메뉴 건너뛰기




Volumn 51, Issue 3, 2014, Pages 158-167

The Meaning and Relevance of B-Cell Receptor Structure and Function in Chronic Lymphocytic Leukemia

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CHEMOKINE RECEPTOR CXCR4; IMMUNOGLOBULIN; IMMUNOGLOBULIN D; IMMUNOGLOBULIN M; PROTEIN KINASE INHIBITOR; SUPERANTIGEN;

EID: 84904429647     PISSN: 00371963     EISSN: 15328686     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2014.05.003     Document Type: Article
Times cited : (35)

References (92)
  • 1
    • 66949168111 scopus 로고    scopus 로고
    • The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors
    • Rossi D., Sozzi E., Puma A., Forconi F. The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors. Br J Haematol 2009, 146:64-75.
    • (2009) Br J Haematol , vol.146 , pp. 64-75
    • Rossi, D.1    Sozzi, E.2    Puma, A.3    Forconi, F.4
  • 2
    • 84860897508 scopus 로고    scopus 로고
    • Monoclonal B-cell lymphocytosis: right track or red herring?
    • Ghia P., Caligaris-Cappio F. Monoclonal B-cell lymphocytosis: right track or red herring?. Blood 2012, 119:4358-4362.
    • (2012) Blood , vol.119 , pp. 4358-4362
    • Ghia, P.1    Caligaris-Cappio, F.2
  • 4
    • 36149000639 scopus 로고    scopus 로고
    • MicroRNAs in the pathogeny of chronic lymphocytic leukaemia
    • Nicoloso M.S., Kipps T.J., Croce C.M., Calin G.A. MicroRNAs in the pathogeny of chronic lymphocytic leukaemia. Br J Haematol 2007, 139:709-716.
    • (2007) Br J Haematol , vol.139 , pp. 709-716
    • Nicoloso, M.S.1    Kipps, T.J.2    Croce, C.M.3    Calin, G.A.4
  • 5
    • 0037103212 scopus 로고    scopus 로고
    • V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia
    • Krober A., Seiler T., Benner A., Bullinger L., Bruckle E., Lichter P., et al. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood 2002, 100:1410-1416.
    • (2002) Blood , vol.100 , pp. 1410-1416
    • Krober, A.1    Seiler, T.2    Benner, A.3    Bullinger, L.4    Bruckle, E.5    Lichter, P.6
  • 6
    • 84863785266 scopus 로고    scopus 로고
    • Quantification of subclonal distributions of recurrent genomic aberrations in paired pre-treatment and relapse samples from patients with B-cell chronic lymphocytic leukemia
    • Knight S.J., Yau C., Clifford R., Timbs A.T., Sadighi Akha E., Dreau H.M., et al. Quantification of subclonal distributions of recurrent genomic aberrations in paired pre-treatment and relapse samples from patients with B-cell chronic lymphocytic leukemia. Leukemia 2012, 26:1564-1575.
    • (2012) Leukemia , vol.26 , pp. 1564-1575
    • Knight, S.J.1    Yau, C.2    Clifford, R.3    Timbs, A.T.4    Sadighi Akha, E.5    Dreau, H.M.6
  • 7
    • 84868370689 scopus 로고    scopus 로고
    • Targeting the B cell receptor pathway in chronic lymphocytic leukemia
    • Davids M.S., Brown J.R. Targeting the B cell receptor pathway in chronic lymphocytic leukemia. Leuk Lymphoma 2012, 53:2362-2370.
    • (2012) Leuk Lymphoma , vol.53 , pp. 2362-2370
    • Davids, M.S.1    Brown, J.R.2
  • 9
    • 0033567968 scopus 로고    scopus 로고
    • Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle R.N., Wasil T., Fais F., Ghiotto F., Valetto A., Allen S.L., et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999, 94:1840-1847.
    • (1999) Blood , vol.94 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3    Ghiotto, F.4    Valetto, A.5    Allen, S.L.6
  • 10
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) Genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin T.J., Davis Z., Gardiner A., Oscier D.G., Stevenson F.K., Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999, 94:1848-1854.
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 11
    • 84893484587 scopus 로고    scopus 로고
    • Molecular pathways: targeting the microenvironment in chronic lymphocytic leukemia-focus on the B-cell receptor
    • Ten Hacken E., Burger J.A. Molecular pathways: targeting the microenvironment in chronic lymphocytic leukemia-focus on the B-cell receptor. Clin Cancer Res 2014, 20:548-556.
    • (2014) Clin Cancer Res , vol.20 , pp. 548-556
    • Ten Hacken, E.1    Burger, J.A.2
  • 12
    • 34248354409 scopus 로고    scopus 로고
    • Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status
    • Mockridge C.I., Potter K.N., Wheatley I., Neville L.A., Packham G., Stevenson F.K. Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status. Blood 2007, 109:4424-4431.
    • (2007) Blood , vol.109 , pp. 4424-4431
    • Mockridge, C.I.1    Potter, K.N.2    Wheatley, I.3    Neville, L.A.4    Packham, G.5    Stevenson, F.K.6
  • 13
    • 0041381374 scopus 로고    scopus 로고
    • What is trogocytosis and what is its purpose?
    • Joly E., Hudrisier D. What is trogocytosis and what is its purpose?. Nat Immunol 2003, 4:815.
