Inhibition of S. aureus α-hemolysin and B. anthracis lethal toxin by β-cyclodextrin derivatives

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 16, 2007, Pages 5424-5431

  Karginov, Vladimir A ^a   Nestorovich, Ekaterina M ^b   Schmidtmann, Frank ^c   Robinson, Tanisha M ^a   Yohannes, Adiamseged ^a   Fahmi, Nour Eddine ^c   Bezrukov, Sergey M ^b   Hecht, Sidney M ^d  

^a Innovative Biologics Inc   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c Pinnacle Pharmaceuticals Inc   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Hemolysin; Cyclodextrin derivatives; Anthrax toxin; Inhibitors; Staphylococcus aureus

Indexed keywords

ALPHA HEMOLYSIN; AMINO ACID DERIVATIVE; ANTHRAX TOXIN; BETA CYCLODEXTRIN DERIVATIVE; HEMOLYSIN; ION; LIPID; PER 6 [(CYSTEINYL)AMINO] BETA CYCLODEXTRIN TRIFLUOROACETIC ACID; PER 6 [(N ALPHA TERT BUTYLOXYCARBONYLORNITHINYL)AMINO] BETA CYCLODEXTRIN TRIFLUOROACETIC ACID; PER 6 [(O BENZYLSERYL)AMINO] BETA CYCLODEXTRIN TRIFLUOROACETIC ACID; PER 6 [(ORNITHINYL)AMINO] BETA CYCLODEXTRIN; PER 6 [(S BENZYLCYSTEINYL)AMINO] BETA CYCLODEXTRIN TRIFLUOROACETIC ACID; PER 6 [(SERYL)AMINO] BETA CYCLODEXTRIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ANIMAL CELL; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; ARTIFICIAL MEMBRANE; BACILLUS ANTHRACIS; CELL ASSAY; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG IDENTIFICATION; ION CONDUCTANCE; LIPID MEMBRANE; MOUSE; NONHUMAN; POROSITY; RABBIT; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; BETA-CYCLODEXTRINS; ELECTROPHYSIOLOGY; ERYTHROCYTES; HEMOLYSIN PROTEINS; HEMOLYSIS; IONS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RABBITS; STAPHYLOCOCCUS AUREUS;

BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

EID: 34250745336     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.058     Document Type: Article

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