메뉴 건너뛰기




Volumn 91, Issue C, 2010, Pages 41-52

G protein-coupled receptor heteromers as new targets for drug development

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR;

EID: 77957278232     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1877-1173(10)91002-8     Document Type: Chapter
Times cited : (47)

References (55)
  • 3
    • 70350381113 scopus 로고    scopus 로고
    • Purification and functional reconstitution of monomeric mu-opioid receptors: Allosteric modulation of agonist binding by Gi2
    • A.J. Kuszak, S. Pitchiaya, J.P. Anand, H.I. Mosberg, N.G. Walter, and R.K. Sunahara Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2 J Biol Chem 284 2009 6732 26741
    • (2009) J Biol Chem , vol.284 , pp. 6732-26741
    • Kuszak, A.J.1    Pitchiaya, S.2    Anand, J.P.3    Mosberg, H.I.4    Walter, N.G.5    Sunahara, R.K.6
  • 7
    • 33747422892 scopus 로고    scopus 로고
    • Brain nicotinic acetylcholine receptors: native subtypes and their relevance
    • DOI 10.1016/j.tips.2006.07.004, PII S0165614706001751
    • C. Gotti, M. Zoli, and F. Clementi Brain nicotinic acetylcholine receptors: native subtypes and their relevance Trends Pharmacol Sci 27 2006 482 491 (Pubitemid 44251225)
    • (2006) Trends in Pharmacological Sciences , vol.27 , Issue.9 , pp. 482-491
    • Gotti, C.1    Zoli, M.2    Clementi, F.3
  • 8
    • 0036581222 scopus 로고    scopus 로고
    • The GDNF family: Signalling, biological functions and therapeutic value
    • DOI 10.1038/nrn812
    • M.S. Airaksinen, and M. Saarma The GDNF family: signalling, biological functions and therapeutic value Nat Rev Neurosci 3 2002 383 394 (Pubitemid 135706635)
    • (2002) Nature Reviews Neuroscience , vol.3 , Issue.5 , pp. 383-394
    • Airaksinen, M.S.1    Saarma, M.2
  • 10
    • 69249158290 scopus 로고    scopus 로고
    • Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation
    • Y. Han, I.S. Moreira, E. Urizar, H. Weinstein, and J.A. Javitch Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation Nat Chem Biol 5 2009 688 695
    • (2009) Nat Chem Biol , vol.5 , pp. 688-695
    • Han, Y.1    Moreira, I.S.2    Urizar, E.3    Weinstein, H.4    Javitch, J.A.5
  • 11
    • 34548530597 scopus 로고    scopus 로고
    • Functional relevance of neurotransmitter receptor heteromers in the central nervous system
    • DOI 10.1016/j.tins.2007.07.001, PII S0166223607001762
    • S. Ferr, F. Ciruela, A.S. Woods, C. Lluis, and R. Franco Functional relevance of neurotransmitter receptor heteromers in the central nervous system Trends Neurosci 30 2007 440 446 (Pubitemid 47381459)
    • (2007) Trends in Neurosciences , vol.30 , Issue.9 , pp. 440-446
    • Ferre, S.1    Ciruela, F.2    Woods, A.S.3    Lluis, C.4    Franco, R.5
  • 12
    • 36448968578 scopus 로고    scopus 로고
    • Allosteric modulation of heterodimeric G-protein-coupled receptors
    • DOI 10.1016/j.tips.2007.11.001, PII S0165614707002581
    • G. Milligan, and N.J. Smith Allosteric modulation of heterodimeric G-protein-coupled receptors Trends Pharmacol Sci 28 2007 615 620 (Pubitemid 350166577)
    • (2007) Trends in Pharmacological Sciences , vol.28 , Issue.12 , pp. 615-620
    • Milligan, G.1    Smith, N.J.2
  • 13
    • 36249020990 scopus 로고    scopus 로고
    • Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: The receptor-dimer cooperativity index
    • DOI 10.1016/j.pharmthera.2007.05.010, PII S0163725807001064
    • V. Casad, A. Corts, F. Ciruela, J. Mallol, S. Ferr, and C. Lluis Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index Pharmacol Ther 116 2007 343 354 (Pubitemid 350123634)
    • (2007) Pharmacology and Therapeutics , vol.116 , Issue.3 , pp. 343-354
    • Casado, V.1    Cortes, A.2    Ciruela, F.3    Mallol, J.4    Ferre, S.5    Lluis, C.6    Canela, E.I.7    Franco, R.8
  • 14
    • 70349109589 scopus 로고    scopus 로고
    • GPCR homomers and heteromers: A better choice as targets for drug development than GPCR monomers?
