메뉴 건너뛰기




Volumn 46, Issue 7, 2014, Pages 1727-1750

Involvement of substance P and the NK-1 receptor in human pathology

Author keywords

Human pathology; Molecular bases; NK 1 receptor; NK 1 receptor antagonists; Substance P

Indexed keywords

APREPITANT; CASOPITANT; CJ 11 974; CJ 12 255; CP 122 721; CP 122 721 1; CP 96 345; CP 99 994; EZLOPITANT; FOSAPREPITANT; GR 205 171; L 703 606; L 732 138; L 733 060; L 754 030; L 759 274; L 822 429; LANEPITANT; LY 303 870; LY 686 017; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; RP 67 580; RPR 100 893; SPANTIDE; SR 140 333; SR 140 333B; SUBSTANCE P; UNCLASSIFIED DRUG; VOFOPITANT; WIN 51 708;

EID: 84903635625     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-014-1736-9     Document Type: Article
Times cited : (185)

References (144)
  • 1
    • 84868486373 scopus 로고    scopus 로고
    • Aprepitant for prevention of nausea and vomiting secondary to high-dose cyclophosphamide administered to patients undergoing autologous peripheral blood stem cells mobilization: A phase II trial
    • Abidi MH, Tageja N, Ayash L, Abrams J, Ratanatharathorn V, Al- Kadhimi Z, Lum L, Cronin S, Ventimiglia M, Uberti J (2012) Aprepitant for prevention of nausea and vomiting secondary to high-dose cyclophosphamide administered to patients undergoing autologous peripheral blood stem cells mobilization: a phase II trial. Support Care Cancer 20:2363-2369
    • (2012) Support Care Cancer , vol.20 , pp. 2363-2369
    • Abidi, M.H.1    Tageja, N.2    Ayash, L.3    Abrams, J.4    Ratanatharathorn, V.5    Al-Kadhimi, Z.6    Lum, L.7    Cronin, S.8    Ventimiglia, M.9    Uberti, J.10
  • 2
    • 0028006409 scopus 로고
    • Molecular aspects of neuropeptide regulation and function in the corpus striatum and nucleus accumbens
    • DOI 10.1016/0165-0173(94)90002-7
    • Angulo JA, McEwen BS (1994) Molecular aspects of neuropeptide regulation and function in the corpus striatum and nucleus accumbens. Brain Res Brain Res Rev 19:1-28 (Pubitemid 24024082)
    • (1994) Brain Research Reviews , vol.19 , Issue.1 , pp. 1-28
    • Angulo, J.A.1    McEwen, B.S.2
  • 3
    • 0032564521 scopus 로고    scopus 로고
    • HIV-1 gp120 increases the permeability of rat brain endothelium cultures by a mechanism involving substance P
    • Annunziata P, Cioni C, Toneatto S, Paccagnini E (1998) HIV-1 gp120 increases the permeability of rat brain endothelium cultures by a mechanism involving substance P. AIDS 12:2377-2385 (Pubitemid 28558595)
    • (1998) AIDS , vol.12 , Issue.18 , pp. 2377-2385
    • Annunziata, P.1    Cioni, C.2    Toneatto, S.3    Paccagnini, E.4
  • 4
    • 0029080641 scopus 로고
    • Stress-induced murine abortion associated with substance P-dependent alteration in cytokines in maternal uterine decidua
    • Arck PC, Merali FS, Stanisz AM, Stead RH, Chaouat G, Manuel J, Clark DA (1995) Stress-induced murine abortion associated with substance P-dependent alteration in cytokines in maternal uterine decidua. Biol Reprod 53:814-819
    • (1995) Biol Reprod , vol.53 , pp. 814-819
    • Arck, P.C.1    Merali, F.S.2    Stanisz, A.M.3    Stead, R.H.4    Chaouat, G.5    Manuel, J.6    Clark, D.A.7
  • 5
    • 0019435012 scopus 로고
    • Immunocytochemical localization of catecholamine systhesizing enzymes and neuropeptides in area postrema and medial nucleus tractus solitarius of rat brain
    • DOI 10.1002/cne.901960312
    • Armstrong DM, Pickel VM, Joh TH, Reis DJ, Miller RJ (1981) Immunocytochemical localization of catecholamine synthesizing enzymes and neuropeptides in the area postrema and medial nucleus tractus solitarius of rat brain. J Comp Neurol 196:505-517 (Pubitemid 11094111)
    • (1981) Journal of Comparative Neurology , vol.196 , Issue.3 , pp. 505-517
    • Armstrong, D.M.1    Pickel, V.M.2    Joh, T.H.3
  • 9
    • 1342287208 scopus 로고    scopus 로고
    • Neurokinin-1 Receptor Antagonists Protect Mice from CD95- and Tumor Necrosis Factor-alpha-Mediated Apoptotic Liver Damage
    • DOI 10.1124/jpet.103.059329
    • Bang R, Biburger M, Neuhuber WL, Tiegs G (2004) Neurokinin-1 receptor antagonists protect mice from CD95- and tumor necrosis factor-alpha-mediated apoptotic liver damage. J Pharmacol Exp Ther 308:1174-1180 (Pubitemid 38263995)
    • (2004) Journal of Pharmacology and Experimental Therapeutics , vol.308 , Issue.3 , pp. 1174-1180
    • Bang, R.1    Biburger, M.2    Neuhuber, W.L.3    Tiegs, G.4
  • 12
    • 0036171973 scopus 로고    scopus 로고
    • Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model
    • DOI 10.1038/nm0202-136
    • Bolay H, Reuter U, Dunn AK, Huang Z, Boas DA, Moskowitz MA (2002) Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 8:136-142 (Pubitemid 34155124)
    • (2002) Nature Medicine , vol.8 , Issue.2 , pp. 136-142
    • Bolay, H.1    Reuter, U.2    Dunn, A.K.3    Huang, Z.4    Boas, D.A.5    Moskowitz, M.A.6
  • 16
    • 18444378433 scopus 로고    scopus 로고
    • 3H-SP receptor binding sites in subjects affected by mood disorders and schizophrenia
    • DOI 10.1111/j.1460-9568.2005.04002.x
    • Carletti R, Corsi M, Melotto S, Caberlotto L (2005) Down-regulation of amygdala preprotachykinin A mRNA but not 3H-SP receptor binding sites in subjects affected by mood disorders and schizophrenia. Eur J Neurosci 21:1712-1718 (Pubitemid 40646616)
    • (2005) European Journal of Neuroscience , vol.21 , Issue.6 , pp. 1712-1718
    • Carletti, R.1    Corsi, M.2    Melotto, S.3    Caberlotto, L.4
  • 18
    • 50949116628 scopus 로고    scopus 로고
    • Neurogenic exacerbation of microglial and astrocyte responses to Neisseria meningitidis and Borrelia burgdorferi
    • Chauhan VS, Sterka DG Jr, Gray DL, Bost KL, Marriott I (2008) Neurogenic exacerbation of microglial and astrocyte responses to Neisseria meningitidis and Borrelia burgdorferi. J Immunol 180:8241-8249
    • (2008) J Immunol , vol.180 , pp. 8241-8249
    • Chauhan, V.S.1    Sterka Jr., D.G.2    Gray, D.L.3    Bost, K.L.4    Marriott, I.5
  • 19
    • 79959563961 scopus 로고    scopus 로고
