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Volumn 83, Issue 1-2, 2004, Pages 93-102

Impact of genetic variation of PPARγ in humans

Author keywords

Obesity; Polymorphism; PPAR ; Type 2 diabetes

Indexed keywords

ALANINE; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROLINE;

EID: 4744340732     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymgme.2004.08.014     Document Type: Review
Times cited : (145)

References (88)
  • 2
    • 0030297919 scopus 로고    scopus 로고
    • Adipogenesis and obesity: Rounding out the big picture
    • B.M. Spiegelman, and J.S. Flier Adipogenesis and obesity: rounding out the big picture Cell 87 1996 377 389
    • (1996) Cell , vol.87 , pp. 377-389
    • Spiegelman, B.M.1    Flier, J.S.2
  • 3
    • 0032582349 scopus 로고    scopus 로고
    • PPARγ3 mRNA: A distinct PPARγ mRNA subtype transcribed from an independent promoter
    • L. Fajas, J.C. Fruchart, and J. Auwerx PPARγ3 mRNA: a distinct PPARγ mRNA subtype transcribed from an independent promoter FEBS Lett. 438 1998 55 60
    • (1998) FEBS Lett. , vol.438 , pp. 55-60
    • Fajas, L.1    Fruchart, J.C.2    Auwerx, J.3
  • 6
    • 0036146384 scopus 로고    scopus 로고
    • A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy
    • A.K. Agarwal, and A. Garg A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy J. Clin. Endocrinol. Metab. 87 2002 408 411
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 408-411
    • Agarwal, A.K.1    Garg, A.2
  • 7
    • 0036894397 scopus 로고    scopus 로고
    • PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy
    • R.A. Hegele, H. Cao, C. Frankowski, S.T. Mathews, and T. Leff PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy Diabetes 51 2002 3586 3590
    • (2002) Diabetes , vol.51 , pp. 3586-3590
    • Hegele, R.A.1    Cao, H.2    Frankowski, C.3    Mathews, S.T.4    Leff, T.5
  • 8
    • 0032189782 scopus 로고    scopus 로고
    • Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
    • M. Ristow, D. Muller-Wieland, A. Pfeiffer, W. Krone, and C.R. Kahn Obesity associated with a mutation in a genetic regulator of adipocyte differentiation N. Engl. J. Med. 339 1998 953 959
    • (1998) N. Engl. J. Med. , vol.339 , pp. 953-959
    • Ristow, M.1    Muller-Wieland, D.2    Pfeiffer, A.3    Krone, W.4    Kahn, C.R.5
  • 10
    • 0034036693 scopus 로고    scopus 로고
    • Variation in the gene for human peroxisome proliferator activated receptor gamma (PPARgamma) does not play a major role in the development of morbid obesity
    • D. Evans, W.A. Mann, J. Heer, U. Michel, D. Wendt, B. Kortner, A. Wolf, and U. Beisiegel Variation in the gene for human peroxisome proliferator activated receptor gamma (PPARgamma) does not play a major role in the development of morbid obesity Int. J. Obes. Relat. Metab. Disord. 24 2000 647 651
    • (2000) Int. J. Obes. Relat. Metab. Disord. , vol.24 , pp. 647-651
    • Evans, D.1    Mann, W.A.2    Heer, J.3    Michel, U.4    Wendt, D.5    Kortner, B.6    Wolf, A.7    Beisiegel, U.8
  • 11
    • 0032781890 scopus 로고    scopus 로고
    • Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-gamma2 (PPAR-gamma2): Divergent modulating effects on body mass index in obese and lean Caucasian men
    • J. Ek, S.A. Urhammer, T.I. Sorensen, T. Andersen, J. Auwerx, and O. Pedersen Homozygosity of the Pro12Ala variant of the peroxisome proliferation-activated receptor-gamma2 (PPAR-gamma2): divergent modulating effects on body mass index in obese and lean Caucasian men Diabetologia 42 1999 892 895
    • (1999) Diabetologia , vol.42 , pp. 892-895