    • V. Casad, A. Corts, J. Mallol, K. Prez-Capote, S. Ferr, and C. Lluis GPCR homomers and heteromers: a better choice as targets for drug development than GPCR monomers? Pharmacol Ther 124 2009 248 257
    • (2009) Pharmacol Ther , vol.124 , pp. 248-257
    • Casad, V.1    Corts, A.2    Mallol, J.3    Prez-Capote, K.4    Ferr, S.5    Lluis, C.6
  • 16
    • 0034714335 scopus 로고    scopus 로고
    • Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties
    • S.R. George, T. Fan, Z. Xie, R. Tse, V. Tam, and G. Varghese Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties J Biol Chem 275 2000 26128 26135
    • (2000) J Biol Chem , vol.275 , pp. 26128-26135
    • George, S.R.1    Fan, T.2    Xie, Z.3    Tse, R.4    Tam, V.5    Varghese, G.6
  • 18
    • 0033578005 scopus 로고    scopus 로고
    • G-protein-coupled receptor heterodimerization modulates receptor function
    • B.A. Jordan, and L.A. Devi G-protein-coupled receptor heterodimerization modulates receptor function Nature 399 1999 697 700
    • (1999) Nature , vol.399 , pp. 697-700
    • Jordan, B.A.1    Devi, L.A.2
  • 19
    • 72449140688 scopus 로고    scopus 로고
    • The delta(1) opioid receptor is a heterodimer that opposes the actions of the delta(2) receptor on alcohol intake
    • R.M. van Rijn, and J.L. Whistler The delta(1) opioid receptor is a heterodimer that opposes the actions of the delta(2) receptor on alcohol intake Biol Psychiatry 66 2009 777 784
    • (2009) Biol Psychiatry , vol.66 , pp. 777-784
    • Van Rijn, R.M.1    Whistler, J.L.2
  • 20
    • 28844437680 scopus 로고    scopus 로고
    • Inhibition of serotonin 5-hydroxytryptamine2C receptor function through heterodimerization: Receptor dimers bind two molecules of ligand and one G-protein
    • DOI 10.1074/jbc.M507396200
    • K. Herrick-Davis, E. Grinde, T.J. Harrigan, and J.E. Mazurkiewicz Inhibition of serotonin 5-hydroxytryptamine 2C receptor function through heterodimerization: receptor dimers bind two molecules of ligand and one G-protein J Biol Chem 280 2005 40144 40151 (Pubitemid 41779150)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.48 , pp. 40144-40151
    • Herrick-Davis, K.1    Grinde, E.2    Harrigan, T.J.3    Mazurkiewicz, J.E.4
  • 21
  • 22
    • 45649085857 scopus 로고    scopus 로고
    • Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization
    • DOI 10.1124/mol.107.043885
    • C. Fiorentini, C. Busi, E. Gorruso, C. Gotti, P. Spano, and C. Missale Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization Mol Pharmacol 74 2008 59 69 (Pubitemid 351872159)
    • (2008) Molecular Pharmacology , vol.74 , Issue.1 , pp. 59-69
    • Fiorentini, C.1    Busi, C.2    Gorruso, E.3    Gotti, C.4    Spano, P.5    Missale, C.6
  • 23
    • 67149084972 scopus 로고    scopus 로고
    • Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors
    • C. Ferrada, E. Moreno, V. Casad, G. Bongers, A. Corts, and J. Mallol Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors Br J Pharmacol 157 2009 64 75
    • (2009) Br J Pharmacol , vol.157 , pp. 64-75
    • Ferrada, C.1    Moreno, E.2    Casad, V.3    Bongers, G.4    Corts, A.5    Mallol, J.6
  • 25
    • 63849271755 scopus 로고    scopus 로고
    • Calcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomers
    • C.H. So, V. Verma, M. Alijaniaram, R. Cheng, A.J. Rashid, and B.F. O'Dowd Calcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomers Mol Pharmacol 75 2009 843 854
    • (2009) Mol Pharmacol , vol.75 , pp. 843-854