    • Prophylactic and therapeutic targeting of the neurokinin-1 receptor limits neuroinflammation in a murine model of pneumococcal meningitis
    • Chauhan VS, Kluttz JM, Bost KL, Marriott I (2011) Prophylactic and therapeutic targeting of the neurokinin-1 receptor limits neuroinflammation in a murine model of pneumococcal meningitis. J Immunol 186:7255-7263
    • (2011) J Immunol , vol.186 , pp. 7255-7263
    • Chauhan, V.S.1    Kluttz, J.M.2    Bost, K.L.3    Marriott, I.4
  • 20
    • 0000128213 scopus 로고    scopus 로고
    • Clinical evaluation of a novel, potent, CNS penetrating NK-1 receptor antagonist in the acute treatment of migraine
    • Connor HE (1998) Clinical evaluation of a novel, potent, CNS penetrating NK-1 receptor antagonist in the acute treatment of migraine. Cephalalgia 18:392
    • (1998) Cephalalgia , vol.18 , pp. 392
    • Connor, H.E.1
  • 21
    • 0018102058 scopus 로고
    • The distribution of substance P immunoreactive fibres in the rat central nervous system
    • Cuello AC, Kanazawa I (1978) The distribution of substance P immunoreactive fibres in the rat central nervous system. J Comp Neurol 178:129-156
    • (1978) J Comp Neurol , vol.178 , pp. 129-156
    • Cuello, A.C.1    Kanazawa, I.2
  • 23
    • 0037395801 scopus 로고    scopus 로고
    • RPR100893, a substance- P antagonist, is not effective in the treatment of migraine attacks
    • RPR100893 Study Group
    • Diener HC (2003) RPR100893 Study Group. RPR100893, a substance- P antagonist, is not effective in the treatment of migraine attacks. Cephalalgia 23:183-185
    • (2003) Cephalalgia , vol.23 , pp. 183-185
    • Diener, H.C.1
  • 26
    • 33749556143 scopus 로고    scopus 로고
    • The role of substance P in stress and anxiety responses
    • DOI 10.1007/s00726-006-0335-9, Special issue: Focus on Neuropeptides in Anxiety and Depression
    • Ebner K, Singewald N (2006) The role of substance P in stress and anxiety responses. Amino Acids 31:251-272 (Pubitemid 44537051)
    • (2006) Amino Acids , vol.31 , Issue.3 , pp. 251-272
    • Ebner, K.1    Singewald, N.2
  • 28
    • 67650569457 scopus 로고    scopus 로고
    • Tachykinin receptors as therapeutic targets in stress-related disorders
    • Ebner K, Sartori SB, Singewald N (2009) Tachykinin receptors as therapeutic targets in stress-related disorders. Curr Pharm Des 15:1647-1674
    • (2009) Curr Pharm des , vol.15 , pp. 1647-1674
    • Ebner, K.1    Sartori, S.B.2    Singewald, N.3
  • 30
    • 45349096499 scopus 로고    scopus 로고
    • Cell motility through plasma membrane blebbing
    • DOI 10.1083/jcb.200802081
    • Fackler OT, Grosse R (2008) Cell motility through plasma membrane blebbing. J Cell Biol 181:879-884 (Pubitemid 351846821)
    • (2008) Journal of Cell Biology , vol.181 , Issue.6 , pp. 879-884
    • Fackler, O.T.1    Grosse, R.2
  • 32
    • 0027092318 scopus 로고
    • Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580
    • Fong TM, Yu H, Strader CD (1992) Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP-67,580. J Biol Chem 267:25668-25671 (Pubitemid 23013958)
    • (1992) Journal of Biological Chemistry , vol.267 , Issue.36 , pp. 25668-25671
    • Tung, M.F.1    Yu, H.2    Strader, C.D.3
  • 35
    • 33847689071 scopus 로고    scopus 로고
    • Increased plasma substance P and CGRP levels, and high ACE activity in migraineurs during headache-free periods
    • DOI 10.1016/j.pain.2006.09.017, PII S0304395906004933
    • Fusayasu E, Kowa H, Takeshima T, Nakaso K, Nakashima K (2007) Increased plasma substance P and CGRP levels, and high ACE activity in migraineurs during headache-free periods. Pain 128:209-214 (Pubitemid 46367415)
    • (2007) Pain , vol.128 , Issue.3 , pp. 209-214
    • Fusayasu, E.1    Kowa, H.2    Takeshima, T.3    Nakaso, K.4    Nakashima, K.5
  • 36
    • 0028811166 scopus 로고
    • Vasoactive peptide levels in the plasma of young migraine patients with and without aura assessed both interictally and ictally
    • Gallai V, Sarchielli P, Flofidi A, Francceschini M, Codini M, Trequattrini A, Palumbo R (1995) Vasoactive peptide levels in the plasma of young migraine patients with and without aura assessed both interictally and ictally. Cephalalgia 15:384-390
    • (1995) Cephalalgia , vol.15 , pp. 384-390
    • Gallai, V.1    Sarchielli, P.2    Flofidi, A.3    Francceschini, M.4    Codini, M.5    Trequattrini, A.6    Palumbo, R.7
  • 37
    • 0022514111 scopus 로고
    • Substance P antagonists in substantia nigra are anticonvulsant
    • DOI 10.1016/0006-8993(86)91347-8
    • Garant DS, Iadarola MJ, Gale K (1986) Substance P antagonists in substantia nigra are anticonvulsant. Brain Res 382:372-378 (Pubitemid 16001745)
    • (1986) Brain Research , vol.382 , Issue.2 , pp. 372-378
    • Garant, D.S.1    Iadarola, M.J.2    Gale, K.3
  • 39
    • 0025143541 scopus 로고
    • Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
    • DOI 10.1002/ana.410280213
    • Goadsby PJ, Edvinsson L, Ekman R (1990) Vasoactive peptide release in the extracerebral circulation of human during migraine headache. Ann Neurol 28:183-187 (Pubitemid 20244522)
    • (1990) Annals of Neurology , vol.28 , Issue.2 , pp. 183-187
    • Goadsby, P.J.1    Edvinsson, L.2    Ekman, R.3
  • 40
    • 0030834838 scopus 로고    scopus 로고
    • Ineffectiveness of neurokinin-1 antagonist in acute migraine: A crossover study
    • DOI 10.1046/j.1468-2982.1997.1707785.x
    • Goldstein DJ, Wang O, Saper JR, Stoltz R, Silberstein SD, Mathew NT (1997) Ineffectiveness of neurokinin-1 antagonist in acute migraine: a crossover study. Cephalalgia 17:785-790 (Pubitemid 27505105)
    • (1997) Cephalalgia , vol.17 , Issue.7 , pp. 785-790
    • Goldstein, D.J.1    Wang, O.2    Saper, J.R.3    Stoltz, R.4    Silberstein, S.D.5    Mathew, N.T.6
  • 41
    • 0035117131 scopus 로고    scopus 로고
    • Dose-response study of the analgesic effect of lanepitant in patients with painful diabetic neuropathy
    • DOI 10.1097/00002826-200101000-00004