    • (2003) Nat Immunol , vol.4 , pp. 815
    • Joly, E.1    Hudrisier, D.2
  • 14
    • 84866152172 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling
    • Duhren-von Minden M., Ubelhart R., Schneider D., Wossning T., Bach M.P., Buchner M., et al. Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature 2012, 489:309-312.
    • (2012) Nature , vol.489 , pp. 309-312
    • Duhren-von Minden, M.1    Ubelhart, R.2    Schneider, D.3    Wossning, T.4    Bach, M.P.5    Buchner, M.6
  • 15
    • 77956646833 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia: a disease of activated monoclonal B cells
    • Damle R.N., Calissano C., Chiorazzi N. Chronic lymphocytic leukaemia: a disease of activated monoclonal B cells. Best Pract Res Clin Haematol 2010, 23:33-45.
    • (2010) Best Pract Res Clin Haematol , vol.23 , pp. 33-45
    • Damle, R.N.1    Calissano, C.2    Chiorazzi, N.3
  • 16
    • 78751549662 scopus 로고    scopus 로고
    • The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia
    • Herishanu Y., Perez-Galan P., Liu D., Biancotto A., Pittaluga S., Vire B., et al. The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood 2011, 117:563-574.
    • (2011) Blood , vol.117 , pp. 563-574
    • Herishanu, Y.1    Perez-Galan, P.2    Liu, D.3    Biancotto, A.4    Pittaluga, S.5    Vire, B.6
  • 17
    • 80054969575 scopus 로고    scopus 로고
    • Cyclin D2 is overexpressed in proliferation centers of chronic lymphocytic leukemia/small lymphocytic lymphoma
    • Igawa T., Sato Y., Takata K., Fushimi S., Tamura M., Nakamura N., et al. Cyclin D2 is overexpressed in proliferation centers of chronic lymphocytic leukemia/small lymphocytic lymphoma. Cancer Sci 2011, 102:2103-2107.
    • (2011) Cancer Sci , vol.102 , pp. 2103-2107
    • Igawa, T.1    Sato, Y.2    Takata, K.3    Fushimi, S.4    Tamura, M.5    Nakamura, N.6
  • 18
    • 84863393559 scopus 로고    scopus 로고
    • Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells
    • Krysov S., Dias S., Paterson A., Mockridge C.I., Potter K.N., Smith K.C., et al. Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells. Blood 2012, 119:170-179.
    • (2012) Blood , vol.119 , pp. 170-179
    • Krysov, S.1    Dias, S.2    Paterson, A.3    Mockridge, C.I.4    Potter, K.N.5    Smith, K.C.6
  • 19
    • 84891519509 scopus 로고    scopus 로고
    • Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function
    • Coelho V., Krysov S., Steele A., Sanchez Hidalgo M., Johnson P.W., Chana P.S., et al. Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function. Blood 2013, 122:2664-2672.
    • (2013) Blood , vol.122 , pp. 2664-2672
    • Coelho, V.1    Krysov, S.2    Steele, A.3    Sanchez Hidalgo, M.4    Johnson, P.W.5    Chana, P.S.6
  • 20
    • 82855177892 scopus 로고    scopus 로고
    • Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells
    • Calissano C., Damle R.N., Marsilio S., Yan X.J., Yancopoulos S., Hayes G., et al. Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells. Mol Med 2011, 17:1374-1382.
    • (2011) Mol Med , vol.17 , pp. 1374-1382
    • Calissano, C.1    Damle, R.N.2    Marsilio, S.3    Yan, X.J.4    Yancopoulos, S.5    Hayes, G.6
  • 21
    • 84901775466 scopus 로고    scopus 로고
    • Ibrutinib in chronic lymphocytic leukemia and B cell malignancies
    • Brown J.R. Ibrutinib in chronic lymphocytic leukemia and B cell malignancies. Leuk Lymphoma 2014, 55:263-269.
    • (2014) Leuk Lymphoma , vol.55 , pp. 263-269
    • Brown, J.R.1
  • 22
    • 84875774940 scopus 로고    scopus 로고
    • Phosphoinositide 3[U+05F3]-kinase inhibition in chronic lymphocytic leukemia
    • Davids M.S., Brown J.R. Phosphoinositide 3[U+05F3]-kinase inhibition in chronic lymphocytic leukemia. Hematol Oncol Clin North Am 2013, 27:329-339.
    • (2013) Hematol Oncol Clin North Am , vol.27 , pp. 329-339
    • Davids, M.S.1    Brown, J.R.2
  • 23
    • 78649792807 scopus 로고    scopus 로고
    • The role of the B-cell receptor in the pathogenesis of chronic lymphocytic leukaemia
    • Packham G., Stevenson F. The role of the B-cell receptor in the pathogenesis of chronic lymphocytic leukaemia. Semin Cancer Biol 2010, 20:391-399.
    • (2010) Semin Cancer Biol , vol.20 , pp. 391-399
    • Packham, G.1    Stevenson, F.2
  • 24
    • 20444389401 scopus 로고    scopus 로고
    • Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells
    • Petlickovski A., Laurenti L., Li X., Marietti S., Chiusolo P., Sica S., et al. Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells. Blood 2005, 105:4820-4827.
