-
1
-
-
1542358787
-
Prediction and functional analysis of native disorder in proteins from the three kingdoms of life
-
Ward JJ, Sodhi JS, McGuffin LJ, Buxton BF, Jones DT (2004) Prediction and functional analysis of native disorder in proteins from the three kingdoms of life. J Mol Biol 337(3-635-645
-
(2004)
J Mol Biol
, vol.337
, Issue.3
, pp. 635-645
-
-
Ward, J.J.1
Sodhi, J.S.2
McGuffin, L.J.3
Buxton, B.F.4
Jones, D.T.5
-
2
-
-
84870057622
-
Intrinsically disordered proteins: A 10-year recap
-
Tompa P (2012) Intrinsically disordered proteins: A 10-year recap. Trends Biochem Sci 37(12-509-516
-
(2012)
Trends Biochem Sci
, vol.37
, Issue.12
, pp. 509-516
-
-
Tompa, P.1
-
3
-
-
33750999318
-
Disorder and sequence repeats in hub proteins and their implications for network evolution
-
Dosztányi Z, Chen J, Dunker AK, Simon I, Tompa P (2006) Disorder and sequence repeats in hub proteins and their implications for network evolution. J Proteome Res 5(11-2985-2995
-
(2006)
J Proteome Res
, vol.5
, Issue.11
, pp. 2985-2995
-
-
Dosztányi, Z.1
Chen, J.2
Dunker, A.K.3
Simon, I.4
Tompa, P.5
-
4
-
-
27144464910
-
Flexible nets the roles of intrinsic disorder in protein interaction networks
-
Dunker AK, Cortese MS, Romero P, Iakoucheva LM, Uversky VN (2005) Flexible nets. The roles of intrinsic disorder in protein interaction networks. FEBS J 272(20- 5129-5148
-
(2005)
FEBS J
, vol.272
, Issue.20
, pp. 5129-5148
-
-
Dunker, A.K.1
Cortese, M.S.2
Romero, P.3
Iakoucheva, L.M.4
Uversky, V.N.5
-
5
-
-
33748074139
-
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes
-
Haynes C, et al. (2006) Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes. PLoS Comput Biol 2(8-e100
-
(2006)
PLoS Comput Biol
, vol.2
, Issue.8
-
-
Haynes, C.1
-
6
-
-
84861327457
-
Interactions via intrinsically disordered regions: What kind of motifs?
-
Pancsa R, Fuxreiter M (2012) Interactions via intrinsically disordered regions: What kind of motifs? IUBMB Life 64(6-513-520
-
(2012)
IUBMB Life
, vol.64
, Issue.6
, pp. 513-520
-
-
Pancsa, R.1
Fuxreiter, M.2
-
7
-
-
2342473198
-
The importance of intrinsic disorder for protein phosphorylation
-
Iakoucheva LM, et al. (2004) The importance of intrinsic disorder for protein phosphorylation. Nucleic Acids Res 32(3-1037-1049
-
(2004)
Nucleic Acids Res
, vol.32
, Issue.3
, pp. 1037-1049
-
-
Iakoucheva, L.M.1
-
8
-
-
47649102449
-
Regulation of cell division by intrinsically unstructured proteins: Intrinsic flexibility, modularity, and signaling conduits
-
Galea CA, Wang Y, Sivakolundu SG, Kriwacki RW (2008) Regulation of cell division by intrinsically unstructured proteins: Intrinsic flexibility, modularity, and signaling conduits. Biochemistry 47(29-7598-7609
-
(2008)
Biochemistry
, vol.47
, Issue.29
, pp. 7598-7609
-
-
Galea, C.A.1
Wang, Y.2
Sivakolundu, S.G.3
Kriwacki, R.W.4
-
9
-
-
67049119327
-
Prediction of protein binding regions in disordered proteins
-
Mészáros B, Simon I, Dosztányi Z (2009) Prediction of protein binding regions in disordered proteins. PLoS Comput Biol 5(5-e1000376
-
(2009)
PLoS Comput Biol
, vol.5
, Issue.5
-
-
Mészáros, B.1
Simon, I.2
Dosztányi, Z.3
-
10
-
-
40949117264
-
Flexible nets: Disorder and induced fit in the associations of p53 and 14-3-3 with their partners
-
Oldfield CJ, et al. (2008) Flexible nets: Disorder and induced fit in the associations of p53 and 14-3-3 with their partners. BMC Genomics 9(Suppl 1-S1
-
(2008)
BMC Genomics
, vol.9
, Issue.SUPPL. 1
-
-
