Enhancing hepatic glycolysis reduces obesity: Differential effects on lipogenesis depend on site of glycolytic modulation

Cell Metabolism

Volumn 2, Issue 2, 2005, Pages 131-140

  Wu, Chaodong ^a   Kang, Johnthomas E ^a   Peng, Li Jen ^a   Li, Honggui ^a   Khan, Salmaan A ^a   Hillard, Christopher J ^a   Okar, David A ^b   Lange, Alex J ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; CARBOHYDRATE BINDING PROTEIN; FATTY ACID; FRUCTOSE 2,6 BISPHOSPHATASE; GLUCOKINASE; GLUCOSE; GLYCOGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; NEUROPEPTIDE Y;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; ENERGY BALANCE; ENERGY EXPENDITURE; FATTY ACID OXIDATION; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; GLYCOLYSIS; INSULIN BLOOD LEVEL; LIPID METABOLISM; LIPOGENESIS; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE; WEIGHT REDUCTION; ADIPOSE TISSUE; ANIMAL; BLOOD; BODY WEIGHT; CELL CULTURE; CYTOLOGY; EATING; ENERGY METABOLISM; GENETICS; HOMEOSTASIS; LIVER CELL; METABOLISM; MOUSE STRAIN; RAT;

ANIMALIA;

ADIPOSE TISSUE; ANIMALS; BODY WEIGHT; CELLS, CULTURED; EATING; ENERGY METABOLISM; GLUCOKINASE; GLUCOSE; GLYCOLYSIS; HEPATOCYTES; HOMEOSTASIS; INSULIN; LIPID METABOLISM; MALE; MICE; MICE, INBRED STRAINS; OBESITY; PHOSPHOFRUCTOKINASE-2; RATS;

EID: 25144466481     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2005.07.003     Document Type: Article

References (51)

