Tailored Cyclodextrin Pore Blocker Protects Mammalian Cells from Clostridium difficile Binary Toxin CDT

Toxins

Volumn 6, Issue 7, 2014, Pages 2097-2114

  Roeder, Maurice ^a   Nestorovich, Ekaterina M ^b   Karginov, Vladimir A ^c   Schwan, Carsten ^d   Aktories, Klaus ^d   Barth, Holger ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b CATHOLIC UNIVERSITY OF AMERICA   (United States)

^c Innovative Biologics Inc   (United States)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Binary toxin; Cellular uptake; Clostridium difficile CDT; Membrane transport; Pore blocker; Translocation pore; cyclodextrin

Indexed keywords

BETA CYCLODEXTRIN DERIVATIVE; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; F ACTIN; PER 6 S (3 AMINOMETHYL)BENZYLTHIO BETA CYCLODEXTRIN; UNCLASSIFIED DRUG; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTECTIVE AGENT;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DENSITOMETRY; DEPOLYMERIZATION; ENZYME ACTIVITY; INCUBATION TIME; INTOXICATION; NONHUMAN; REPRODUCIBILITY; WESTERN BLOTTING; ANIMAL; CELL MEMBRANE; CHLOROCEBUS AETHIOPS; DRUG EFFECTS; METABOLISM; PEPTOCLOSTRIDIUM DIFFICILE; TOXICITY; VERO CELL LINE;

ADP RIBOSE TRANSFERASES; ANIMALS; BETA-CYCLODEXTRINS; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; CLOSTRIDIUM DIFFICILE; PROTECTIVE AGENTS; VERO CELLS;

EID: 84904507553     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins6072097     Document Type: Article

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