    • (2005) Blood , vol.105 , pp. 4820-4827
    • Petlickovski, A.1    Laurenti, L.2    Li, X.3    Marietti, S.4    Chiusolo, P.5    Sica, S.6
  • 25
    • 84857497433 scopus 로고    scopus 로고
    • Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia
    • Paterson A., Mockridge C.I., Adams J.E., Krysov S., Potter K.N., Dunscombe M.S., et al. Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia. Blood 2012, 119:1726-1736.
    • (2012) Blood , vol.119 , pp. 1726-1736
    • Paterson, A.1    Mockridge, C.I.2    Adams, J.E.3    Krysov, S.4    Potter, K.N.5    Dunscombe, M.S.6
  • 26
    • 0037114744 scopus 로고    scopus 로고
    • Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia
    • Chen L., Widhopf G., Huynh L., Rassenti L., Rai K.R., Weiss A., et al. Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood 2002, 100:4609-4614.
    • (2002) Blood , vol.100 , pp. 4609-4614
    • Chen, L.1    Widhopf, G.2    Huynh, L.3    Rassenti, L.4    Rai, K.R.5    Weiss, A.6
  • 27
    • 0037306842 scopus 로고    scopus 로고
    • Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia
    • Lanham S., Hamblin T., Oscier D., Ibbotson R., Stevenson F., Packham G. Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia. Blood 2003, 101:1087-1093.
    • (2003) Blood , vol.101 , pp. 1087-1093
    • Lanham, S.1    Hamblin, T.2    Oscier, D.3    Ibbotson, R.4    Stevenson, F.5    Packham, G.6
  • 28
    • 84880110373 scopus 로고    scopus 로고
    • Cell trafficking in chronic lymphocytic leukemia
    • pii
    • Davids M.S., Burger J.A. Cell trafficking in chronic lymphocytic leukemia. Open J Hematol 2012, 3:pii.
    • (2012) Open J Hematol , vol.3
    • Davids, M.S.1    Burger, J.A.2
  • 29
    • 77955916272 scopus 로고    scopus 로고
    • Molecular underpinning of B-cell anergy
    • Yarkoni Y., Getahun A., Cambier J.C. Molecular underpinning of B-cell anergy. Immunol Rev 2010, 237:249-263.
    • (2010) Immunol Rev , vol.237 , pp. 249-263
    • Yarkoni, Y.1    Getahun, A.2    Cambier, J.C.3
  • 30
    • 60549091762 scopus 로고    scopus 로고
    • Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors
    • Duty J.A., Szodoray P., Zheng N.Y., Koelsch K.A., Zhang Q., Swiatkowski M., et al. Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors. J Exp Med 2009, 206:139-151.
    • (2009) J Exp Med , vol.206 , pp. 139-151
    • Duty, J.A.1    Szodoray, P.2    Zheng, N.Y.3    Koelsch, K.A.4    Zhang, Q.5    Swiatkowski, M.6
  • 31
    • 84875375348 scopus 로고    scopus 로고
    • IgD cross-linking induces gene expression profiling changes and enhances apoptosis in chronic lymphocytic leukemia cells
    • Tavolaro S., Peragine N., Chiaretti S., Ricciardi M.R., Raponi S., Messina M., et al. IgD cross-linking induces gene expression profiling changes and enhances apoptosis in chronic lymphocytic leukemia cells. Leuk Res 2013, 37:455-462.
    • (2013) Leuk Res , vol.37 , pp. 455-462
    • Tavolaro, S.1    Peragine, N.2    Chiaretti, S.3    Ricciardi, M.R.4    Raponi, S.5    Messina, M.6
  • 32
    • 70349237504 scopus 로고    scopus 로고
    • B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406
    • Quiroga M.P., Balakrishnan K., Kurtova A.V., Sivina M., Keating M.J., Wierda W.G., et al. B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Blood 2009, 114:1029-1037.
    • (2009) Blood , vol.114 , pp. 1029-1037
    • Quiroga, M.P.1    Balakrishnan, K.2    Kurtova, A.V.3    Sivina, M.4    Keating, M.J.5    Wierda, W.G.6
  • 33
    • 69249120197 scopus 로고    scopus 로고
    • Down-regulation of CXCR4 and CD62L in chronic lymphocytic leukemia cells is triggered by B-cell receptor ligation and associated with progressive disease
    • Vlad A., Deglesne P.A., Letestu R., Saint-Georges S., Chevallier N., Baran-Marszak F., et al. Down-regulation of CXCR4 and CD62L in chronic lymphocytic leukemia cells is triggered by B-cell receptor ligation and associated with progressive disease. Cancer Res 2009, 69:6387-6395.
    • (2009) Cancer Res , vol.69 , pp. 6387-6395
    • Vlad, A.1    Deglesne, P.A.2    Letestu, R.3    Saint-Georges, S.4    Chevallier, N.5    Baran-Marszak, F.6
  • 36
    • 84863116430 scopus 로고    scopus 로고
    • Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease
    • Roberts A.W., Seymour J.F., Brown J.R., Wierda W.G., Kipps T.J., Khaw S.L., et al. Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease. J Clin Oncol 2012, 30:488-496.
    • (2012) J Clin Oncol , vol.30 , pp. 488-496
    • Roberts, A.W.1    Seymour, J.F.2    Brown, J.R.3    Wierda, W.G.4    Kipps, T.J.5    Khaw, S.L.6
  • 37
    • 0342711256 scopus 로고    scopus 로고
    • In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
    • Lam K.P., Kuhn R., Rajewsky K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 1997, 90:1073-1083.