    • Goldstein DJ, Wang O, Gitter BD, Iyengar S (2001) Dose-response study of the analgesic effect of lanepitant in patients with painful diabetic neuropathy. Clin Neuropharmacol 24:16-22 (Pubitemid 32176476)
    • (2001) Clinical Neuropharmacology , vol.24 , Issue.1 , pp. 16-22
    • Goldstein, D.J.1    Wang, O.2    Gitter, B.D.3    Iyengar, S.4
  • 44
    • 33750520115 scopus 로고    scopus 로고
    • Efficacy and Safety of a Neurokinin-1 Receptor Antagonist in Postmenopausal Women With Overactive Bladder With Urge Urinary Incontinence
    • DOI 10.1016/j.juro.2006.08.018, PII S0022534706019628
    • Green SA, Alon A, Ianus J, McNaughton KS, Tozzi CA, Reiss TF (2006) Efficacy and safety of a neurokinin-1 receptor antagonist in postmenopausal women with overactive bladder with urge urinary incontinence. J Urol 176:2535-2540 (Pubitemid 44665982)
    • (2006) Journal of Urology , vol.176 , Issue.6 , pp. 2535-2540
    • Green, S.A.1    Alon, A.2    Ianus, J.3    McNaughton, K.S.4    Tozzi, C.A.5    Reiss, T.F.6
  • 45
    • 16844365620 scopus 로고    scopus 로고
    • 11]SP: A dual inhibitor of growth and angiogenesis in pancreatic cancer
    • DOI 10.1158/0008-5472.CAN-04-3197
    • Guha S, Eibl G, Kisfalvi K, Fan RS, Burdick M, Reber H, Hines OJ, Strieter R, Rozengurt E (2005) Broad-spectrum G protein- coupled receptor antagonist, [D-Arg1, DTrp5,7,9, Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer. Cancer Res 65:2738-2745 (Pubitemid 40490075)
    • (2005) Cancer Research , vol.65 , Issue.7 , pp. 2738-2745
    • Guha, S.1    Eibl, G.2    Kisfalvi, K.3    Fan, R.S.4    Burdick, M.5    Reber, H.6    Hines, O.J.7    Strieter, R.8    Rozengurt, E.9
  • 47
    • 0025374020 scopus 로고
    • Measles virus-substance P receptor interactions. Possible novel mechanism of viral fusion
    • Harrowe G, Mitsuhashi M, Payan DG (1990) Measles virus-substance P receptor interactions. Possible novel mechanism of viral fusion. J Clin Invest 85:1324-1327 (Pubitemid 20123781)
    • (1990) Journal of Clinical Investigation , vol.85 , Issue.4 , pp. 1324-1327
    • Harrowe, G.1    Mitsuhashi, M.2    Payan, D.G.3
  • 48
    • 34548405221 scopus 로고    scopus 로고
    • Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis
    • DOI 10.1189/jlb.0407217
    • Hegde A, Zhang H, Moochhala SM, Bhatia M (2007) Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis. J Leukoc Biol 82:678-685 (Pubitemid 47367160)
    • (2007) Journal of Leukocyte Biology , vol.82 , Issue.3 , pp. 678-685
    • Hegde, A.1    Zhang, H.2    Moochhala, S.M.3    Bhatia, M.4
  • 49
    • 77951942383 scopus 로고    scopus 로고
    • Substance P in polymicrobial sepsis: Molecular fingerprint of lung injury in preprotachykinin-A -/- mice
    • Hegde A, Tamizhselvi R, Manikandan J, Melendez AJ, Moochhala SM, Bhatia M (2010a) Substance P in polymicrobial sepsis: molecular fingerprint of lung injury in preprotachykinin-A -/- mice. Mol Med 16:188-198
    • (2010) Mol Med , vol.16 , pp. 188-198
    • Hegde, A.1    Tamizhselvi, R.2    Manikandan, J.3    Melendez, A.J.4    Moochhala, S.M.5    Bhatia, M.6
  • 50
    • 84858206016 scopus 로고    scopus 로고
    • Neurokinin-1 receptor antagonist treatment in polymicrobial sepsis: Molecular insights
    • Hegde A, Koh YH, Moochhala SM, Bhatia M (2010b) Neurokinin-1 receptor antagonist treatment in polymicrobial sepsis: molecular insights. Int J Inflam 2010:601098
    • (2010) Int J Inflam , vol.2010 , pp. 601098
    • Hegde, A.1    Koh, Y.H.2    Moochhala, S.M.3    Bhatia, M.4
  • 53
    • 0034214841 scopus 로고    scopus 로고
    • NK1 (substance P) receptor antagonists: Why are they not analgesic in humans?
    • Hill R (2000) NK1 (substance P) receptor antagonists: why are they not analgesic in humans? Trends Pharmacol Sci 21:244-246
    • (2000) Trends Pharmacol Sci , vol.21 , pp. 244-246
    • Hill, R.1
  • 54
    • 0030040791 scopus 로고    scopus 로고
    • Substance P modulates human immunodeficiency virus replication in human peripheral blood monocyte-derived macrophages
    • Ho WZ, Cnaan A, Li YH, Zhao H, Lee HR, Song L, Douglas SD (1996) Substance P modulates human immunodeficiency virus replication in human peripheral blood monocyte-derived macrophages. AIDS Res Hum Retroviruses 12:195-198 (Pubitemid 26054163)
    • (1996) AIDS Research and Human Retroviruses , vol.12 , Issue.3 , pp. 195-198
    • Wen-Zhe, H.1    Cnaan, A.2    Li, Y.-H.3    Zhao, H.4    Lee, H.-R.5    Song, L.6    Douglas, S.D.7
  • 57
    • 0035137002 scopus 로고    scopus 로고
    • Substance P: A pioneer amongst neuropeptides
    • DOI 10.1046/j.0954-6820.2000.00773.x
    • Hökfelt T, Pernow B, Wahren J (2001) Substance P: a pioneer amongst neuropeptides. J Intern Med 249:27-40 (Pubitemid 32147090)
    • (2001) Journal of Internal Medicine , vol.249 , Issue.1 , pp. 27-40
    • Hokfelt, T.1    Pernow, B.2    Wahren, J.3
  • 58
    • 0023898089 scopus 로고
    • Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides
    • Holzer P (1988) Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 24:739-768
    • (1988) Neuroscience , vol.24 , pp. 739-768
    • Holzer, P.1
  • 59
    • 63849298539 scopus 로고    scopus 로고
    • Proinflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity
    • Janelsins BM, Mathers AR, Tkacheva OA, Erdos G, Shufesky WJ, Morelli AE, Larregina AT (2009) Proinflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity. Blood 113:3017-3026
    • (2009) Blood , vol.113 , pp. 3017-3026
    • Janelsins, B.M.1    Mathers, A.R.2    Tkacheva, O.A.3    Erdos, G.4    Shufesky, W.J.5    Morelli, A.E.6    Larregina, A.T.7
  • 60
    • 1842685406 scopus 로고    scopus 로고
    • Involvement of peripherally released substance P and calcitonin gene-related peptide in mediating mechanical hyperalgesia in a traumatic neuropathy model of the rat
    • DOI 10.1016/j.neulet.2004.02.043, PII S0304394004002368
    • Jang JH, Nam TS, Paik KS, Leem JW (2004) Involvement of peripherally released substance P and calcitonin gene-related peptide in mediating mechanical hyperalgesia in a traumatic neuropathy model of the rat. Neurosci Lett 360:129-132 (Pubitemid 38479750)
