메뉴 건너뛰기




Volumn 92, Issue 7, 2014, Pages 615-626

White, brite, and brown adipocytes: The evolution and function of a heater organ in mammals1

Author keywords

Adipocytes; Brite; Brown; Evolution; Fat; Ucp1; White

Indexed keywords

ADULT; BODY SHAPE; BODY TEMPERATURE; FAT; FATTY ACID; JUVENILE; MARSUPIAL; METABOLITE; NUTRIENT; OXYGEN CONSUMPTION; PHYLOGENY; PROTEIN; SUBSTITUTION;

EID: 84903315596     PISSN: 00084301     EISSN: 14803283     Source Type: Journal    
DOI: 10.1139/cjz-2013-0165     Document Type: Review
Times cited : (21)

References (142)
  • 2
    • 33847768085 scopus 로고    scopus 로고
    • Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice
    • doi:10.1073/pnas.0610416104. PMID:17283342
    • Almind, K., Manieri, M., Sivitz, W.I., Cinti, S., and Kahn, C.R. 2007. Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proc. Natl. Acad. Sci. U.S.A. 104(7): 2366-2371. doi:10.1073/pnas.0610416104. PMID:17283342.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , Issue.7 , pp. 2366-2371
    • Almind, K.1    Manieri, M.2    Sivitz, W.I.3    Cinti, S.4    Kahn, C.R.5
  • 3
    • 0023266408 scopus 로고
    • Immunological, histological and biochemical assessment of brown adipose tissue activity in neonatal, control and beta-stimulant-treated adult dogs
    • PMID:2889691
    • Ashwell, M., Stirling, D., Freeman, S., and Holloway, B.R. 1987. Immunological, histological and biochemical assessment of brown adipose tissue activity in neonatal, control and beta-stimulant-treated adult dogs. Int. J. Obes. 11(4): 357-365. PMID:2889691.
    • (1987) Int. J. Obes. , vol.11 , Issue.4 , pp. 357-365
    • Ashwell, M.1    Stirling, D.2    Freeman, S.3    Holloway, B.R.4
  • 4
    • 77952623888 scopus 로고    scopus 로고
    • The emergence of coldinduced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation
    • doi:10.1152/ajpendo.00600.2009
    • Barbatelli, G., Murano, I., Madsen, L., Hao, Q., Jimenez, M., Kristiansen, K., Giacobino, J.P., De Matteis, R., and Cinti, S. 2010. The emergence of coldinduced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. Am. J. Physiol. Endocrinol. Metab. 298(6): E1244-E1253. doi:10.1152/ajpendo.00600.2009.
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.298 , Issue.6
    • Barbatelli, G.1    Murano, I.2    Madsen, L.3    Hao, Q.4    Jimenez, M.5    Kristiansen, K.6    Giacobino, J.P.7    De Matteis, R.8    Cinti, S.9
  • 5
    • 0022559279 scopus 로고
    • Multilocular adipocytes from muscovy ducklings differentiated in response to cold acclimation
    • PMID:3795059
    • Barre, H., Cohen-Adad, F., Duchamp, C., and Rouanet, J.L. 1986. Multilocular adipocytes from muscovy ducklings differentiated in response to cold acclimation. J. Physiol. (Lond.), 375: 27-38. PMID:3795059.
    • (1986) J. Physiol. (Lond.) , vol.375 , pp. 27-38
    • Barre, H.1    Cohen-Adad, F.2    Duchamp, C.3    Rouanet, J.L.4
  • 6
    • 84863229962 scopus 로고    scopus 로고
    • Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
    • doi:10.1172/JCI59701. PMID:22307324
    • Bordicchia, M., Liu, D., Amri, E.-Z., Ailhaud, G., Dessì-Fulgheri, P., Zhang, C., Takahashi, N., Sarzani, R., and Collins, S. 2012. Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. J. Clin. Invest. 122(3): 1022-1036. doi:10.1172/JCI59701. PMID:22307324.
    • (2012) J. Clin. Invest. , vol.122 , Issue.3 , pp. 1022-1036
    • Bordicchia, M.1    Liu, D.2    Amri, E.-Z.3    Ailhaud, G.4    Dessì-Fulgheri, P.5    Zhang, C.6    Takahashi, N.7    Sarzani, R.8    Collins, S.9
  • 7
    • 0035174486 scopus 로고    scopus 로고
    • Mitochondrial uncoupling proteins in mammals and plants
    • doi:10.1023/A: 1013604526175. PMID:11725869
    • Borecký, J., Maia, I.G., and Arruda, P. 2001. Mitochondrial uncoupling proteins in mammals and plants. Biosci. Rep. 21(2): 201-212. doi:10.1023/A: 1013604526175. PMID:11725869.
    • (2001) Biosci. Rep. , vol.21 , Issue.2 , pp. 201-212
    • Borecký, J.1    Maia, I.G.2    Arruda, P.3
  • 10
    • 0025851174 scopus 로고
    • The mitochondrial uncoupling protein gene in brown fat: Correlation between DNase I hypersensitivity and expression in transgenic mice
    • PMID:1712903
    • Boyer, B.B., and Kozak, L.P. 1991. The mitochondrial uncoupling protein gene in brown fat: correlation between DNase I hypersensitivity and expression in transgenic mice. Mol. Cell. Biol. 11(8): 4147-4156. PMID:1712903.
