메뉴 건너뛰기




Volumn 17, Issue 6, 2010, Pages 504-516

A new frontier in the treatment of cancer: NK-1 receptor antagonists

Author keywords

Antitumour; Cancer; Drug; Metastasis; Neoangiogenesis; NK 1 receptor; NK 1 receptor antagonists; Substance P

Indexed keywords

APREPITANT; CJ 11 974; CP 122 721; CP 96 345; CP 99 994; EZLOPITANT; L 732 138; L 733 060; MEN 11 149; MEN 11 467; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; PLACEBO; RP 67 580; SUBSTANCE P; UNCLASSIFIED DRUG; VINBLASTINE; VOFOPITANT;

EID: 77950639335     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986710790416308     Document Type: Review
Times cited : (91)

References (124)
  • 1
    • 0029961467 scopus 로고    scopus 로고
    • Substance P-induced mitogenesis in human astrocytoma cells correlates with activation of the mitogen-activated protein kinase signaling pathway
    • Luo, W.; Sharif, T.R.; Sharif, M. Substance P-induced mitogenesis in human astrocytoma cells correlates with activation of the mitogen-activated protein kinase signaling pathway. Cancer Res., 1996, 56, 4983-4991 (Pubitemid 26374439)
    • (1996) Cancer Research , vol.56 , Issue.21 , pp. 4983-4991
    • Luo, W.1    Sharif, T.R.2    Sharif, M.3
  • 2
    • 3042799978 scopus 로고    scopus 로고
    • Antitumoral action of the neurokinin-1 receptor antagonist L-733 060 on human melanoma cell lines
    • DOI 10.1097/01.cmr.0000129376.22141.a3
    • Muñoz, M.; Pérez, A.; Rosso, M.; Zamarriego, C.; Rosso, R. Antitumoural action of NK-1 receptor antagonist L-733,060 on human melanoma cell lines. Melanoma Res., 2004, 14, 183-188 (Pubitemid 38879579)
    • (2004) Melanoma Research , vol.14 , Issue.3 , pp. 183-188
    • Munoz, M.1    Perez, A.2    Rosso, M.3    Zamarriego, C.4    Rosso, R.5
  • 3
    • 23044450652 scopus 로고    scopus 로고
    • The NK1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on neuroblastoma and glioma cell lines
    • DOI 10.1016/j.npep.2005.03.004, PII S014341790500034X
    • Muñoz, M.; Rosso, M.; Pérez, A.; Coveñas, R.; Rosso, R.; Zamarriego, C.; Piruat, J.I. The NK-1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on neuroblastoma and glioma cell lines. Neuropeptides, 2005, 39, 427-432 (Pubitemid 41073623)
    • (2005) Neuropeptides , vol.39 , Issue.4 , pp. 427-432
    • Munoz, M.1    Rosso, M.2    Perez, A.3    Covenas, R.4    Rosso, R.5    Zamarriego, C.6    Piruat, J.I.7
  • 4
    • 23244463917 scopus 로고    scopus 로고
    • Antitumoral action of the neurokinin-1-receptor antagonist L-733,060 and mitogenic action of substance P on human retinoblastoma cell lines
    • DOI 10.1167/iovs.04-1530
    • Muñoz, M.; Rosso, M.; Pérez, A.; Coveñas, R.; Rosso, R.; Zamarriego, C.; Soult, J.A.; Montero, I. Antitumoural action of the neurokinin- 1- receptor antagonist L-733,060 and mitogenic action of substance P on human retinoblastoma cell lines. Invest. Ophthalmol. Vis. Sci., 2005, 46, 2567-2570 (Pubitemid 43119507)
    • (2005) Investigative Ophthalmology and Visual Science , vol.46 , Issue.7 , pp. 2567-2570
    • Munoz, M.1    Rosso, M.2    Perez, A.3    Covenas, R.4    Rosso, R.5    Zamarriego, C.6    Soult, J.A.7    Montero, I.8
  • 5
    • 33745590666 scopus 로고    scopus 로고
    • The NK-1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on human pancreatic cancer cell lines
    • DOI 10.2174/157018006777574168
    • Muñoz, M.; Rosso, M.; Coveñas, R. The NK-1 receptor is involved in the antitumoural action of L-733,060 and in the mitogenic action of substance P on human pancreatic cancer cell lines. Lett. Drug Des. Discov., 2006, 3, 323-329 (Pubitemid 43988115)
    • (2006) Letters in Drug Design and Discovery , vol.3 , Issue.5 , pp. 323-329
    • Munoz, M.1    Rosso, M.2    Covenas, R.3
  • 7
    • 40549118238 scopus 로고    scopus 로고
    • NK-1 receptor antagonists induce apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2
    • Muñoz, M.; Rosso, M.; Aguilar, F.J. ; González-Moles M.A.; Redondo, M.; Esteban, F. NK-1 receptor antagonists induce apoptosis and counteract substance P-related mitogenesis in human laryngeal cancer cell line HEp-2. Investig. New Drugs, 2008, 26, 111-118
    • (2008) Investig. New Drugs , vol.26 , pp. 111-118
    • Muñoz, M.1    Rosso, M.2    Aguilar, F.J.3    González-Moles, M.A.4    Redondo, M.5    Esteban, F.6
  • 8
    • 51049102605 scopus 로고    scopus 로고
    • The NK-1 receptor is involved in the antitumor action of L-733,060 and in the mitogenic action of substance P on human gastrointestinal cancer cell lines
    • Rosso, M.; Robles-Frias, M.J.; Coveñas, R.; Salinas-Martín, M.V.; Muñoz, M. The NK-1 receptor is involved in the antitumor action of L-733,060 and in the mitogenic action of substance P on human gastrointestinal cancer cell lines. Tumor Biol., 2008, 29, 245-254
    • (2008) Tumor Biol. , vol.29 , pp. 245-254
    • Rosso, M.1    Robles-Frias, M.J.2    Coveñas, R.3    Salinas-Martín, M.V.4    Muñoz, M.5
  • 9
    • 0020964719 scopus 로고
    • Specific stimulation of human T lymphocytes by substance P
    • Payan, D.G.; Brewster, D.R.; Goetzl, E.J. Specific stimulation of human T lymphocytes by substance P. J. Immunol., 1983, 131, 1613-1615 (Pubitemid 13010122)
    • (1983) Journal of Immunology , vol.131 , Issue.4 , pp. 1613-1615
    • Payan, D.G.1    Brewster, D.R.2    Goetzl, E.J.3
  • 10
    • 0021847460 scopus 로고
    • Stimulation of connective tissue cell growth by substance P and substance K
    • DOI 10.1038/315061a0
    • Nilsson, J.; von Euler, A.M.; Dalsgaard, C.J. Stimulation of connective tissue cell growth by substance P and substance K. Nature, 1985, 315, 61-63 (Pubitemid 15064899)
    • (1985) Nature , vol.315 , Issue.6014 , pp. 61-63
    • Nilsson, J.1    Von Euler, A.M.2    Dalsgaard, C.J.3
  • 11
    • 0023100630 scopus 로고
