The γH2AX assay for genotoxic and nongenotoxic agents: Comparison of H2AX phosphorylation with cell death response

Toxicological Sciences

Volumn 140, Issue 1, 2014, Pages 103-117

  Nikolova, Teodora ^a   Dvorak, Mirek ^a   Jung, Fabian ^a   Adam, Isabell ^a   Krämer, Elisabeth ^a   Gerhold Ay, Aslihan ^a   Kaina, Bernd ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

DNA damage; Flow cytometry; Genotoxicants; MTT assay; Testing; H2AX assay

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; BENZO[A]PYRENE 7,8 DIHYDRODIOL 9,10 OXIDE; BENZYL ALCOHOL; BINDING PROTEIN; CISPLATIN; CURCUMIN; DICLOFENAC; DIMENHYDRINATE; DOUBLE STRANDED DNA; ENALAPRIL MALEATE; ETOPOSIDE; GAMMAHISTONE2AX; HISTONE H2AX; HYDROGEN PEROXIDE; LOMUSTINE; MAFOSFAMIDE; MENTHOL; MESYLIC ACID METHYL ESTER; METFORMIN; METHYLNITRONITROSOGUANIDINE; MITOMYCIN; OXALIPLATIN; PHTHALIC ACID; RAD51 PROTEIN; SODIUM CHLORIDE; TEMOZOLOMIDE; TERT BUTYL HYDROPEROXIDE; TOPOTECAN; TUMOR SUPPRESSOR P53 BINDING PROTEIN 1; UNCLASSIFIED DRUG; UREA; HISTONE; MUTAGENIC AGENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CHO CELL LINE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; FLOW CYTOMETRY; GAMMAHISTONE2AX ASSAY; GENOTOXICITY; HIGH THROUGHPUT SCREENING; HISTONE PHOSPHORYLATION; MTT ASSAY; NONHUMAN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STAINING; ANIMAL; CELL SURVIVAL; CRICETULUS; DRUG EFFECTS; GENETICS; METABOLISM; MUTAGEN TESTING; PHOSPHORYLATION; TOXICITY;

ANIMALS; CELL SURVIVAL; CHO CELLS; CRICETULUS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; FLOW CYTOMETRY; HISTONES; MUTAGENICITY TESTS; MUTAGENS; PHOSPHORYLATION;

EID: 84903848227     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu066     Document Type: Article

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