Res. 1:1993;94-99.
54. T. Simchowicz, Histologische Studien uber die senile Demenz, in: F. Nissl, A. Alzheimer (Eds.), Histologische und histopathologische Arbeiten uber die Grosshirnrinde mit besonderer Berucksichtigung der pathologischen Anatomie der Geisteskrankheiten, Fischer Verlag, Jena, 1911, pp. 267-444.
55. Snow A., Sekiguchi R., Nochlin D., Kalaria R., Kimata K. Heparan sulfate proteoglycan in diffuse plaques of hippocampus but not of cerebellum in Alzheimer's disease brain. Am. J. Pathol. 144:1994;337-347.
56. Souren L.E.M., Franssen E.H., Reisberg B. Contractures and loss of function in patients with Alzheimer's disease. J. Am. Geriatr. Soc. 43:1995;650-655.
57. Suenaga T., Hirano A., Llena J.F., Ksiezak-Reding H., Yen S.-H., Dickson D.W. Modified Bielschowsky and immunocytochemical studies on cerebellar plaques in Alzheimer's disease. J. Neuropathol. Exp. Neurol. 49:1990;31-40.
58. Tomlinson B.E. Plaques, tangles and Alzheimer's disease. Psychol. Med. 12:1982;449-459.
59. Torack R.M. Congophilic angiopathy complicated by surgery and massive hemorrhage. Am. J. Pathol. 81:1975;349-366.
60. Vakili S.T., Muller J. Juvenile Alzheimer's disease with cerebellar involvement. Arch. Pathol. Lab. Med. 111:1987;480-482.
61. Wallesch C.-W., Horn A. Long-term effects of cerebellar pathology on cognitive functions. Brain Cogn. 14:1990;19-25.
62. Wegiel J., Wisniewski H.M. The complex of microglial cells and amyloid star in three-dimensional reconstruction. Acta Neuropathol. 81:1990;116-124.
63. Wegiel J., Wisniewski H.M., Dziewiatkowski J., Tarnawski M., Nowakowski J., Dziewiatkowska A., Soltysiak Z. The origin of amyloid in cerebral vessels of dogs. Brain Res. 705:1995;225-234.
64. Wisniewski H.M., Bancher C., Barcikowska M., Wen G.Y., Currie J. Spectrum of morphological appearance of amyloid deposits in Alzheimer disease. Acta Neuropathol. 78:1989;337-347.
65. Wisniewski H.M., Wegiel J., Wang G.P., Kujawa M., Lach B. Ultrastructural studies of the cells forming amyloid fibers in the classical plaques. Can. J. Neurol. Sci. 16:1989;535-542.
66. H.M. Wisniewski, J. Wegiel, J. Morys, C. Bancher, Z. Soltysiak, K.-S. Kim, Aged dogs: an animal model to study beta-protein amyloidogenesis, in: K. Maurer, P. Riederer, H. Beckmann (Eds.), Alzheimer's Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics, Springer Verlag, Wien, 1990, pp. 151-168.
67. Wisniewski H.M., Wegiel J., Wang K.C., Lach B. Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease. Acta Neuropathol. 84:1992;117-127.
68. Wisniewski H.M., Wegiel J. Migration of perivascular cells into the neuropil and their involvement in β-amyloid plaque formation. Acta Neuropathol. 85:1993;586-595.
69. Wisniewski H.M., Wegiel J. β-amyloid formation by myocytes of leptomeningeal vessels. Acta Neuropathol. 87:1994;233-241.
70. Wisniewski H.M., Wegiel J., Popovitch E.R. Age associated development of diffuse and thioflavin posative plaques in Down syndrome. Dev. Brain Dysfun. 7:1994;330-339.
71. Yamaguchi H., Hirai S., Morimatsu M., Shoji M., Nakazato Y. Diffuse type of senile plaques in the cerebellum of Alzheimer-type dementia demonstrated by β protein immunostain. Acta Neuropathol. 77:1989;314-319.
72. Yamamoto T., Hirano A. Hirano bodies in the perikaryon of the Purkinje cell in a case of Alzheimer's disease. Acta Neuropathol. 67:1985;167-169.
73. Yamazaki T., Yamaguchi H., Nakazato Y., Ishiguro K., Kawarabayashi T., Hirai S. Ultrastructural characterization of cerebellar diffuse plaques in Alzheimer's disease. J. Neuropathol. Exp. Neurol. 51:1992;281-286.