    • (1991) Mol. Cell. Biol. , vol.11 , Issue.8 , pp. 4147-4156
    • Boyer, B.B.1    Kozak, L.P.2
  • 11
    • 36649015243 scopus 로고    scopus 로고
    • Thematic review series: Adipocyte biology. The perilipin family of structural lipid droplet proteins: Stabilization of lipid droplets and control of lipolysis
    • doi:10.1194/jlr.R700014-JLR200. PMID:17878492
    • Brasaemle, D.L. 2007. Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J. Lipid Res. 48(12): 2547-2559. doi:10.1194/jlr.R700014-JLR200. PMID:17878492.
    • (2007) J. Lipid Res. , vol.48 , Issue.12 , pp. 2547-2559
    • Brasaemle, D.L.1
  • 13
    • 10544239654 scopus 로고
    • Studies on rat adipose tissue in vitro. III. Synthesis of glycogen and glyceride glycerol
    • PMID:13806795
    • Cahill, G.F., Jr., Leboeuf, B., and Renold, A.E. 1959. Studies on rat adipose tissue in vitro. III. Synthesis of glycogen and glyceride glycerol. J. Biol. Chem. 234: 2540-2543. PMID:13806795.
    • (1959) J. Biol. Chem. , vol.234 , pp. 2540-2543
    • Cahill Jr., G.F.1    Leboeuf, B.2    Renold, A.E.3
  • 14
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • doi:10.1152/physrev.00015. 2003. PMID:14715917
    • Cannon, B., and Nedergaard, J. 2004. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84(1): 277-359. doi:10.1152/physrev.00015. 2003. PMID:14715917.
    • (2004) Physiol. Rev. , vol.84 , Issue.1 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 15
    • 1642293248 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene
    • doi:10.1128/MCB.24.7.3057-3067.2004. PMID:15024092
    • Cao, W., Daniel, K.W., Robidoux, J., Puigserver, P., Medvedev, A.V., Bai, X., Floering, L.M., Spiegelman, B.M., and Collins, S. 2004. p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol. Cell Biol. 24(7): 3057-3067. doi:10.1128/MCB.24.7.3057-3067.2004. PMID:15024092.
    • (2004) Mol. Cell Biol. , vol.24 , Issue.7 , pp. 3057-3067
    • Cao, W.1    Daniel, K.W.2    Robidoux, J.3    Puigserver, P.4    Medvedev, A.V.5    Bai, X.6    Floering, L.M.7    Spiegelman, B.M.8    Collins, S.9
  • 16
    • 0027300035 scopus 로고
    • Tissue-specific and β-adrenergic regulation of the mitochondrial uncoupling protein gene: Control by cis-acting elements in the 5′-flanking region
    • doi:10.1210/me.7.4.497. PMID:8388995
    • Cassard-Doulcier, A.M., Gelly, C., Fox, N., Schrementi, J., Raimbault, S., Klaus, S., Forest, C., Bouillaud, F., and Ricquier, D. 1993. Tissue-specific and β-adrenergic regulation of the mitochondrial uncoupling protein gene: control by cis-acting elements in the 5′-flanking region. Mol. Endocrinol. 7(4): 497-506. doi:10.1210/me.7.4.497. PMID:8388995.
    • (1993) Mol. Endocrinol. , vol.7 , Issue.4 , pp. 497-506
    • Cassard-Doulcier, A.M.1    Gelly, C.2    Fox, N.3    Schrementi, J.4    Raimbault, S.5    Klaus, S.6    Forest, C.7    Bouillaud, F.8    Ricquier, D.9
  • 17
    • 0032528252 scopus 로고    scopus 로고
    • A 211-bp enhancer of the rat uncoupling protein-1 (UCP-1) gene controls specific and regulated expression in brown adipose tissue
    • PMID:9657961
    • Cassard-Doulcier, A.M., Gelly, C., Bouillaud, F., and Ricquier, D. 1998. A 211-bp enhancer of the rat uncoupling protein-1 (UCP-1) gene controls specific and regulated expression in brown adipose tissue. Biochem. J. 333: 243-246. PMID:9657961.
    • (1998) Biochem. J. , vol.333 , pp. 243-246
    • Cassard-Doulcier, A.M.1    Gelly, C.2    Bouillaud, F.3    Ricquier, D.4
  • 18
    • 0028173856 scopus 로고
    • 3-adrenergic receptors with Gi in rat adipocytes
    • doi:10.1016/0898-6568(94)90093-0. PMID:7946969
    • 3-adrenergic receptors with Gi in rat adipocytes. Cell Signall. 6(4): 457-465. doi:10.1016/0898-6568(94)90093-0. PMID:7946969.
    • (1994) Cell Signall. , vol.6 , Issue.4 , pp. 457-465
    • Chaudhry, A.1    McKenzie, R.G.2    Georgic, L.M.3    Granneman, J.G.4
  • 19
    • 0035787319 scopus 로고    scopus 로고
    • The β-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis
    • doi:10.1210/rp.56.1.309. PMID:11237219
    • Collins, S., and Surwit, R.S. 2001. The β-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. Recent Prog. Horm. Res. 56: 309-328. doi:10.1210/rp.56.1.309. PMID:11237219.
