Structural basis of the transactivation deficiency of the human PPARγ F360L mutant associated with familial partial lipodystrophy

Acta Crystallographica Section D: Biological Crystallography

Volumn 70, Issue 7, 2014, Pages 1965-1976

  Lori, Clorinda ^a   Pasquo, Alessandra ^a   Montanari, Roberta ^a   Capelli, Davide ^a   Consalvi, Valerio ^a   Chiaraluce, Roberta ^a   Cervoni, Laura ^a   Loiodice, Fulvio ^a   Laghezza, Antonio ^a   Aschi, Massimiliano ^a   Giorgi, Alessandra ^a   Pochetti, Giorgio ^a  

^a CNR   (Italy)

Author keywords

circular dichroism spectroscopy; familial partial lipodystrophy; molecular dynamics; nuclear receptors; PPAR mutants; transactivation activity

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

CHEMISTRY; CRYSTALLIZATION; FAMILIAL PARTIAL LIPODYSTROPHY; GENETICS; HUMAN; MUTATION; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION INITIATION;

CRYSTALLIZATION; HUMANS; LIPODYSTROPHY, FAMILIAL PARTIAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; PPAR GAMMA; TRANSCRIPTIONAL ACTIVATION;

EID: 84903978156     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S1399004714009638     Document Type: Article

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