    • So, C.H.1    Verma, V.2    Alijaniaram, M.3    Cheng, R.4    Rashid, A.J.5    O'Dowd, B.F.6
  • 26
    • 33947136255 scopus 로고    scopus 로고
    • Heterodimerization and surface localization of G protein coupled receptors
    • K.P. Minneman Heterodimerization and surface localization of G protein coupled receptors Biochem Pharmacol 73 2007 1043 1050
    • (2007) Biochem Pharmacol , vol.73 , pp. 1043-1050
    • Minneman, K.P.1
  • 27
    • 23344447877 scopus 로고    scopus 로고
    • The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities
    • DOI 10.1074/jbc.M413475200
    • S. Wilson, G. Wilkinson, and G. Milligan The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities J Biol Chem 280 2005 28663 28674 (Pubitemid 41105767)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.31 , pp. 28663-28674
    • Wilson, S.1    Wilkinson, G.2    Milligan, G.3
  • 29
    • 1442309077 scopus 로고    scopus 로고
    • Applications of bioluminescence- and fluorescence resonance energy transfer to drug discovery at G protein-coupled receptors
    • DOI 10.1016/j.ejps.2003.11.010, PII S0928098703003300
    • G. Milligan Applications of bioluminescence- and fluorescence resonance energy transfer to drug discovery at G protein-coupled receptors Eur J Pharm Sci 21 2004 397 405 (Pubitemid 38283913)
    • (2004) European Journal of Pharmaceutical Sciences , vol.21 , Issue.4 , pp. 397-405
    • Milligan, G.1
  • 30
    • 13444269196 scopus 로고    scopus 로고
    • Monitoring the formation of the dynamic G-protein-coupled receptor-protein complexes in living cells
    • K.D. Pfleger, and K.A. Eidne Monitoring the formation of the dynamic G-protein-coupled receptor-protein complexes in living cells Biochem J 385 2005 625 637
    • (2005) Biochem J , vol.385 , pp. 625-637
    • Pfleger, K.D.1    Eidne, K.A.2
  • 31
    • 34447645129 scopus 로고    scopus 로고
    • Resonance energy transfer approaches in molecular pharmacology and beyond
    • DOI 10.1016/j.tips.2007.06.007, PII S0165614707001526, Allosterism and Collateral Efficacy
    • S. Marullo, and M. Bouvier Resonance energy transfer approaches in molecular pharmacology and beyond Trends Pharmacol Sci 28 2007 362 365 (Pubitemid 47087970)
    • (2007) Trends in Pharmacological Sciences , vol.28 , Issue.8 , pp. 362-365
    • Marullo, S.1    Bouvier, M.2
  • 32
    • 72449197630 scopus 로고    scopus 로고
    • Recent advances in bioluminescence resonance energy transfer technologies to study GPCR heteromerization
    • M.A. Ayoub, and K.D.G. Pfleger Recent advances in bioluminescence resonance energy transfer technologies to study GPCR heteromerization Curr Opin Pharmacol 10 2010 44 52
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 44-52
    • Ayoub, M.A.1    Pfleger, K.D.G.2
  • 33
    • 3342965731 scopus 로고    scopus 로고
    • 2 homodimers
    • DOI 10.1124/mol.104.000398
    • M.A. Ayoub, A. Levoye, P. Delagrange, and R. Jockers Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers Mol Pharmacol 66 2004 312 321 (Pubitemid 38989488)
    • (2004) Molecular Pharmacology , vol.66 , Issue.2 , pp. 312-321
    • Ayoub, M.A.1    Levoye, A.2    Delagrange, P.3    Jockers, R.4
  • 34
    • 38349054282 scopus 로고    scopus 로고
    • Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling
    • J.P. Vilardaga, V.O. Nikolaev, K. Lorenz, S. Ferrandon, Z. Zhuang, and M.J. Lohse Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling Nat Chem Biol 4 2008 126 131