    • Ek, J.1    Urhammer, S.A.2    Sorensen, T.I.3    Andersen, T.4    Auwerx, J.5    Pedersen, O.6
  • 12
    • 0033925584 scopus 로고    scopus 로고
    • The Pro-115 → Gln mutation in peroxisome-proliferator-activated receptor (PPAR) gamma2 is extremely rare in a large cohort of US Caucasians
    • J. Terrett, J. Chamberlain, S. Rastan, R. Marshall, R. McGinnis, N. Spurr, E. O'Brien, C. Evans, and A. Rut The Pro-115 → Gln mutation in peroxisome-proliferator-activated receptor (PPAR) gamma2 is extremely rare in a large cohort of US Caucasians Clin. Sci. (Lond.) 99 2000 89 90
    • (2000) Clin. Sci. (Lond.) , vol.99 , pp. 89-90
    • Terrett, J.1    Chamberlain, J.2    Rastan, S.3    Marshall, R.4    McGinnis, R.5    Spurr, N.6    O'Brien, E.7    Evans, C.8    Rut, A.9
  • 14
    • 0037396071 scopus 로고    scopus 로고
    • Analysis of the relationship between PPAR-gamma 2 gene variants and severe insulin resistance in obese patients with impaired glucose tolerance
    • M. Bluher, and R. Paschke Analysis of the relationship between PPAR-gamma 2 gene variants and severe insulin resistance in obese patients with impaired glucose tolerance Exp. Clin. Endocrinol. Diabetes 111 2003 85 90
    • (2003) Exp. Clin. Endocrinol. Diabetes , vol.111 , pp. 85-90
    • Bluher, M.1    Paschke, R.2
  • 18
    • 0033434025 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma C161 → T polymorphism and coronary artery disease
    • X.L. Wang, J. Oosterhof, and N. Duarte Peroxisome proliferator-activated receptor gamma C161 → T polymorphism and coronary artery disease Cardiovasc. Res. 44 1999 588 594
    • (1999) Cardiovasc. Res. , vol.44 , pp. 588-594
    • Wang, X.L.1    Oosterhof, J.2    Duarte, N.3
  • 19
    • 0345164399 scopus 로고    scopus 로고
    • Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPARγ) gene in diabetic Caucasians: Identification of a Pro12Ala PPAR gamma 2 missense mutation
    • C.J. Yen, B.A. Beamer, C. Negri, K. Silver, K.A. Brown, D.P. Yarnall, D.K. Burns, J. Roth, and A.R. Shuldiner Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPARγ) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation Biochem. Biophys. Res. Commun. 241 1997 270 274
    • (1997) Biochem. Biophys. Res. Commun. , vol.241 , pp. 270-274
    • Yen, C.J.1    Beamer, B.A.2    Negri, C.3    Silver, K.4    Brown, K.A.5    Yarnall, D.P.6    Burns, D.K.7    Roth, J.8    Shuldiner, A.R.9
  • 20
    • 0031595923 scopus 로고    scopus 로고
    • A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • S.S. Deeb, L. Fajas, M. Nemoto, J. Pihlajamaki, L. Mykkanen, J. Kuusisto, M. Laakso, W. Fujimoto, and J. Auwerx A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity Nat. Genet. 20 1998 284 287
    • (1998) Nat. Genet. , vol.20 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3    Pihlajamaki, J.4    Mykkanen, L.5    Kuusisto, J.6    Laakso, M.7    Fujimoto, W.8    Auwerx, J.9
  • 23
    • 0033940426 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor gamma 2 Pro12Ala mutation is associated with early onset extreme obesity and reduced fasting glucose
    • W.D. Li, J.H. Lee, and R.A. Price The peroxisome proliferator-activated receptor gamma 2 Pro12Ala mutation is associated with early onset extreme obesity and reduced fasting glucose Mol. Genet. Metab. 70 2000 159 161
    • (2000) Mol. Genet. Metab. , vol.70 , pp. 159-161
    • Li, W.D.1    Lee, J.H.2    Price, R.A.3
  • 25
    • 0037221208 scopus 로고    scopus 로고
    • Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: Thrifty genotype, thrifty phenotype, or both?
