Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats

Neuropharmacology

Volumn 41, Issue 4, 2001, Pages 413-420

  Ossowska, K ^a   Konieczny, J ^a   Wolfarth, S ^a   Wieronska J ^a   Pilc, A ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

2 Methyl 6 (phenylethynyl)pyridine; Antiparkinsonian like effects; Catalepsy; Locomotor activity; mGluR5 glutamate receptors; Muscle rigidity

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; ANTIPARKINSON AGENT; HALOPERIDOL; METABOTROPIC GLUTAMATE 5 RECEPTOR; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR ANTAGONIST; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

AKINESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALEPSY; CONTROLLED STUDY; DRUG EFFECT; ELECTROMYOGRAPHY; GASTROCNEMIUS MUSCLE; LOCOMOTION; MALE; MUSCLE CONTRACTION; MUSCLE RIGIDITY; MUSCLE TONE; NONHUMAN; OPEN FIELD TEST; PARKINSON DISEASE; PASSIVE MOVEMENT; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; TASK PERFORMANCE; TIBIALIS ANTERIOR MUSCLE;

ANIMALS; ANTIPARKINSON AGENTS; ANTIPSYCHOTIC AGENTS; CATALEPSY; DYSKINESIA, DRUG-INDUCED; ELECTROMYOGRAPHY; EXCITATORY AMINO ACID ANTAGONISTS; HALOPERIDOL; MALE; MOTOR ACTIVITY; MUSCLE RIGIDITY; MYOGRAPHY; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 0034868541     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00083-1     Document Type: Article

References (40)

1. Characterization of MK-801-induced behavior as a putative rat model of psychosis
2. Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus
3. In vitro inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY 354740 in rats
4. Reversal of experimental parkinsonism by lesion of the subthalamic nucleus
5. Functional changes of the basal ganglia circuitry in Parkinson's disease
6. Activation of group II metabotropic glutamate receptors inhibits synaptic excitation of the substantia nigra pars reticulata
7. The group II metabotropic glutamate receptor agonist, DCG-IV, alleviates akinesia following intranigral or intraventricular administration in the reserpine-treated rat
8. Multiplicity of glutamate receptor subunit in single striatal neurons: An RNA amplification study
9. Comparison of the behavioral and biochemical effects of the NMDA receptor antagonists, MK-801 and phencyclidine
10. Differential effects of intrastriatal and intranigral injections of glutamate antagonists on motor behaviour in the reserpine-treated rat
11. Expression of group one metabotropic glutamate receptor subunit mRNA in neurochemically identified neurons in the rat neostriatum, neocortex and hippocampus
12. Excitatory amino acids and the basal ganglia: Implications for the therapy of Parkinson's disease
13. NMDA antagonists potentiate antiparkinsonian actions of L-dopa in monoamine-depleted rats
14. LY354740, a group II metabotropic glutamate receptor agonist with potential antiparkinsonian properties in rats
15. Behavioural effects mediated by the modulatory glycine site of the NMDA receptor in the anterodorsal striatum and nucleus accumbens
16. Pathophysiology of rigidity and akinesia in Parkinson's disease
17. Efficacy of pramipexole, a new dopamine receptor agonist, to relieve the parkinsonian-like muscle rigidity in rats
18. Haloperidol-increased muscle tone in rats as a model of parkinsonian rigidity
19. Contribution of the glycine site of the NMDA receptor in the rostral and intermediate caudal parts of the striatum in the regulation of the muscle tone
20. (S)-4C3HPG, a mixed group I mGlu receptor antagonist and a group II agonist, administered intrastriatally counteracts parkinsonian-like muscle rigidity in rats
21. Anticonvulsant and behavioral effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551 in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine
22. MGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethynyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors
23. Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism
24. The role of excitatory amino acids in experimental models of Parkinson's disease
25. NMDA receptors in the rostral and intermediate-caudal striatum play an opposite role in regulation of the muscle tone in rats
26. Antiparkinsonian action of MK-801 on the reserpine-induced rigidity: A mechanomyographic analysis
27. The role of reflex activity in the regulation of muscle tone in rats
28. The influence of dizocilpine (MK-801) on the reserpine-enhanced electromyographic stretch reflex in rats
29. Antidepressant treatment influences group I of glutamate metabotropic receptors in slices from hippocampal CA1 region
30. Enhancement of NMDA responses by group I metabotropic glutamate receptor activation in striatal neurones
31. Anticataleptic effects of the N-methyl-D-aspartate antagonist MK-801 in rats
32. Behavioural pharmacology of glutamate in the basal ganglia
33. Pharmacological agents acting at subtypes of metabotropic glutamate receptors
34. 5 receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats
35. Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat
36. Differential expression of mGluR5 metabotropic glutamate mRNA by rat striatal neurons
37. Localization of mGluR1a-like immunoreactivity and mGluR5-like immunoreactivity in identified populations of striatal neurons
38. 2A adenosine receptor antagonist, counteracts parkinsonian-like muscle rigidity in rats
39. The role of metabotropic glutamate receptor (mGluR) ligands in parkinsonian muscle rigidity
40. Distinct sites of dopaminergic and glutamatergic regulation of haloperidol-induced catalepsy within the rat caudate-putamen