    • (2008) Nat Chem Biol , vol.4 , pp. 126-131
    • Vilardaga, J.P.1    Nikolaev, V.O.2    Lorenz, K.3    Ferrandon, S.4    Zhuang, Z.5    Lohse, M.J.6
  • 35
    • 48449100036 scopus 로고    scopus 로고
    • Detection of heteromerization of more than two proteins by sequential BRET-FRET
    • P. Carriba, G. Navarro, F. Ciruela, S. Ferr, V. Casad, and L.F. Agnati Detection of heteromerization of more than two proteins by sequential BRET-FRET Nat Methods 5 2008 727 733
    • (2008) Nat Methods , vol.5 , pp. 727-733
    • Carriba, P.1    Navarro, G.2    Ciruela, F.3    Ferr, S.4    Casad, V.5    Agnati, L.F.6
  • 36
    • 65549160499 scopus 로고    scopus 로고
    • Metabotropic glutamate type 5, dopamine D2 and adenosine A2A receptors form higher-order oligomers in living cells
    • N. Cabello, J. Ganda, D.C. Bertarelli, M. Watanabe, C. Llus, and R. Franco Metabotropic glutamate type 5, dopamine D2 and adenosine A2A receptors form higher-order oligomers in living cells J Neurochem 109 2009 1497 1507
    • (2009) J Neurochem , vol.109 , pp. 1497-1507
    • Cabello, N.1    Ganda, J.2    Bertarelli, D.C.3    Watanabe, M.4    Llus, C.5    Franco, R.6
  • 37
    • 55549147195 scopus 로고    scopus 로고
    • Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer
    • G. Navarro, P. Carriba, J. Ganda, F. Ciruela, V. Casad, and A. Corts Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer ScientificWorldJournal 8 2008 1088 1097
    • (2008) ScientificWorldJournal , vol.8 , pp. 1088-1097
    • Navarro, G.1    Carriba, P.2    Ganda, J.3    Ciruela, F.4    Casad, V.5    Corts, A.6
  • 38
    • 38049061740 scopus 로고    scopus 로고
    • Light resonance energy transfer-based methods in the study of G protein-coupled receptor oligomerization
    • J. Ganda, C. Llus, S. Ferr, R. Franco, and F. Ciruela Light resonance energy transfer-based methods in the study of G protein-coupled receptor oligomerization Bioessays 30 2008 82 89
    • (2008) Bioessays , vol.30 , pp. 82-89
    • Ganda, J.1    Llus, C.2    Ferr, S.3    Franco, R.4    Ciruela, F.5
  • 41
    • 70349192980 scopus 로고    scopus 로고
    • Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers
    • A. Soriano, R. Ventura, A. Molero, R. Hoen, V. Casad, and A. Corts Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers J Med Chem 52 2009 5590 5602
    • (2009) J Med Chem , vol.52 , pp. 5590-5602
    • Soriano, A.1    Ventura, R.2    Molero, A.3    Hoen, R.4    Casad, V.5    Corts, A.6
  • 42
    • 72449150733 scopus 로고    scopus 로고
    • Bioinformatics and molecular modeling approaches to GPCR oligomerization
    • L.M. Simpson, B. Taddese, I.D. Wall, and C.A. Reynolds Bioinformatics and molecular modeling approaches to GPCR oligomerization Curr Opin Pharmacol 10 2010 30 37
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 30-37
    • Simpson, L.M.1    Taddese, B.2    Wall, I.D.3    Reynolds, C.A.4
  • 43
    • 34248355605 scopus 로고    scopus 로고
    • Blocking striatal adenosine A2A receptors: A new strategy for basal ganglia disorders
    • C.E. Mller, and S. Ferr Blocking striatal adenosine A2A receptors: a new strategy for basal ganglia disorders Recent Pat CNS Drug Discov 2 2007 1 21
    • (2007) Recent Pat CNS Drug Discov , vol.2 , pp. 1-21
    • Mller, C.E.1    Ferr, S.2
  • 46
    • 23944488806 scopus 로고    scopus 로고
    • The amazing stability of the arginine-phosphate electrostatic interaction
    • A.S. Woods, and S. Ferr The amazing stability of the arginine-phosphate electrostatic interaction J Proteome Res 4 2005 1397 1402