Oldfield, C.J.1
-
11
-
-
0038148710
-
Conformational diversity and protein evolution - A 60- year-old hypothesis revisited
-
James LC, Tawfik DS (2003) Conformational diversity and protein evolution - a 60- year-old hypothesis revisited. Trends Biochem Sci 28(7-361-368
-
(2003)
Trends Biochem Sci
, vol.28
, Issue.7
, pp. 361-368
-
-
James, L.C.1
Tawfik, D.S.2
-
12
-
-
70350340728
-
The role of dynamic conformational ensembles in biomolecular recognition
-
Boehr DD, Nussinov R, Wright PE (2009) The role of dynamic conformational ensembles in biomolecular recognition. Nat Chem Biol 5(11-789-796
-
(2009)
Nat Chem Biol
, vol.5
, Issue.11
, pp. 789-796
-
-
Boehr, D.D.1
Nussinov, R.2
Wright, P.E.3
-
13
-
-
82655180384
-
Fuzziness: Linking regulation to protein dynamics
-
FuxreiterM(2012) Fuzziness: Linking regulation to protein dynamics. Mol Biosyst 8(1- 168-177
-
(2012)
Mol Biosyst
, vol.8
, Issue.1
, pp. 168-177
-
-
Fuxreiter, M.1
-
14
-
-
76649114676
-
Protein dynamics and conformational disorder in molecular recognition
-
Mittag T, Kay LE, Forman-Kay JD (2010) Protein dynamics and conformational disorder in molecular recognition. J Mol Recognit 23(2-105-116
-
(2010)
J Mol Recognit
, vol.23
, Issue.2
, pp. 105-116
-
-
Mittag, T.1
Kay, L.E.2
Forman-Kay, J.D.3
-
15
-
-
0030931648
-
Stimulation of CFTR activity by its phosphorylated R domain
-
Winter MC, Welsh MJ (1997) Stimulation of CFTR activity by its phosphorylated R domain. Nature 389(6648-294-296
-
(1997)
Nature
, vol.389
, Issue.6648
, pp. 294-296
-
-
Winter, M.C.1
Welsh, M.J.2
-
16
-
-
0033817333
-
Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domains
-
Csanády L, et al. (2000) Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domains. J Gen Physiol 116(3-477-500
-
(2000)
J Gen Physiol
, vol.116
, Issue.3
, pp. 477-500
-
-
Csanády, L.1
-
17
-
-
2342449944
-
Gating of CFTR by the STAS domain of SLC26 transporters
-
Ko SBH, et al. (2004) Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol 6(4-343-350
-
(2004)
Nat Cell Biol
, vol.6
, Issue.4
, pp. 343-350
-
-
Sbh, K.1
-
18
-
-
84863377687
-
Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis
-
Liang X, et al. (2012) Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis. Mol Biol Cell 23(6-996-1009
-
(2012)
Mol Biol Cell
, vol.23
, Issue.6
, pp. 996-1009
-
-
Liang, X.1
-
19
-
-
0034625153
-
A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solution
-
Ostedgaard LS, Baldursson O, Vermeer DW, Welsh MJ, Robertson AD (2000) A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solution. Proc Natl Acad Sci USA 97(10-5657-5662
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.10
, pp. 5657-5662
-
-
Ostedgaard, L.S.1
Baldursson, O.2
Vermeer, D.W.3
Welsh, M.J.4
Robertson, A.D.5
-
20
-
-
0037452680
-
Effects of C-terminal deletions on cystic fibrosis transmembrane conductance regulator function in cystic fibrosis airway epithelia
-
Ostedgaard LS, et al. (2003) Effects of C-terminal deletions on cystic fibrosis transmembrane conductance regulator function in cystic fibrosis airway epithelia. Proc Natl Acad Sci USA 100(4-1937-1942
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.4
, pp. 1937-1942
-
-
Ostedgaard, L.S.1
-
21
-
-
84555194937
-
Purification of CFTR for mass spectrometry analysis: Identification of palmitoylation and other post-translational modifications
-
McClure M, et al. (2012) Purification of CFTR for mass spectrometry analysis: Identification of palmitoylation and other post-translational modifications. Protein Eng Des Sel 25(1-7-14