    • (2004) Neuroscience Letters , vol.360 , Issue.3 , pp. 129-132
    • Jang, J.H.1    Nam, T.S.2    Paik, K.S.3    Leem, J.W.4
  • 64
    • 0025860937 scopus 로고
    • Somatostatin, substance P, prolactin and vasoactive intestinal peptide levels in serum and cerebrospinal fluid of children with seizure disorders
    • Ko FJ, Chiang CH, Liu WJ, Chiang W (1991) Somatostatin, substance P, prolactin and vasoactive intestinal peptide levels in serum and cerebrospinal fluid of children with seizure disorders. Gaoxiong Yi Xue Ke Xue Za Zhi 7:391-397
    • (1991) Gaoxiong Yi Xue Ke Xue Za Zhi , vol.7 , pp. 391-397
    • Ko, F.J.1    Chiang, C.H.2    Liu, W.J.3    Chiang, W.4
  • 67
    • 0032476647 scopus 로고    scopus 로고
    • Identification of a delta isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes
    • DOI 10.1016/S0165-5728(98)00170-2, PII S0165572898001702
    • Lai JP, Douglas SD, Rappaport E, Wu JM, Ho WZ (1998) Identification of a delta isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes. J Neuroimmunol 91:121-128 (Pubitemid 28545252)
    • (1998) Journal of Neuroimmunology , vol.91 , Issue.1-2 , pp. 121-128
    • Lai, J.-P.1    Douglas, S.D.2    Rappaport, E.3    Wu, J.M.4    Ho, W.-Z.5
  • 70
    • 0026570879 scopus 로고
    • The nonpeptide tachykinin antagonist, CP-96.345, is a potent inhibitor of neurogenic inflammation
    • Lembeck F, Donnerer J, Tsuchiya M, Nagahisa A (1992) The nonpeptide tachykinin antagonist, CP-96.345, is a potent inhibitor of neurogenic inflammation. Br J Pharmacol 105:527-530
    • (1992) Br J Pharmacol , vol.105 , pp. 527-530
    • Lembeck, F.1    Donnerer, J.2    Tsuchiya, M.3    Nagahisa, A.4
  • 71
    • 0031573083 scopus 로고    scopus 로고
    • The Neuropeptide Substance P Activates Transcription Factor NF-kappaB and kappaB-Dependent Gene Expression in Human Astrocytoma Cells
    • Lieb K, Fiebich BL, Berger M, Bauer J, Schulze-Osthoff K (1997) The neuropeptide substance P activates transcription factor NFkappa B and kappa B-dependent gene expression in human astrocytoma cells. J Immunol 159:4952-4958 (Pubitemid 127471032)
    • (1997) Journal of Immunology , vol.159 , Issue.10 , pp. 4952-4958
    • Lieb, K.1    Fiebich, B.L.2    Berger, M.3    Bauer, J.4    Schulze-Osthoff, K.5
  • 72
    • 0038647491 scopus 로고    scopus 로고
    • Valproic acid inhibits substance P-induced activation of protein kinase C epsilon and expression of the substance P receptor
    • DOI 10.1046/j.1471-4159.2003.01802.x
    • Lieb KL, Treffurth Y, Hamke M, Akundi RS, von Kleinsorgen M, Fiebich BL (2003) Valproic acid inhibits substance P-induced activation of protein kinase C epsilon and expression of the substance P receptor. J Neurochem 86:69-76 (Pubitemid 36753847)
    • (2003) Journal of Neurochemistry , vol.86 , Issue.1 , pp. 69-76
    • Lieb, K.1    Treffurth, Y.2    Hamke, M.3    Akundi, R.S.4    Von Kleinsorgen, M.5    Fiebich, B.L.6
  • 74
    • 0023753067 scopus 로고
    • Effect of neuropeptides on production of inflammatory cytokines by human monocytes
    • Lotz M, Vaughan JH, Carson DA (1988) Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science 241:1218-1221
    • (1988) Science , vol.241 , pp. 1218-1221
    • Lotz, M.1    Vaughan, J.H.2    Carson, D.A.3
  • 75
    • 0027466839 scopus 로고
    • Distribution of the substance P (NK1) receptor in the central nervous system
    • Maeno H, Kiyama H, Tohyama M (1993) Distribution of the substance P (NK1) receptor in the central nervous system. Mol Brain Res 18:43-58
    • (1993) Mol Brain Res , vol.18 , pp. 43-58
    • Maeno, H.1    Kiyama, H.2    Tohyama, M.3
  • 76
    • 0022588287 scopus 로고
    • Substance P in the human brain
    • DOI 10.1016/0306-4522(86)90041-2
    • Mai JK, Stephens PH, Hopf A, Cuello AC (1986) Substance P in the human brain. Neuroscience 17:709-739 (Pubitemid 16131267)
    • (1986) Neuroscience , vol.17 , Issue.3 , pp. 709-739
    • Mai, J.K.1    Stephens, P.H.2    Hopf, A.3    Cuello, A.C.4
  • 77
    • 34247261574 scopus 로고    scopus 로고
    • Neurokinin-1 enables measles virus trans-synaptic spread in neurons
    • DOI 10.1016/j.virol.2007.02.033, PII S0042682207001328
    • Makhortova NR, Askovich P, Patterson CE, Gechman LA, Gerard NP, Rall GF (2007) Neurokinin-1 enables measles virus transsynaptic spread in neurons. Virology 362:235-244 (Pubitemid 46617700)
    • (2007) Virology , vol.362 , Issue.1 , pp. 235-244
    • Makhortova, N.R.1    Askovich, P.2    Patterson, C.E.3    Gechman, L.A.4    Gerard, N.P.5    Rall, G.F.6
  • 78
    • 78549255861 scopus 로고    scopus 로고
    • Anti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergistic interactions with other antiretrovirals
    • Manak MM, Moshkoff DA, Nguyen LT, Meshki J, Tebas P, Tuluc F, Douglas SD (2010) Anti-HIV-1 activity of the neurokinin-1 receptor antagonist aprepitant and synergistic interactions with other antiretrovirals. AIDS 24:2789-2796
    • (2010) AIDS , vol.24 , pp. 2789-2796
    • Manak, M.M.1    Moshkoff, D.A.2    Nguyen, L.T.3    Meshki, J.4    Tebas, P.5    Tuluc, F.6    Douglas, S.D.7
  • 79
    • 0033992327 scopus 로고    scopus 로고
    • Substance P activates NF-kappaB independent of elevations in intracellular calcium in murine macrophages and dendritic cells
    • Marriott I, Mason MJ, Elhofy A, Bost KL (2000) Substance P activates NF-kappaB independent of elevations in intracellular calcium in murine macrophages and dendritic cells. J Neuroimmunol 102:163-171
    • (2000) J Neuroimmunol , vol.102 , pp. 163-171
    • Marriott, I.1    Mason, M.J.2    Elhofy, A.3    Bost, K.L.4
  • 80
    • 66149137995 scopus 로고    scopus 로고
    • Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil kinasedependent mechanism
    • Meshki J, Douglas SD, Lai JP, Schwartz L, Kilpatrick LE, Tuluc F (2009) Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil kinasedependent mechanism. J Biol Chem 284:9280-9289
    • (2009) J Biol Chem , vol.284 , pp. 9280-9289
