HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice

Gastroenterology

Volumn 123, Issue 3, 2002, Pages 790-802

  Sappington, Penny L ^a   Yang, Runkuan ^a   Yang, Huan ^b   Tracey, Kevin J ^b   Delude, Russell L ^a   Fink, Mitchell P ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b North Shore Long Island Jewish Research Institute ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN; FLUORESCEIN ISOTHIOCYANATE; HIGH MOBILITY GROUP PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NONHISTONE PROTEIN; PEROXYNITRITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL TRANSLOCATION; CELL STRAIN CACO 2; CELL VIABILITY; CONTROLLED STUDY; ELECTROPHORESIS; HUMAN; HUMAN CELL; INTESTINE CELL; INTESTINE MUCOSA PERMEABILITY; KNOCKOUT MOUSE; MALE; MESENTERY LYMPH NODE; MONOLAYER CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0036724929     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2002.35391     Document Type: Article

References (44)

1. A new group of chromatin-associated proteins with a high content of acidic and basic amino acids
2. The HMG-1 box protein family: Classification and functional relationships
3. Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins
4. Interaction with p53 enhances binding of cisplatinmodified DNA by high mobility group 1 protein
5. HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation
6. HMG-1 as a late mediator of endotoxin lethality in mice
7. HMG-1 as a mediator of acute lung inflammation
8. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes
9. Inhibition of inducible nitric oxide synthase ameliorates lipopolysaccharide-induced gut mucosal barrier dysfunction in rats
10. Inhibition of endotoxin-induced bacterial translocation in mice
11. Glutamine depletion and increased gut permeability in non-anorectic, non-weight losing tumor bearing rats
12. The HMG B box confers cytokine activity and signals via RAGE
13. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
14. BBe cultured intestinal epithelial monolayers
15. Effect of mesenteric ischemia and reperfusion or hemorrhagic shock on intestinal mucosal permeability and ATP content in rats
16. The biology of the receptor for advanced glycation end products and its ligands
17. The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system
18. Nitric oxide mediates interferon-gamma-induced hyperpermeability in cultured human intestinal epithelial monolayers
19. Cytokine-induced epithelial hyperpermeability: Role of nitric oxide
20. Acquired interferon-γ responsiveness during Caco-2 cell differentiation: Effects on iNOS gene expression
21. Induction and activity of nitric oxide synthase in cultured human intestinal epithelial monolayers
22. Antagonist action of imidazolineoxyl N-oxides against endothelium derived relaxing factor/NO through a radical reaction
23. Evaluation of free radical scavengers in studies of lymphocyte mediated cytolysis
24. Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure
25. 51Cr-EDTA in patients with active inflammatory bowel disease
26. Comparison of different measurements of intestinal permeability in inflammatory bowel disease
27. Increased gut permeability early after burns correlates with the extent of burn injury
28. Intestinal permeability is increased in burn patients shortly after injury
29. Intestinal permeability after severe trauma and hemorrhagic shock is increased without relation to septic complications
30. A single dose of endotoxin increases intestinal permeability in healthy humans
31. Increased intestinal permeability associated with infection in burn patients
32. Tumor necrosis factor-alpha increases sodium and chloride conductance across the tight junction of Caco-2 BBe, a human intestinal epithelial cell line
33. Autocrine regulation of epithelial permeability by hypoxia: Role for polarized release of tumor necrosis factor alpha
34. Superantigen activation of immune cells evokes epithelial (T84) transport and barrier abnormalities via IFN-gamma and TNF alpha: Inhibition of increased permeability, but not diminished secretory responses by TGF-beta2
35. 30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane
36. Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation
37. RAGE expression and AGE-induced MAP kinase activation in Caco-2 cells
38. Nitric oxide dilates tight junctions and depletes ATP in cultured Caco-2BBe intestinal epithelial monolayers
39. The effect of nitric oxide donors on the permeability of cultured intestinal epithelial monolayers: Role of superoxide, hydroxyl radical, and peroxynitrite
40. Interaction of the receptor for advanced glycation end products (RAGE) with transthyretin triggers nuclear transcription factor κB (NF-κB) activation
41. Requirement for p38 and p44/p42 mitogen-activated protein kinases in RAGE-mediated nuclear factor-kappaB transcriptional activation and cytokine secretion
42. Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide
43. Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes
44. Extracellular release of the 'differentiation enhancing factor', a HMG1 protein type, is an early step in murine erythroleukemia cell differentiation