-
(2012)
Protein Eng des Sel
, vol.25
, Issue.1
, pp. 7-14
-
-
McClure, M.1
-
22
-
-
33750842131
-
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis
-
Wang X, et al. (2006) Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell 127(4-803-815
-
(2006)
Cell
, vol.127
, Issue.4
, pp. 803-815
-
-
Wang, X.1
-
23
-
-
34547652267
-
CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices
-
Baker JMR, et al. (2007) CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices. Nat Struct Mol Biol 14(8-738-745
-
(2007)
Nat Struct Mol Biol
, vol.14
, Issue.8
, pp. 738-745
-
-
Jmr, B.1
-
24
-
-
77950872530
-
Bioinformatic and experimental survey of 14-3-3-binding sites
-
Johnson C, et al. (2010) Bioinformatic and experimental survey of 14-3-3-binding sites. Biochem J 427(1-69-78
-
(2010)
Biochem J
, vol.427
, Issue.1
, pp. 69-78
-
-
Johnson, C.1
-
25
-
-
57649136393
-
Regulation of CFTR trafficking by its R domain
-
Lewarchik CM, Peters KW, Qi J, Frizzell RA (2008) Regulation of CFTR trafficking by its R domain. J Biol Chem 283(42-28401-28412
-
(2008)
J Biol Chem
, vol.283
, Issue.42
, pp. 28401-28412
-
-
Lewarchik, C.M.1
Peters, K.W.2
Qi, J.3
Frizzell, R.A.4
-
26
-
-
0035917466
-
Crystal structure of the 14-3- 3zeta: Serotonin N-acetyltransferase complex. A role for scaffolding in enzyme regulation
-
Obsil T, Ghirlando R, Klein DC, Ganguly S, Dyda F (2001) Crystal structure of the 14-3- 3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation. Cell 105(2-257-267
-
(2001)
Cell
, vol.105
, Issue.2
, pp. 257-267
-
-
Obsil, T.1
Ghirlando, R.2
Klein, D.C.3
Ganguly, S.4
Dyda, F.5
-
27
-
-
84865234037
-
Conformational changes relevant to channel activity and folding within the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator
-
Hudson RP, et al. (2012) Conformational changes relevant to channel activity and folding within the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator. J Biol Chem 287(34-28480-28494
-
(2012)
J Biol Chem
, vol.287
, Issue.34
, pp. 28480-28494
-
-
Hudson, R.P.1
-
28
-
-
84884239140
-
Allosteric coupling between the intracellular coupling helix 4 and regulatory sites of the first nucleotide-binding domain of CFTR
-
Dawson JE, Farber PJ, Forman-Kay JD (2013) Allosteric coupling between the intracellular coupling helix 4 and regulatory sites of the first nucleotide-binding domain of CFTR. PLoS One 8(9-e74347
-
(2013)
PLoS One
, vol.8
, Issue.9
-
-
Dawson, J.E.1
Farber, P.J.2
Forman-Kay, J.D.3
-
29
-
-
82755176172
-
The cystic fibrosis transmembrane conductance regulator (CFTR- Three-dimensional structure and localization of a channel gate
-
Rosenberg MF, et al. (2011) The cystic fibrosis transmembrane conductance regulator (CFTR- Three-dimensional structure and localization of a channel gate. J Biol Chem 286(49-42647-42654
-
(2011)
J Biol Chem
, vol.286
, Issue.49
, pp. 42647-42654
-
-
Rosenberg, M.F.1
-
30
-
-
78649761241
-
Domain location within the cystic fibrosis transmembrane conductance regulator protein investigated by electron microscopy and gold labeling
-
Zhang L, Aleksandrov LA, Riordan JR, Ford RC (2011) Domain location within the cystic fibrosis transmembrane conductance regulator protein investigated by electron microscopy and gold labelling. Biochim Biophys Acta 1808(1-399-404
-
(2011)
Biochim Biophys Acta
, vol.1
, pp. 399-404
-
-
Zhang, L.1
Aleksandrov, L.A.2
Riordan, J.R.3
Ford, R.C.4
-
31
-
-
57649178312
-