    • (2001) Recent Prog. Horm. Res. , vol.56 , pp. 309-328
    • Collins, S.1    Surwit, R.S.2
  • 20
    • 0027051199 scopus 로고
    • Occurrence of brown adipocytes in rat white adipose tissue: Molecular and morphological characterization
    • PMID:1362571
    • Cousin, B., Cinti, S., Morroni, M., Raimbault, S., Ricquier, D., Pénicaud, L., and Casteilla, L. 1992. Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J. Cell Sci. 103(4): 931-942. PMID:1362571.
    • (1992) J. Cell Sci. , vol.103 , Issue.4 , pp. 931-942
    • Cousin, B.1    Cinti, S.2    Morroni, M.3    Raimbault, S.4    Ricquier, D.5    Pénicaud, L.6    Casteilla, L.7
  • 23
    • 0034289797 scopus 로고    scopus 로고
    • The human uncoupling protein-1 gene (UCP1): Present status and perspectives in obesity research
    • doi:10.1046/j.1467-789x.2000. 00009.x. PMID:12119988
    • Del Mar Gonzalez-Barroso, M., Ricquier, D., and Cassard-Doulcier, A.M. 2000. The human uncoupling protein-1 gene (UCP1): present status and perspectives in obesity research. Obes. Rev. 1(2): 61-72. doi:10.1046/j.1467-789x.2000. 00009.x. PMID:12119988.
    • (2000) Obes. Rev. , vol.1 , Issue.2 , pp. 61-72
    • Del Mar Gonzalez-Barroso, M.1    Ricquier, D.2    Cassard-Doulcier, A.M.3
  • 24
    • 84863012459 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones
    • doi: 10.1016/j.cell.2011.11.062. PMID:22304921
    • Dutchak, P.A., Katafuchi, T., Bookout, A.L., Choi, J.H., Yu, R.T., Mangelsdorf, D.J., and Kliewer, S.A. 2012. Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell, 148(3): 556-567. doi: 10.1016/j.cell.2011.11.062. PMID:22304921.
    • (2012) Cell , vol.148 , Issue.3 , pp. 556-567
    • Dutchak, P.A.1    Katafuchi, T.2    Bookout, A.L.3    Choi, J.H.4    Yu, R.T.5    Mangelsdorf, D.J.6    Kliewer, S.A.7
  • 25
    • 1842409029 scopus 로고    scopus 로고
    • Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
    • doi:10. 1038/387090a0. PMID:9139827
    • Enerbäck, S., Jacobsson, A., Simpson, E.M., Guerra, C., Yamashita, H., Harper, M.E., and Kozak, L.P. 1997. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature, 387(6628): 90-94. doi:10. 1038/387090a0. PMID:9139827.
    • (1997) Nature , vol.387 , Issue.6628 , pp. 90-94
    • Enerbäck, S.1    Jacobsson, A.2    Simpson, E.M.3    Guerra, C.4    Yamashita, H.5    Harper, M.E.6    Kozak, L.P.7
  • 26
    • 0031916832 scopus 로고    scopus 로고
    • Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
    • doi:10.1074/jbc.273.3.1741. PMID:9430721
    • Enslen, H., Raingeaud, J., and Davis, R.J. 1998. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J. Biol. Chem. 273(3): 1741-1748. doi:10.1074/jbc.273.3.1741. PMID:9430721.
    • (1998) J. Biol. Chem. , vol.273 , Issue.3 , pp. 1741-1748
    • Enslen, H.1    Raingeaud, J.2    Davis, R.J.3
  • 27
    • 84867564026 scopus 로고    scopus 로고
    • Mechanism of fatty-aciddependent UCP1 uncoupling in brown fat mitochondria
    • doi:10.1016/j.cell.2012.09.010. PMID:23063128
    • Fedorenko, A., Lishko, P.V., and Kirichok, Y. 2012. Mechanism of fatty-aciddependent UCP1 uncoupling in brown fat mitochondria. Cell, 151(2): 400-413. doi:10.1016/j.cell.2012.09.010. PMID:23063128.
    • (2012) Cell , vol.151 , Issue.2 , pp. 400-413
    • Fedorenko, A.1    Lishko, P.V.2    Kirichok, Y.3
  • 28
    • 33750345334 scopus 로고    scopus 로고
    • Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects
    • doi:10.1073/pnas. 0607501103
    • Feldman, B.J., Streeper, R.S., Farese, R.V., Jr., and Yamamoto, K.R. 2006. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc. Natl. Acad. Sci. U.S.A. 103(42): 15675-15680. doi:10.1073/pnas. 0607501103.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , Issue.42 , pp. 15675-15680
    • Feldman, B.J.1    Streeper, R.S.2    Farese Jr., R.V.3    Yamamoto, K.R.4
  • 30
    • 0034085884 scopus 로고    scopus 로고
    • A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice
    • doi:10.2337/diabetes. 49.5.759. PMID:10905484
    • Fukui, Y., Masui, S., Osada, S., Umesono, K., and Motojima, K. 2000. A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes, 49(5): 759-767. doi:10.2337/diabetes. 49.5.759. PMID:10905484.