    • (1997) Cell , vol.90 , pp. 1073-1083
    • Lam, K.P.1    Kuhn, R.2    Rajewsky, K.3
  • 38
    • 2942582913 scopus 로고    scopus 로고
    • Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer
    • Kraus M., Alimzhanov M.B., Rajewsky N., Rajewsky K. Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. Cell 2004, 117:787-800.
    • (2004) Cell , vol.117 , pp. 787-800
    • Kraus, M.1    Alimzhanov, M.B.2    Rajewsky, N.3    Rajewsky, K.4
  • 39
    • 0030639650 scopus 로고    scopus 로고
    • Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features
    • Johnson T.A., Rassenti L.Z., Kipps T.J. Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features. J Immunol 1997, 158:235-246.
    • (1997) J Immunol , vol.158 , pp. 235-246
    • Johnson, T.A.1    Rassenti, L.Z.2    Kipps, T.J.3
  • 40
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000, 102:553-563.
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 41
    • 33646181086 scopus 로고    scopus 로고
    • Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus
    • Jung D., Giallourakis C., Mostoslavsky R., Alt F.W. Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol 2006, 24:541-570.
    • (2006) Annu Rev Immunol , vol.24 , pp. 541-570
    • Jung, D.1    Giallourakis, C.2    Mostoslavsky, R.3    Alt, F.W.4
  • 42
    • 0030610529 scopus 로고    scopus 로고
    • Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells
    • Brezinschek H.P., Foster S.J., Brezinschek R.I., Dorner T., Domiati-Saad R., Lipsky P.E. Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells. J Clin Invest 1997, 99:2488-2501.
    • (1997) J Clin Invest , vol.99 , pp. 2488-2501
    • Brezinschek, H.P.1    Foster, S.J.2    Brezinschek, R.I.3    Dorner, T.4    Domiati-Saad, R.5    Lipsky, P.E.6
  • 43
    • 17644399099 scopus 로고    scopus 로고
    • Molecular basis of immunoglobulin variable region gene usage in systemic autoimmunity
    • Dorner T., Lipsky P.E. Molecular basis of immunoglobulin variable region gene usage in systemic autoimmunity. Clin Exp Med 2005, 4:159-169.
    • (2005) Clin Exp Med , vol.4 , pp. 159-169
    • Dorner, T.1    Lipsky, P.E.2
  • 44
    • 0026611386 scopus 로고
    • VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities
    • Pascual V., Victor K., Spellerberg M., Hamblin T.J., Stevenson F.K., Capra J.D. VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities. J Immunol 1992, 149:2337-2344.
    • (1992) J Immunol , vol.149 , pp. 2337-2344
    • Pascual, V.1    Victor, K.2    Spellerberg, M.3    Hamblin, T.J.4    Stevenson, F.K.5    Capra, J.D.6
  • 45
    • 0036785583 scopus 로고    scopus 로고
    • Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen
    • Potter K.N., Hobby P., Klijn S., Stevenson F.K., Sutton B.J. Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen. J Immunol 2002, 169:3777-3782.
    • (2002) J Immunol , vol.169 , pp. 3777-3782
    • Potter, K.N.1    Hobby, P.2    Klijn, S.3    Stevenson, F.K.4    Sutton, B.J.5
  • 46
    • 0029979577 scopus 로고    scopus 로고
    • The I binding specificity of human VH 4-34 (VH 4-21) encoded antibodies is determined by both VH framework region 1 and complementarity determining region 3
    • Li Y., Spellerberg M.B., Stevenson F.K., Capra J.D., Potter K.N. The I binding specificity of human VH 4-34 (VH 4-21) encoded antibodies is determined by both VH framework region 1 and complementarity determining region 3. J Mol Biol 1996, 256:577-589.
    • (1996) J Mol Biol , vol.256 , pp. 577-589
    • Li, Y.1    Spellerberg, M.B.2    Stevenson, F.K.3    Capra, J.D.4    Potter, K.N.5
  • 47
    • 0028978504 scopus 로고
    • Dual recognition of lipid A and DNA by human antibodies encoded by the VH4-21 gene: a possible link between infection and lupus
    • Spellerberg M.B., Chapman C.J., Mockridge C.I., Isenberg D.A., Stevenson F.K. Dual recognition of lipid A and DNA by human antibodies encoded by the VH4-21 gene: a possible link between infection and lupus. Hum Antibodies Hybridomas 1995, 6:52-56.
    • (1995) Hum Antibodies Hybridomas , vol.6 , pp. 52-56
    • Spellerberg, M.B.1    Chapman, C.J.2    Mockridge, C.I.3    Isenberg, D.A.4    Stevenson, F.K.5
  • 48
    • 0033198629 scopus 로고    scopus 로고
    • Gene sequences from primary central nervous system lymphomas indicate derivation from highly mutated germinal center B cells with ongoing mutational activity
    • Thompsett A.R., Ellison D.W., Stevenson F.K., Zhu D.V(H) gene sequences from primary central nervous system lymphomas indicate derivation from highly mutated germinal center B cells with ongoing mutational activity. Blood 1999, 94:1738-1746.
    • (1999) Blood , vol.94 , pp. 1738-1746
    • Thompsett, A.R.1    Ellison, D.W.2    Stevenson, F.K.3    Zhu, D.V.H.4
  • 49
    • 0033199296 scopus 로고    scopus 로고
    • Mutation of the p53 gene is not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin[U+05F3]s disease
    • Montesinos-Rongen M., Roers A., Kuppers R., Rajewsky K., Hansmann M.L. Mutation of the p53 gene is not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin[U+05F3]s disease. Blood 1999, 94:1755-1760.
