A unified view of cystic fibrosis transmembrane conductance regulator (CFTR) gating: Combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporter

Journal of Biological Chemistry

Volumn 286, Issue 15, 2011, Pages 12813-12819

  Kirk, Kevin L ^a   Wang, Wei ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

ALLOSTERIC PROPERTIES; ATP BINDING CASSETTE TRANSPORTERS; ATP HYDROLYSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; ENZYMATIC ACTIVITIES; EVOLUTIONARY ORIGIN; GATED CHANNELS; ION CHANNEL;

LIGANDS;

ABC TRANSPORTER; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ALLOSTERISM; CHANNEL GATING; ENZYME ACTIVITY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REVIEW; STRUCTURE ANALYSIS;

EID: 79953853890     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.R111.219634     Document Type: Review

References (64)

1. Riordan, J. R., Rommens, J. M., Kerem, B., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., and Chou, J. L. (1989) Science 245, 1066-1073
2. Gabriel, S. E., Brigman, K. N., Koller, B. H., Boucher, R. C., and Stutts, M. J. (1994) Science 266, 107-109
3. De Braekeleer, M., and Férec, C. (1996) Mol. Hum. Reprod. 2, 669-677
4. Locher, K. P., Lee, A. T., and Rees, D. C. (2002) Science 296, 1091-1098
5. Dawson, R. J., and Locher, K. P. (2006) Nature 443, 180-185
6. Aller, S. G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P. M., Trinh, Y. T., Zhang, Q., Urbatsch, I. L., and Chang, G. (2009) Science 323, 1718-1722
7. Ward, A., Reyes, C. L., Yu, J., Roth, C. B., and Chang, G. (2007) Proc. Natl. Acad. Sci. U. S.A. 104, 19005-19010
8. Locher, K. P. (2009) Philos. Trans. R. Soc. Lond. B Biol. Sci. 364, 239-245
9. Sheppard, D. N., and Welsh, M. J. (1999) Physiol. Rev. 79, S23-S45
10. Vergani, P., Lockless, S. W., Nairn, A. C., and Gadsby, D. C. (2005) Nature 433, 876-880
11. Mense, M., Vergani, P., White, D. M., Altberg, G., Nairn, A. C., and Gadsby, D. C. (2006) EMBO J. 25, 4728-4739
12. Li, C., Ramjeesingh, M., Wang, W., Garami, E., Hewryk, M., Lee, D., Rommens, J. M., Galley, K., and Bear, C. E. (1996) J. Biol. Chem. 271, 28463-28468
13. Aleksandrov, L., Aleksandrov, A. A., Chang, X. B., and Riordan, J. R. (2002) J. Biol. Chem. 277, 15419-15425
14. Basso, C., Vergani, P., Nairn, A. C., and Gadsby, D. C. (2003) J. Gen. Physiol. 122, 333-348
15. Hwang, T. C., and Sheppard, D. N. (2009) J. Physiol. 587, 2151-2161
16. Csanády, L., Vergani, P., and Gadsby, D. C. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 1241-1246
17. Szollosi, A., Vergani, P., and Csanády, L. (2010) J. Gen. Physiol. 136, 407-423
18. Hwang, T. C., Nagel, G., Nairn, A. C., and Gadsby, D. C. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 4698-4702
19. Vergani, P., Nairn, A. C., and Gadsby, D. C. (2003) J. Gen. Physiol. 121, 17-36
20. Gunderson, K. L., and Kopito, R. R. (1995) Cell 82, 231-239
21. Baukrowitz, T., Hwang, T. C., Nairn, A. C., and Gadsby, D. C. (1994) Neuron 12, 473-482
22. Carson, M. R., Travis, S. M., and Welsh, M. J. (1995) J. Biol. Chem. 270, 1711-1717
23. Cheng, S. H., Rich, D. P., Marshall, J., Gregory, R. J., Welsh, M. J., and Smith, A. E. (1991) Cell 66, 1066-1072
24. Mathews, C. J., Tabcharani, J. A., Chang, X. B., Jensen, T. J., Riordan, J. R., and Hanrahan, J. W. (1998) J. Physiol. 508, 365-377
25. Wilkinson, D. J., Strong, T. V., Mansoura, M. K., Wood, D. L., Smith, S. S., Collins, F. S., and Dawson, D. C. (1997) Am. J. Physiol. 273, L127-L133
26. He, L., Aleksandrov, A. A., Serohijos, A. W., Hegedus, T., Aleksandrov, L. A., Cui, L., Dokholyan, N. V., and Riordan, J. R. (2008) J. Biol. Chem. 283, 26383-26390
27. Purohit, P., and Auerbach, A. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 115-120
