Tailored ß-cyclodextrin blocks the translocation pores of binary exotoxins from C. botulinum and C. perfringens and protects cells from intoxication

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Nestorovich, Ekaterina M ^a,b   Karginov, Vladimir A ^c   Popoff, Michel R ^d   Bezrukov, Sergey M ^b   Barth, Holger ^e  

^a CATHOLIC UNIVERSITY OF AMERICA   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c Innovative Biologics Inc   (United States)

^d INSTITUT PASTEUR   (France)

^e UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

(3 AMINOMETHYL)BENZYLTHIO BETA CYCLODEXTRIN; ACTIN; ANTHRAX TOXIN; BETA CYCLODEXTRIN DERIVATIVE; BOTULINUM TOXIN; CLOSTRIDIUM PERFRINGENS IOTA TOXIN; CLOSTRIDIUM TOXIN; UNCLASSIFIED DRUG; EXOTOXIN; PROTECTIVE AGENT;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL CULTURE; CELL PROTECTION; CELL VACUOLE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSKELETON; CYTOSOL; ENDOCYTOSIS; ENDOSOME; ENZYME ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; INTOXICATION; LIPID BILAYER; MAMMAL CELL; MEMBRANE CHANNEL; NONHUMAN; PROTEIN TRANSPORT; TOXIN STRUCTURE; CELL LINE; CLOSTRIDIUM BOTULINUM; CLOSTRIDIUM PERFRINGENS; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; PATHOGENICITY; TRANSPORT AT THE CELLULAR LEVEL;

BACILLUS ANTHRACIS; CLOSTRIDIUM BOTULINUM; CLOSTRIDIUM PERFRINGENS; MAMMALIA;

BETA-CYCLODEXTRINS; BIOLOGICAL TRANSPORT; CELL LINE; CLOSTRIDIUM BOTULINUM; CLOSTRIDIUM PERFRINGENS; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCYTOSIS; ENDOSOMES; EXOTOXINS; HUMANS; LIPID BILAYERS; PROTECTIVE AGENTS;

EID: 80051937100     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023927     Document Type: Article

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