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Volumn 121, Issue 19, 2013, Pages 3879-3888

Targeting B-cell anergy in chronic lymphocytic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 11R VIVIT PEPTIDE; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; ANTILEUKEMIC AGENT; B LYMPHOCYTE RECEPTOR; CALCIUM; IMMUNOGLOBULIN M; LYMPHOCYTE MEMBRANE IMMUNOGLOBULIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEPTIDE DERIVATIVE; PROTEIN INHIBITOR; PROTEIN KINASE ZAP 70; SELUMETINIB; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DNA BINDING PROTEIN; IMMUNOGLOBULIN HEAVY CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR; RAG2 PROTEIN, MOUSE;

EID: 84880494754     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-12-474718     Document Type: Article
Times cited : (67)

References (31)
  • 2
    • 10744222814 scopus 로고    scopus 로고
    • Zap-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile
    • Wiestner A, Rosenwald A, Barry TS, et al. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. Blood. 2003;101(12): 4944-4951.
    • (2003) Blood , vol.101 , Issue.12 , pp. 4944-4951
    • Wiestner, A.1    Rosenwald, A.2    Barry, T.S.3
  • 3
    • 0037406968 scopus 로고    scopus 로고
    • Zap-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia
    • Crespo M, Bosch F, Villamor N, et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med. 2003;348(18): 1764-1775.
    • (2003) N Engl J Med , vol.348 , Issue.18 , pp. 1764-1775
    • Crespo, M.1    Bosch, F.2    Villamor, N.3
  • 4
    • 0042971643 scopus 로고    scopus 로고
    • B cell chronic lymphocytic leukemia: Lessons learned from studies of the b cell antigen receptor
    • Chiorazzi N, Ferrarini M. B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor. Annu Rev Immunol. 2003;21:841-894.
    • (2003) Annu Rev Immunol. , vol.21 , pp. 841-894
    • Chiorazzi, N.1    Ferrarini, M.2
  • 5
    • 2942584865 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia: Revelations from the b-cell receptor
    • Stevenson FK, Caligaris-Cappio F. Chronic lymphocytic leukemia: revelations from the B-cell receptor. Blood. 2004;103(12): 4389-4395.
    • (2004) Blood , vol.103 , Issue.12 , pp. 4389-4395
    • Stevenson, F.K.1    Caligaris-Cappio, F.2
  • 6
    • 84866152172 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling
    • Dühren-von Minden M, Übelhart R, Schneider D, et al. Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature. 2012;489(7415):309-312.
    • (2012) Nature , vol.489 , Issue.7415 , pp. 309-312
    • Dühren-Von Minden, M.1    Übelhart, R.2    Schneider, D.3
  • 7
    • 80054853285 scopus 로고    scopus 로고
    • B-cell receptor signaling in chronic lymphocytic leukemia
    • Stevenson FK, Krysov S, Davies AJ, Steele AJ, Packham G. B-cell receptor signaling in chronic lymphocytic leukemia. Blood. 2011;118(16): 4313-4320.
    • (2011) Blood , vol.118 , Issue.16 , pp. 4313-4320
    • Stevenson, F.K.1    Krysov, S.2    Davies, A.J.3    Steele, A.J.4    Packham, G.5
  • 8
    • 84865176364 scopus 로고    scopus 로고
    • The b-cell receptor signaling pathway as a therapeutic target in Cll
    • Woyach JA, Johnson AJ, Byrd JC. The B-cell receptor signaling pathway as a therapeutic target in CLL. Blood. 2012;120(6):1175-1184.
    • (2012) Blood , vol.120 , Issue.6 , pp. 1175-1184
    • Woyach, J.A.1    Johnson, A.J.2    Byrd, J.C.3
  • 9
    • 47249152803 scopus 로고    scopus 로고
    • Constitutive activation of distinct bcr-signaling pathways in a subset of cll patients: A molecular signature of anergy
    • Muzio M, Apollonio B, Scielzo C, et al. Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy. Blood. 2008; 112(1):188-195.
    • (2008) Blood , vol.112 , Issue.1 , pp. 188-195
    • Muzio, M.1    Apollonio, B.2    Scielzo, C.3
  • 10
    • 34248354409 scopus 로고    scopus 로고
    • Reversible anergy of sigm-mediated signaling in the two subsets of cll defined by vh-gene mutational status
    • Mockridge CI, Potter KN, Wheatley I, Neville LA, Packham G, Stevenson FK. Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status. Blood. 2007;109(10):4424-4431.
    • (2007) Blood , vol.109 , Issue.10 , pp. 4424-4431
    • Mockridge, C.I.1    Potter, K.N.2    Wheatley, I.3    Neville, L.A.4    Packham, G.5    Stevenson, F.K.6
  • 11
    • 0030966218 scopus 로고    scopus 로고
    • Different nuclear signals are activated by the b cell receptor during positive versus negative signaling
    • Healy JI, Dolmetsch RE, Timmerman LA, et al. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity. 1997;6(4): 419-428.