    • Substance P activation of rheumatoid synoviocytes: Neural pathway in pathogenesis of arthritis
    • Lotz, M.; Carson, D.A.; Vaughan, J.H. Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis. Science, 1987, 235, 893-895
    • (1987) Science , vol.235 , pp. 893-895
    • Lotz, M.1    Carson, D.A.2    Vaughan, J.H.3
  • 12
    • 0025193496 scopus 로고
    • NK1-receptors mediate the proliferative response of human fibroblasts to tachykinins
    • Ziche, M.; Morbidelli, L.; Pacini, M.; Dolara, P.; Maggi, C.A. NK1-receptors mediate the proliferative response of human fibroblasts to tachykinins. Br. J. Pharmacol., 1990, 100, 11-14
    • (1990) Br. J. Pharmacol. , vol.100 , pp. 11-14
    • Ziche, M.1    Morbidelli, L.2    Pacini, M.3    Dolara, P.4    Maggi, C.A.5
  • 13
    • 0029071971 scopus 로고
    • Substance-P receptors in human primary neoplasms: Tumoral and vascular localization
    • Hennig, I.M.; Laissue, J.A.; Horisberger, U.; Reubi, J.C. Substance-P receptors in human primary neoplasms: tumoral and vascular localization. Int. J. Cancer., 1995, 61, 786-792
    • (1995) Int. J. Cancer. , vol.61 , pp. 786-792
    • Hennig, I.M.1    Laissue, J.A.2    Horisberger, U.3    Reubi, J.C.4
  • 16
    • 2542435999 scopus 로고    scopus 로고
    • Antitumoural action of L-733,060 on neuroblastoma and glioma cell lines
    • Muñoz, M.; Pérez, A.; Coveñas, R.; Rosso, M.; Castro, E. Antitumoural action of L-733,060 on neuroblastoma and glioma cell lines. Arch. Ital. Biol., 2004, 142, 105-112 (Pubitemid 38691234)
    • (2004) Archives Italiennes de Biologie , vol.142 , Issue.2 , pp. 105-112
    • Munoz, M.1    Perez, A.2    Covenas, R.3    Rosso, M.4    Castro, E.5
  • 18
  • 19
    • 65649138814 scopus 로고    scopus 로고
    • A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas
    • Akazawa, T.; Kwatra, S.G.; Goldsmith, L.E.; Richardson, M.D.; Cox. E.A.; Sampom, J.H.; Kwatra, M.M. A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas. J. Neurochem., 2009, 109, 1079-1086
    • (2009) J. Neurochem. , vol.109 , pp. 1079-1086
    • Akazawa, T.1    Kwatra, S.G.2    Goldsmith, L.E.3    Richardson, M.D.4    Cox, E.A.5    Sampom, J.H.6    Kwatra, M.M.7
  • 20
    • 34948856407 scopus 로고    scopus 로고
    • Substance P and its receptors - A potential target for novel medicines in malignant brain tumour therapies
    • Lazarczyk, M.; Matyja, E.; Lipkowski, A. Substance P and its receptors - a potential target for novel medicines in malignant brain tumour therapies. Folia Neuropathol., 2007, 45, 99-107.
    • (2007) Folia Neuropathol. , vol.45 , pp. 99-107
    • Lazarczyk, M.1    Matyja, E.2    Lipkowski, A.3
  • 21
    • 77952240278 scopus 로고    scopus 로고
    • The NK-1 receptor antagonist aprepitant as a broad spectrum antitumor drug
    • doi: 10.1007/s10637-009-9218-8
    • Muñoz, M.; Rosso, M. The NK-1 receptor antagonist aprepitant as a broad spectrum antitumor drug. Invest. New Drugs., 2009, doi: 10.1007/s10637-009-9218-8.
    • (2009) Invest. New Drugs.
    • Muñoz, M.1    Rosso, M.2
  • 23
    • 27644463170 scopus 로고    scopus 로고
    • Role of NK-1 and NK-2 tachykinin receptor antagonism on the growth of human breast carcinoma cell line MDA-MB-231
    • DOI 10.1097/00001813-200511000-00007
    • Bigioni, M.; Benzo, A.; Irrissuto, C.; Maggi, C.A.; Goso, C. Role of NK-1 and NK-2 tachykinin receptor antagonism on the growth of human breast carcinoma cell line MDA-MB-231. Anticancer Drugs, 2005, 16, 1083-1089 (Pubitemid 41565774)
    • (2005) Anti-Cancer Drugs , vol.16 , Issue.10 , pp. 1083-1089
    • Bigioni, M.1    Benzo, A.2    Irrissuto, C.3    Maggi, C.A.4    Goso, C.5
  • 24
    • 34548243190 scopus 로고    scopus 로고
    • Substance P analogs containing alpha-dialkylated amino acids with potent anticancer activity
    • DOI 10.1002/psc.886
    • Prasad, S.; Mathur, A.; Jaggi, M.; Singh, A.T.; Mukherjee, R. Substance P analogs containing alpha-dialkylated amino acids with potent anticancer activity. J. Pept. Sci., 2007, 13, 544-548 (Pubitemid 47322354)
    • (2007) Journal of Peptide Science , vol.13 , Issue.8 , pp. 544-548
    • Prasad, S.1    Mathur, A.2    Jaggi, M.3    Singh, A.T.4    Mukherjee, R.5
  • 25
    • 0018102058 scopus 로고
    • The distribution of substance P immunoreactive fibers in the rat central nervous system
    • Cuello, AC.; Kanazawa, I. The distribution of substance P immunoreactive fibres in the rat central nervous system. J. Comp. Neurol., 1978, 178, 129-156 (Pubitemid 8374096)
    • (1978) Journal of Comparative Neurology , vol.178 , Issue.1 , pp. 129-135
    • Cuello, A.C.1    Kanazawa, I.2
  • 28
    • 0024203060 scopus 로고
    • Immunocytochemical study of substance P-like fibres and cell bodies in cat diencephalon
    • Burgos, C.; Aguirre, J.A.; Alonso, J.R.; Coveñas, R. Immunocytochemical study of substance P-like fibres and cell bodies in the cat diencephalon. J. Hirnforsch., 1988, 29, 651-657 (Pubitemid 19046442)
    • (1988) Journal fur Hirnforschung , vol.29 , Issue.6 , pp. 651-657
    • Burgos, C.1    Aguirre, J.A.2    Alonso, J.R.3    Covenas, R.4
  • 29
    • 15544363087 scopus 로고    scopus 로고
    • Neurons derived from human mesenchymal stem cells show synaptic transmission and can be induced to produce the neurotransmitter substance P by interleukin-1alpha
    • DOI 10.1634/stemcells.2004-0251
    • Cho, K.J.; Trzaska, K.A., Greco, S.J.; McArdle, J.; Wang, F.S.; Ye, J.H.; Rameshwar, P. Neurons derived from human mesenchymal stem cells show synaptic transmission and can be induced to produce the neurotransmitter substance P by interleukin-1 alpha. Stem Cells, 2005, 23, 383-391, (Pubitemid 40404457)
    • (2005) Stem Cells , vol.23 , Issue.3 , pp. 383-391
    • Cho, K.J.1    Trzaska, K.A.2    Greco, S.J.3    McArdle, J.4    Wang, F.S.5    Ye, J.-H.6    Rameshwar, P.7