    • (1999) Blood , vol.94 , pp. 1755-1760
    • Montesinos-Rongen, M.1    Roers, A.2    Kuppers, R.3    Rajewsky, K.4    Hansmann, M.L.5
  • 50
    • 33745698861 scopus 로고    scopus 로고
    • Confounding B-cell defences: lessons from a staphylococcal superantigen
    • Silverman G.J., Goodyear C.S. Confounding B-cell defences: lessons from a staphylococcal superantigen. Nat Rev Immunol 2006, 6:465-475.
    • (2006) Nat Rev Immunol , vol.6 , pp. 465-475
    • Silverman, G.J.1    Goodyear, C.S.2
  • 51
    • 0000634555 scopus 로고
    • Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia
    • Kipps T.J., Tomhave E., Pratt L.F., Duffy S., Chen P.P., Carson D.A. Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 1989, 86:5913-5917.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 5913-5917
    • Kipps, T.J.1    Tomhave, E.2    Pratt, L.F.3    Duffy, S.4    Chen, P.P.5    Carson, D.A.6
  • 52
    • 38949203770 scopus 로고    scopus 로고
    • Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis
    • Murray F., Darzentas N., Hadzidimitriou A., Tobin G., Boudjogra M., Scielzo C., et al. Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood 2008, 111:1524-1533.
    • (2008) Blood , vol.111 , pp. 1524-1533
    • Murray, F.1    Darzentas, N.2    Hadzidimitriou, A.3    Tobin, G.4    Boudjogra, M.5    Scielzo, C.6
  • 53
    • 42449120194 scopus 로고    scopus 로고
    • Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3
    • Widhopf G.F., Goldberg C.J., Toy T.L., Rassenti L.Z., Wierda W.G., Byrd J.C., et al. Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3. Blood 2008, 111:3137-3144.
    • (2008) Blood , vol.111 , pp. 3137-3144
    • Widhopf, G.F.1    Goldberg, C.J.2    Toy, T.L.3    Rassenti, L.Z.4    Wierda, W.G.5    Byrd, J.C.6
  • 54
    • 33947644251 scopus 로고    scopus 로고
    • Similarities and differences between the light and heavy chain Ig variable region gene repertoires in chronic lymphocytic leukemia
    • Ghiotto F., Fais F., Albesiano E., Sison C., Valetto A., Gaidano G., et al. Similarities and differences between the light and heavy chain Ig variable region gene repertoires in chronic lymphocytic leukemia. Mol Med 2006, 12:300-308.
    • (2006) Mol Med , vol.12 , pp. 300-308
    • Ghiotto, F.1    Fais, F.2    Albesiano, E.3    Sison, C.4    Valetto, A.5    Gaidano, G.6
  • 55
    • 4344704897 scopus 로고    scopus 로고
    • Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia
    • Messmer B.T., Albesiano E., Efremov D.G., Ghiotto F., Allen S.L., Kolitz J., et al. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med 2004, 200:519-525.
    • (2004) J Exp Med , vol.200 , pp. 519-525
    • Messmer, B.T.1    Albesiano, E.2    Efremov, D.G.3    Ghiotto, F.4    Allen, S.L.5    Kolitz, J.6
  • 56
    • 33846108722 scopus 로고    scopus 로고
    • Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations
    • Stamatopoulos K., Belessi C., Moreno C., Boudjograh M., Guida G., Smilevska T., et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood 2007, 109:259-270.
    • (2007) Blood , vol.109 , pp. 259-270
    • Stamatopoulos, K.1    Belessi, C.2    Moreno, C.3    Boudjograh, M.4    Guida, G.5    Smilevska, T.6
  • 57
    • 84861033763 scopus 로고    scopus 로고
    • Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies
    • Agathangelidis A., Darzentas N., Hadzidimitriou A., Brochet X., Murray F., Yan X.J., et al. Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies. Blood 2012, 119:4467-4475.
    • (2012) Blood , vol.119 , pp. 4467-4475
    • Agathangelidis, A.1    Darzentas, N.2    Hadzidimitriou, A.3    Brochet, X.4    Murray, F.5    Yan, X.J.6
  • 58
    • 74949107027 scopus 로고    scopus 로고
    • The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL
    • Forconi F., Potter K.N., Wheatley I., Darzentas N., Sozzi E., Stamatopoulos K., et al. The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL. Blood 2010, 115:71-77.
    • (2010) Blood , vol.115 , pp. 71-77
    • Forconi, F.1    Potter, K.N.2    Wheatley, I.3    Darzentas, N.4    Sozzi, E.5    Stamatopoulos, K.6
  • 61
    • 84860335491 scopus 로고    scopus 로고
    • Innate immunity mediates follicular transport of particulate but not soluble protein antigen
    • Link A., Zabel F., Schnetzler Y., Titz A., Brombacher F., Bachmann M.F. Innate immunity mediates follicular transport of particulate but not soluble protein antigen. J Immunol 2012, 188:3724-3733.