    • P. Poulsen, G. Andersen, M. Fenger, T. Hansen, S.M. Echwald, A. Volund, H. Beck-Nielsen, O. Pedersen, and A. Vaag Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both? Diabetes 52 2003 194 198
    • (2003) Diabetes , vol.52 , pp. 194-198
    • Poulsen, P.1    Andersen, G.2    Fenger, M.3    Hansen, T.4    Echwald, S.M.5    Volund, A.6    Beck-Nielsen, H.7    Pedersen, O.8    Vaag, A.9
  • 27
    • 0035002488 scopus 로고    scopus 로고
    • Association between the P12A and c1431t polymorphisms in the peroxisome proliferator activated receptor gamma (PPAR gamma) gene and type 2 diabetes
    • D. Evans, J. de Heer, C. Hagemann, D. Wendt, A. Wolf, U. Beisiegel, and W.A. Mann Association between the P12A and c1431t polymorphisms in the peroxisome proliferator activated receptor gamma (PPAR gamma) gene and type 2 diabetes Exp. Clin. Endocrinol. Diabetes 109 2001 151 154
    • (2001) Exp. Clin. Endocrinol. Diabetes , vol.109 , pp. 151-154
    • Evans, D.1    De Heer, J.2    Hagemann, C.3    Wendt, D.4    Wolf, A.5    Beisiegel, U.6    Mann, W.A.7
  • 29
    • 0033060302 scopus 로고    scopus 로고
    • Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes
    • F.P. Mancini, O. Vaccaro, L. Sabatino, A. Tufano, A.A. Rivellese, G. Riccardi, and V. Colantuoni Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes Diabetes 48 1999 1466 1468
    • (1999) Diabetes , vol.48 , pp. 1466-1468
    • Mancini, F.P.1    Vaccaro, O.2    Sabatino, L.3    Tufano, A.4    Rivellese, A.A.5    Riccardi, G.6    Colantuoni, V.7
  • 30
    • 0033582258 scopus 로고    scopus 로고
    • Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus
    • J. Ringel, S. Engeli, A. Distler, and A.M. Sharma Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus Biochem. Biophys. Res. Commun. 254 1999 450 453
    • (1999) Biochem. Biophys. Res. Commun. , vol.254 , pp. 450-453
    • Ringel, J.1    Engeli, S.2    Distler, A.3    Sharma, A.M.4
  • 31
    • 0036222003 scopus 로고    scopus 로고
    • Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 (PPARγ2) is associated with higher levels of total cholesterol and LDL-cholesterol in male caucasian type 2 diabetes patients
    • B. Zietz, N. Barth, D. Spiegel, G. Schmitz, J. Scholmerich, and A. Schaffler Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 (PPARγ2) is associated with higher levels of total cholesterol and LDL-cholesterol in male caucasian type 2 diabetes patients Exp. Clin. Endocrinol. Diabetes 110 2002 60 66
    • (2002) Exp. Clin. Endocrinol. Diabetes , vol.110 , pp. 60-66
    • Zietz, B.1    Barth, N.2    Spiegel, D.3    Schmitz, G.4    Scholmerich, J.5    Schaffler, A.6
  • 32
  • 33
    • 0034186496 scopus 로고    scopus 로고
    • Significance of Pro12Ala mutation in peroxisome proliferator-activated receptor-gamma2 in Korean diabetic and obese subjects
    • E.Y. Oh, K.M. Min, J.H. Chung, Y.K. Min, M.S. Lee, K.W. Kim, and M.K. Lee Significance of Pro12Ala mutation in peroxisome proliferator-activated receptor-gamma2 in Korean diabetic and obese subjects J. Clin. Endocrinol. Metab. 85 2000 1801 1804
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 1801-1804
    • Oh, E.Y.1    Min, K.M.2    Chung, J.H.3    Min, Y.K.4    Lee, M.S.5    Kim, K.W.6    Lee, M.K.7
  • 34
    • 0037677523 scopus 로고    scopus 로고
    • A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians
    • Y.L. Muller, C. Bogardus, B.A. Beamer, A.R. Shuldiner, and L.J. Baier A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians Diabetes 52 2003 1864 1871
    • (2003) Diabetes , vol.52 , pp. 1864-1871
    • Muller, Y.L.1    Bogardus, C.2    Beamer, B.A.3    Shuldiner, A.R.4    Baier, L.J.5
  • 37
    • 0034076660 scopus 로고    scopus 로고
    • Fuel selection in human skeletal muscle in insulin resistance: A reexamination
    • D.E. Kelley, and L.J. Mandarino Fuel selection in human skeletal muscle in insulin resistance: a reexamination Diabetes 49 2000 677 683
    • (2000) Diabetes , vol.49 , pp. 677-683
    • Kelley, D.E.1    Mandarino, L.J.2
