Conserved allosteric hot spots in the transmembrane domains of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channels and Multidrug Resistance Protein (MRP) pumps

Journal of Biological Chemistry

Volumn 289, Issue 29, 2014, Pages 19942-19957

  Wei, Shipeng ^a   Roessler, Bryan C ^a   Chauvet, Sylvain ^a   Guo, Jingyu ^b   Hartman IV, John L ^b   Kirk, Kevin L ^a,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CELL MEMBRANES; CYTOLOGY; ION EXCHANGE;

ATP-BINDING CASSETTE TRANSPORTERS; CONFORMATIONAL CHANGE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; LIGAND-GATED ION CHANNELS; MULTIPLE SUBSTITUTIONS; NUCLEOTIDE-BINDING DOMAIN; TRANS-MEMBRANE DOMAINS; TRANS-MEMBRANE PROTEINS;

PROTEINS;

ADENOSINE TRIPHOSPHATE; ALANINE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; MULTIDRUG RESISTANCE PROTEIN; PHENYLALANINE; PROLINE; SERINE;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GAIN OF FUNCTION MUTATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; ISOMERIZATION; PATCH CLAMP TECHNIQUE; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTEIN TRANSPORT; SEQUENCE ALIGNMENT;

ABC TRANSPORTER; ALLOSTERIC REGULATION; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR); ION CHANNEL; MOLECULAR DYNAMICS; MULTIDRUG TRANSPORTER;

ADENOSINE TRIPHOSPHATE; ADENYLYL IMIDODIPHOSPHATE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ATP-BINDING CASSETTE TRANSPORTERS; CONSERVED SEQUENCE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HEK293 CELLS; HUMANS; ION CHANNEL GATING; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; PROLINE; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84904488768     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.562116     Document Type: Article

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