1. L. Abu-Elheiga M.M. Matzuk K.A. Abo-Hashema S.J. Wakil Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2 Science 291 2001 2613-2616
2. R.A. Baar C.S. Dingfelder L.A. Smith D.A. Bernlohr C. Wu A.J. Lange E.J. Parks Investigation of in vivo fatty acid metabolism in AFABP/aP2-/- mice Am. J. Physiol. Endocrinol. Metab. 288 2004 E187-E193
3. L.L. Baggio Q. Huang T.J. Brown D.J. Drucker Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure Gastroenterology 127 2004 546-558
4. N. Barzilai L. She L. Liu J. Wang M. Hu P. Vuguin L. Rossetti Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action Am. J. Physiol. 277 1999 E291-E298
5. P.N. Bavenholm J. Pigon A.K. Saha N.B. Ruderman S. Efendic Fatty acid oxidation and the regulation of malonyl-CoA in human muscle Diabetes 49 2000 1078-1083
6. D. Becard I. Hainault D. Azzout-Marniche L. Bertry-Coussot P. Ferre F. Foufelle Adenovirus-mediated overexpression of sterol regulatory element binding protein-1c mimics insulin effects on hepatic gene expression and glucose homeostasis in diabetic mice Diabetes 50 2001 2425-2430
7. G. Bouchard D. Johnson T. Carver B. Paigen M.C. Carey Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk J. Lipid Res. 43 2002 1105-1113
8. Y. Chen M.L. Heiman Increased weight gain after ovariectomy is not a consequence of leptin resistance Am. J. Physiol. Endocrinol. Metab. 280 2001 E315-E322
9. D. Chien D. Dean A.K. Saha J.P. Flatt N.B. Ruderman Malonyl-CoA content and fatty acid oxidation in rat muscle and liver in vivo Am. J. Physiol. Endocrinol. Metab. 279 2000 E259-E265
10. P. Cohen M. Miyazaki N.D. Socci A. Hagge-Greenberg W. Liedtke A.A. Soukas R. Sharma L.C. Hudgins J.M. Ntambi J.M. Friedman Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss Science 297 2002 240-243
11. J.S. Flier Obesity wars: Molecular progress confronts an expanding epidemic Cell 116 2004 337-350
12. J.M. Friedman Modern science versus the stigma of obesity Nat. Med. 10 2004 563-569
13. P.J. Havel Peripheral signals conveying metabolic information to the brain: Short-term and long-term regulation of food intake and energy homeostasis Exp. Biol. Med. 226 2001 963-977
14. M. Igel B.A. Taylor S.J. Phillips W. Becker L. Herberg H.G. Joost Hyperleptinemia and leptin receptor variant Asp600Asn in the obese, hyperinsulinemic KK mouse strain J. Mol. Endocrinol. 21 1998 337-345
15. E. Jequier Leptin signaling, adiposity, and energy balance Ann. NY Acad. Sci. 967 2002 379-388
16. G. Jiang Z. Li F. Liu K. Ellsworth Q. Dallas-Yang M. Wu J. Ronan C. Esau C. Murphy D. Szalkowski et. al. Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1 J. Clin. Invest. 115 2005 1030-1038
17. T. Kabashima T. Kawaguchi B.E. Wadzinski K. Uyeda Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver Proc. Natl. Acad. Sci. USA 100 2003 5107-5112
18. B.B. Kahn T. Alquier D. Carling D.G. Hardie AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism Cell Metab. 1 2005 15-25
19. F.C. Kauffman J.G. Brown J.V. Passonneau O.H. Lowry Effects of changes in brain metabolism on levels of pentose phosphate pathway intermediates J. Biol. Chem. 244 1969 3647-3653
20. T. Kawaguchi K. Osatomi H. Yamashita T. Kabashima K. Uyeda Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase J. Biol. Chem. 277 2002 3829-3835
21. R. Koishi Y. Ando M. Ono M. Shimamura H. Yasumo T. Fujiwara H. Horikoshi H. Furukawa Angptl3 regulates lipid metabolism in mice Nat. Genet. 30 2002 151-157
22. P.J. Larsen C. Fledelius L.B. Knudsen M. Tang-Christensen Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats Diabetes 50 2001 2530-2539
23. Y. Minokoshi T. Alquier N. Furukawa Y.B. Kim A. Lee B. Xue J. Mu F. Foufelle P. Ferre M.J. Birnbaum et. al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus Nature 428 2004 569-574
24. E.D. Muse S. Obici S. Bhanot B.P. Monia R.A. McKay M.W. Rajala P.E. Scherer L. Rossetti Role of resistin in diet-induced hepatic insulin resistance J. Clin. Invest. 114 2004 232-239
25. I. Nagase T. Yoshida K. Kumamoto T. Umekawa N. Sakane H. Nikami T. Kawada M. Saito Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist J. Clin. Invest. 97 1996 2898-2904
26. R.C. Nordlie J.D. Foster A.J. Lange Regulation of glucose production by the liver Annu. Rev. Nutr. 19 1999 379-406