  • 38
    • 0035163768 scopus 로고    scopus 로고
    • Sibling-based association study of the PPARgamma2 Pro12Ala polymorphism and metabolic variables in Chinese and Japanese hypertension families: A SAPPHIRe study. Stanford Asian-Pacific Program in Hypertension and Insulin Resistance
    • L.M. Chuang, C.A. Hsiung, Y.D. Chen, L.T. Ho, W.H. Sheu, D. Pei, C.H. Nakatsuka, D. Cox, R.E. Pratt, H.H. Lei, and T.Y. Tai Sibling-based association study of the PPARgamma2 Pro12Ala polymorphism and metabolic variables in Chinese and Japanese hypertension families: a SAPPHIRe study. Stanford Asian-Pacific Program in Hypertension and Insulin Resistance J. Mol. Med. 79 2001 656 664
    • (2001) J. Mol. Med. , vol.79 , pp. 656-664
    • Chuang, L.M.1    Hsiung, C.A.2    Chen, Y.D.3    Ho, L.T.4    Sheu, W.H.5    Pei, D.6    Nakatsuka, C.H.7    Cox, D.8    Pratt, R.E.9    Lei, H.H.10    Tai, T.Y.11
  • 39
    • 0037407432 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma2 gene polymorphism (Pro12Ala) beneficially influences insulin resistance and its tracking from childhood to adulthood: The Bogalusa Heart Study
    • S. Li, W. Chen, S.R. Srinivasan, E. Boerwinkle, and G.S. Berenson The peroxisome proliferator-activated receptor-gamma2 gene polymorphism (Pro12Ala) beneficially influences insulin resistance and its tracking from childhood to adulthood: the Bogalusa Heart Study Diabetes 52 2003 1265 1269
    • (2003) Diabetes , vol.52 , pp. 1265-1269
    • Li, S.1    Chen, W.2    Srinivasan, S.R.3    Boerwinkle, E.4    Berenson, G.S.5
  • 40
    • 0036170755 scopus 로고    scopus 로고
    • Insulin resistance is attenuated in women with polycystic ovary syndrome with the Pro(12)Ala polymorphism in the PPARgamma gene
    • M. Hara, S.Y. Alcoser, A. Qaadir, K.K. Beiswenger, N.J. Cox, and D.A. Ehrmann Insulin resistance is attenuated in women with polycystic ovary syndrome with the Pro(12)Ala polymorphism in the PPARgamma gene J. Clin. Endocrinol. Metab. 87 2002 772 775
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 772-775
    • Hara, M.1    Alcoser, S.Y.2    Qaadir, A.3    Beiswenger, K.K.4    Cox, N.J.5    Ehrmann, D.A.6
  • 41
    • 0036772369 scopus 로고    scopus 로고
    • Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population
    • J.L. Gonzalez Sanchez, M. Serrano Rios, P.C. Fernandez, M. Laakso, and M.T. Martinez Larrad Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population Eur. J. Endocrinol. 147 2002 495 501
    • (2002) Eur. J. Endocrinol. , vol.147 , pp. 495-501
    • Gonzalez Sanchez, J.L.1    Serrano Rios, M.2    Fernandez, P.C.3    Laakso, M.4    Martinez Larrad, M.T.5
  • 42
    • 4243353569 scopus 로고    scopus 로고
    • Comment: Studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: Homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome
    • L. Frederiksen, K. Brodbaek, M. Fenger, T. Jorgensen, K. Borch-Johnsen, S. Madsbad, and S.A. Urhammer Comment: studies of the Pro12Ala polymorphism of the PPAR-gamma gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome J. Clin. Endocrinol. Metab. 87 2002 3989 3992
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 3989-3992
    • Frederiksen, L.1    Brodbaek, K.2    Fenger, M.3    Jorgensen, T.4    Borch-Johnsen, K.5    Madsbad, S.6    Urhammer, S.A.7
  • 44
    • 0001491179 scopus 로고    scopus 로고
    • Impact of the peroxisome proliferator activated receptor gamma2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus
    • A. Meirhaeghe, L. Fajas, N. Helbecque, D. Cottel, J. Auwerx, S.S. Deeb, and P. Amouyel Impact of the peroxisome proliferator activated receptor gamma2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus Int. J. Obes. Relat. Metab. Disord. 24 2000 195 199
    • (2000) Int. J. Obes. Relat. Metab. Disord. , vol.24 , pp. 195-199
    • Meirhaeghe, A.1    Fajas, L.2    Helbecque, N.3    Cottel, D.4    Auwerx, J.5    Deeb, S.S.6    Amouyel, P.7
  • 45
    • 0031667127 scopus 로고    scopus 로고
    • Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations
    • B.A. Beamer, C.J. Yen, R.E. Andersen, D. Muller, D. Elahi, L.J. Cheskin, R. Andres, J. Roth, and A.R. Shuldiner Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations Diabetes 47 1998 1806 1808
    • (1998) Diabetes , vol.47 , pp. 1806-1808
    • Beamer, B.A.1    Yen, C.J.2    Andersen, R.E.3    Muller, D.4    Elahi, D.5    Cheskin, L.J.6    Andres, R.7    Roth, J.8    Shuldiner, A.R.9
  • 48
    • 0033624612 scopus 로고    scopus 로고
    • The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia
    • J. Pihlajamaki, R. Miettinen, R. Valve, L. Karjalainen, L. Mykkanen, J. Kuusisto, S. Deeb, J. Auwerx, and M. Laakso The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia Atherosclerosis 151 2000 567 574
    • (2000) Atherosclerosis , vol.151 , pp. 567-574
    • Pihlajamaki, J.1    Miettinen, R.2    Valve, R.3    Karjalainen, L.4    Mykkanen, L.5    Kuusisto, J.6    Deeb, S.7    Auwerx, J.8    Laakso, M.9
  • 50
    • 0035062772 scopus 로고    scopus 로고
    • A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity
    • M.M. Swarbrick, C.M. Chapman, B.M. McQuillan, J. Hung, P.L. Thompson, and J.P. Beilby A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity Eur. J. Endocrinol. 144 2001 277 282
    • (2001) Eur. J. Endocrinol. , vol.144 , pp. 277-282
    • Swarbrick, M.M.1    Chapman, C.M.2    McQuillan, B.M.3    Hung, J.4    Thompson, P.L.5    Beilby, J.P.6
  • 51
    • 0142209179 scopus 로고    scopus 로고
    • Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: A meta-analysis
    • S. Masud, and S. Ye Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: a meta-analysis J. Med. Genet. 40 2003 773 780
    • (2003) J. Med. Genet. , vol.40 , pp. 773-780
    • Masud, S.1    Ye, S.2
  • 53
    • 0036320727 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma2 polymorphism Pro12Ala is associated with nephropathy in type 2 diabetes: The Berlin Diabetes Mellitus (BeDiaM) Study
    • S.M. Herrmann, J. Ringel, J.G. Wang, J.A. Staessen, and E. Brand Peroxisome proliferator-activated receptor-gamma2 polymorphism Pro12Ala is associated with nephropathy in type 2 diabetes: The Berlin Diabetes Mellitus (BeDiaM) Study Diabetes 51 2002 2653 2657
    • (2002) Diabetes , vol.51 , pp. 2653-2657
    • Herrmann, S.M.1    Ringel, J.2    Wang, J.G.3    Staessen, J.A.4    Brand, E.5
  • 54
    • 0345275787 scopus 로고    scopus 로고
    • The human peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism is associated with decreased risk of diabetic nephropathy in patients with type 2 diabetes
    • M.L. Caramori, L.H. Canani, L.A. Costa, and J.L. Gross The human peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism is associated with decreased risk of diabetic nephropathy in patients with type 2 diabetes Diabetes 52 2003 3010 3013
    • (2003) Diabetes , vol.52 , pp. 3010-3013
    • Caramori, M.L.1    Canani, L.H.2    Costa, L.A.3    Gross, J.L.4
  • 55
    • 0034057069 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in the cardiovascular system
    • D. Bishop-Bailey Peroxisome proliferator-activated receptors in the cardiovascular system Br. J. Pharmacol. 129 2000 823 834
    • (2000) Br. J. Pharmacol. , vol.129 , pp. 823-834
    • Bishop-Bailey, D.1
  • 56
    • 0037625000 scopus 로고    scopus 로고
    • Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction
    • P.M. Ridker, N.R. Cook, S. Cheng, H.A. Erlich, K. Lindpaintner, J. Plutzky, and R.Y. Zee Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction Arterioscler. Thromb. Vasc. Biol. 23 2003 859 863
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 859-863
    • Ridker, P.M.1    Cook, N.R.2    Cheng, S.3    Erlich, H.A.4    Lindpaintner, K.5    Plutzky, J.6    Zee, R.Y.7
  • 58
    • 0031939716 scopus 로고    scopus 로고
    • Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor gamma
    • M.J. Reginato, S.L. Krakow, S.T. Bailey, and M.A. Lazar Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor gamma J. Biol. Chem. 273 1998 1855 1858