    • (2000) Diabetes , vol.49 , Issue.5 , pp. 759-767
    • Fukui, Y.1    Masui, S.2    Osada, S.3    Umesono, K.4    Motojima, K.5
  • 31
    • 64849107591 scopus 로고    scopus 로고
    • UCP1 and oxidative capacity of adipose tissue in adult ferrets (Mustela putorius furo)
    • doi:10.1016/j.cbpa.2009.01.007
    • Fuster, A., Oliver, P., Sanchez, J., Pico, C., and Palou, A. 2009. UCP1 and oxidative capacity of adipose tissue in adult ferrets (Mustela putorius furo). Comp. Biochem. Physiol. A, 153(2): 106-112. doi:10.1016/j.cbpa.2009.01.007.
    • (2009) Comp. Biochem. Physiol. A , vol.153 , Issue.2 , pp. 106-112
    • Fuster, A.1    Oliver, P.2    Sanchez, J.3    Pico, C.4    Palou, A.5
  • 32
    • 84867616942 scopus 로고    scopus 로고
    • An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes
    • doi:10.1152/ajpendo.00104.2012. PMID:22912368
    • Gburcik, V., Cawthorn, W.P., Nedergaard, J., Timmons, J.A., and Cannon, B. 2012. An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes. Am. J. Physiol. Endocrinol. Metab. 303(8): E1053-E1060. doi:10.1152/ajpendo.00104.2012. PMID:22912368.
    • (2012) Am. J. Physiol. Endocrinol. Metab. , vol.303 , Issue.8
    • Gburcik, V.1    Cawthorn, W.P.2    Nedergaard, J.3    Timmons, J.A.4    Cannon, B.5
  • 33
    • 0033017879 scopus 로고    scopus 로고
    • Stimulation of the extracellular signal-regulated kinase 1/2 pathway by human beta-3 adrenergic receptor: New pharmacological profile and mechanism of activation
    • PMID:9927616
    • Gerhardt, C.C., Gros, J., Strosberg, A.D., and Issad, T. 1999. Stimulation of the extracellular signal-regulated kinase 1/2 pathway by human beta-3 adrenergic receptor: new pharmacological profile and mechanism of activation. Mol. Pharmacol. 55(2): 255-262. PMID:9927616.
    • (1999) Mol. Pharmacol. , vol.55 , Issue.2 , pp. 255-262
    • Gerhardt, C.C.1    Gros, J.2    Strosberg, A.D.3    Issad, T.4
  • 35
    • 0345327617 scopus 로고    scopus 로고
    • White adipose tissue contributes to UCP1-independent thermogenesis
    • doi:10.1152/ajpendo.00197.2003. PMID:12954594
    • Granneman, J.G., Burnazi, M., Zhu, Z., and Schwamb, L.A. 2003. White adipose tissue contributes to UCP1-independent thermogenesis. Am. J. Physiol. Endocrinol. Metab. 285(6): E1230-E1236. doi:10.1152/ajpendo.00197.2003. PMID:12954594.
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.285 , Issue.6
    • Granneman, J.G.1    Burnazi, M.2    Zhu, Z.3    Schwamb, L.A.4
  • 36
    • 34247168090 scopus 로고    scopus 로고
    • Analysis of lipolytic protein trafficking and interactions in adipocytes
    • doi:10.1074/jbc.M610580200. PMID:17189257
    • Granneman, J.G., Moore, H.P., Granneman, R.L., Greenberg, A.S., Obin, M.S., and Zhu, Z. 2007. Analysis of lipolytic protein trafficking and interactions in adipocytes. J. Biol. Chem. 282(8): 5726-5735. doi:10.1074/jbc.M610580200. PMID:17189257.
    • (2007) J. Biol. Chem. , vol.282 , Issue.8 , pp. 5726-5735
    • Granneman, J.G.1    Moore, H.P.2    Granneman, R.L.3    Greenberg, A.S.4    Obin, M.S.5    Zhu, Z.6
  • 37
    • 0025772167 scopus 로고
    • Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets
    • PMID:2040638
    • Greenberg, A.S., Egan, J.J., Wek, S.A., Garty, N.B., Blanchette-Mackie, E.J., and Londos, C. 1991. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J. Biol. Chem. 266(17): 11341-11346. PMID:2040638.
    • (1991) J. Biol. Chem. , vol.266 , Issue.17 , pp. 11341-11346
    • Greenberg, A.S.1    Egan, J.J.2    Wek, S.A.3    Garty, N.B.4    Blanchette-McKie, E.J.5    Londos, C.6
  • 38
    • 0027145164 scopus 로고
    • Isolation of cDNAs for perilipins A and B: Sequence and expression of lipid droplet-associated proteins of adipocytes
    • doi:10.1073/pnas.90.24.12035. PMID: 7505452
    • Greenberg, A.S., Egan, J.J., Wek, S.A., Moos, M.C., Jr., Londos, C., and Kimmel, A.R. 1993. Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. Proc. Natl. Acad. Sci. U.S.A. 90(24): 12035-12039. doi:10.1073/pnas.90.24.12035. PMID: 7505452.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , Issue.24 , pp. 12035-12039
    • Greenberg, A.S.1    Egan, J.J.2    Wek, S.A.3    Moos Jr., M.C.4    Londos, C.5    Kimmel, A.R.6
  • 39
    • 0032528169 scopus 로고    scopus 로고
    • Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity
    • doi:10.1172/JCI3155
    • Guerra, C., Koza, R.A., Yamashita, H., Walsh, K., and Kozak, L.P. 1998. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J. Clin. Invest. 102(2): 412-420. doi:10.1172/JCI3155.