  • 30
    • 33644866842 scopus 로고    scopus 로고
    • Administration of hematopoietic cytokines in the subacute phase after cerebral infarction is effective for functional recovery facilitating proliferation of intrinsic neural stem/progenitor cells and transition of bone marrow-derived neuronal cells
    • DOI 10.1161/CIRCULATIONAHA.105.563668, PII 0000301720060207000017
    • Kawada, H.; Takizawa, S.; Takanashi, T.; Morita, Y.; Fujita, J.; Fukuda, K.; Takagi, S.; Okano, H.; Ando, K.; Hotta, T. Administration of hematopoietic cytokines in the subacute phase after cerebral infarction is effective for functional recovery facilitating proliferation of intrinsic neural stem/progenitor cells and transition of bone marrow-derived neuronal cells. Circulation, 2006, 113, 701-710 (Pubitemid 43754334)
    • (2006) Circulation , vol.113 , Issue.5 , pp. 701-710
    • Kawada, H.1    Takizawa, S.2    Takanashi, T.3    Morita, Y.4    Fujita, J.5    Fukuda, K.6    Takagi, S.7    Okano, H.8    Ando, K.9    Hotta, T.10
  • 31
    • 34548833893 scopus 로고    scopus 로고
    • Substance P is a promoter of adult neural progenitor cell proliferation under normal and ischemic conditions
    • Park, S.W.; Yan, Y.P.; Satriotomo, I.; Vemuganti, R.; Dempsey, R.J. Substance P is a promoter of adult neural progenitor cell proliferation under normal and ischemic conditions. J. Neurosurg., 2007, 107, 593-599
    • (2007) J. Neurosurg. , vol.107 , pp. 593-599
    • Park, S.W.1    Yan, Y.P.2    Satriotomo, I.3    Vemuganti, R.4    Dempsey, R.J.5
  • 32
    • 0002800004 scopus 로고
    • Endopeptidase-24.11 and neuropeptide metabolism
    • Turner, Ed.; Ellis Horwood: Chichester
    • Turner, A.J. Endopeptidase-24.11 and neuropeptide metabolism. In Neuropeptides and Their Peptidases. Turner, Ed.; Ellis Horwood: Chichester, 1987; pp. 183-201.
    • (1987) Neuropeptides and Their Peptidases , pp. 183-201
    • Turner, A.J.1
  • 33
    • 84944496221 scopus 로고
    • An unidentified depressor substance in certain tissue extracts
    • von Euler, U.S. ; Gaddum, J.H. An unidentified depressor substance in certain tissue extracts. J. Physiol., 1931, 72, 74-87.
    • (1931) J. Physiol. , vol.72 , pp. 74-87
    • Von Euler, U.S.1    Gaddum, J.H.2
  • 34
    • 0020959817 scopus 로고
    • Substance P
    • Pernow, B. Substance P. Pharmacol. Rev., 1983, 35, 85-141.
    • (1983) Pharmacol. Rev. , vol.35 , pp. 85-141
    • Pernow, B.1
  • 35
    • 0035137002 scopus 로고    scopus 로고
    • Substance P: A pioneer amongst neuropeptides
    • Hökfelt, T.; Pernow, B.; Wahren, J. Substance P: a pioneer amongst neuropeptides. J. Intern. Med., 2001, 249, 27-40.
    • (2001) J. Intern. Med. , vol.249 , pp. 27-40
    • Hökfelt, T.1    Pernow, B.2    Wahren, J.3
  • 36
    • 0019520093 scopus 로고
    • Central blood pressure effects of substance P and angiotensin II: Role of the sympathetic nervous system and vasopressin
    • DOI 10.1016/0014-2999(81)90384-8
    • Unger, T.; Rascher, W.; Schuster, C.; Pavlovitch, R.; Schömig, A.; Dietz, R.; Ganten, D. Central blood pressure effects of substance P and angiotensin II: role of the sympathetic nervous system and vasopressin. Eur. J. Pharmacol., 1981, 71, 33-42. (Pubitemid 11112563)
    • (1981) European Journal of Pharmacology , vol.71 , Issue.1 , pp. 33-42
    • Unger, T.1    Rascher, W.2    Schuster, C.3
  • 37
    • 0026377062 scopus 로고
    • Molecular and genetic characterization, functional expression, and mRNA expression patterns of a rat substance P receptor
    • Hershey, A.D.; Polenzani, L.; Woodward, R.M.; Miledi, R.; Krause, J.E. Molecular and genetic characterization, functional expression, and mRNA expression patterns of a rat substance P receptor. Ann. NY Acad. Sci., 1991, 632, 63-78.
    • (1991) Ann. NY Acad. Sci. , vol.632 , pp. 63-78
    • Hershey, A.D.1    Polenzani, L.2    Woodward, R.M.3    Miledi, R.4    Krause, J.E.5
  • 38
    • 0031594899 scopus 로고    scopus 로고
    • The tachykinin NK1 receptor. Part II: Distribution and pathophysiological roles
    • Quartara, L.; Maggi, C.A. The tachykinin NK1 receptor. Part II: distribution and pathophysiological roles. Neuropeptides, 1998, 32, 1-49.
    • (1998) Neuropeptides , vol.32 , pp. 1-49
    • Quartara, L.1    Maggi, C.A.2
  • 39
    • 0030246919 scopus 로고    scopus 로고
    • Enantioselective inhibition of the formalin paw late phase by the NK1 receptor antagonist L-733,060 in gerbils
    • Rupniak, N.M.; Carlson, E.; Boyce, S.; Webb, J.K.; Hill, R.G. Enantioselective inhibition of the formalin paw late phase by the NK1 receptor antagonist L-733,060 in gerbils. Pain, 1996, 67, 189-195
    • (1996) Pain , vol.67 , pp. 189-195
    • Rupniak, N.M.1    Carlson, E.2    Boyce, S.3    Webb, J.K.4    Hill, R.G.5
  • 41
    • 0343820002 scopus 로고    scopus 로고
    • Simultaneous depletion of neurokinin A, substance P and calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat during electrical stimulation of the trigeminal ganglion
    • DOI 10.1016/S0304-3959(99)00240-7, PII S0304395999002407
    • Samsam, M.; Coveñas, R.; Ahangari, R.; Yajeya, J.; Narváez, J.A.; Tramu, G. Simultaneous depletion of neurokinin A, substance P and calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat during electrical stimulation of the trigeminal ganglion. Pain, 2000, 84, 389-395 (Pubitemid 30074242)
    • (2000) Pain , vol.84 , Issue.2-3 , pp. 389-395
    • Samsam, M.1    Covenas, R.2    Ahangari, R.3    Yajeya, J.4    Narvaez, J.A.5    Tramu, G.6
  • 44
    • 0037331104 scopus 로고    scopus 로고
    • The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test
    • Varty, G.B.; Cohen-Williams, M.E.; Hunter, J.C. The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test. Behav. Pharmacol., 2003, 14, 87-95.