    • Meshki, J.1    Douglas, S.D.2    Lai, J.P.3    Schwartz, L.4    Kilpatrick, L.E.5    Tuluc, F.6
  • 81
    • 77950639335 scopus 로고    scopus 로고
    • A new frontier in the treatment of cancer: NK-1 receptor antagonists
    • Muñoz M, Coveñas R (2010) A new frontier in the treatment of cancer: NK-1 receptor antagonists. Curr Med Chem 17:504-516
    • (2010) Curr Med Chem , vol.17 , pp. 504-516
    • Muñoz, M.1    Coveñas, R.2
  • 82
    • 79955680163 scopus 로고    scopus 로고
    • NK-1 receptor antagonists: A new paradigm in pharmacological therapy
    • Muñoz M, Coveñas R (2011) NK-1 receptor antagonists: a new paradigm in pharmacological therapy. Curr Med Chem 18:1820-1831
    • (2011) Curr Med Chem , vol.18 , pp. 1820-1831
    • Muñoz, M.1    Coveñas, R.2
  • 83
    • 84882491636 scopus 로고    scopus 로고
    • Involvement of substance P and the NK-1 receptor in cancer
    • Muñoz M, Coveñas R (2013a) Involvement of substance P and the NK-1 receptor in cancer. Peptides 48:1-9
    • (2013) Peptides , vol.48 , pp. 1-9
    • Muñoz, M.1    Coveñas, R.2
  • 84
    • 84883007375 scopus 로고    scopus 로고
    • Safety of neurokinin-1 receptor antagonists
    • Muñoz M, Coveñas R (2013b) Safety of neurokinin-1 receptor antagonists. Expert Opin Drug Saf 12:673-685
    • (2013) Expert Opin Drug Saf , vol.12 , pp. 673-685
    • Muñoz, M.1    Coveñas, R.2
  • 86
    • 77955151651 scopus 로고    scopus 로고
    • The NK-1 receptor is expressed in human melanoma and is involved in the antitumor action of the NK-1 receptor antagonist aprepitant on melanoma cell lines
    • Muñoz M, Rosso M, Robles-Frías MJ, Salinas-Martín MV, Coveñas R (2010) The NK-1 receptor is expressed in human melanoma and is involved in the antitumor action of the NK-1 receptor antagonist aprepitant on melanoma cell lines. Lab Invest 90:1259-1269
    • (2010) Lab Invest , vol.90 , pp. 1259-1269
    • Muñoz, M.1    Rosso, M.2    Robles-Frías, M.J.3    Salinas-Martín, M.V.4    Coveñas, R.5
  • 88
    • 84891949800 scopus 로고    scopus 로고
    • Antitumor activity of neurokinin-1 receptor antagonists in MG-63 human osteosarcoma xenografts
    • Muñoz M, Berger M, Rosso M, González-Ortega A, Carranza A, Coveñas R (2014) Antitumor activity of neurokinin-1 receptor antagonists in MG-63 human osteosarcoma xenografts. Int J Oncol 44:137-146
    • (2014) Int J Oncol , vol.44 , pp. 137-146
    • Muñoz, M.1    Berger, M.2    Rosso, M.3    González-Ortega, A.4    Carranza, A.5    Coveñas, R.6
  • 89
    • 0034636497 scopus 로고    scopus 로고
    • Rewarding effects of opiates are absent in mice lacking the receptor for substance P
    • DOI 10.1038/35012069
    • Murtra P, Sheasby AM, Hunt SP, de Felipe C (2000) Rewarding effects of opiates are absent in mice lacking the receptor for substance P. Nature 405:180-183 (Pubitemid 30313535)
    • (2000) Nature , vol.405 , Issue.6783 , pp. 180-183
    • Murtra, P.1    Sheasby, A.M.2    Hunt, S.P.3    De Felipe, C.4
  • 90
    • 0028070434 scopus 로고
    • Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat
    • Nakaya Y, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N (1994) Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. J Comp Neurol 347:249-274 (Pubitemid 24273427)
    • (1994) Journal of Comparative Neurology , vol.347 , Issue.2 , pp. 249-274
    • Nakaya, Y.1    Kaneko, T.2    Shigemoto, R.3    Nakanishi, S.4    Mizuno, N.5
  • 91
    • 0033516871 scopus 로고    scopus 로고
    • The neurokinin-1 receptor antagonist WIN51,708 attenuates the anxiolyticlike effects of ventralpallidal substance P injection
    • Nikolaus S, Huston JP, Hasenohrl RU (1999a) The neurokinin-1 receptor antagonist WIN51,708 attenuates the anxiolytic-like effects of ventralpallidal substance P injection. NeuroReport 10:2293-2296 (Pubitemid 29367926)
    • (1999) NeuroReport , vol.10 , Issue.11 , pp. 2293-2296
    • Nikolaus, S.1    Huston, J.P.2    Hasenohri, R.U.3
  • 92
    • 0033007998 scopus 로고    scopus 로고
    • 1 receptor
    • DOI 10.1016/S0014-2999(99)00105-3, PII S0014299999001053
    • Nikolaus S, Huston JP, Hasenohrl RU (1999b) Reinforcing effects of neurokinin substance P in the ventral pallidum: mediation by the tachykinin NK1 receptor. Eur J Pharmacol 370:93-99 (Pubitemid 29185094)
    • (1999) European Journal of Pharmacology , vol.370 , Issue.2 , pp. 93-99
    • Nikolaus, S.1    Huston, J.P.2    Hasenohrl, R.U.3
  • 93
    • 0034737539 scopus 로고    scopus 로고
    • Anxiolytic-like effects in rats produced by ventral pallidal injection of both N- and C-terminal fragments of substance P
    • DOI 10.1016/S0304-3940(00)00902-2, PII S0304394000009022
    • Nikolaus S, Huston JP, Hasenohrl RU (2000) Anxiolytic-like effects in rats produced by ventral pallidal injection of both N- and C-terminal fragments of substance P. Neurosci Lett 283:37-40 (Pubitemid 30145491)
    • (2000) Neuroscience Letters , vol.283 , Issue.1 , pp. 37-40
    • Nikolaus, S.1    Huston, J.P.2    Hasenohrl, R.U.3
  • 94
    • 0027195970 scopus 로고
    • Modulation of T lymphocyte function by neuropeptides: Evidence for their role as local immunoregulatory elements
    • Nio DA, Moylan RN, Roche JK (1993) Modulation of T lymphocyte function by neuropeptides. Evidence for their role as local immunoregulatory elements. J Immunol 150:5281-5288 (Pubitemid 23180641)
    • (1993) Journal of Immunology , vol.150 , Issue.12 , pp. 5281-5288
    • Nio, D.A.1    Moylan, R.N.2    Roche, J.K.3
  • 95
    • 0000128214 scopus 로고    scopus 로고
    • A placebo-controlled, in-clinic study to explore the preliminary safety and efficacy of intravenous L-758,298 (a prodrug of the NK-1 receptor antagonist L-754,030) in the acute treatment of migraine
    • Norman B (1998) A placebo-controlled, in-clinic study to explore the preliminary safety and efficacy of intravenous L-758,298 (a prodrug of the NK-1 receptor antagonist L-754,030) in the acute treatment of migraine. Cephalalgia 18:407
    • (1998) Cephalalgia , vol.18 , pp. 407
    • Norman, B.1
  • 98