    • (1998) J. Clin. Invest. , vol.102 , Issue.2 , pp. 412-420
    • Guerra, C.1    Koza, R.A.2    Yamashita, H.3    Walsh, K.4    Kozak, L.P.5
  • 40
    • 63349107479 scopus 로고    scopus 로고
    • Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity
    • doi:10.1371/ journal.pone.0004937
    • Guo, T., Jou, W., Chanturiya, T., Portas, J., Gavrilova, O., and McPherron, A.C. 2009. Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity. PLoS ONE, 4(3): e4937. doi:10.1371/ journal.pone.0004937.
    • (2009) PLoS ONE , vol.4 , Issue.3
    • Guo, T.1    Jou, W.2    Chanturiya, T.3    Portas, J.4    Gavrilova, O.5    McPherron, A.C.6
  • 41
    • 0037085450 scopus 로고    scopus 로고
    • Hormonesensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis
    • doi:10.1074/ jbc.M110355200. PMID:11717312
    • Haemmerle, G., Zimmermann, R., Hayn, M., Theussl, C., Waeg, G., Wagner, E., Sattler, W., Magin, T.M., Wagner, E.F., and Zechner, R. 2002. Hormonesensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis. J. Biol. Chem. 277(7): 4806-4815. doi:10.1074/ jbc.M110355200. PMID:11717312.
    • (2002) J. Biol. Chem. , vol.277 , Issue.7 , pp. 4806-4815
    • Haemmerle, G.1    Zimmermann, R.2    Hayn, M.3    Theussl, C.4    Waeg, G.5    Wagner, E.6    Sattler, W.7    Magin, T.M.8    Wagner, E.F.9    Zechner, R.10
  • 43
    • 0035957755 scopus 로고    scopus 로고
    • Mitochondrial uncoupling proteins and phylogenesis-UCP4 as the ancestral uncoupling protein
    • doi:10.1016/S0014-5793(01)02338-9. PMID:11334880
    • Hanák, P., and Jězek, P. 2001. Mitochondrial uncoupling proteins and phylogenesis-UCP4 as the ancestral uncoupling protein. FEBS Lett. 495(3): 137-141. doi:10.1016/S0014-5793(01)02338-9. PMID:11334880.
    • (2001) FEBS Lett. , vol.495 , Issue.3 , pp. 137-141
    • Hanák, P.1    Jězek, P.2
  • 44
    • 0344896634 scopus 로고    scopus 로고
    • Resistance to high-fat diet-induced obesity and altered expression of adipose-specific genes in HSL-deficient mice
    • PMID:12954598
    • Harada, K., Shen, W.J., Patel, S., Natu, V., Wang, J., Osuga, J., Ishibashi, S., and Kraemer, F.B. 2003. Resistance to high-fat diet-induced obesity and altered expression of adipose-specific genes in HSL-deficient mice. Am. J. Physiol. Endocrinol. Metab. 285(6): E1182-E1195. PMID:12954598.
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.285 , Issue.6
    • Harada, K.1    Shen, W.J.2    Patel, S.3    Natu, V.4    Wang, J.5    Osuga, J.6    Ishibashi, S.7    Kraemer, F.B.8
  • 45
    • 0000960221 scopus 로고
    • Evolution of brown fat: Its absence in marsupials and monotremes
    • doi:10.1139/z92-025
    • Hayward, J.S., and Lisson, P.A. 1992. Evolution of brown fat: its absence in marsupials and monotremes. Can. J. Zool. 70(1): 171-179. doi:10.1139/z92-025.
    • (1992) Can. J. Zool. , vol.70 , Issue.1 , pp. 171-179
    • Hayward, J.S.1    Lisson, P.A.2
  • 47
    • 58249118050 scopus 로고    scopus 로고
    • Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis
    • doi:10.1186/1471-2148-9-4. PMID:19128480
    • Hughes, D.A., Jastroch, M., Stoneking, M., and Klingenspor, M. 2009. Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis. BMC Evol. Biol. 9: 4. doi:10.1186/1471-2148-9-4. PMID:19128480.
    • (2009) BMC Evol. Biol. , vol.9 , pp. 4
    • Hughes, D.A.1    Jastroch, M.2    Stoneking, M.3    Klingenspor, M.4
  • 48
    • 77953010087 scopus 로고    scopus 로고
    • Medicine
    • doi:10.1126/science.1190816
    • Ishibashi, J., and Seale, P. 2010. Medicine. Beige can be slimming. Science, 328(5982): 1113-1114. doi:10.1126/science.1190816.
    • (2010) Beige can be slimming. Science , vol.328 , Issue.5982 , pp. 1113-1114
    • Ishibashi, J.1    Seale, P.2
  • 49
    • 25144489463 scopus 로고    scopus 로고
    • Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis
    • doi:10.1152/ physiolgenomics.00070.2005
    • Jastroch, M., Wuertz, S., Kloas, W., and Klingenspor, M. 2005. Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis. Physiol. Genomics, 22(2): 150-156. doi:10.1152/ physiolgenomics.00070.2005.