    • (2003) Behav. Pharmacol. , vol.14 , pp. 87-95
    • Varty, G.B.1    Cohen-Williams, M.E.2    Hunter, J.C.3
  • 46
    • 0022346134 scopus 로고
    • Substance P receptor-mediated chemotaxis of human monocytes
    • Ruff, M.R.; Wahl, S.M.; Pert, C.B. Substance P receptor-mediated chemotaxis of human monocytes. Peptides, 1985, 6, 107-111 (Pubitemid 16211115)
    • (1985) Peptides , vol.6 , Issue.SUPPL. 2 , pp. 107-111
    • Ruff, M.R.1    Wahl, S.M.2    Pert, C.B.3
  • 47
    • 0031730550 scopus 로고    scopus 로고
    • Signaling in neuropeptide-induced migration of human eosinophils
    • Dunzendorfer, S.; Meierhofer, C.; Wiedermann, C.J. Signaling in neuropeptide-induced migration of human eosinophils J. Leukocyte Biol., 1998, 64, 828-834
    • (1998) J. Leukocyte Biol. , vol.64 , pp. 828-834
    • Dunzendorfer, S.1    Meierhofer, C.2    Wiedermann, C.J.3
  • 49
    • 66149137995 scopus 로고    scopus 로고
    • Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil kinasedependent mechanism
    • Meshki, J.; Douglas, S.D.; Lai, J.P.; Schwartz, L.; Kilpatrick, L.E.; Tuluc, F. Neurokinin 1 receptor mediates membrane blebbing in HEK293 cells through a Rho/Rho-associated coiled-coil kinasedependent mechanism. J. Biol. Chem., 2009, 284, 9280-9289
    • (2009) J. Biol. Chem. , vol.284 , pp. 9280-9289
    • Meshki, J.1    Douglas, S.D.2    Lai, J.P.3    Schwartz, L.4    Kilpatrick, L.E.5    Tuluc, F.6
  • 50
    • 45349096499 scopus 로고    scopus 로고
    • Cell motility through plasma membrane blebbing
    • DOI 10.1083/jcb.200802081
    • Fackler, O.T.; Grosse, R. Cell motility through plasma membrane blebbing. J. Cell Biol., 2008, 181, 879-884 (Pubitemid 351846821)
    • (2008) Journal of Cell Biology , vol.181 , Issue.6 , pp. 879-884
    • Fackler, O.T.1    Grosse, R.2
  • 51
    • 63849298539 scopus 로고    scopus 로고
    • Proinflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity
    • Janelsins, B.M.; Mathers, A.R.; Tkacheva, O.A.; Erdos, G.; Shufesky, W.J; Morelli, A.E.; Larregina, A.T. Proinflammatory tachykinins that signal through the neurokinin 1 receptor promote survival of dendritic cells and potent cellular immunity. Blood, 2009, 113, 3017-3026
    • (2009) Blood , vol.113 , pp. 3017-3026
    • Janelsins, B.M.1    Mathers, A.R.2    Tkacheva, O.A.3    Erdos, G.4    Shufesky, W.J.5    Morelli, A.E.6    Larregina, A.T.7
  • 52
    • 0031283503 scopus 로고    scopus 로고
    • The tachykinin NK1 receptor. Part I: Ligands and mechanisms of cellular activation
    • Quartara, L.; Maggi, C.A. The tachykinin NK1 receptor. Part I: ligands and mechanisms of cellular activation. Neuropeptides, 1997, 31, 537-563
    • (1997) Neuropeptides , vol.31 , pp. 537-563
    • Quartara, L.1    Maggi, C.A.2
  • 53
    • 0024353064 scopus 로고
    • Regulation of substance P receptor affinity by guanine nucleotide-binding proteins
    • DOI 10.1111/j.1471-4159.1989.tb07323.x
    • MacDonald, S.G.; Boyd, N.D. Regulation of substance P receptor affinity by guanine nucleotide binding proteins. J. Neurochem., 1989, 53, 264-272 (Pubitemid 19158138)
    • (1989) Journal of Neurochemistry , vol.53 , Issue.1 , pp. 264-272
    • Macdonald, S.G.1    Boyd, N.D.2
  • 54
    • 0021957091 scopus 로고
    • Biochemical characterization and autoradiographic localization of central SP receptor using [125I] physalaemin
    • Wolf, S.S.; Moody, T.W.; Quirion, R.; O'Donahue, T.L. Biochemical characterization and autoradiographic localization of central SP receptor using [125I] physalaemin. Brain Res., 1985, 332, 299-307.
    • (1985) Brain Res. , vol.332 , pp. 299-307
    • Wolf, S.S.1    Moody, T.W.2    Quirion, R.3    O'Donahue, T.L.4
  • 55
    • 0023018025 scopus 로고
    • Pharmacological characterization and autoradiographic localization of substance P receptors in guinea pig brain
    • DOI 10.1016/0196-9781(86)90106-3
    • Dam, T.V.; Quirion, R. Pharmacological characterization and autoradiographic characterization of substance P receptors in guinea-pig brain. Peptides, 1986, 7, 855-864 (Pubitemid 17182354)
    • (1986) Peptides , vol.7 , Issue.5 , pp. 855-864
    • Dam, T.-V.1    Quirion, R.2
  • 56
    • 0022480480 scopus 로고
    • A comparative autoradiographic study of the distributions of substance P and eledoisin binding sites in rat brain
    • DOI 10.1016/0006-8993(86)91073-5
    • Danks, J.A.; Rothman, R.B.; Cascieri, M.A.; Chicchi, G.G.; Liang, T.; Herkenham, M. A comparative autoradiographic study of the distributions of substance P and eledoisin binding sites in rat brain. Brain Res., 1986, 385, 273-281 (Pubitemid 16006841)
    • (1986) Brain Research , vol.385 , Issue.2 , pp. 273-281
    • Danks, J.A.1    Rothman, R.B.2    Cascieri, M.A.3
  • 58
    • 0027466839 scopus 로고
    • Distribution of the substance P receptor (NK-1 receptor) in the central nervous system
    • Maeno, H.; Kiyama, H.; Tohyama, M. Distribution of the substance P (NK1) receptor in the central nervous system. Mol. Brain Res., 1993, 18, 43-58. (Pubitemid 23100236)
    • (1993) Molecular Brain Research , vol.18 , Issue.1-2 , pp. 43-58
    • Maeno, H.1    Kiyama, H.2    Tohyama, M.3
  • 59
    • 0028070434 scopus 로고
    • Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat
    • Nakaya, Y.; Kaneko, T.; Shigemoto, R.; Nakanishi, S.; Mizuno, N. Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. J. Comp. Neurol., 1994, 347, 249-274 (Pubitemid 24273427)
    • (1994) Journal of Comparative Neurology , vol.347 , Issue.2 , pp. 249-274
    • Nakaya, Y.1    Kaneko, T.2    Shigemoto, R.3    Nakanishi, S.4    Mizuno, N.5
