Common genetic variants in peroxisome proliferator-activated receptor-γ (PPARG) and type 2 diabetes risk among women's health initiative postmenopausal women

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 3, 2013, Pages

  Chan, Kei Hang K ^a   Niu, Tianhua ^b   Ma, Yunsheng ^c   You, Nai Chieh Y ^a   Song, Yiqing ^d   Sobel, Eric M ^a   Hsu, Yi Hsiang ^d,e   Balasubramanian, Raji ^f   Qiao, Yongxia ^c   Tinker, Lesley ^g   Liu, Simin ^a,h  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TULANE UNIVERSITY   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^f UNIVERSITY OF MASSACHUSETTS   (United States)

^g USA   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROLINE;

AFRICAN AMERICAN; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HAPLOTYPE; HISPANIC; HUMAN; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBSERVATIONAL STUDY; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA GENE; POPULATION BASED CASE CONTROL STUDY; POPULATION GENETICS; POSTMENOPAUSE; PRIORITY JOURNAL; PROMOTER REGION; PROSPECTIVE STUDY; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; WOMEN'S HEALTH;

ADIPOGENESIS; AFRICAN AMERICANS; AGED; ASIAN AMERICANS; BLOOD GLUCOSE; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HAPLOTYPES; HISPANIC AMERICANS; HUMANS; LOGISTIC MODELS; MIDDLE AGED; MULTIVARIATE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTMENOPAUSE; PPAR GAMMA; RISK FACTORS; UNITED STATES;

EID: 84874910905     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-3644     Document Type: Article

References (19)

1. Szanto A, Nagy L. The many faces of PPARγ: anti-inflammatory by any means? Immunobiology. 2008;213:789-803.
2. Ahmed W, Ziouzenkova O, Brown J, et al. PPARs and their metabolic modulation: new mechanisms for transcriptional regulation? J Intern Med. 2007;262:184-198. (Pubitemid 47087629)
3. Blackburn GL. From bench to bedside: novel mechanisms and therapeutic advances through the development of selective peroxisome proliferator-activated receptor γ modulators. Am J Clin Nutr. 91: 251S-253S.
4. Cheatham WW. Peroxisome proliferator-activated receptor translational research and clinical experience. Am J Clin Nutr. 91:262S- 266S.
5. Ryan KK, Li B, Grayson BE, Matter EK, Woods SC, Seeley RJ. Arole for central nervous system PPAR-γ in the regulation of energy balance. Nat Med. 17:623-626.
6. Gaulton KJ, Willer CJ, Li Y, et al. Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes. Diabetes. 2008;57:3136-3144.
7. Gouda HN, Sagoo GS, Harding AH, Yates J, Sandhu MS, Higgins JP. The association between the peroxisome proliferator-activated receptor-γ2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis. Am J Epidemiol. 171: 645-655.
8. Herder C, Rathmann W, Strassburger K, et al. Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies. Horm Metab Res. 2008;40:722-726.
9. Lin Y, Li P, Cai L, et al. Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population. BMC Med Genet. 11:97.
10. Lyssenko V, Jonsson A, Almgren P, et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med. 2008;359:2220-2232.
11. Meigs JB, Manning AK, Fox CS, et al. Genome-wide association with diabetes-related traits in the Framingham Heart Study. BMC Med Genet. 2007;8(suppl 1):S16.
12. Sanghera DK, Ortega L, Han S, et al. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med Genet. 2008;9:59.
13. Wen J, Ronn T, Olsson A, et al. Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. PLoS One. 5:e9153.
14. Palmer ND, McDonough CW, Hicks PJ, et al. A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One. 2012;7:e29202.
15. Cho YS, Chen CH, Hu C, et al. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet. 2012;44:67-72.
16. Kooner JS, Saleheen D, Sim X, et al. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet. 2011;43:984-989.
17. Rothman KJ. Curbing type I and type II errors. Eur J Epidemiol. 2010;25:223-224.
18. He Y, Li C, Amos CI, Xiong M, Ling H, Jin L. Accelerating haplotype-based genome-wide association study using perfect phylogeny and phase-known reference data. PLoS One. 6:e22097.
19. Luan J, Browne PO, Harding AH, et al. Evidence for gene-nutrient interaction at the PPARγ locus. Diabetes. 2001;50:686-689. (Pubitemid 32195237)