    • (2012) J Immunol , vol.188 , pp. 3724-3733
    • Link, A.1    Zabel, F.2    Schnetzler, Y.3    Titz, A.4    Brombacher, F.5    Bachmann, M.F.6
  • 62
    • 43549093570 scopus 로고    scopus 로고
    • A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies
    • Lanemo Myhrinder A., Hellqvist E., Sidorova E., Soderberg A., Baxendale H., Dahle C., et al. A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies. Blood 2008, 111:3838-3848.
    • (2008) Blood , vol.111 , pp. 3838-3848
    • Lanemo Myhrinder, A.1    Hellqvist, E.2    Sidorova, E.3    Soderberg, A.4    Baxendale, H.5    Dahle, C.6
  • 63
    • 33847373538 scopus 로고    scopus 로고
    • Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia
    • Landgren O., Rapkin J.S., Caporaso N.E., Mellemkjaer L., Gridley G., Goldin L.R., et al. Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia. Blood 2007, 109:2198-2201.
    • (2007) Blood , vol.109 , pp. 2198-2201
    • Landgren, O.1    Rapkin, J.S.2    Caporaso, N.E.3    Mellemkjaer, L.4    Gridley, G.5    Goldin, L.R.6
  • 64
    • 84858019141 scopus 로고    scopus 로고
    • Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B-cell superantigen
    • Steininger C., Widhopf G.F., Ghia E.M., Morello C.S., Vanura K., Sanders R., et al. Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B-cell superantigen. Blood 2012, 119:2293-2301.
    • (2012) Blood , vol.119 , pp. 2293-2301
    • Steininger, C.1    Widhopf, G.F.2    Ghia, E.M.3    Morello, C.S.4    Vanura, K.5    Sanders, R.6
  • 65
    • 56349161598 scopus 로고    scopus 로고
    • B-cell tolerance checkpoints in health and autoimmunity
    • Meffre E., Wardemann H. B-cell tolerance checkpoints in health and autoimmunity. Curr Opin Immunol 2008, 20:632-638.
    • (2008) Curr Opin Immunol , vol.20 , pp. 632-638
    • Meffre, E.1    Wardemann, H.2
  • 66
    • 0038375997 scopus 로고    scopus 로고
    • Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL
    • Binder C.J., Horkko S., Dewan A., Chang M.K., Kieu E.P., Goodyear C.S., et al. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med 2003, 9:736-743.
    • (2003) Nat Med , vol.9 , pp. 736-743
    • Binder, C.J.1    Horkko, S.2    Dewan, A.3    Chang, M.K.4    Kieu, E.P.5    Goodyear, C.S.6
  • 67
    • 55749114077 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation
    • Catera R., Silverman G.J., Hatzi K., Seiler T., Didier S., Zhang L., et al. Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation. Mol Med 2008, 14:665-674.
    • (2008) Mol Med , vol.14 , pp. 665-674
    • Catera, R.1    Silverman, G.J.2    Hatzi, K.3    Seiler, T.4    Didier, S.5    Zhang, L.6
  • 68
    • 84879255556 scopus 로고    scopus 로고
    • IGHV1-69-encoded antibodies expressed in chronic lymphocytic leukemia react with malondialdehyde-acetaldehyde adduct, an immunodominant oxidation-specific epitope
    • Que X., Widhopf G.F., Amir S., Hartvigsen K., Hansen L.F., Woelkers D., et al. IGHV1-69-encoded antibodies expressed in chronic lymphocytic leukemia react with malondialdehyde-acetaldehyde adduct, an immunodominant oxidation-specific epitope. PLoS One 2013, 8:e65203.
    • (2013) PLoS One , vol.8
    • Que, X.1    Widhopf, G.F.2    Amir, S.3    Hartvigsen, K.4    Hansen, L.F.5    Woelkers, D.6
  • 69
    • 4944244255 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins
    • Widhopf G.F., Rassenti L.Z., Toy T.L., Gribben J.G., Wierda W.G., Kipps T.J. Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins. Blood 2004, 104:2499-2504.
    • (2004) Blood , vol.104 , pp. 2499-2504
    • Widhopf, G.F.1    Rassenti, L.Z.2    Toy, T.L.3    Gribben, J.G.4    Wierda, W.G.5    Kipps, T.J.6
  • 70
    • 77952965028 scopus 로고    scopus 로고
    • Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin
    • Chu C.C., Catera R., Zhang L., Didier S., Agagnina B.M., Damle R.N., et al. Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin. Blood 2010, 115:3907-3915.
    • (2010) Blood , vol.115 , pp. 3907-3915
    • Chu, C.C.1    Catera, R.2    Zhang, L.3    Didier, S.4    Agagnina, B.M.5    Damle, R.N.6
  • 71
    • 84857711341 scopus 로고    scopus 로고
    • The IGHV1-69/IGHJ3 recombinations of unmutated CLL are distinct from those of normal B cells
    • Forconi F., Potter K.N., Sozzi E., Henderson I., Cencini E., Rossi D., et al. The IGHV1-69/IGHJ3 recombinations of unmutated CLL are distinct from those of normal B cells. Blood 2012, 119:2106-2109.
    • (2012) Blood , vol.119 , pp. 2106-2109
    • Forconi, F.1    Potter, K.N.2    Sozzi, E.3    Henderson, I.4    Cencini, E.5    Rossi, D.6
  • 72
    • 33344467759 scopus 로고    scopus 로고
    • Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes
    • Kienle D., Benner A., Krober A., Winkler D., Mertens D., Buhler A., et al. Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes. Blood 2006, 107:2090-2093.