28. Cadugan, D. J., and Auerbach, A. (2010) Biophys. J. 99, 798-807
29. Monod, J., Wyman, J., and Changeux, J. P. (1965) J. Mol. Biol. 12, 88-118
30. Edelstein, S. J. (1975) Annu. Rev. Biochem. 44, 209-232
31. Changeux, J. P., and Edelstein, S. J. (1998) Neuron 21, 959-980
32. Changeux, J. P., and Edelstein, S. J. (2005) Science 308, 1424-1428
33. Volkman, B. F., Lipson, D., Wemmer, D. E., and Kern, D. (2001) Science 291, 2429-2433
34. Tsai, C. J., Ma, B., Sham, Y. Y., Kumar, S., and Nussinov, R. (2001) Proteins 44, 418-427
35. Boehr, D. D., Nussinov, R., and Wright, P. E. (2009) Nat. Chem. Biol. 5, 789-796
36. Gardino, A. K., and Kern, D. (2007) Methods Enzymol. 423, 149-165
37. Cui, J., and Aldrich, R. W. (2000) Biochemistry 39, 15612-15619
38. Chang, Y., and Weiss, D. S. (1999) Biophys. J. 77, 2542-2551
39. Luque, I., Leavitt, S. A., and Freire, E. (2002) Annu. Rev. Biophys. Biomol. Struct. 31, 235-256
40. Farber, P. J., and Mittermaier, A. (2011) J. Mol. Biol. 405, 819-830
41. Colquhoun, D. (1998) Br. J. Pharmacol. 125, 924-947
42. Galzi, J. L., Edelstein, S. J., and Changeux, J. P. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 1853-1858
43. Aleksandrov, A. A., and Riordan, J. R. (1998) FEBS Lett. 431, 97-101
44. Aleksandrov, A. A., Chang, X., Aleksandrov, L., and Riordan, J. R. (2000) J. Physiol. 528, 259-265
45. Aleksandrov, A. A., Aleksandrov, L. A., and Riordan, J. R. (2007) Pflugers Arch. 453, 693-702
46. Aleksandrov, A. A., Cui, L., and Riordan, J. R. (2009) J. Physiol. 587, 2875-2886
47. Csanády, L., Nairn, A. C., and Gadsby, D. C. (2006) J. Gen. Physiol. 128, 523-533
48. Csanády, L. (2009) J. Gen. Physiol. 134, 129-136
49. Hennager, D. J., Ikuma, M., Hoshi, T., and Welsh, M. J. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 3594-3599
50. Bompadre, S. G., Sohma, Y., Li, M., and Hwang, T. C. (2007) J. Gen. Physiol. 129, 285-298
51. Wang, W., Wu, J., Bernard, K., Li, G., Wang, G., Bevensee, M. O., and Kirk, K. L. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 3888-3893
52. Cui, L., Aleksandrov, L., Chang, X. B., Hou, Y. X., He, L., Hegedus, T., Gentzsch, M., Aleksandrov, A., Balch, W. E., and Riordan, J. R. (2007) J. Mol. Biol. 365, 981-994
53. Wang, W., Bernard, K., Li, G., and Kirk, K. L. (2007) J. Biol. Chem. 282, 4533-4544
54. Gerber, S., Comellas-Bigler, M., Goetz, B. A., and Locher, K. P. (2008) Science 321, 246-250
55. Chen, T. Y., and Hwang, T. C. (2008) Physiol. Rev. 88, 351-387
56. Zhou, Z., Hu, S., and Hwang, T. C. (2001) J. Physiol. 532, 435-448
57. Cai, Z., Scott-Ward, T. S., and Sheppard, D. N. (2003) J. Gen. Physiol. 122, 605-620
58. Szellas, T., and Nagel, G. (2003) FEBS Lett. 535, 141-146
59. Wang, F., Zeltwanger, S., Hu, S., and Hwang, T. C. (2000) J. Physiol. 524, 637-648
60. Wang, W., Li, G., Clancy, J. P., and Kirk, K. L. (2005) J. Biol. Chem. 280, 23622-23630
61. Miki, H., Zhou, Z., Li, M., Hwang, T. C., and Bompadre, S. G. (2010) J. Biol. Chem. 285, 19967-19975
62. Serohijos, A. W., Hegedus, T., Aleksandrov, A. A., He, L., Cui, L., Dokholyan, N. V., and Riordan, J. R. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 3256-3261
63. Van Goor, F., Hadida, S., Grootenhuis, P. D., Burton, B., Cao, D., Neuberger, T., Turnbull, A., Singh, A., Joubran, J., Hazlewood, A., Zhou, J., McCartney, J., Arumugam, V., Decker, C., Yang, J., Young, C., Olson, E. R., Wine, J. J., Frizzell, R. A., Ashlock, M., and Negulescu, P. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 18825-18830
64. Pedemonte, N., Sonawane, N. D., Taddei, A., Hu, J., Zegarra-Moran, O., Suen, Y. F., Robins, L. I., Dicus, C. W., Willenbring, D., Nantz, M. H., Kurth, M. J., Galietta, L. J., and Verkman, A. S. (2005) Mol. Pharmacol. 67, 1797-1807