Three-dimensional reconstruction of human cystic fibrosis transmembrane conductance regulator chloride channel revealed an ellipsoidal structure with orifices beneath the putative transmembrane domain
-
Mio K, et al. (2008) Three-dimensional reconstruction of human cystic fibrosis transmembrane conductance regulator chloride channel revealed an ellipsoidal structure with orifices beneath the putative transmembrane domain. J Biol Chem 283(44- 30300-30310
-
(2008)
J Biol Chem
, vol.283
, Issue.44
, pp. 30300-30310
-
-
Mio, K.1
-
32
-
-
70349847830
-
Molecular models of the open and closed states of the whole human CFTR protein
-
Mornon JP, Lehn P, Callebaut I (2009) Molecular models of the open and closed states of the whole human CFTR protein. Cell Mol Life Sci 66(21-3469-3486
-
(2009)
Cell Mol Life Sci
, vol.66
, Issue.21
, pp. 3469-3486
-
-
Mornon, J.P.1
Lehn, P.2
Callebaut, I.3
-
33
-
-
42149120706
-
Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function
-
Serohijos AWR, et al. (2008) Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function. Proc Natl Acad Sci USA 105(9-3256-3261
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.9
, pp. 3256-3261
-
-
Awr, S.1
-
34
-
-
63449139456
-
Structure of P-glycoprotein reveals a molecular basis for polyspecific drug binding
-
Aller SG, et al. (2009) Structure of P-glycoprotein reveals a molecular basis for polyspecific drug binding. Science 323(5922-1718-1722
-
(2009)
Science
, vol.323
, Issue.5922
, pp. 1718-1722
-
-
Aller, S.G.1
-
35
-
-
0036829096
-
Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators
-
Zor T, Mayr BM, Dyson HJ, Montminy MR, Wright PE (2002) Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators. J Biol Chem 277(44- 42241-42248
-
(2002)
J Biol Chem
, vol.277
, Issue.44
, pp. 42241-42248
-
-
Zor, T.1
Mayr, B.M.2
Dyson, H.J.3
Montminy, M.R.4
Wright, P.E.5
-
36
-
-
0035896542
-
Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by its R domain
-
Ostedgaard LS, Baldursson O, Welsh MJ (2001) Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by its R domain. J Biol Chem 276(11-7689-7692
-
(2001)
J Biol Chem
, vol.276
, Issue.11
, pp. 7689-7692
-
-
Ostedgaard, L.S.1
Baldursson, O.2
Welsh, M.J.3
-
37
-
-
23844483240
-
Phosphorylation of CFTR by PKA promotes binding of the regulatory domain
-
Chappe V, Irvine T, Liao J, Evagelidis A, Hanrahan JW (2005) Phosphorylation of CFTR by PKA promotes binding of the regulatory domain. EMBO J 24(15-2730-2740
-
(2005)
EMBO J
, vol.24
, Issue.15
, pp. 2730-2740
-
-
Chappe, V.1
Irvine, T.2
Liao, J.3
Evagelidis, A.4
Hanrahan, J.W.5
-
38
-
-
77951631601
-
Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase
-
Mittag T, et al. (2010) Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase. Structure 18(4-494-506
-
(2010)
Structure
, vol.18
, Issue.4
, pp. 494-506
-
-
Mittag, T.1
-
39
-
-
56649112976
-
Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor
-
Mittag T, et al. (2008) Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor. Proc Natl Acad Sci USA 105(46-17772-17777
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.46
, pp. 17772-17777
-
-
Mittag, T.1
-
40
-
-
27144528728
-
Disordered p27Kip1 exhibits intrinsic structure resembling the Cdk2/cyclin A-bound conformation
-
Sivakolundu SG, Bashford D, Kriwacki RW (2005) Disordered p27Kip1 exhibits intrinsic structure resembling the Cdk2/cyclin A-bound conformation. J Mol Biol 353(5- 1118-1128
-
(2005)
J Mol Biol
, vol.353
, Issue.5