    • (2005) Physiol. Genomics , vol.22 , Issue.2 , pp. 150-156
    • Jastroch, M.1    Wuertz, S.2    Kloas, W.3    Klingenspor, M.4
  • 50
    • 34548802573 scopus 로고    scopus 로고
    • Functional characterisation of UCP1 in the common carp: Uncoupling activity in liver mitochondria and cold-induced expression in the brain
    • doi:10.1007/s00360-007-0171-6
    • Jastroch, M., Buckingham, J.A., Helwig, M., Klingenspor, M., and Brand, M.D. 2007. Functional characterisation of UCP1 in the common carp: uncoupling activity in liver mitochondria and cold-induced expression in the brain. J. Comp. Physiol. B, 177(7): 743-752. doi:10.1007/s00360-007-0171-6.
    • (2007) J. Comp. Physiol. B , vol.177 , Issue.7 , pp. 743-752
    • Jastroch, M.1    Buckingham, J.A.2    Helwig, M.3    Klingenspor, M.4    Brand, M.D.5
  • 54
    • 69349088117 scopus 로고    scopus 로고
    • Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-β transcriptional complex
    • doi: 10.1038/nature08262. PMID:19641492
    • Kajimura, S., Seale, P., Kubota, K., Lunsford, E., Frangioni, J.V., Gygi, S.P., and Spiegelman, B.M. 2009. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-β transcriptional complex. Nature, 460(7259): 1154-1158. doi: 10.1038/nature08262. PMID:19641492.
    • (2009) Nature , vol.460 , Issue.7259 , pp. 1154-1158
    • Kajimura, S.1    Seale, P.2    Kubota, K.3    Lunsford, E.4    Frangioni, J.V.5    Gygi, S.P.6    Spiegelman, B.M.7
  • 55
    • 11844291416 scopus 로고    scopus 로고
    • Ectopic overexpression of adipogenic transcription factors induces transdifferentiation of MC3T3-E1 osteoblasts
    • doi:10.1016/j. bbrc.2004.12.076. PMID:15649418
    • Kim, S.W., Her, S.J., Kim, S.Y., and Shin, C.S. 2005. Ectopic overexpression of adipogenic transcription factors induces transdifferentiation of MC3T3-E1 osteoblasts. Biochem. Biophys. Res. Commun. 327(3): 811-819. doi:10.1016/j. bbrc.2004.12.076. PMID:15649418.
    • (2005) Biochem. Biophys. Res. Commun. , vol.327 , Issue.3 , pp. 811-819
    • Kim, S.W.1    Her, S.J.2    Kim, S.Y.3    Shin, C.S.4
  • 57
    • 0037251008 scopus 로고    scopus 로고
    • Cold-induced recruitment of brown adipose tissue thermogenesis
    • doi:10.1113/eph8802508. PMID: 12525862
    • Klingenspor, M. 2003. Cold-induced recruitment of brown adipose tissue thermogenesis. Exp. Physiol. 88(1): 141-148. doi:10.1113/eph8802508. PMID: 12525862.
    • (2003) Exp. Physiol. , vol.88 , Issue.1 , pp. 141-148
    • Klingenspor, M.1
  • 58
    • 84874334781 scopus 로고    scopus 로고
    • Brown adipose tissue
    • In Edited by M.E. Symonds. Springer-Verlag, New York
    • Klingenspor, M., and Fromme, T. 2012. Brown adipose tissue. In Adipose tissue biology. Edited by M.E. Symonds. Springer-Verlag, New York. pp. 39-79.
    • (2012) Adipose tissue biology. , pp. 39-79
    • Klingenspor, M.1    Fromme, T.2
  • 60
    • 84871852805 scopus 로고    scopus 로고
    • Brown fat develops a brite future
    • doi:10.1159/000346337
    • Klingenspor, M., Herzig, S., and Pfeifer, A. 2012. Brown fat develops a brite future. Obes. Facts, 5(6): 890-896. doi:10.1159/000346337.
    • (2012) Obes. Facts , vol.5 , Issue.6 , pp. 890-896
    • Klingenspor, M.1    Herzig, S.2    Pfeifer, A.3
  • 61
    • 0028153698 scopus 로고
    • An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene
    • PMID: 8264627
    • Kozak, U.C., Kopecky, J., Teisinger, J., Enerbäck, S., Boyer, B., and Kozak, L.P. 1994. An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene. Mol. Cell. Biol. 14(1): 59-67. PMID: 8264627.
    • (1994) Mol. Cell. Biol. , vol.14 , Issue.1 , pp. 59-67
    • Kozak, U.C.1    Kopecky, J.2    Teisinger, J.3    Enerbäck, S.4    Boyer, B.5    Kozak, L.P.6
  • 63
    • 0029856392 scopus 로고    scopus 로고
    • Essential cis-acting elements in rat uncoupling protein gene are in an enhancer containing a complex retinoic acid response domain
    • doi:10.1074/jbc.271.49. 31533. PMID:8940169
    • Larose, M., Cassard-Doulcier, A.-M., Fleury, C., Serra, F., Champigny, O., Bouillaud, F., and Ricquier, D. 1996. Essential cis-acting elements in rat uncoupling protein gene are in an enhancer containing a complex retinoic acid response domain. J. Biol. Chem. 271(49): 31533-31542. doi:10.1074/jbc.271.49. 31533. PMID:8940169.