    • (1997) Immunity , vol.6 , Issue.4 , pp. 419-428
    • Healy, J.I.1    Dolmetsch, R.E.2    Timmerman, L.A.3
  • 12
    • 20444485767 scopus 로고    scopus 로고
    • Cellular and genetic mechanisms of self tolerance and autoimmunity
    • Goodnow CC, Sprent J, Fazekas de St Groth B, Vinuesa CG. Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature. 2005; 435(7042):590-597.
    • (2005) Nature , vol.435 , Issue.7042 , pp. 590-597
    • Goodnow, C.C.1    Sprent, J.2    Fazekas De St Groth, B.3    Vinuesa, C.G.4
  • 13
    • 0030818799 scopus 로고    scopus 로고
    • Balancing immunity, autoimmunity, and self-tolerance
    • Goodnow CC. Balancing immunity, autoimmunity, and self-tolerance. Ann N Y Acad Sci. 1997;815: 55-66.
    • (1997) Ann N Y Acad Sci. , vol.815 , pp. 55-66
    • Goodnow, C.C.1
  • 14
    • 27544458293 scopus 로고    scopus 로고
    • Maintenance of b cell anergy requires constant antigen receptor occupancy and signaling
    • Gauld SB, Benschop RJ, Merrell KT, Cambier JC. Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling. Nat Immunol. 2005;6(11): 1160-1167.
    • (2005) Nat Immunol , vol.6 , Issue.11 , pp. 1160-1167
    • Gauld, S.B.1    Benschop, R.J.2    Merrell, K.T.3    Cambier, J.C.4
  • 15
    • 33745867300 scopus 로고    scopus 로고
    • Essential role of membrane cholesterol in accelerated bcr internalization and uncoupling from nf-kappa b in b cell clonal anergy
    • Bléry M, Tze L, Miosge LA, Jun JE, Goodnow CC. Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kappa B in B cell clonal anergy. J Exp Med. 2006;203(7): 1773-1783.
    • (2006) J Exp Med , vol.203 , Issue.7 , pp. 1773-1783
    • Bléry, M.1    Tze, L.2    Miosge, L.A.3    Jun, J.E.4    Goodnow, C.C.5
  • 16
    • 0030888186 scopus 로고    scopus 로고
    • Differential activation of transcription factors induced by ca21 response amplitude and duration
    • Dolmetsch RE, Lewis RS, Goodnow CC, Healy JI. Differential activation of transcription factors induced by Ca21 response amplitude and duration. Nature. 1997;386(6627): 855-858.
    • (1997) Nature , vol.386 , Issue.6627 , pp. 855-858
    • Dolmetsch, R.E.1    Lewis, R.S.2    Goodnow, C.C.3    Healy, J.I.4
  • 17
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the international workshop on chronic lymphocytic leukemia updating the national cancer institute-working group 1996 guidelines
    • International Workshop on Chronic Lymphocytic Leukemia
    • Hallek M, Cheson BD, Catovsky D, et al; International Workshop on Chronic Lymphocytic Leukemia. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111(12): 5446-5456.
    • (2008) Blood , vol.111 , Issue.12 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3
  • 18
    • 0019427092 scopus 로고
    • A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis
    • Binet JL, Auquier A, Dighiero G, et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer. 1981;48(1):198-206.
    • (1981) Cancer , vol.48 , Issue.1 , pp. 198-206
    • Binet, J.L.1    Auquier, A.2    Dighiero, G.3
  • 20
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated ig v(h) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94(6): 1848-1854.
    • (1999) Blood , vol.94 , Issue.6 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 21
    • 0032950122 scopus 로고    scopus 로고
    • Mec1 and mec2: Two new cell lines derived from b-chronic lymphocytic leukaemia in prolymphocytoid transformation
    • Stacchini A, Aragno M, Vallario A, et al. MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformation. Leuk Res. 1999; 23(2):127-136.
    • (1999) Leuk Res , vol.23 , Issue.2 , pp. 127-136
    • Stacchini, A.1    Aragno, M.2    Vallario, A.3
  • 22
    • 77949890578 scopus 로고    scopus 로고
    • A novel rag2-/-gammac-/-xenograft model of human cll
    • Bertilaccio MT, Scielzo C, Simonetti G, et al. A novel Rag2-/-gammac-/-xenograft model of human CLL. Blood. 2010;115(8): 1605-1609.
