Cellular Uptake of Clostridium botulinum C2 Toxin: Membrane Translocation of a Fusion Toxin Requires Unfolding of Its Dihydrofolate Reductase Domain

Biochemistry

Volumn 42, Issue 51, 2003, Pages 15284-15291

  Haug, Gerd ^a   Wilde, Christian ^a   Leemhuis, Jost ^a   Meyer, Dieter K ^a   Aktories, Klaus ^a   Barth, Holger ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CLEAVAGE;

BIOLOGICAL MEMBRANES; CATALYSIS; CELL CULTURE; CELLS; ENZYME INHIBITION; TOXICITY;

ENZYMES;

ACTIN; ADENOSINE DIPHOSPHATE; BOTULINUM TOXIN; BOTULINUM TOXIN C 2; DIHYDROFOLATE REDUCTASE; FOLIC ACID DERIVATIVE; HYBRID PROTEIN; METHOTREXATE; TRYPSIN; UNCLASSIFIED DRUG;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL CULTURE; CELL MEMBRANE TRANSPORT; CLOSTRIDIUM BOTULINUM; CYTOSOL; ENDOSOME; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN TRANSPORT; TARGET CELL;

ANIMALS; BOTULINUM TOXINS; CELL DEATH; CELL MEMBRANE; CELL SIZE; CERCOPITHECUS AETHIOPS; CLONING, MOLECULAR; HUMANS; INTRACELLULAR FLUID; MEMBRANE PROTEINS; METHOTREXATE; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE; VERO CELLS;

CLOSTRIDIUM BOTULINUM; POSIBACTERIA;

EID: 0346333312     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0354278     Document Type: Article

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