  • 60
    • 0028814683 scopus 로고
    • Quantitation, cellular localization and regulation of neurokinin receptor gene expression whithin the rat substantia nigra
    • Whitty, C.J.; Walker, P.D.; Goebel, D.J.; Poosch, M.S.; Bannon, M.J. Quantitation, cellular localization and regulation of neurokinin receptor gene expression whithin the rat substantia nigra. Neuroscience, 1995, 64, 419-425
    • (1995) Neuroscience , vol.64 , pp. 419-425
    • Whitty, C.J.1    Walker, P.D.2    Goebel, D.J.3    Poosch, M.S.4    Bannon, M.J.5
  • 61
    • 3242753679 scopus 로고    scopus 로고
    • Tachykinins and tachykinin receptor: Structure and activity relationships
    • Almeida, T.; Rojo, J.; Nieto, P.M. Tachykinins and tachykinin receptor: structure and activity relationships. Curr. Med. Chem., 2004, 11, 763-771
    • (2004) Curr. Med. Chem. , vol.11 , pp. 763-771
    • Almeida, T.1    Rojo, J.2    Nieto, P.M.3
  • 63
    • 0036318706 scopus 로고    scopus 로고
    • Comparison of the cell immunophenotype of metastatic and primary foci in stage IV-S neuroblastoma
    • Nowicki, M.; Miskowiak, B. Comparison of the cell immunophenotype of metastatic and primary foci in stage IV-S neuroblastoma. Folia Histochem. Cytobiol., 2002, 40, 297-303. (Pubitemid 34830563)
    • (2002) Folia Histochemica et Cytobiologica , vol.40 , Issue.3 , pp. 297-303
    • Nowicki, M.1    Miskowiak, B.2
  • 64
    • 0032920530 scopus 로고    scopus 로고
    • Substance P activates responses correlated with tumour growth in human glioma cells line bearing tachykinin NK1 receptors
    • Palma, C.; Nardelli, F.; Manzini, S.; Maggi, C.A. Substance P activates responses correlated with tumour growth in human glioma cells line bearing tachykinin NK1 receptors. Br. J. Cancer., 1999, 79, 236-243
    • (1999) Br. J. Cancer. , vol.79 , pp. 236-243
    • Palma, C.1    Nardelli, F.2    Manzini, S.3    Maggi, C.A.4
  • 66
    • 0031964247 scopus 로고    scopus 로고
    • The neuropeptide/mast cell secretagogue substance P is expressed in cutaneus melanocytic lesions
    • Khare, V.K.; Albino, A.P.; Reed, J.A. The neuropeptide/mast cell secretagogue substance P is expressed in cutaneus melanocytic lesions. J. Cutan. Pathol., 1998, 25, 2-10.
    • (1998) J. Cutan. Pathol. , vol.25 , pp. 2-10
    • Khare, V.K.1    Albino, A.P.2    Reed, J.A.3
  • 67
    • 58649098981 scopus 로고    scopus 로고
    • Expression of substance P and neurokinin-1-receptor in laryngeal cancer: Linking chronic inflammation to cancer promotion and progression
    • Esteban, F.; González-Moles, M.A.; Castro, D.; Martín-Jaén, M.M.; Redondo, M.; Ruíz-Avila, I.; Muñoz, M. Expression of substance P and neurokinin-1-receptor in laryngeal cancer: linking chronic inflammation to cancer promotion and progression. Histopathology, 2009, 54, 258-260
    • (2009) Histopathology , vol.54 , pp. 258-260
    • Esteban, F.1    González-Moles, M.A.2    Castro, D.3    Martín-Jaén, M.M.4    Redondo, M.5    Ruíz-Avila, I.6    Muñoz, M.7
  • 68
    • 0022929837 scopus 로고
    • Binding characteristics and affinity labeling of protein constituents of the human IM-9 lymphoblast receptor for substance P
    • Payan, D.G.; McGillis, J.P.; Organist, M.L. Binding characteristics and affinity labeling of protein constituents of the human IM-9 lymphoblast receptor for substance P. J. Biol. Chem., 1986, 261, 14321-14329
    • (1986) J. Biol. Chem. , vol.261 , pp. 14321-14329
    • Payan, D.G.1    McGillis, J.P.2    Organist, M.L.3
  • 71
    • 73349109802 scopus 로고    scopus 로고
    • Why cerebellar glioblastoma is rare and how that indicates adjunctive use of the FDA-approved anti-emetic aprepitant might retard cerebral glioblatoma growth: A new hypothesis to an old question
    • Kast, R.E. Why cerebellar glioblastoma is rare and how that indicates adjunctive use of the FDA-approved anti-emetic aprepitant might retard cerebral glioblatoma growth: a new hypothesis to an old question. Clin. Transl. Oncol., 2009, 11, 408-410
    • (2009) Clin. Transl. Oncol. , vol.11 , pp. 408-410
    • Kast, R.E.1
  • 72
    • 0028176931 scopus 로고
    • 1 receptors in human IM9 and U373 MG cells, using antagonist (FK888, (+/-)-CP-96,345, and RP 67580) binding
    • Goso, C.; Potier, E.; Manzini, S.; Szallasi, A. Comparison of tachykinin NK1 receptors in human IM9 and U373 MG cells, using antagonist (FK888, (+/-)-CP-96,345, and RP 67580) binding. Eur. J. Pharmacol., 1994, 254, 221-227 (Pubitemid 24098557)
    • (1994) European Journal of Pharmacology , vol.254 , Issue.3 , pp. 221-227
    • Goso, C.1    Potier, E.2    Manzini, S.3    Szallasi, A.4
  • 75
    • 0023872006 scopus 로고
    • Processing of the human IM-9 lymphoblast substance P receptor. Biosynthetic and degradation studies using a monoclonal anti-receptor antibody
    • Organist, M.L.; Harvey, J.P.; McGillis, J.P.; Payan, D.G. Processing of the human IM-9 lymphoblast substance P receptor. Biosynthetic and degradation studies using a monoclonal anti-receptor antibody. Biochem. Biophys. Res. Commun., 1988, 151, 535-541
    • (1988) Biochem. Biophys. Res. Commun. , vol.151 , pp. 535-541
    • Organist, M.L.1    Harvey, J.P.2    McGillis, J.P.3    Payan, D.G.4
  • 76
    • 0030176186 scopus 로고    scopus 로고
    • Recognition of neurokinin 1 receptor (NK1-R): An antibody to a peptide sequence from the third extracellular region binds to brain NK1-R
    • van Ginkel, F.W.; Pascual, D.W. Recognition of neurokinin 1 receptor (NK1-R): an antibody to a peptide sequence from the third extracellular region binds to brain NK1-R. J. Neuroimmunol., 1996, 67, 49-58.