    • 0024987339 scopus 로고
    • Substance P production by P388D1 macrophages: A possible autocrine function for this neuropeptide
    • Pascual DW, Bost KL (1990) Substance P production by P388D1 macrophages: a possible autocrine function for this neuropeptide. Immunology 71:52-56 (Pubitemid 20296071)
    • (1990) Immunology , vol.71 , Issue.1 , pp. 52-56
    • Pascual, D.W.1    Bost, K.L.2
  • 99
    • 0029071038 scopus 로고
    • Involvement of substance P in pial arteriolar vasodilatation during pneumococcal meningitis in the rat
    • Pfister HW, Kümpfel T, Koedel U (1995) Involvement of substance P in pial arteriolar vasodilatation during pneumococcal meningitis in the rat. NeuroReport 6:1301-1305
    • (1995) NeuroReport , vol.6 , pp. 1301-1305
    • Pfister, H.W.1    Kümpfel, T.2    Koedel, U.3
  • 101
    • 33644845136 scopus 로고    scopus 로고
    • Preprotachykinin-A gene products are key mediators of lung injury in polymicrobial sepsis
    • Puneet P, Hegde A, Ng SW, Lau HY, Lu J, Moochhala SM, Bhatia M (2006) Preprotachykinin-A gene products are key mediators of lung injury in polymicrobial sepsis. J Immunol 176:3813-3820 (Pubitemid 43364030)
    • (2006) Journal of Immunology , vol.176 , Issue.6 , pp. 3813-3820
    • Puneet, P.1    Hegde, A.2    Ng, S.W.3    Lau, H.Y.4    Lu, J.5    Moochhala, S.M.6    Bhatia, M.7
  • 102
    • 0031594899 scopus 로고    scopus 로고
    • The tachykinin receptor. Part II: Distribution and pathophysiological roles
    • DOI 10.1016/S0143-4179(98)90015-4
    • Quartara L, Maggi CA (1998) The tachykinin NK1 receptor part II: distribution and pathophysiological roles. Neuropeptides 32:1-49 (Pubitemid 28167857)
    • (1998) Neuropeptides , vol.32 , Issue.1 , pp. 1-49
    • Quartara, L.1    Maggi, C.A.2
  • 104
    • 0025042666 scopus 로고
    • Effects of intranigral substance P and neurokinin A on striatal dopamine release - I. Interactions with substance P antagonists
    • DOI 10.1016/0306-4522(90)90007-Q
    • Reid MS, Herrera-Marschitz M, Hökfelt T, Ohlin M, Valentino KL, Ungerstedt U (1990a) Effects of intranigral substance P and neurokinin A on striatal dopamine release-I. Interactions with substance P antagonists. Neuroscience 36:643-658 (Pubitemid 20282179)
    • (1990) Neuroscience , vol.36 , Issue.3 , pp. 643-658
    • Reid, M.S.1    Herrera-Marschitz, M.2    Hokfelt, T.3    Ohlin, M.4    Valentino, K.L.5    Ungerstedt, U.6
  • 105
    • 0025647094 scopus 로고
    • Striatal dopamine and glutamate release: Effects of intranigral injections of substance P
    • Reid MS, Herrera-Marschitz M, Kehr J, Ungerstedt U (1990b) Striatal dopamine and glutamate release: effects of intranigral injections of substance P. Acta Physiol Scand 140:527-537
    • (1990) Acta Physiol Scand , vol.140 , pp. 527-537
    • Reid, M.S.1    Herrera-Marschitz, M.2    Kehr, J.3    Ungerstedt, U.4
  • 106
    • 0002462931 scopus 로고    scopus 로고
    • Comparison of neurokinin-1 antagonist, L-745,030, to placebo, acetaminophen and ibuprofen in the dental pain model
    • Reinhardt R (1998) Comparison of neurokinin-1 antagonist, L-745,030, to placebo, acetaminophen and ibuprofen in the dental pain model. Clin Pharmacol Ther 63:168
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 168
    • Reinhardt, R.1
  • 107
    • 0036951193 scopus 로고    scopus 로고
    • Lack of self-administration and behavioural sensitisation to morphine, but not cocaine, in mice lacking NK1 receptors
    • DOI 10.1016/S0028-3908(02)00295-2
    • Ripley TL, Gadd CA, De Felipe C, Hunt SP, Stephens DN (2002) Lack of self-administration and behavioural sensitisation to morphine, but not cocaine, in mice lacking NK1 receptors. Neuropharmacology 43:1258-1268 (Pubitemid 36084436)
    • (2002) Neuropharmacology , vol.43 , Issue.8 , pp. 1258-1268
    • Ripley, T.L.1    Gadd, C.A.2    De Felipe, C.3    Hunt, S.P.4    Stephens, D.N.5
  • 108
    • 36448967916 scopus 로고    scopus 로고
    • Neurokinin-1 receptor antagonists inhibit the recruitment of opioid-containing leukocytes and impair peripheral antinociception
    • DOI 10.1097/01.anes.0000291454.90754.de, PII 0000054220071200000021
    • Rittner HL, Lux C, Labuz D, Mousa SA, Achäfer M, Stein C, Brack A (2007) Neurokinin-1 receptor antagonists inhibit the recruitment of opioid-containing leukocytes and impair peripheral antinociception. Anesthesiology 107:1009-1017 (Pubitemid 350175684)
    • (2007) Anesthesiology , vol.107 , Issue.6 , pp. 1009-1017
    • Rittner, H.L.1    Lux, C.2    Labuz, D.3    Mousa, S.A.4    Schafer, M.5    Stein, C.6    Brack, A.7
  • 111
    • 80052917261 scopus 로고    scopus 로고
    • Targeting opioid and neurokinin-1 receptors to treat alcoholism
    • Rodríguez FD, Coveñas R (2011) Targeting opioid and neurokinin-1 receptors to treat alcoholism. Curr Med Chem 18:4321-4334
    • (2011) Curr Med Chem , vol.18 , pp. 4321-4334
    • Rodríguez, F.D.1    Coveñas, R.2
  • 112
    • 44949266148 scopus 로고
    • Immunopathogenic mechanisms of HIV infection: Cytokine induction of HIV expression
    • Rosenberg ZF, Fauci AS (1990) Immunopathogenic mechanisms of HIV infection: cytokine induction of HIV expression. Immunol Today 11:176-180 (Pubitemid 20118082)
    • (1990) Immunology Today , vol.11 , Issue.5 , pp. 176-180
    • Rosenberg, Z.F.1    Fauci, A.S.2
  • 113
    • 0025887046 scopus 로고
    • Immunopathogenesis of HIV infection
    • Rosenberg ZF, Fauci AS (1991) Immunopathogenesis of HIV infection. FASEB J 5:2382-2390 (Pubitemid 21905785)
    • (1991) FASEB Journal , vol.5 , Issue.10 , pp. 2382-2390
    • Rosenberg, Z.F.1    Fauci, A.S.2
  • 114
    • 0022346134 scopus 로고
    • Substance P receptor-mediated chemotaxis of human monocytes
    • Ruff MR, Wahl SM, Pert CB (1985) Substance P receptor-mediated chemotaxis of human monocytes. Peptides 6:107-111 (Pubitemid 16211115)
    • (1985) Peptides , vol.6 , Issue.SUPPL. 2 , pp. 107-111
    • Ruff, M.R.1    Wahl, S.M.2    Pert, C.B.3
  • 115
    • 0030246919 scopus 로고    scopus 로고