    • (2006) Blood , vol.107 , pp. 2090-2093
    • Kienle, D.1    Benner, A.2    Krober, A.3    Winkler, D.4    Mertens, D.5    Buhler, A.6
  • 73
    • 33845329570 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia patients with a V1-69 gene rearrangement do not have inferior survival with respect to patients that express other unmutated V(H) genes
    • Panovska-Stavridis I., Ivanovski M., Siljanovski N., Cevreska L., Efremov D.G. Chronic lymphocytic leukemia patients with a V1-69 gene rearrangement do not have inferior survival with respect to patients that express other unmutated V(H) genes. Leuk Res 2007, 31:245-248.
    • (2007) Leuk Res , vol.31 , pp. 245-248
    • Panovska-Stavridis, I.1    Ivanovski, M.2    Siljanovski, N.3    Cevreska, L.4    Efremov, D.G.5
  • 74
    • 84887317173 scopus 로고    scopus 로고
    • Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2
    • Strefford J.C., Sutton L.A., Baliakas P., Agathangelidis A., Malčíková J., Plevova K., et al. Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2. Leukemia 2013, 27:2196-2199.
    • (2013) Leukemia , vol.27 , pp. 2196-2199
    • Strefford, J.C.1    Sutton, L.A.2    Baliakas, P.3    Agathangelidis, A.4    Malčíková, J.5    Plevova, K.6
  • 75
    • 84881266955 scopus 로고    scopus 로고
    • Association between molecular lesions and specific B-cell receptor subsets in chronic lymphocytic leukemia
    • Rossi D., Spina V., Bomben R., Rasi S., Dal-Bo M., Bruscaggin A., et al. Association between molecular lesions and specific B-cell receptor subsets in chronic lymphocytic leukemia. Blood 2013, 121:4902-4905.
    • (2013) Blood , vol.121 , pp. 4902-4905
    • Rossi, D.1    Spina, V.2    Bomben, R.3    Rasi, S.4    Dal-Bo, M.5    Bruscaggin, A.6
  • 76
    • 20444454585 scopus 로고    scopus 로고
    • Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity
    • Herve M., Xu K., Ng Y.S., Wardemann H., Albesiano E., Messmer B.T., et al. Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. J Clin Invest 2005, 115:1636-1643.
    • (2005) J Clin Invest , vol.115 , pp. 1636-1643
    • Herve, M.1    Xu, K.2    Ng, Y.S.3    Wardemann, H.4    Albesiano, E.5    Messmer, B.T.6
  • 77
    • 0032532668 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
    • Fais F., Ghiotto F., Hashimoto S., Sellars B., Valetto A., Allen S.L., et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998, 102:1515-1525.
    • (1998) J Clin Invest , vol.102 , pp. 1515-1525
    • Fais, F.1    Ghiotto, F.2    Hashimoto, S.3    Sellars, B.4    Valetto, A.5    Allen, S.L.6
  • 78
    • 79952593462 scopus 로고    scopus 로고
    • B-cell receptor, clinical course and prognosis in chronic lymphocytic leukaemia: the growing saga of the IGHV3 subgroup gene usage
    • Dal-Bo M., Del Giudice I., Bomben R., Capello D., Bertoni F., Forconi F., et al. B-cell receptor, clinical course and prognosis in chronic lymphocytic leukaemia: the growing saga of the IGHV3 subgroup gene usage. Br J Haematol 2011, 153:3-14.
    • (2011) Br J Haematol , vol.153 , pp. 3-14
    • Dal-Bo, M.1    Del Giudice, I.2    Bomben, R.3    Capello, D.4    Bertoni, F.5    Forconi, F.6
  • 79
    • 0024604730 scopus 로고
    • Identification of normal B-cell counterparts of neoplastic cells which secrete cold agglutinins of anti-I and anti-i specificity
    • Stevenson F.K., Smith G.J., North J., Hamblin T.J., Glennie M.J. Identification of normal B-cell counterparts of neoplastic cells which secrete cold agglutinins of anti-I and anti-i specificity. Br J Haematol 1989, 72:9-15.
    • (1989) Br J Haematol , vol.72 , pp. 9-15
    • Stevenson, F.K.1    Smith, G.J.2    North, J.3    Hamblin, T.J.4    Glennie, M.J.5
  • 80
    • 33645679597 scopus 로고    scopus 로고
    • Structural and functional features of the B-cell receptor in IgG-positive chronic lymphocytic leukemia
    • Potter K.N., Mockridge C.I., Neville L., Wheatley I., Schenk M., Orchard J., et al. Structural and functional features of the B-cell receptor in IgG-positive chronic lymphocytic leukemia. Clin Cancer Res 2006, 12:1672-1679.
    • (2006) Clin Cancer Res , vol.12 , pp. 1672-1679
    • Potter, K.N.1    Mockridge, C.I.2    Neville, L.3    Wheatley, I.4    Schenk, M.5    Orchard, J.6
  • 81
    • 84892578245 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia in young (<= 55 years) patients: a comprehensive analysis of prognostic factors and outcomes
    • Parikh S.A., Rabe K.G., Kay N.E., Call T.G., Ding W., Schwager S.M., et al. Chronic lymphocytic leukemia in young (<= 55 years) patients: a comprehensive analysis of prognostic factors and outcomes. Haematologica 2014, 99:140-147.