    • (1996) J. Neuroimmunol. , vol.67 , pp. 49-58
    • Van Ginkel, F.W.1    Pascual, D.W.2
  • 77
    • 0023788933 scopus 로고
    • Apparent molecular weight of the substance P binding site in rat brain
    • Nakata, Y.; Hiraoka, C.; Segawa, T. Apparent molecular weight of the substance P binding site in rat brain. Eur. J. Pharmacol., 1988, 152, 171-174
    • (1988) Eur. J. Pharmacol. , vol.152 , pp. 171-174
    • Nakata, Y.1    Hiraoka, C.2    Segawa, T.3
  • 79
    • 0026795882 scopus 로고
    • Direct linkage of three tachykinin receptors to stimulation of both phosphatidylinositol hydrolysis and cAMP cascades in transfected Chinese hamster ovary cells
    • Nakajima, Y.; Tsuchida, K.; Negishi, M.; Ito, S.; Nakanishi, S. Direct linkage of three tachykinin receptors to stimulation of both phosphatidylinositol hydrolysis and cAMP cascades in transfected Chinese hamster ovary cells. J. Biol. Chem., 1992, 267, 2437-2442
    • (1992) J. Biol. Chem. , vol.267 , pp. 2437-2442
    • Nakajima, Y.1    Tsuchida, K.2    Negishi, M.3    Ito, S.4    Nakanishi, S.5
  • 80
    • 0026683453 scopus 로고
    • Ligand binding kinetics of substance P and neurokinin a receptors stably expressed in Chinese hamster ovary cells and evidence for differential stimulation of inositol 1, 4, 5-triphosphate and cyclic AMP second messenger responses
    • Takeda, Y.; Blount, P.; Sachais, B.S.; Hershey, A.D.; Raddatz, R.; Krause, J.E. Ligand binding kinetics of substance P and neurokinin A receptors stably expressed in Chinese hamster ovary cells and evidence for differential stimulation of inositol 1, 4, 5-triphosphate and cyclic AMP second messenger responses. J. Neurochem., 1992, 59, 740-745
    • (1992) J. Neurochem. , vol.59 , pp. 740-745
    • Takeda, Y.1    Blount, P.2    Sachais, B.S.3    Hershey, A.D.4    Raddatz, R.5    Krause, J.E.6
  • 81
    • 0027318274 scopus 로고
    • Thapsigargin blocks the mobilization of intracellular calcium caused by activation of human NK1 (long) receptors expressed in Chinese hamster ovary cells
    • Seabrook, G.R.; Fong, T.M. Thapsigargin blocks the mobilization of intracellular calcium caused by activation of human NK1 (long) receptors expressed in Chinese hamster ovary cells. Neurosci. Lett., 1993, 152, 9-12.
    • (1993) Neurosci. Lett. , vol.152 , pp. 9-12
    • Seabrook, G.R.1    Fong, T.M.2
  • 82
    • 0027961056 scopus 로고
    • Multiple mechanisms of arachidonic acid release in Chinese hamster ovary cells transfected with cDNA of substance P receptor
    • DOI 10.1016/0006-2952(94)90459-6
    • García, M.; Sakamoto, K.; Shigekawa, M.; Nakanishi, S.; Ito, S. Multiple mechanisms of arachidonic acid release in Chinese hamster ovary cells transfected with cDNA of substance P receptor. Biochem. Pharmacol., 1994, 48, 1735-1741 (Pubitemid 24338999)
    • (1994) Biochemical Pharmacology , vol.48 , Issue.9 , pp. 1735-1741
    • Garcia, M.1    Sakamoto, K.2    Shigekawa, M.3    Nakanishi, S.4    Ito, S.5
  • 83
    • 0028291775 scopus 로고
    • Characterization of the substance P receptor-mediated calcium influx in cDNA transfected Chinese hamster ovary cells
    • Mochizuki-Oda, N.; Nakajima, Y.; Nakanishi, S.; Ito, S. Characterization of the substance P receptor-mediated calcium influx in cDNA transfected Chinese hamster ovary cells. J. Biol. Chem., 1994; 269, 9651-9658
    • (1994) J. Biol. Chem. , vol.269 , pp. 9651-9658
    • Mochizuki-Oda, N.1    Nakajima, Y.2    Nakanishi, S.3    Ito, S.4
  • 85
    • 0034714292 scopus 로고    scopus 로고
    • Epidermal growth factor receptor transactivation mediates substance Pinduced mitogenic responses in U-373 MG cells
    • Castagliuolo I., Valenick L., Liu J.; Pothoulakis C. Epidermal growth factor receptor transactivation mediates substance Pinduced mitogenic responses in U-373 MG cells. J. Biol. Chem., 2000, 275, 26545-26550
    • (2000) J. Biol. Chem. , vol.275 , pp. 26545-26550
    • Castagliuolo, I.1    Valenick, L.2    Liu, J.3    Pothoulakis, C.4
  • 86
    • 0030860466 scopus 로고    scopus 로고
    • Transforming activity and mitosisrelated expression of the AKT2 oncogene: Evidence suggesting a link between cell cycle regulation and oncogenesis
    • Cheng, J.Q.; Altomare, D.A.; Klein, M.A.; Lee, W.C.; Kruh, G.D.; Lissy, N.A.; Testa, J.R. Transforming activity and mitosisrelated expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis. Oncogene, 1997, 14, 2793-2801
    • (1997) Oncogene , vol.14 , pp. 2793-2801
    • Cheng, J.Q.1    Altomare, D.A.2    Klein, M.A.3    Lee, W.C.4    Kruh, G.D.5    Lissy, N.A.6    Testa, J.R.7
  • 89
    • 0027989702 scopus 로고
    • Agonist induced internalization of the substance P (NK1) receptor expressed in epithelial cells
    • Garlan, A.M.; Grady, E.F.; Payan, D.G.; Vigna, S.R.; Bunnett, N.W. Agonist induced internalization of the substance P (NK1) receptor expressed in epithelial cells. Biochem. J., 1994, 303, 177-186
    • (1994) Biochem. J. , vol.303 , pp. 177-186
    • Garlan, A.M.1    Grady, E.F.2    Payan, D.G.3    Vigna, S.R.4    Bunnett, N.W.5
  • 90
    • 0029071430 scopus 로고
    • Delineation of the endocytic pathway of substance P and its seven transmembrane domains NK1 receptor
    • Grady, E.F.; Garland, A.M.; Gamp, P.D.; Lovett, M.; Payan, D.G.; Bunnett, N.W. Delineation of the endocytic pathway of substance P and its seven transmembrane domains NK1 receptor. Mol. Biol. Cell., 1995, 6, 509-524
    • (1995) Mol. Biol. Cell. , vol.6 , pp. 509-524
    • Grady, E.F.1    Garland, A.M.2    Gamp, P.D.3    Lovett, M.4    Payan, D.G.5    Bunnett, N.W.6
  • 92
    • 0000186799 scopus 로고    scopus 로고
    • Substance K peptide induces mitogenesis by activating the mitogen-activated protein kinase signalling pathway through the substance P receptor (NK-1 subtype) in human astrocytoma
    • Sharif, T.R.; Luo, W.; Houghron, P.J.; Sharif, M. Substance K peptide induces mitogenesis by activating the mitogen-activated protein kinase signalling pathway through the substance P receptor (NK-1 subtype) in human astrocytoma. Cell Pharmacol., 1996, 3, 441-449
    • (1996) Cell Pharmacol. , vol.3 , pp. 441-449
    • Sharif, T.R.1    Luo, W.2    Houghron, P.J.3    Sharif, M.4
  • 95
    • 0029767698 scopus 로고    scopus 로고
    • Signalling patways mediating secretory and mitogenic responses to galanin and pituitary adenylate cyclaseactivating polypeptide in the 235-1 clonal rat lactotroph cell line
    • Hammond, P.J.; Smith, D.M.; Akinsanya, K.O.; Mufti, W.A.; Wynick, D.; Bloom, S.R. Signalling patways mediating secretory and mitogenic responses to galanin and pituitary adenylate cyclaseactivating polypeptide in the 235-1 clonal rat lactotroph cell line. J. Neuroendocrinol., 1996, 8, 457-464
    • (1996) J. Neuroendocrinol. , vol.8 , pp. 457-464
    • Hammond, P.J.1    Smith, D.M.2    Akinsanya, K.O.3    Mufti, W.A.4    Wynick, D.5    Bloom, S.R.6
  • 96
    • 0024371378 scopus 로고
    • Functional substance P receptors on a human astrocytoma cell line (U-373 MG)
    • DOI 10.1016/0006-8993(89)90724-5
    • Lee, C.M.; Kum, W.; Cockram, C.S.; Teoh, R.; Young, J.D. Functional substance P receptors on a human astrocytoma cell line (U-373 MG). Brain Res., 1989, 488, 328-331 (Pubitemid 19136818)
    • (1989) Brain Research , vol.488 , Issue.1-2 , pp. 328-331
    • Lee, C.-M.1    Kum, W.2    Cockram, C.S.3    Teoh, R.4    Young, J.D.5
  • 97
    • 0026677964 scopus 로고
    • Functional characterization of neurokinin-1 receptors on human U373MG astrocytoma cells
    • Eistetter, H.R.; Mills, A.; Brewster, R.; Alouani, S.; Rambosson, C.; Kawashima, E. Functional characterization of neurokinin-1 receptors on human U373MG astrocytoma cells. Glia, 1992, 6, 89-95.