    • (1996) J. Biol. Chem. , vol.271 , Issue.49 , pp. 31533-31542
    • Larose, M.1    Cassard-Doulcier, A.-M.2    Fleury, C.3    Serra, F.4    Champigny, O.5    Bouillaud, F.6    Ricquier, D.7
  • 64
    • 84875860413 scopus 로고    scopus 로고
    • Browning attenuates murine white adipose tissue expansion during postnatal development
    • doi:10.1016/j. bbalip.2013.01.016
    • Lasar, D., Julius, A., Fromme, T., and Klingenspor, M. 2013. Browning attenuates murine white adipose tissue expansion during postnatal development. Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1831(5): 960-968. doi:10.1016/j. bbalip.2013.01.016.
    • (2013) Biochim. Biophys. Acta Mol. Cell Biol. Lipids , vol.1831 , Issue.5 , pp. 960-968
    • Lasar, D.1    Julius, A.2    Fromme, T.3    Klingenspor, M.4
  • 65
    • 1842414968 scopus 로고
    • Effect of epinephrine on glucose uptake and glycerol release by adipose tissue in vitro
    • doi:10.3181/00379727-102-25306. PMID:14415032
    • Leboeuf, B., Flinn, R.B., and Cahill, G.F., Jr. 1959. Effect of epinephrine on glucose uptake and glycerol release by adipose tissue in vitro. Proc. Soc. Exp. Biol. Med. 102: 527-529. doi:10.3181/00379727-102-25306. PMID:14415032.
    • (1959) Proc. Soc. Exp. Biol. Med. , vol.102 , pp. 527-529
    • Leboeuf, B.1    Flinn, R.B.2    Cahill Jr., G.F.3
  • 66
    • 0036932298 scopus 로고    scopus 로고
    • The mitochondrial uncoupling proteins
    • reviews PMID:12537581
    • Ledesma, A., de Lacoba, M.G., and Rial, E. 2002. The mitochondrial uncoupling proteins. Genome Biol. 3(12): reviews 3015.1-3015.9. PMID:12537581.
    • (2002) Genome Biol. , vol.3 , Issue.12 , pp. 1-9
    • Ledesma, A.1    de Lacoba, M.G.2    Rial, E.3
  • 67
    • 84859465056 scopus 로고    scopus 로고
    • 3-adrenoceptor activation and high-fat feeding
    • doi:10.1016/j.cmet. 2012.03.009. PMID:22482730
    • 3-adrenoceptor activation and high-fat feeding. Cell Metab. 15(4): 480-491. doi:10.1016/j.cmet. 2012.03.009. PMID:22482730.
    • (2012) Cell Metab. , vol.15 , Issue.4 , pp. 480-491
    • Lee, Y.-H.1    Petkova, A.P.2    Mottillo, E.P.3    Granneman, J.G.4
  • 70
    • 0037314231 scopus 로고    scopus 로고
    • Paradoxical resistance to diet-induced obesity in UCP1-deficient mice
    • doi:10.1172/JCI200315737. PMID:12569166
    • Liu, X., Rossmeisl, M., McClaine, J., and Kozak, L.P. 2003. Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. J. Clin. Invest. 111(3): 399-407. doi:10.1172/JCI200315737. PMID:12569166.
    • (2003) J. Clin. Invest. , vol.111 , Issue.3 , pp. 399-407
    • Liu, X.1    Rossmeisl, M.2    McClaine, J.3    Kozak, L.P.4
  • 71
    • 0022943269 scopus 로고
    • The effect of intermittent cold treatment on the adipose tissue of the cat. Apparent transformation from white to brown adipose tissue
    • PMID:3453365
    • Loncar, D., Bedrica, L., Mayer, J., Cannon, B., Nedergaard, J., Afzelius, B.A., and Svajger, A. 1986. The effect of intermittent cold treatment on the adipose tissue of the cat. Apparent transformation from white to brown adipose tissue. J. Ultrastruct. Mol. Struct. Res. 97(1-3): 119-129. PMID:3453365.
    • (1986) J. Ultrastruct. Mol. Struct. Res. , vol.97 , Issue.1-3 , pp. 119-129
    • Loncar, D.1    Bedrica, L.2    Mayer, J.3    Cannon, B.4    Nedergaard, J.5    Afzelius, B.A.6    Svajger, A.7
  • 73
    • 0013954216 scopus 로고
    • The association of lipid droplets with cytoplasmic filaments in avian subsynovial adipose tissue
    • PMID:5971971
    • Luckenbill, L.M., and Cohen, A.S. 1966. The association of lipid droplets with cytoplasmic filaments in avian subsynovial adipose tissue. J. Cell. Biol. 31(1): 195-199. PMID:5971971.
    • (1966) J. Cell. Biol. , vol.31 , Issue.1 , pp. 195-199
    • Luckenbill, L.M.1    Cohen, A.S.2
  • 76
    • 41449098953 scopus 로고    scopus 로고
    • Hepatic steatosis in leptin-deficient mice is promoted by the PPARγ target gene Fsp27
    • doi:10.1016/ j.cmet.2008.03.003. PMID:18396136
    • Matsusue, K., Kusakabe, T., Noguchi, T., Takiguchi, S., Suzuki, T., Yamano, S., and Gonzalez, F.J. 2008. Hepatic steatosis in leptin-deficient mice is promoted by the PPARγ target gene Fsp27. Cell Metab. 7(4): 302-311. doi:10.1016/ j.cmet.2008.03.003. PMID:18396136.