    • (2014) Haematologica , vol.99 , pp. 140-147
    • Parikh, S.A.1    Rabe, K.G.2    Kay, N.E.3    Call, T.G.4    Ding, W.5    Schwager, S.M.6
  • 82
    • 0028988007 scopus 로고
    • Pattern of usage of the VH4-21 gene by B lymphocytes in a patient with EBV infection indicates ongoing mutation and class switching
    • Chapman C.J., Spellerberg M.B., Hamblin T.J., Stevenson F.K. Pattern of usage of the VH4-21 gene by B lymphocytes in a patient with EBV infection indicates ongoing mutation and class switching. Mol Immunol 1995, 32:347-353.
    • (1995) Mol Immunol , vol.32 , pp. 347-353
    • Chapman, C.J.1    Spellerberg, M.B.2    Hamblin, T.J.3    Stevenson, F.K.4
  • 83
    • 67349164793 scopus 로고    scopus 로고
    • Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors
    • Kostareli E., Hadzidimitriou A., Stavroyianni N., Darzentas N., Athanasiadou A., Gounari M., et al. Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors. Leukemia 2009, 23:919-924.
    • (2009) Leukemia , vol.23 , pp. 919-924
    • Kostareli, E.1    Hadzidimitriou, A.2    Stavroyianni, N.3    Darzentas, N.4    Athanasiadou, A.5    Gounari, M.6
  • 84
    • 84861021139 scopus 로고    scopus 로고
    • IGHV3-21 gene frequency in a Swedish cohort of patients with newly diagnosed chronic lymphocytic leukemia
    • Cahill N., Sutton L.A., Jansson M., Murray F., Mansouri L., Gunnarsson R., et al. IGHV3-21 gene frequency in a Swedish cohort of patients with newly diagnosed chronic lymphocytic leukemia. Clin Lymphoma Myeloma Leuk 2012, 12:201-206.
    • (2012) Clin Lymphoma Myeloma Leuk , vol.12 , pp. 201-206
    • Cahill, N.1    Sutton, L.A.2    Jansson, M.3    Murray, F.4    Mansouri, L.5    Gunnarsson, R.6
  • 85
    • 10744230550 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope
    • Tobin G., Thunberg U., Johnson A., Eriksson I., Soderberg O., Karlsson K., et al. Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope. Blood 2003, 101:4952-4957.
    • (2003) Blood , vol.101 , pp. 4952-4957
    • Tobin, G.1    Thunberg, U.2    Johnson, A.3    Eriksson, I.4    Soderberg, O.5    Karlsson, K.6
  • 86
    • 33947598891 scopus 로고    scopus 로고
    • Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study
    • Bomben R., Dal Bo M., Capello D., Benedetti D., Marconi D., Zucchetto A., et al. Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study. Blood 2007, 109:2989-2998.
    • (2007) Blood , vol.109 , pp. 2989-2998
    • Bomben, R.1    Dal Bo, M.2    Capello, D.3    Benedetti, D.4    Marconi, D.5    Zucchetto, A.6
  • 88
    • 78649786581 scopus 로고    scopus 로고
    • Antigens in chronic lymphocytic leukemia-implications for cell origin and leukemogenesis
    • Rosen A., Murray F., Evaldsson C., Rosenquist R. Antigens in chronic lymphocytic leukemia-implications for cell origin and leukemogenesis. Semin Cancer Biol 2010, 20:400-409.
    • (2010) Semin Cancer Biol , vol.20 , pp. 400-409
    • Rosen, A.1    Murray, F.2    Evaldsson, C.3    Rosenquist, R.4
  • 89
    • 84875222788 scopus 로고    scopus 로고
    • A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient
    • Hoogeboom R., Wormhoudt T.A., Schipperus M.R., Langerak A.W., Dunn-Walters D.K., Guikema J.E., et al. A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient. Leukemia 2013, 27:738-740.
    • (2013) Leukemia , vol.27 , pp. 738-740
    • Hoogeboom, R.1    Wormhoudt, T.A.2    Schipperus, M.R.3    Langerak, A.W.4    Dunn-Walters, D.K.5    Guikema, J.E.6
  • 90
    • 0025813213 scopus 로고
    • Autoantibody activity of immunoglobulins isolated from B-cell follicular lymphomas
    • Dighiero G., Hart S., Lim A., Borche L., Levy R., Miller R.A. Autoantibody activity of immunoglobulins isolated from B-cell follicular lymphomas. Blood 1991, 78:581-585.
    • (1991) Blood , vol.78 , pp. 581-585
    • Dighiero, G.1    Hart, S.2    Lim, A.3    Borche, L.4    Levy, R.5    Miller, R.A.6
  • 91
    • 79955601718 scopus 로고    scopus 로고
    • CD49d is an independent prognostic marker that is associated with CXCR4 expression in CLL
    • Majid A., Lin T.T., Best G., Fishlock K., Hewamana S., Pratt G., et al. CD49d is an independent prognostic marker that is associated with CXCR4 expression in CLL. Leuk Res 2011, 35:750-756.
    • (2011) Leuk Res , vol.35 , pp. 750-756
    • Majid, A.1    Lin, T.T.2    Best, G.3    Fishlock, K.4    Hewamana, S.5    Pratt, G.6
  • 92
    • 84904424964 scopus 로고    scopus 로고
    • Unpublished data.
    • Pepper C. Unpublished data.
    • Pepper, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.