27. R.M. O'Doherty D.L. Lehman S. Telemaque-Potts C.B. Newgard Metabolic impact of glucokinase overexpression in liver: Lowering of blood glucose in fed rats is accompanied by hyperlipidemia Diabetes 48 1999 2022-2027
28. M.M. Ollmann B.D. Wilson Y.K. Yang J.A. Kerns Y. Chen I. Gantz G.S. Barsh Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein Science 278 1997 135-138
29. G. Perseghin Pathogenesis of obesity and diabetes mellitus: Insights provided by indirect calorimetry in humans Acta Diabetol. 38 2001 7-21
30. A. Pocai S. Obici G.J. Schwartz L. Rossetti A brain-liver circuit regulates glucose homeostasis Cell Metab. 1 2005 53-61
31. J. Ran T. Hirano M. Adachi Chronic ANG II infusion increases plasma triglyceride level by stimulating hepatic triglyceride production in rats Am. J. Physiol. Endocrinol. Metab. 287 2004 E955-E961
32. B.B. Rasmussen U.C. Holmback E. Volpi B. Morio-Liondore D. Paddon-Jones R.R. Wolfe Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle J. Clin. Invest. 110 2002 1687-1693
33. G.M. Reaven Pathophysiology of insulin resistance in human disease Physiol. Rev. 75 1995 473-486
34. S. Reitman S. Frankel A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases Am. J. Clin. Pathol. 28 1957 56-63
35. L. Rossetti A. Giaccari Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal and diabetic rats J. Clin. Invest. 85 1990 1785-1792
36. L. Rossetti A.E. Stenbit C. Wei M. Hu N. Barzilai E.B. Katz M.J. Charron Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene J. Clin. Invest. 100 1997 1831-1839
37. N.B. Ruderman A.K. Saha E.W. Kraegen Minireview: Malonyl CoA, AMP-activated protein kinase, and adiposity Endocrinology 144 2003 5166-5171
38. L.S. Sidossis R.R. Wolfe Glucose and insulin-induced inhibition of fatty acid oxidation: The glucose-fatty acid cycle reversed Am. J. Physiol. 270 1996 E733-E738
39. B.M. Spiegelman J.S. Flier Obesity and the regulation of energy balance Cell 104 2001 531-543
40. A.K. Stoeckman H.C. Towle The role of SREBP-1c in nutritional regulation of lipogenic enzymes gene expression J. Biol. Chem. 277 2002 27029-27035
41. M. Stumvoll S. Jacob H.G. Wahl B. Hauer K. Loblein P. Grauer R. Becker M. Nielsen W. Renn H. Haring Suppression of systemic, intramuscular, and subcutaneous adipose tissue lipolysis by insulin in humans J. Clin. Endocrinol. Metab. 85 2000 3740-3745
42. E. Tomlinson L. Fu L. John B. Hultgren X. Huang M. Renz J.P. Stephan S.P. Tsai L. Powell-Braxton D. French T.A. Stewart Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity Endocrinology 143 2002 1741-1747
43. H.C. Towle E.N. Kaytor H.-M. Shih Regulation of expression of lipogenic enzyme genes by carbohydrate Annu. Rev. Nutr. 17 1997 405-433
44. K. Uyeda H. Yamashita T. Kawaguchi Carbohydrate responsive element-binding protein (ChREBP): A key regulator of glucose metabolism and fat storage Biochem. Pharmacol. 63 2002 2075-2080
45. J.P. Wilding S.G. Gilbey C.J. Bailey R.A. Batt G. Williams M.A. Ghatei S.R. Bloom Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse Endocrinology 132 1993 1939-1944
46. G. Williams J.A. Harrold D.J. Cutler The hypothalamus and the regulation of energy homeostasis: Lifting the lid on a black box Proc. Nutr. Soc. 59 2000 385-396
47. C. Wu D.A. Okar C.B. Newgard A.J. Lange Overexpression of 6-phosphofructo-2- kinase/fructose- 2,6-bisphosphatase in mouse liver lowers blood glucose by suppression of hepatic glucose production J. Clin. Invest. 107 2001 91-98
48. C. Wu D.A. Okar A.K. Stoeckman L. Peng A.H. Herrera J.E. Herrera H.C. Towle A.J. Lange A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression Endocrinology 145 2004 650-658
49. C. Wu D.A. Okar J. Kang A.J. Lange Reduction of hepatic glucose production as a therapeutic target in the treatment of diabetes Curr. Drug Targets Immune Endocr. Metabol. Disord. 5 2005 51-59
50. A. Xu Y. Wang H. Keshaw L.Y. Xu K.S. Lam G.J. Cooper The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice J. Clin. Invest. 112 2003 91-100
51. X.X. Yu J.K. Drackley J. Odle Rates of mitochondrial and peroxisomal beta-oxidation of palmitate change during postnatal development and food deprivation in liver, kidney and heart of pigs J. Nutr. 127 1997 1814-1821