    • (2005) J Proteome Res , vol.4 , pp. 1397-1402
    • Woods, A.S.1    Ferr, S.2
  • 47
    • 51049112029 scopus 로고    scopus 로고
    • Dopamine D2 receptors form higher order oligomers at physiological expression levels
    • W. Guo, E. Urizar, M. Kralikova, J.C. Mobarec, L. Shi, and M. Filizola Dopamine D2 receptors form higher order oligomers at physiological expression levels EMBO J 27 2008 2293 2304
    • (2008) EMBO J , vol.27 , pp. 2293-2304
    • Guo, W.1    Urizar, E.2    Kralikova, M.3    Mobarec, J.C.4    Shi, L.5    Filizola, M.6
  • 49
    • 59949090278 scopus 로고    scopus 로고
    • Dopamine D2 and adenosine A2A receptors regulate NMDA-mediated excitation in accumbens neurons through A2A-D2 receptor heteromerization
    • K. Azdad, D. Gall, A.S. Woods, C. Ledent, S. Ferr, and S.N. Schiffmann Dopamine D2 and adenosine A2A receptors regulate NMDA-mediated excitation in accumbens neurons through A2A-D2 receptor heteromerization Neuropsychopharmacology 34 2009 972 986
    • (2009) Neuropsychopharmacology , vol.34 , pp. 972-986
    • Azdad, K.1    Gall, D.2    Woods, A.S.3    Ledent, C.4    Ferr, S.5    Schiffmann, S.N.6
  • 50
    • 30044442319 scopus 로고    scopus 로고
    • Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series
    • D.J. Daniels, N.R. Lenard, C.L. Etienne, P.Y. Law, S.C. Roerig, and P.S. Portoghese Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series Proc Natl Acad Sci USA 102 2005 19208 19213
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 19208-19213
    • Daniels, D.J.1    Lenard, N.R.2    Etienne, C.L.3    Law, P.Y.4    Roerig, S.C.5    Portoghese, P.S.6
  • 51
    • 66749154689 scopus 로고    scopus 로고
    • Dissociation of the opioid receptor mechanisms that control mechanical and heat pain
    • G. Scherrer, N. Imamachi, Y.Q. Cao, C. Contet, F. Mennicken, and D. O'Donnell Dissociation of the opioid receptor mechanisms that control mechanical and heat pain Cell 137 2009 1148 1159
    • (2009) Cell , vol.137 , pp. 1148-1159
    • Scherrer, G.1    Imamachi, N.2    Cao, Y.Q.3    Contet, C.4    Mennicken, F.5    O'Donnell, D.6
  • 53
    • 51749093358 scopus 로고    scopus 로고
    • Distinct subcellular distribution of delta-opioid receptor fused with various tags in PC12 cells
    • H.B. Wang, J.S. Guan, L. Bao, and X. Zhang Distinct subcellular distribution of delta-opioid receptor fused with various tags in PC12 cells Neurochem Res 33 2008 2028 2034
    • (2008) Neurochem Res , vol.33 , pp. 2028-2034
    • Wang, H.B.1    Guan, J.S.2    Bao, L.3    Zhang, X.4
  • 54
    • 57349129484 scopus 로고    scopus 로고
    • Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4
    • F.M. Dcaillot, R. Rozenfeld, A. Gupta, and L.A. Devi Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4 Proc Natl Acad Sci USA 105 2008 16045 16050
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16045-16050
    • Dcaillot, F.M.1    Rozenfeld, R.2    Gupta, A.3    Devi, L.A.4
  • 55
    • 54449099573 scopus 로고    scopus 로고
    • Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum
    • D. Marcellino, S. Ferr, V. Casad, A. Corts, B. Le Foll, and C. Mazzola Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum J Biol Chem 283 2008 26016 26025
    • (2008) J Biol Chem , vol.283 , pp. 26016-26025
    • Marcellino, D.1    Ferr, S.2    Casad, V.3    Corts, A.4    Le Foll, B.5    Mazzola, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.