Clostridium botulinum C2 toxin: Low pH-induced pore formation is required for translocation of the enzyme component C2I into the cytosol of host cells

Journal of Biological Chemistry

Volumn 278, Issue 39, 2003, Pages 37360-37367

  Blöcker, Dagmar ^a   Pohlmann, Kathrin ^a   Haug, Gerd ^a   Bachmeyer, Christoph ^b   Benz, Roland ^b   Aktories, Klaus ^a   Barth, Holger ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDITY; BIOLOGICAL MEMBRANES; CELLS; CONFORMATIONS; PH EFFECTS; PORE SIZE; TOXIC MATERIALS;

ENDOSOMES;

PROTEINS;

BOTULINUM TOXIN; BOTULINUM TOXIN C 2; CELL RECEPTOR; ENZYME; G ACTIN; RUBIDIUM; TRYPSIN; UNCLASSIFIED DRUG;

ACIDIFICATION; ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL CELL; ARTICLE; CELL MEMBRANE TRANSPORT; CHANNEL GATING; CLOSTRIDIUM BOTULINUM; CONTROLLED STUDY; CYTOSOL; ENDOSOME; ENZYME ACTIVATION; ENZYME CONFORMATION; HOST CELL; HOST PATHOGEN INTERACTION; INTOXICATION; LIPID MEMBRANE; MEMBRANE BINDING; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RECEPTOR BINDING;

ANIMALIA; CLOSTRIDIUM; CLOSTRIDIUM BOTULINUM; CRICETINAE; CRICETULUS GRISEUS; INSERTION SEQUENCES; POSIBACTERIA;

EID: 18144441577     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305849200     Document Type: Article

References (32)

1. Olsnes, S., Wesche, J., and Falnes, P. O. (2000) in Bacterial Protein Toxins (Aktories, K., and Just, I., eds) pp. 1-14, Springer-Verlag, Berlin
2. Barth, H., Blöcker, D., and Aktories, K. (2002) Naunyn-Schmiedeberg's Arch. Pharmacol. 366, 501-512
3. Leppla, S. H. (1995) in Bacterial Toxins and Virulence Factors in Disease (Moss, J., Iglewski, B., Vaughan, M., and Tu, A. T., eds) pp. 543-572, Marcel Dekker, Inc., New York
4. Aktories, K., Bärmann, M., Ohishi, I., Tsuyama, S., Jakobs, K. H., and Habermann, E. (1986) Nature 322, 390-392
5. Perelle, S., Gibert, M., Boquet, P., and Popoff, M. R. (1995) Infect. Immun. 63, 4967
6. Popoff, M. R., Rubin, E. J., Gill, D. M., and Boquet, P. (1988) Infect. Immun. 56, 2299-2306
7. Popoff, M. R., and Boquet, P. (1988) Biochem. Biophys. Res. Commun. 152, 1361-1368
8. Stiles, B. G., and Wilkens, T. D. (1986) Infect. Immun. 54, 683-688
9. Han, S., Craig, J. A., Putnam, C. D., Carozzi, N. B., and Tainer, J. A. (1999) Nat. Struct. Biol. 6, 932-936
10. Aktories, K., and Wegner, A. (1992) Mol. Microbiol. 6, 2905-2908
11. Ohishi, I. (2000) in Bacterial Protein Toxins (Aktories, K., and Just, I., eds) pp. 253-269, Springer-Verlag, Berlin
12. Milne, J. C., Furlong, D., Hanna, P. C., Wall, J. S., and Collier, R. J. (1994) J. Biol. Chem. 269, 20607-20612
13. Klimpel, K. R., Molloy, S. S., Thomas, G., and Leppla, S. H. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 10277-10281
14. Sellman, B. R., Nassi, S., and Collier, R. J. (2001) J. Biol. Chem. 276, 8371-8376
15. Barth, H., Blöcker, D., Behlke, J., Bergsma-Schutter, W., Brisson, A., Benz, R., and Aktories, K. (2000) J. Biol. Chem. 275, 18704-18711
16. Ohishi, I., Morikawa, Y., and Baba, T. (1990) J. Biochem. (Tokyo) 107, 420-425
17. Ohishi, I., Iwasaki, M., and Sakaguchi, G. (1980) Infect. Immun. 30, 668-673
18. Ohishi, I. (1987) Infect. Immun. 55, 1461-1465
19. Eckhardt, M., Barth, H., Blöcker, D., and Aktories, K. (2000) J. Biol. Chem. 275, 2328-2334
20. Simpson, L. L. (1989) J. Pharmacol. Exp. Ther. 251, 1223-1228
21. Schmid, A., Benz, R., Just, I., and Aktories, K. (1994) J. Biol. Chem. 269, 16706-16711
22. Barth, H., Preiss, J. C., Hofmann, F., and Aktories, K. (1998) J. Biol. Chem. 273, 29506-29511
23. Barth, H., Roebling, R., Fritz, M., and Aktories, K. (2002) J. Biol. Chem. 277, 5074-5081
24. Barth, H., Pfeifer, G., Hofmann, F., Maier, E., Benz, R., and Aktories, K. (2001) J. Biol. Chem. 276, 10670-10676
25. Benz, R., Janko, K., Boos, W., and Lauger, P. (1978) Biochim. Biophys. Acta 511,305-319
26. Fritz, G., Schroeder, P., and Aktories, K. (1995) Infect. Immun. 63, 2334-2340
27. Bachmeyer, C., Benz, R., Barth, H., Aktories, K., Gibert, M., and Popoff, M. (2001) FASEB J. 15, 1658-1660
28. Miller, C. J., Elliott, J. L., and Collier, R. J. (1999) Biochemistry 38, 10432-10441
29. Knapp, O., Benz, R., Gibert, M., Marvaud, J. C., and Popoff, M. R. (2002) J. Biol. Chem. 277, 6143-6152
30. Mourez, M., Lacy, D. B., Cunningham, K., Legmann, R., Sellman, B. R., Mogridge, J., and Collier, R. J. (2002) Trends Microbiol. 10, 287-293
31. Milne, J. C., and Collier, R. J. (1993) Mol. Microbiol. 10, 647-653
32. Haug, G., Leemhuis, J., Tiemann, D., Aktories, K., and Barth, H. (2003) J. Biol. Chem. 278, 32266-32274