Insights into the mechanism of partial agonism: Crystal structures of the peroxisome proliferator-activated receptor γ ligand-binding domain in the complex with two enantiomeric ligands

Journal of Biological Chemistry

Volumn 282, Issue 23, 2007, Pages 17314-17324

  Pochetti, Giorgio ^a   Godio, Cristina ^b   Mitro, Nico ^b   Caruso, Donatella ^b   Galmozzi, Andrea ^b   Scurati, Samuele ^b   Loiodice, Fulvio ^c   Fracchiolla, Giuseppe ^c   Tortorella, Paolo ^c   Laghezza, Antonio ^c   Lavecchia, Antonio ^d   Novellino, Ettore ^d   Mazza, Fernando ^a,e   Crestani, Maurizio ^b  

^a CNR   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF BARI   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOLIPIDEMIC DRUGS; MUTATION ANALYSIS; TRANSACTIVATION ACTIVITY;

BIOASSAY; CRYSTAL STRUCTURE; DRUG PRODUCTS; ENZYME ACTIVITY; GLUCOSE; LIPIDS; TRANSCRIPTION;

CELL PROLIFERATION;

LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENANTIOMER; HUMAN; HUMAN CELL; LIGAND BINDING; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; CHEMISTRY; DRUG POTENTIATION; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; STEREOISOMERISM; TUMOR CELL LINE;

AMINO ACID SEQUENCE; CELL LINE, TUMOR; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PPAR GAMMA; PROTEIN CONFORMATION; STEREOISOMERISM;

EID: 34447128782     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M702316200     Document Type: Article

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