    • (1992) Glia , vol.6 , pp. 89-95
    • Eistetter, H.R.1    Mills, A.2    Brewster, R.3    Alouani, S.4    Rambosson, C.5    Kawashima, E.6
  • 98
    • 0034718604 scopus 로고    scopus 로고
    • The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta-arrestindependent scaffolding complex
    • DeFea, K.A.; Vaughn, Z.D.; O'Bryan, E.M.; Nishijima, D.; Dery, O.; Bunnett, N.W: The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta-arrestindependent scaffolding complex. Proc. Natl. Acad. Sci. USA, 2000, 97, 11086-11091
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11086-11091
    • DeFea, K.A.1    Vaughn, Z.D.2    O'Bryan, E.M.3    Nishijima, D.4    Dery, O.5    Bunnett, N.W.6
  • 99
    • 0025092876 scopus 로고
    • Substance P stimulates neovascularization in vivo and proliferation of cultured endothelial cells
    • DOI 10.1016/0026-2862(90)90024-L
    • Ziche, M.; Morbidelli, L.; Pacini, M.; Geppetti, P.; Alessandri, G.; Maggi, C.A. Substance P stimulates neovascularization in vivo and proliferation of cultured endothelial cells. Microvasc. Res., 1990, 40, 264-278 (Pubitemid 20327679)
    • (1990) Microvascular Research , vol.40 , Issue.2 , pp. 264-278
    • Ziche, M.1    Morbidelli, L.2    Pacini, M.3    Geppetti, P.4    Alessandri, G.5    Maggi, C.A.6
  • 100
    • 0029870954 scopus 로고    scopus 로고
    • The war on cancer
    • Sporn, M.B. The war on cancer. Lancet, 1996, 347, 1377-1381
    • (1996) Lancet , vol.347 , pp. 1377-1381
    • Sporn, M.B.1
  • 102
    • 4544321026 scopus 로고    scopus 로고
    • Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs
    • DOI 10.1002/ijc.20410
    • Lang, K.; Drell, T.L.; Lindecke, A.; Niggemann, B.; Kaltschmidt, C.; Zaenker, K.S.; Entschladen, F. Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs. Int. J. Cancer, 2004, 112, 231-238 (Pubitemid 39244363)
    • (2004) International Journal of Cancer , vol.112 , Issue.2 , pp. 231-238
    • Lang, K.1    Drell IV, T.L.2    Lindecke, A.3    Niggemann, B.4    Kaltschmidt, C.5    Zaenker, K.S.6    Entschladen, F.7
  • 103
    • 0043195904 scopus 로고    scopus 로고
    • Antagonists at the neurokinin receptors - Recent patent literature
    • Giardina, G.A.M.; Gagliardi, S.; Martinelli, M. Antagonists at the neurokinin receptors-recent patent literature. Drugs, 2003, 6, 758-772 (Pubitemid 37086786)
    • (2003) IDrugs , vol.6 , Issue.8 , pp. 758-772
    • Giardina, G.A.M.1    Gagliardi, S.2    Martinelli, M.3
  • 104
  • 105
    • 33747193244 scopus 로고    scopus 로고
    • Tachykinin receptors antagonists: From research to clinic
    • DOI 10.2174/138945006778019381
    • Quartara, L.; Altamura, M. Tachykinin receptors antagonists: from research to clinic. Curr. Drug Targets, 2006, 7, 975-992 (Pubitemid 44227581)
    • (2006) Current Drug Targets , vol.7 , Issue.8 , pp. 975-992
    • Quartara, L.1    Altamura, M.2
  • 107
    • 0027997928 scopus 로고
    • Piperidineether based hNK1 antagonists 1: Determination of the relative and absolute stereochemical requirements
    • Harrison, T.; Williams, B.J.; Swain, C.J.; Ball, R.G. Piperidineether based hNK1 antagonists 1: determination of the relative and absolute stereochemical requirements. Biomed. Chem. Lett., 1994, 4, 2545-2550
    • (1994) Biomed. Chem. Lett. , vol.4 , pp. 2545-2550
    • Harrison, T.1    Williams, B.J.2    Swain, C.J.3    Ball, R.G.4
  • 108
    • 0034057760 scopus 로고    scopus 로고
    • 1) receptors attenuates neonatal vocalisation in guinea-pigs and mice
    • DOI 10.1016/S0028-3908(00)00052-6, PII S0028390800000526
    • Rupniak, N.M.; Carlson, E.C.; Harrison, T.; Oates, B.; Seward, E.; Owen, S.; de Felipe, C.; Hunt, S.; Wheeldon, A. Pharmacological blockade or genetic deletion of substance P (NK(1)) receptors attenuates neonatal vocalisation in guinea-pigs and mice. Neuropharmacology, 2000, 39, 1413-1421 (Pubitemid 30249203)
    • (2000) Neuropharmacology , vol.39 , Issue.8 , pp. 1413-1421
    • Rupniak, N.M.J.1    Carlson, E.C.2    Harrison, T.3    Oates, B.4    Seward, E.5    Owen, S.6    De Felipe, C.7    Hunt, S.8    Wheeldon, A.9
  • 109
    • 0141707706 scopus 로고    scopus 로고
    • Medicinal chemistry of selective neurokinin-1 antagonists
    • Humphrey, J.M. Medicinal chemistry of selective neurokinin-1 antagonists. Curr. Top. Med. Chem., 2003, 3, 1423-1435
    • (2003) Curr. Top. Med. Chem. , vol.3 , pp. 1423-1435
    • Humphrey, J.M.1
  • 111
    • 39549115523 scopus 로고    scopus 로고
    • Fosaprepitant (MK-0517): A neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting
    • DOI 10.1517/13543784.16.12.1977
    • Navari, R.M. Fosaprepitant (MK-0517): a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting. Expert Opin. Invest. Drug, 2007, 16, 1977-1985 (Pubitemid 351403728)
    • (2007) Expert Opinion on Investigational Drugs , vol.16 , Issue.12 , pp. 1977-1985
    • Navari, R.M.1
  • 114
    • 0036160387 scopus 로고    scopus 로고
    • Attenuation of hyperalgesia in a rat model of neuropathic pain after intrathecal pre- Or post-treatment with a neurokinin-1 antagonist