    • (1998) J. Biol. Chem. , vol.273 , pp. 1855-1858
    • Reginato, M.J.1    Krakow, S.L.2    Bailey, S.T.3    Lazar, M.A.4
  • 59
    • 0036581304 scopus 로고    scopus 로고
    • Frequent polymorphism of peroxisome proliferator activated receptor gamma gene in colorectal cancer containing wild-type K-ras gene
    • S. Tomita, H. Kawamata, J. Imura, F. Omotehara, Y. Ueda, and T. Fujimori Frequent polymorphism of peroxisome proliferator activated receptor gamma gene in colorectal cancer containing wild-type K-ras gene Int. J. Mol. Med. 9 2002 485 488
    • (2002) Int. J. Mol. Med. , vol.9 , pp. 485-488
    • Tomita, S.1    Kawamata, H.2    Imura, J.3    Omotehara, F.4    Ueda, Y.5    Fujimori, T.6
  • 61
    • 0042335764 scopus 로고    scopus 로고
    • Enhancement of BRCA1 gene expression by the peroxisome proliferator-activated receptor gamma in the MCF-7 breast cancer cell line
    • M. Pignatelli, C. Cocca, A. Santos, and A. Perez-Castillo Enhancement of BRCA1 gene expression by the peroxisome proliferator-activated receptor gamma in the MCF-7 breast cancer cell line Oncogene 22 2003 5446 5450
    • (2003) Oncogene , vol.22 , pp. 5446-5450
    • Pignatelli, M.1    Cocca, C.2    Santos, A.3    Perez-Castillo, A.4
  • 62
    • 0036866649 scopus 로고    scopus 로고
    • Lack of association of the codon 12 polymorphism of the peroxisome proliferator-activated receptor gamma gene with breast cancer and body mass
    • A. Memisoglu, S.E. Hankinson, J.E. Manson, G.A. Colditz, and D.J. Hunter Lack of association of the codon 12 polymorphism of the peroxisome proliferator-activated receptor gamma gene with breast cancer and body mass Pharmacogenetics 12 2002 597 603
    • (2002) Pharmacogenetics , vol.12 , pp. 597-603
    • Memisoglu, A.1    Hankinson, S.E.2    Manson, J.E.3    Colditz, G.A.4    Hunter, D.J.5
  • 64
    • 0032145363 scopus 로고    scopus 로고
    • Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo
    • T. Kubota, K. Koshizuka, E.A. Williamson, H. Asou, J.W. Said, S. Holden, I. Miyoshi, and H.P. Koeffler Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo Cancer Res. 58 1998 3344 3352
    • (1998) Cancer Res. , vol.58 , pp. 3344-3352
    • Kubota, T.1    Koshizuka, K.2    Williamson, E.A.3    Asou, H.4    Said, J.W.5    Holden, S.6    Miyoshi, I.7    Koeffler, H.P.8
  • 65
    • 0037470401 scopus 로고    scopus 로고
    • Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene and risk of prostate cancer among men in a large cancer prevention study
    • D. Paltoo, K. Woodson, P. Taylor, D. Albanes, J. Virtamo, and J. Tangrea Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene and risk of prostate cancer among men in a large cancer prevention study Cancer Lett. 191 2003 67 74
    • (2003) Cancer Lett. , vol.191 , pp. 67-74
    • Paltoo, D.1    Woodson, K.2    Taylor, P.3    Albanes, D.4    Virtamo, J.5    Tangrea, J.6
  • 66
    • 0036314819 scopus 로고    scopus 로고
    • The proline 12 alanine substitution in the peroxisome proliferator-activated receptor-gamma2 gene is associated with lower lipoprotein lipase activity in vivo
    • J. Schneider, J. Kreuzer, A. Hamann, P.P. Nawroth, and K.A. Dugi The proline 12 alanine substitution in the peroxisome proliferator-activated receptor-gamma2 gene is associated with lower lipoprotein lipase activity in vivo Diabetes 51 2002 867 870
    • (2002) Diabetes , vol.51 , pp. 867-870
    • Schneider, J.1    Kreuzer, J.2    Hamann, A.3    Nawroth, P.P.4    Dugi, K.A.5
  • 67
    • 0034607051 scopus 로고    scopus 로고
    • Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor-gamma 2 on thiazolidinedione-induced adipogenesis
    • J. Masugi, Y. Tamori, H. Mori, T. Koike, and M. Kasuga Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor-gamma 2 on thiazolidinedione-induced adipogenesis Biochem. Biophys. Res. Commun. 268 2000 178 182
    • (2000) Biochem. Biophys. Res. Commun. , vol.268 , pp. 178-182
    • Masugi, J.1    Tamori, Y.2    Mori, H.3    Koike, T.4    Kasuga, M.5