    • 1 receptor antagonist L-733,060 in gerbils
    • DOI 10.1016/0304-3959(96)03109-0
    • Rupniak NM, Carlson EC, Boyce S, Webb JK, Hill RG (1996) Enantioselective inhibition of the formalin paw late phase by the NK-1 receptor antagonist L-733,060 in gerbils. Pain 67:189-195 (Pubitemid 26319652)
    • (1996) Pain , vol.67 , Issue.1 , pp. 189-195
    • Rupniak, N.M.J.1    Carlson, E.2    Boyce, S.3    Webb, J.K.4    Hill, R.G.5
  • 116
    • 0034057760 scopus 로고    scopus 로고
    • 1) receptors attenuates neonatal vocalisation in guinea-pigs and mice
    • DOI 10.1016/S0028-3908(00)00052-6, PII S0028390800000526
    • Rupniak NM, Carlson EC, Harrison T, Oates B, Seward E, Owen S, de Felipe C, Hunt S, Wheeldon A (2000) Pharmacological blockade or genetic deletion of substance P (NK1) receptors attenuates neonatal vocalisation in guinea-pigs and mice. Neuropharmacology 39:1413-1421 (Pubitemid 30249203)
    • (2000) Neuropharmacology , vol.39 , Issue.8 , pp. 1413-1421
    • Rupniak, N.M.J.1    Carlson, E.C.2    Harrison, T.3    Oates, B.4    Seward, E.5    Owen, S.6    De Felipe, C.7    Hunt, S.8    Wheeldon, A.9
  • 118
  • 120
    • 84875628814 scopus 로고    scopus 로고
    • Efficacy and safety of singledose fosaprepitant in the prevention of chemotherapy-induced nausea and vomiting in patients receiving high-dose cisplatin: A multicentre, randomised, double-bind, placebo-controlled phase 3 trial
    • Saito H, Yoshizawa H, Yoshimori K, Katakami N, Katsumata N, Kawahara M, Eguchi K (2013) Efficacy and safety of singledose fosaprepitant in the prevention of chemotherapy-induced nausea and vomiting in patients receiving high-dose cisplatin: a multicentre, randomised, double-bind, placebo-controlled phase 3 trial. Ann Oncol 24:1067-1073
    • (2013) Ann Oncol , vol.24 , pp. 1067-1073
    • Saito, H.1    Yoshizawa, H.2    Yoshimori, K.3    Katakami, N.4    Katsumata, N.5    Kawahara, M.6    Eguchi, K.7
  • 121
    • 0343820002 scopus 로고    scopus 로고
    • Simultaneous depletion of neurokinin A, substance P and calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat during electrical stimulation of the trigeminal ganglion
    • DOI 10.1016/S0304-3959(99)00240-7, PII S0304395999002407
    • Samsam M, Coveñas R, Ahangari R, Yajeya J, Narváez JA, Tramu G (2000) Simultaneous depletion of neurokinin A, substance P and calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat during electrical stimulation of the trigeminal ganglion. Pain 84:389-395 (Pubitemid 30074242)
    • (2000) Pain , vol.84 , Issue.2-3 , pp. 389-395
    • Samsam, M.1    Covenas, R.2    Ahangari, R.3    Yajeya, J.4    Narvaez, J.A.5    Tramu, G.6
  • 122
    • 0035057675 scopus 로고    scopus 로고
    • Depletion of substance P, neurokinin A and calcitonin gene-related peptide from the contralateral and ipsilateral caudal trigeminal nucleus following unilateral electrical stimulation of the trigeminal ganglion; a possible neurophysiological and neuroanatomical link to generalized head pain
    • DOI 10.1016/S0891-0618(01)00088-6, PII S0891061801000886
    • Samsam M, Coveñas R, Csillik B, Ahangari R, Yajeya J, Riquelme R, Narváez JA, Tramu G (2001) Depletion of substance P, neurokinin A and calcitonin gene-related peptide from the contralateral and ipsilateral caudal trigeminal nucleus following unilateral electrical stimulation of the trigeminal ganglion; A possible neurophysiological and neuroanatomical link to generalized head pain. J Chem Neuroanat 21:161-169 (Pubitemid 32324239)
    • (2001) Journal of Chemical Neuroanatomy , vol.21 , Issue.2 , pp. 161-169
    • Samsam, M.1    Covenas, R.2    Csillik, B.3    Ahangari, R.4    Yajeya, J.5    Riquelme, R.6    Narvaez, J.A.7    Tramu, G.8
  • 124
    • 1942436848 scopus 로고    scopus 로고
    • Evaluation of the effect of chronic antidepressant treatment on neurokinin-1 receptor expression in the rat brain
    • DOI 10.1016/j.neuropharm.2004.02.013, PII S0028390804000516
    • Sartori SB, Burnet PWJ, Sharp T, Singewald N (2004) Evaluation of the effect of chronic antidepressant treatment on neurokinin-1 receptor expression in the rat brain. Neuropharmacology 46:1177-1183 (Pubitemid 38529941)
    • (2004) Neuropharmacology , vol.46 , Issue.8 , pp. 1177-1183
    • Sartori, S.B.1    Burnet, P.W.J.2    Sharp, T.3    Singewald, N.4
  • 126
    • 0023890991 scopus 로고
    • In vivo immunomodulation by the neuropeptide substance P
    • Scicchinato R, Biennenstock J, Stanisz AM (1988) In vivo immunomodulation by the neuropeptide substance P. Immunology 63:733-735
    • (1988) Immunology , vol.63 , pp. 733-735
    • Scicchinato, R.1    Biennenstock, J.2    Stanisz, A.M.3
  • 128
    • 0030580383 scopus 로고    scopus 로고
    • Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat
    • DOI 10.1016/S0006-8993(96)00812-8, PII S0006899396008128
    • Shirayama Y, Mitsushio H, Takashima M, Ichinawa H, Takahashi K (1996) Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat. Brain Res 739:70-78 (Pubitemid 26387364)
    • (1996) Brain Research , vol.739 , Issue.1-2 , pp. 70-78
    • Shirayama, Y.1    Mitsushio, H.2    Takashima, M.3    Ichikawa, H.4    Takahashi, K.5
  • 130
    • 0022510795 scopus 로고
    • Kainic acid induced seizures: Changes in somatostatin, substance P and neurotensin
    • DOI 10.1016/0306-4522(86)90081-3
    • Sperk G, Wieser R, Widmann R, Singer EA (1986) Kainic acid induced seizures: changes in somatostatin, substance P and neurotensin. Neuroscience 17:1117-1126 (Pubitemid 16080100)
    • (1986) Neuroscience , vol.17 , Issue.4 , pp. 1117-1126
    • Sperk, G.1    Wieser, R.2    Widmann, R.3    Singer, E.A.4
  • 131
    • 0029870954 scopus 로고    scopus 로고
    • The war on cancer
    • Sporn MB (1996) The war on cancer. Lancet 347:1377-1381
    • (1996) Lancet , vol.347 , pp. 1377-1381
    • Sporn, M.B.1
  • 132
  • 133
    • 80052541730 scopus 로고    scopus 로고
    • A randomized, placebo controlled, double masked phase Ib study evaluating the safety and antiviral activity of aprepitant, a neurokinin-1 receptor antagonist in HIV-1 infected adults