    • DOI 10.1016/S0304-3959(01)00410-9, PII S0304395901004109
    • Cahill, C.M.; Coderre, T.J. Attenuation of hyperalgesia in a rat model of neuropathic pain after intrathecal pre- or post-treatment with a neurokinin-1 antagonist. Pain, 2002, 95, 277-285 (Pubitemid 34142651)
    • (2002) Pain , vol.95 , Issue.3 , pp. 277-285
    • Cahill, C.M.1    Coderre, T.J.2
  • 115
    • 0024163078 scopus 로고
    • [D-Arg1-D-Phe5, D-Trp7, 9, Leu11] Substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro
    • Woll, P.J.; Rozengurt E. [D-Arg1-D-Phe5, D-Trp7, 9, Leu11] Substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro. Proc. Natl. Acad. Sci. USA., 1988, 35, 1859-1863
    • (1988) Proc. Natl. Acad. Sci. USA , vol.35 , pp. 1859-1863
    • Woll, P.J.1    Rozengurt, E.2
  • 116
    • 33646558897 scopus 로고    scopus 로고
    • A role for substance P in cancer promotion and progression: A mechanism to counteract intracellular death signals following oncogene activation or DNA damage
    • DOI 10.1007/s10555-006-8161-9, Metalloproteinases and Cancer
    • Esteban, F.; Muñoz, M.; González-Moles, M.A.; Rosso, M. A role for substance P in cancer promotion and progression: a mechanism to counteract intracellular death signals following oncogene activation or DNA damage. Cancer Metast. Rev., 2006, 25, 137-145 (Pubitemid 43723988)
    • (2006) Cancer and Metastasis Reviews , vol.25 , Issue.1 , pp. 137-145
    • Esteban, F.1    Munoz, M.2    Gonzalez-Moles, M.A.3    Rosso, M.4
  • 117
    • 0028174947 scopus 로고
    • [D-Arg1-D-Phe5, D-Trp7, 9, Leu11] Substance P induces apoptosis in lung cancer cell lines in vitro
    • Reeve, J.G.; Bleehen, N.M. [D-Arg1-D-Phe5, D-Trp7, 9, Leu11] Substance P induces apoptosis in lung cancer cell lines in vitro. Biochem. Bioph. Res. Commun., 1994, 199, 1313-1319
    • (1994) Biochem. Bioph. Res. Commun. , vol.199 , pp. 1313-1319
    • Reeve, J.G.1    Bleehen, N.M.2
  • 118
    • 0032413398 scopus 로고    scopus 로고
    • Induction of apoptosis by a short-chain neuropeptide analog in small cell lung cancer-stimulation of multiple neuropeptides and inhibition by broad spectrum antagonists in vitro and in vivo
    • Rosati, R.; Adil, M.R.; Ali, M.A.; Eliason, J.; Orosz, A.; Sebestye, N.F.; Kalemkerian, G.P. Induction of apoptosis by a short-chain neuropeptide analog in small cell lung cancer-stimulation of multiple neuropeptides and inhibition by broad spectrum antagonists in vitro and in vivo. Peptides, 1998, 19, 1519-1523
    • (1998) Peptides , vol.19 , pp. 1519-1523
    • Rosati, R.1    Adil, M.R.2    Ali, M.A.3    Eliason, J.4    Orosz, A.5    Sebestye, N.F.6    Kalemkerian, G.P.7
  • 120
    • 16844365620 scopus 로고    scopus 로고
    • 11]SP: A dual inhibitor of growth and angiogenesis in pancreatic cancer
    • DOI 10.1158/0008-5472.CAN-04-3197
    • Guha, S.; Eibl, G.; Kisfalvi, K.; Fan, R.S.; Burdick, M.; Reber, H.; Hines, O.J.; Strieter, R.; Rozengurt, E. Broad-spectrum G protein- coupled receptor antagonist, [D-Arg1,DTrp5,7,9,Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer. Cancer Res., 2005; 65, 2738-2745 (Pubitemid 40490075)
    • (2005) Cancer Research , vol.65 , Issue.7 , pp. 2738-2745
    • Guha, S.1    Eibl, G.2    Kisfalvi, K.3    Fan, R.S.4    Burdick, M.5    Reber, H.6    Hines, O.J.7    Strieter, R.8    Rozengurt, E.9
  • 121
    • 33749165919 scopus 로고    scopus 로고
    • Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis?
    • Exadaktylos, A.K.; Buggy, D.J.; Moriarty, D.C.; Mascha, E.; Sessler, D.I. Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis? Anesthesiology, 2006, 105, 660-664
    • (2006) Anesthesiology , vol.105 , pp. 660-664
    • Exadaktylos, A.K.1    Buggy, D.J.2    Moriarty, D.C.3    Mascha, E.4    Sessler, D.I.5
  • 122
    • 0036171973 scopus 로고    scopus 로고
    • Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model
    • Bolay, H.; Reuter, U.; Dunn, A.K.; Huang, Z.; Boas, D,A.; Moskowitz, M.A. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat. Med., 2002, 8, 136-142
    • (2002) Nat. Med. , vol.8 , pp. 136-142
    • Bolay, H.1    Reuter, U.2    Dunn, A.K.3    Huang, Z.4    Boas, D.5    Moskowitz, M.A.6
  • 123
    • 0033774032 scopus 로고    scopus 로고
    • Potential of substance P antagonists as antiemetics
    • Diemunsch, P.; Grelot, L. Potential of substance P antagonists as antiemetics. Drugs, 2000, 60, 533-546
    • (2000) Drugs , vol.60 , pp. 533-546
    • Diemunsch, P.1    Grelot, L.2
  • 124
    • 0036829194 scopus 로고    scopus 로고
    • Neurokinin-1 (NK-1) receptor antagonists abrogate methamphetamine-induced striatal dopaminergic neurotoxicity in the murine brain
    • Yu, J.; Cadet, J.L.; Angulo, J.A. Neurokinin-1 (NK-1) receptor antagonists abrogate methamphetamine-induced striatal dopaminergic neurotoxicity in the murine brain. J. Neurochem., 2002, 83, 613-622
    • (2002) J. Neurochem. , vol.83 , pp. 613-622
    • Yu, J.1    Cadet, J.L.2    Angulo, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.