  • 68
    • 0032589053 scopus 로고    scopus 로고
    • The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects
    • M. Koch, K. Rett, E. Maerker, A. Volk, K. Haist, M. Deninger, W. Renn, and H.U. Haring The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects Diabetologia 42 1999 758 762
    • (1999) Diabetologia , vol.42 , pp. 758-762
    • Koch, M.1    Rett, K.2    Maerker, E.3    Volk, A.4    Haist, K.5    Deninger, M.6    Renn, W.7    Haring, H.U.8
  • 70
    • 0034745183 scopus 로고    scopus 로고
    • Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene is associated with increased antilipolytic insulin sensitivity
    • M. Stumvoll, H.G. Wahl, K. Loblein, R. Becker, F. Machicao, S. Jacob, and H. Haring Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene is associated with increased antilipolytic insulin sensitivity Diabetes 50 2001 876 881
    • (2001) Diabetes , vol.50 , pp. 876-881
    • Stumvoll, M.1    Wahl, H.G.2    Loblein, K.3    Becker, R.4    MacHicao, F.5    Jacob, S.6    Haring, H.7
  • 71
    • 0036399092 scopus 로고    scopus 로고
    • Fasting plasma free fatty acid concentrations and Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR) gamma2 gene in healthy individuals
    • O. Vaccaro, F.P. Mancini, G. Ruffa, L. Sabatino, C. Iovine, M. Masulli, V. Colantuoni, and G. Riccardi Fasting plasma free fatty acid concentrations and Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR) gamma2 gene in healthy individuals Clin. Endocrinol. (Oxf.) 57 2002 481 486
    • (2002) Clin. Endocrinol. (Oxf.) , vol.57 , pp. 481-486
    • Vaccaro, O.1    Mancini, F.P.2    Ruffa, G.3    Sabatino, L.4    Iovine, C.5    Masulli, M.6    Colantuoni, V.7    Riccardi, G.8
  • 73
    • 0036389428 scopus 로고    scopus 로고
    • Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma is associated with increased leptin levels in women with type-2 diabetes mellitus
    • I. Simon, J. Vendrell, C. Gutierrez, J.M. Fernandez-Real, I. Vendrell, L. Gallart, R. Fontova, and C. Richart Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma is associated with increased leptin levels in women with type-2 diabetes mellitus Horm. Res. 58 2002 143 149
    • (2002) Horm. Res. , vol.58 , pp. 143-149
    • Simon, I.1    Vendrell, J.2    Gutierrez, C.3    Fernandez-Real, J.M.4    Vendrell, I.5    Gallart, L.6    Fontova, R.7    Richart, C.8
  • 74
    • 0036835826 scopus 로고    scopus 로고
    • PPAR(gamma)2 gene Pro12Ala polymorphism may influence serum level of an adipocyte-derived protein, adiponectin, in the Japanese population
    • Y. Yamamoto, H. Hirose, K. Miyashita, K. Nishikai, I. Saito, M. Taniyama, M. Tomita, and T. Saruta PPAR(gamma)2 gene Pro12Ala polymorphism may influence serum level of an adipocyte-derived protein, adiponectin, in the Japanese population Metabolism 51 2002 1407 1409
    • (2002) Metabolism , vol.51 , pp. 1407-1409
    • Yamamoto, Y.1    Hirose, H.2    Miyashita, K.3    Nishikai, K.4    Saito, I.5    Taniyama, M.6    Tomita, M.7    Saruta, T.8
  • 75
    • 0037683722 scopus 로고    scopus 로고
    • Effect of the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene on the expression of PPARgamma target genes in adipose tissue of massively obese subjects
    • M. Kolehmainen, M.I. Uusitupa, E. Alhava, M. Laakso, and H. Vidal Effect of the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene on the expression of PPARgamma target genes in adipose tissue of massively obese subjects J. Clin. Endocrinol. Metab. 88 2003 1717 1722
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 1717-1722
    • Kolehmainen, M.1    Uusitupa, M.I.2    Alhava, E.3    Laakso, M.4    Vidal, H.5
  • 76
    • 0034744183 scopus 로고    scopus 로고
    • The expression of the p85alpha subunit of phosphatidylinositol 3-kinase is induced by activation of the peroxisome proliferator-activated receptor gamma in human adipocytes
