The IGHV1-69/IGHJ3 recombinations of unmutated CLL are distinct from those of normal B cells

Blood

Volumn 119, Issue 9, 2012, Pages 2106-2109

  Forconi, Francesco ^a,b,c   Potter, Kathleen N ^c   Sozzi, Elisa ^a,b   Henderson, Isla ^c   Cencini, Emanuele ^a,b   Rossi, Davide ^d   Bomben, Riccardo ^e   Gattei, Valter ^e   Gaidano, Gianluca ^d   Packham, Graham ^c   Stevenson, Freda K ^c,f  

^a UNIVERSITY OF SIENA   (Italy)

^b AOUS   (Italy)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^e CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^f SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IGHV1 69 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; B LYMPHOCYTE; CHRONIC LYMPHATIC LEUKEMIA; GENE REARRANGEMENT; HUMAN; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STEREOTYPY;

EID: 84857711341     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-08-375501     Document Type: Article

References (22)

1. Kipps TJ, Tomhave E, Pratt LF, Duffy S, Chen PP, Carson DA. Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 1989;86(15): 5913-5917. (Pubitemid 19217558)
2. Murray F, Darzentas N, Hadzidimitriou A, et al. Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood. 2008;111(3):1524- 1533.
3. Stamatopoulos K, Belessi C, Moreno C, et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations. Blood. 2007;109(1):259-270. (Pubitemid 46070124)
4. Forconi F, Potter KN, Wheatley I, et al. The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL. Blood. 2010;115(1):71-77.
5. Johnson TA, Rassenti LZ, Kipps TJ. Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features. J Immunol. 1997;158(1):235-246. (Pubitemid 127483861)
6. Lefranc MP, Giudicelli V, Kaas Q, et al. IMGT, the international ImMunoGeneTics information system. Nucleic Acids Res. 2005;33(database issue): D593-D597.
7. Widhopf GF, 2nd Rassenti LZ, Toy TL, Gribben JG, Wierda WG, Kipps TJ. Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins. Blood. 2004;104(8):2499-2504.
8. Chu CC, Catera R, Hatzi K, et al. Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA. Blood. 2008;112(13): 5122-5129.
9. Chu CC, Catera R, Zhang L, et al. Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin. Blood. 2010;115(19):3907- 3915.
10. Potter KN, Orchard J, Critchley E, Mockridge CI, Jose A, Stevenson FK. Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire. Blood. 2003;101(8):3082-3084. (Pubitemid 36857999)
11. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94(6):1848- 1854.
12. Messmer BT, Albesiano E, Efremov DG, et al. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med. 2004; 200(4):519-525. (Pubitemid 39121908)
13. Gurrieri C, McGuire P, Zan H, et al. Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification. J Exp Med. 2002; 196(5):629-639. (Pubitemid 35024441)
14. Nikitin EA, Pivnik AV, Sudarikov AB, et al. [A comparison of the forms of chronic lympholeukemia in relation to the mutational status of the genes of the immunoglobulin variable region]. Ter Arkh. 2000;72(7):52-56.
15. Nardini E, Neri F, Vicenzi E, et al. Thymic function and immunoglobulin mutation genotype in B-cell chronic lymphocytic leukemia patients. Int J Cancer. 2003;107(6):958-961. (Pubitemid 37429837)
16. Tschumper RC, Geyer SM, Campbell ME, et al. Immunoglobulin diversity gene usage predicts unfavorable outcome in a subset of chronic lymphocytic leukemia patients. J Clin Invest. 2008; 118(1):306-315.
17. Lanemo Myhrinder A, Hellqvist E, Sidorova E, et al. A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies. Blood. 2008;111(7):3838-3848.
18. Stamatopoulos K, Belessi C, Hadzidimitriou A, et al. Immunoglobulin light chain repertoire in chronic lymphocytic leukemia. Blood. 2005; 106(10):3575-3583. (Pubitemid 41609196)
19. Tobin G, Thunberg U, Karlsson K, et al. Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood. 2004;104(9):2879- 2885. (Pubitemid 39434975)
20. Giudicelli V, Chaume D, Lefranc MP. IMGT/ GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 2005;33(database issue): D256-D261.
21. Herve M, Xu K, Ng YS, et al. Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. J Clin Invest. 2005; 115(6):1636-1643. (Pubitemid 40814672)
22. Rosen A, Murray F, Evaldsson C, Rosenquist R. Antigens in chronic lymphocytic leukemia-implications for cell origin and leukemogenesis. Semin Cancer Biol. 2010;20(6):400-409.