, pp. 1118-1128
-
-
Sivakolundu, S.G.1
Bashford, D.2
Kriwacki, R.W.3
-
41
-
-
70349996473
-
ANCHOR: Web server for predicting protein binding regions in disordered proteins
-
Dosztányi Z, Mészáros B, Simon I (2009) ANCHOR: Web server for predicting protein binding regions in disordered proteins. Bioinformatics 25(20-2745-2746
-
(2009)
Bioinformatics
, vol.25
, Issue.20
, pp. 2745-2746
-
-
Dosztányi, Z.1
Mészáros, B.2
Simon, I.3
-
42
-
-
34249695447
-
Local structural disorder imparts plasticity on linear motifs
-
Fuxreiter M, Tompa P, Simon I (2007) Local structural disorder imparts plasticity on linear motifs. Bioinformatics 23(8-950-956
-
(2007)
Bioinformatics
, vol.23
, Issue.8
, pp. 950-956
-
-
Fuxreiter, M.1
Tompa, P.2
Simon, I.3
-
43
-
-
77951118320
-
Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant
-
Atwell S, et al. (2010) Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant. Protein Eng Des Sel 23(5-375-384
-
(2010)
Protein Eng des Sel
, vol.23
, Issue.5
, pp. 375-384
-
-
Atwell, S.1
-
44
-
-
0029400480
-
NMRPipe: A multidimensional spectral processing system based on UNIX pipes
-
Delaglio F, et al. (1995) NMRPipe: A multidimensional spectral processing system based on UNIX pipes. J Biomol NMR 6(3-277-293
-
(1995)
J Biomol NMR
, vol.6
, Issue.3
, pp. 277-293
-
-
Delaglio, F.1
-
45
-
-
0028282555
-
Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation
-
Farrow NA, et al. (1994) Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation. Biochemistry 33(19- 5984-6003
-
(1994)
Biochemistry
, vol.33
, Issue.19
, pp. 5984-6003
-
-
Farrow, N.A.1
-
46
-
-
0001689741
-
Gradient-enhanced triple-resonance three-dimensional NMR experiments with improved sensitivity
-
Muhandiram DR, Kay LE (1994) Gradient-enhanced triple-resonance three-dimensional NMR experiments with improved sensitivity. J Magn Reson 103(3-203-216
-
(1994)
J Magn Reson
, vol.103
, Issue.3
, pp. 203-216
-
-
Muhandiram, D.R.1
Kay, L.E.2
-
47
-
-
0028541866
-
Backbone 1H and 15N resonance assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques
-
Zhang O, Kay LE, Olivier JP, Forman-Kay JD (1994) Backbone 1H and 15N resonance assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques. J Biomol NMR 4(6- 845-858
-
(1994)
J Biomol NMR
, vol.4
, Issue.6
, pp. 845-858
-
-
Zhang, O.1
Kay, L.E.2
Olivier, J.P.3
Forman-Kay, J.D.4
-
48
-
-
0030612833
-
Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution
-
Pervushin K, Riek R, Wider G, Wüthrich K (1997) Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution. Proc Natl Acad Sci USA 94(23-12366-12371
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, Issue.23
, pp. 12366-12371
-
-
Pervushin, K.1
Riek, R.2
Wider, G.3
Wüthrich, K.4
-
49
-
-
0037442962
-
HADDOCK: A protein-protein docking approach based on biochemical or biophysical information
-
Dominguez C, Boelens R, Bonvin AMJ (2003) HADDOCK: A protein-protein docking approach based on biochemical or biophysical information. J Am Chem Soc 125(7- 1731-1737
-
(2003)
J Am Chem Soc
, vol.125
, Issue.7
, pp. 1731-1737
-
-
Dominguez, C.1
Boelens, R.2
Amj, B.3
-
50
-
-
21044449889
-
RECOORD: A recalculated coordinate database of 500+ proteins from the PDB using restraints from the BioMagResBank
-
Nederveen AJ, et al. (2005) RECOORD: A recalculated coordinate database of 500+ proteins from the PDB using restraints from the BioMagResBank. Proteins 59(4- 662-672.
-
(2005)
Proteins
, vol.59
, Issue.4
, pp. 662-672
-
-
Nederveen, A.J.1
|