Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity

Biochemical Journal

Volumn 462, Issue 1, 2014, Pages 77-88

  Funk, Kristen E ^a   Thomas, Stefani N ^b   Schafer, Kelsey N ^a   Cooper, Grace L ^a   Liao, Zhongping ^b   Clark, David J ^b   Yang, Austin J ^b   Kuret, Jeff ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Aggregation; Alzheimer's disease; Methylation; Microtubule; Post translational modification; Tau protein

Indexed keywords

LYSINE; RECOMBINANT PROTEIN; RECOMBINANT TAU PROTEIN; TAU PROTEIN; TUBULIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BRAIN; BRAIN TISSUE; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY; MALE; MICROTUBULE; MICROTUBULE ASSEMBLY; MIDDLE AGED; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METHYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; HUMANS; LYSINE; MALE; METHYLATION; MICROTUBULES; MIDDLE AGED; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, QUATERNARY; TANDEM MASS SPECTROMETRY; TAU PROTEINS; TUBULIN;

EID: 84904602584     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140372     Document Type: Article

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