    • (2010) Blood , vol.115 , Issue.8 , pp. 1605-1609
    • Bertilaccio, M.T.1    Scielzo, C.2    Simonetti, G.3
  • 23
    • 0025812171 scopus 로고
    • Breakdown of self-tolerance in anergic b lymphocytes
    • Goodnow CC, Brink R, Adams E. Breakdown of self-tolerance in anergic B lymphocytes. Nature. 1991;352(6335):532-536.
    • (1991) Nature , vol.352 , Issue.6335 , pp. 532-536
    • Goodnow, C.C.1    Brink, R.2    Adams, E.3
  • 24
    • 43749103335 scopus 로고    scopus 로고
    • Phase i pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor azd6244 (arry-142886) in patients with advanced cancers
    • Adjei AA, Cohen RB, Franklin W, et al. Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J Clin Oncol. 2008;26(13): 2139-2146.
    • (2008) J Clin Oncol , vol.26 , Issue.13 , pp. 2139-2146
    • Adjei, A.A.1    Cohen, R.B.2    Franklin, W.3
  • 25
    • 77952716949 scopus 로고    scopus 로고
    • Opposing roles for calcineurin and atf3 in squamous skin cancer
    • Wu X, Nguyen BC, Dziunycz P, et al. Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature. 2010; 465(7296):368-372.
    • (2010) Nature , vol.465 , Issue.7296 , pp. 368-372
    • Wu, X.1    Nguyen, B.C.2    Dziunycz, P.3
  • 26
    • 34547193611 scopus 로고    scopus 로고
    • B-cell anergy: From transgenic models to naturally occurring anergic b cells?
    • Cambier JC, Gauld SB, Merrell KT, Vilen BJ. B-cell anergy: from transgenic models to naturally occurring anergic B cells? Nat Rev Immunol. 2007;7(8):633-643.
    • (2007) Nat Rev Immunol. , vol.7 , Issue.8 , pp. 633-643
    • Cambier, J.C.1    Gauld, S.B.2    Merrell, K.T.3    Vilen, B.J.4
  • 27
    • 84864075343 scopus 로고    scopus 로고
    • The degree of bcr and nfat activation predicts clinical outcomes in chronic lymphocytic leukemia
    • Le Roy C, Deglesne PA, Chevallier N, et al. The degree of BCR and NFAT activation predicts clinical outcomes in chronic lymphocytic leukemia. Blood. 2012;120(2): 356-365.
    • (2012) Blood , vol.120 , Issue.2 , pp. 356-365
    • Le Roy, C.1    Deglesne, P.A.2    Chevallier, N.3
  • 28
    • 0030973579 scopus 로고    scopus 로고
    • Transcription factors of the nfat family: Regulation and function
    • Rao A, Luo C, Hogan PG. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol. 1997;15: 707-747.
    • (1997) Annu Rev Immunol , vol.15 , pp. 707-747
    • Rao, A.1    Luo, C.2    Hogan, P.G.3
  • 29
    • 0029836635 scopus 로고    scopus 로고
    • Cd38 expression distinguishes two groups of b-cell chronic lymphocytic leukemias with different responses to anti-igm antibodies and propensity to apoptosis
    • Zupo S, Isnardi L, Megna M, et al. CD38 expression distinguishes two groups of B-cell chronic lymphocytic leukemias with different responses to anti-IgM antibodies and propensity to apoptosis. Blood. 1996;88(4): 1365-1374.
    • (1996) Blood , vol.88 , Issue.4 , pp. 1365-1374
    • Zupo, S.1    Isnardi, L.2    Megna, M.3
  • 30
    • 0034651926 scopus 로고    scopus 로고
    • Apoptosis or plasma cell differentiation of cd38-positive b-chronic lymphocytic leukemia cells induced by cross-linking of surface igm or igD
    • Zupo S, Massara R, Dono M, Rossi E, Malavasi F, Cosulich ME, Ferrarini M. Apoptosis or plasma cell differentiation of CD38-positive B-chronic lymphocytic leukemia cells induced by cross-linking of surface IgM or IgD. Blood. 2000;95(4): 1199-1206.
    • (2000) Blood , vol.95 , Issue.4 , pp. 1199-1206
    • Zupo, S.1    Massara, R.2    Dono, M.3    Rossi, E.4    Malavasi, F.5    Cosulich, M.E.6    Ferrarini, M.7
  • 31
    • 33746924345 scopus 로고    scopus 로고
    • Survival response to b-cell receptor ligation is restricted to progressive chronic lymphocytic leukemia cells irrespective of zap70 expression
    • Deglesne PA, Chevallier N, Letestu R, et al. Survival response to B-cell receptor ligation is restricted to progressive chronic lymphocytic leukemia cells irrespective of Zap70 expression. Cancer Res. 2006;66(14): 7158-7166.
    • (2006) Cancer Res. , vol.66 , Issue.14 , pp. 7158-7166
    • Deglesne, P.A.1    Chevallier, N.2    Letestu, R.3


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