    • J. Rieusset, C. Chambrier, K. Bouzakri, E. Dusserre, J. Auwerx, J.P. Riou, M. Laville, and H. Vidal The expression of the p85alpha subunit of phosphatidylinositol 3-kinase is induced by activation of the peroxisome proliferator-activated receptor gamma in human adipocytes Diabetologia 44 2001 544 554
    • (2001) Diabetologia , vol.44 , pp. 544-554
    • Rieusset, J.1    Chambrier, C.2    Bouzakri, K.3    Dusserre, E.4    Auwerx, J.5    Riou, J.P.6    Laville, M.7    Vidal, H.8
  • 78
    • 0034741548 scopus 로고    scopus 로고
    • Interactions between variants in the beta3-adrenergic receptor and peroxisome proliferator-activated receptor-gamma2 genes and obesity
    • W.C. Hsueh, S.A. Cole, A.R. Shuldiner, B.A. Beamer, J. Blangero, J.E. Hixson, J.W. MacCluer, and B.D. Mitchell Interactions between variants in the beta3-adrenergic receptor and peroxisome proliferator-activated receptor-gamma2 genes and obesity Diabetes Care 24 2001 672 677
    • (2001) Diabetes Care , vol.24 , pp. 672-677
    • Hsueh, W.C.1    Cole, S.A.2    Shuldiner, A.R.3    Beamer, B.A.4    Blangero, J.5    Hixson, J.E.6    MacCluer, J.W.7    Mitchell, B.D.8
  • 79
    • 0033656675 scopus 로고    scopus 로고
    • Thiazolidinediones inhibit the expression of beta3-adrenergic receptors at a transcriptional level
    • E. Bakopanos, and J.E. Silva Thiazolidinediones inhibit the expression of beta3-adrenergic receptors at a transcriptional level Diabetes 49 2000 2108 2115
    • (2000) Diabetes , vol.49 , pp. 2108-2115
    • Bakopanos, E.1    Silva, J.E.2
  • 80
    • 0041630975 scopus 로고    scopus 로고
    • The PPAR-gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: Results from the Quebec Family Study
    • J. Robitaille, J.P. Despres, L. Perusse, and M.C. Vohl The PPAR-gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: results from the Quebec Family Study Clin. Genet. 63 2003 109 116
    • (2003) Clin. Genet. , vol.63 , pp. 109-116
    • Robitaille, J.1    Despres, J.P.2    Perusse, L.3    Vohl, M.C.4
  • 81
    • 0345306138 scopus 로고    scopus 로고
    • Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass
    • A. Memisoglu, F.B. Hu, S.E. Hankinson, J.E. Manson, V. De, I.W.C. Willett, and D.J. Hunter Interaction between a peroxisome proliferator-activated receptor gamma gene polymorphism and dietary fat intake in relation to body mass Hum. Mol. Genet. 12 2003 2923 2929
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 2923-2929
    • Memisoglu, A.1    Hu, F.B.2    Hankinson, S.E.3    Manson, J.E.4    De, V.5    Willett, I.W.C.6    Hunter, D.J.7
  • 83
    • 0347316400 scopus 로고    scopus 로고
    • Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level?
    • P.W. Franks, J. Luan, P.O. Browne, A.H. Harding, S. O'Rahilly, V.K. Chatterjee, and N.J. Wareham Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level? Metabolism 53 2004 11 16
    • (2004) Metabolism , vol.53 , pp. 11-16
    • Franks, P.W.1    Luan, J.2    Browne, P.O.3    Harding, A.H.4    O'Rahilly, S.5    Chatterjee, V.K.6    Wareham, N.J.7
  • 86
    • 0036303247 scopus 로고    scopus 로고
    • The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth
    • J.G. Eriksson, V. Lindi, M. Uusitupa, T.J. Forsen, M. Laakso, C. Osmond, and D.J. Barker The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth Diabetes 51 2002 2321 2324
    • (2002) Diabetes , vol.51 , pp. 2321-2324
    • Eriksson, J.G.1    Lindi, V.2    Uusitupa, M.3    Forsen, T.J.4    Laakso, M.5    Osmond, C.6    Barker, D.J.7
  • 87
    • 0037329337 scopus 로고    scopus 로고
    • A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population
    • A. Meirhaeghe, L. Fajas, F. Gouilleux, D. Cottel, N. Helbecque, J. Auwerx, and P. Amouyel A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population Arterioscler. Thromb. Vasc. Biol 23 2003 289 294
    • (2003) Arterioscler. Thromb. Vasc. Biol , vol.23 , pp. 289-294
    • Meirhaeghe, A.1    Fajas, L.2    Gouilleux, F.3    Cottel, D.4    Helbecque, N.5    Auwerx, J.6    Amouyel, P.7


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