    • Tebas P, Tuluc F, Barret JS, Wagner W, Kim D, Zhao H, Gonin R, Korelitz J, Douglas SD (2011) A randomized, placebo controlled, double masked phase Ib study evaluating the safety and antiviral activity of aprepitant, a neurokinin-1 receptor antagonist in HIV-1 infected adults. PLoS One 6:e24180
    • (2011) PLoS One , vol.6
    • Tebas, P.1    Tuluc, F.2    Barret, J.S.3    Wagner, W.4    Kim, D.5    Zhao, H.6    Gonin, R.7    Korelitz, J.8    Douglas, S.D.9
  • 134
    • 84878380808 scopus 로고    scopus 로고
    • Peripheral substance P and neurokinin- 1 receptors have a role in inflammatory and neuropathic orofacial pain models
    • Teodoro FC, Tronco Júnior MF, Zampronio AR, Martini AC, Rae GA, Chichorro JG (2013) Peripheral substance P and neurokinin- 1 receptors have a role in inflammatory and neuropathic orofacial pain models. Neuropeptides 47:199-206
    • (2013) Neuropeptides , vol.47 , pp. 199-206
    • Teodoro, F.C.1    Tronco Júnior, M.F.2    Zampronio, A.R.3    Martini, A.C.4    Rae, G.A.5    Chichorro, J.G.6
  • 135
    • 84859219632 scopus 로고    scopus 로고
    • Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's disease
    • Thornton E, Vink R (2012) Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's disease. PLoS One 7:e34138
    • (2012) PLoS One , vol.7
    • Thornton, E.1    Vink, R.2
  • 136
    • 77649236090 scopus 로고    scopus 로고
    • Neurokinin-1 receptors (NK1R:S), alcohol consumption, and alcohol reward in mice
    • Thorsell A, Schank JR, Singley E, Hunt SP, Heilig M (2010) Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice. Psychopharmacology 209:103-111
    • (2010) Psychopharmacology , vol.209 , pp. 103-111
    • Thorsell, A.1    Schank, J.R.2    Singley, E.3    Hunt, S.P.4    Heilig, M.5
  • 137
    • 77956624273 scopus 로고    scopus 로고
    • Serum concentrations of substance P in cholestasis
    • Trivedi M, Bergasa NV (2010) Serum concentrations of substance P in cholestasis. Ann Hepatol 9:177-180
    • (2010) Ann Hepatol , vol.9 , pp. 177-180
    • Trivedi, M.1    Bergasa, N.V.2
  • 138
    • 84855388865 scopus 로고    scopus 로고
    • Substance P in the corneal stroma regulates the severity of herpetic stromal keratitis lesions
    • Twardy BS, Channappanavar R, Suvas S (2011) Substance P in the corneal stroma regulates the severity of herpetic stromal keratitis lesions. Invest Ophthalmol Vis Sci 52:8604-8613
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 8604-8613
    • Twardy, B.S.1    Channappanavar, R.2    Suvas, S.3
  • 139
    • 0019520093 scopus 로고
    • Central blood pressure effects of substance P and angiotensin II: Role of the sympathetic nervous system and vasopressin
    • DOI 10.1016/0014-2999(81)90384-8
    • Unger T, Rascher W, Schuster C, Pavlovitch R, Schömig A, Dietz R, Ganten D (1981) Central blood pressure effects of substance P and angiotensin II: role of the sympathetic nervous system and vasopressin. Eur J Pharmacol 71:33-42 (Pubitemid 11112563)
    • (1981) European Journal of Pharmacology , vol.71 , Issue.1 , pp. 33-42
    • Unger, T.1    Rascher, W.2    Schuster, C.3
  • 140
    • 45149083874 scopus 로고    scopus 로고
    • Behavioral and pharmacological validation of the gerbil forced-swim test: Effects of neurokinin-1 receptor antagonists
    • DOI 10.1038/sj.npp.1301586, PII 1301586
    • Wallace-Boone TL, Newton AE, Wright RN, Lodge NJ, McElroy JF (2008) Behavioral and pharmacological validation of the gerbil forced-swim test: effects of neurokinin-1 receptor antagonists. Neuropsychopharmacology 33:1919-1928 (Pubitemid 351832600)
    • (2008) Neuropsychopharmacology , vol.33 , Issue.8 , pp. 1919-1928
    • Wallace-Boone, T.L.1    Newton, A.E.2    Wright, R.N.3    Lodge, N.J.4    McElroy, J.F.5
  • 141
    • 0021957091 scopus 로고
    • Biochemical characterization and autoradiographic localization of central
    • DOI 10.1016/0006-8993(85)90598-0
    • Wolf SS, Moody TW, Quirion R, O'Donohue TL (1985) Biochemical characterization and autoradiographic localization of central SP receptor using [125I] physalaemin. Brain Res 332:299-307 (Pubitemid 15108000)
    • (1985) Brain Research , vol.332 , Issue.2 , pp. 299-307
    • Wolf, S.S.1    Moody, T.W.2    Quirion, R.3    O'Donohue, T.L.4
  • 142
    • 0036829194 scopus 로고    scopus 로고
    • Neurokinin-1 (NK-1) receptor antagonists abrogate methamphetamine-induced striatal dopaminergic neurotoxicity in the murine brain
    • DOI 10.1046/j.1471-4159.2002.01155.x
    • Yu J, Cadet JL, Angulo JA (2002) Neurokinin-1 (NK-1) receptor antagonists abrogate methamphetamine-induced striatal dopaminergic neurotoxicity in the murine brain. J Neurochem 83:613-622 (Pubitemid 35231815)
    • (2002) Journal of Neurochemistry , vol.83 , Issue.3 , pp. 613-622
    • Yu, J.1    Cadet, J.L.2    Angulo, J.A.3
  • 143
    • 0032185613 scopus 로고    scopus 로고
    • 1 receptor antagonist, CP-122,721-1, attenuates kainic acid-induced seizure activity
    • DOI 10.1016/S0169-328X(98)00191-0, PII S0169328X98001910
    • Zachrisson O, Lindefors N, Brené S (1998) A tachykinin NK1 receptor antagonist, CP-122,721-1, attenuates kainic acidinduced seizure activity. Brain Res Mol Brain Res 60:291-295 (Pubitemid 28466593)
    • (1998) Molecular Brain Research , vol.60 , Issue.2 , pp. 291-295
    • Zachrisson, O.1    Lindefors, N.2    Brene, S.3
  • 144
    • 0025092876 scopus 로고
    • Substance P stimulates neovascularization in vivo and proliferation of cultured endothelial cells
    • DOI 10.1016/0026-2862(90)90024-L
    • Ziche M, Morbidelli L, Pacini M, Gepetti P, Alessandri G, Maggi CA (1990) Substance P stimulates neovascularization in vivo and proliferation of cultured endothelial cells. Microvasc Res 40:264-278 (Pubitemid 20327679)
    • (1990) Microvascular Research , vol.40 , Issue.2 , pp. 264-278
    • Ziche, M.1    Morbidelli, L.2    Pacini, M.3    Geppetti, P.4    Alessandri, G.5    Maggi, C.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.