    • (2008) Cell Metab. , vol.7 , Issue.4 , pp. 302-311
    • Matsusue, K.1    Kusakabe, T.2    Noguchi, T.3    Takiguchi, S.4    Suzuki, T.5    Yamano, S.6    Gonzalez, F.J.7
  • 77
    • 0030840359 scopus 로고    scopus 로고
    • Double muscling in cattle due to mutations in the myostatin gene
    • doi: 10.1073/pnas.94.23.12457. PMID:9356471
    • McPherron, A.C., and Lee, S.-J. 1997. Double muscling in cattle due to mutations in the myostatin gene. Proc. Natl. Acad. Sci. U.S.A. 94(23): 12457-12461. doi: 10.1073/pnas.94.23.12457. PMID:9356471.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , Issue.23 , pp. 12457-12461
    • McPherron, A.C.1    Lee, S.-J.2
  • 78
    • 0031010050 scopus 로고    scopus 로고
    • Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member
    • doi:10.1038/387083a0. PMID:9139826
    • McPherron, A.C., Lawler, A.M., and Lee, S.-J. 1997. Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member. Nature, 387(6628): 83-90. doi:10.1038/387083a0. PMID:9139826.
    • (1997) Nature , vol.387 , Issue.6628 , pp. 83-90
    • McPherron, A.C.1    Lawler, A.M.2    Lee, S.-J.3
  • 80
    • 43549085512 scopus 로고    scopus 로고
    • The brown adipocyte differentiation pathway in birds: An evolutionary road not taken
    • doi:10.1186/1741-7007-6-17. PMID:18426587
    • Mezentseva, N.V., Kumaratilake, J.S., and Newman, S.A. 2008. The brown adipocyte differentiation pathway in birds: an evolutionary road not taken. BMC Biol. 6: 17. doi:10.1186/1741-7007-6-17. PMID:18426587.
    • (2008) BMC Biol. , vol.6 , pp. 17
    • Mezentseva, N.V.1    Kumaratilake, J.S.2    Newman, S.A.3
  • 83
    • 0027025179 scopus 로고
    • Strain distribution pattern of 25 simple sequence length polymorphisms in the AXB and BXA recombinant inbred strains
    • doi:10.1007/BF00444366
    • Mu, J.-L., Cheah, Y.-C., and Paigen, B. 1992. Strain distribution pattern of 25 simple sequence length polymorphisms in the AXB and BXA recombinant inbred strains. Mamm. Genome, 3(12): 705-708. doi:10.1007/BF00444366.
    • (1992) Mamm. Genome , vol.3 , Issue.12 , pp. 705-708
    • Mu, J.-L.1    Cheah, Y.-C.2    Paigen, B.3
  • 84
    • 0027354373 scopus 로고
    • Strain distribution pattern in AXB and BXA recombinant inbred strains for loci on murine chromosomes 10, 13, 17, and 18
    • doi: 10.1007/BF00352230
    • Mu, J.-L., Naggert, J.K., Nishina, P.M., Cheah, Y.-C., and Paigen, B. 1993. Strain distribution pattern in AXB and BXA recombinant inbred strains for loci on murine chromosomes 10, 13, 17, and 18. Mamm. Genome, 4(3): 148-152. doi: 10.1007/BF00352230.
    • (1993) Mamm. Genome , vol.4 , Issue.3 , pp. 148-152
    • Mu, J.-L.1    Naggert, J.K.2    Nishina, P.M.3    Cheah, Y.-C.4    Paigen, B.5
  • 86
    • 36049046928 scopus 로고    scopus 로고
    • The molecular and biochemical basis of nonshivering thermogenesis in an African endemic mammal, Elephantulus myurus
    • doi:10.1152/ajpregu.00427.2007. PMID:17686883
    • Mzilikazi, N., Jastroch, M., Meyer, C.W., and Klingenspor, M. 2007. The molecular and biochemical basis of nonshivering thermogenesis in an African endemic mammal, Elephantulus myurus. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293(5): R2120-R2127. doi:10.1152/ajpregu.00427.2007. PMID:17686883.
    • (2007) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.293 , Issue.5
    • Mzilikazi, N.1    Jastroch, M.2    Meyer, C.W.3    Klingenspor, M.4
  • 88
    • 20044395797 scopus 로고    scopus 로고
    • A humanspecific role of cell death-inducing DFFA (DNA fragmentation factor-α)-like effector A (CIDEA) in adipocyte lipolysis and obesity
    • doi:10.2337/diabetes.54.6.1726. PMID:15919794
    • Nordström, E.A., Rydén, M., Backlund, E.C., Dahlman, I., Kaaman, M., Blomqvist, L., Cannon, B., Nedergaard, J., and Arner, P. 2005. A humanspecific role of cell death-inducing DFFA (DNA fragmentation factor-α)-like effector A (CIDEA) in adipocyte lipolysis and obesity. Diabetes, 54(6): 1726-1734. doi:10.2337/diabetes.54.6.1726. PMID:15919794.
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1726-1734
    • Nordström, E.A.1    Rydén, M.2    Backlund, E.C.3    Dahlman, I.4    Kaaman, M.5    Blomqvist, L.6    Cannon, B.7    Nedergaard, J.8    Arner, P.9
  • 89
    • 84862665085 scopus 로고    scopus 로고
    • Seasonal changes in thermogenesis of a free-ranging afrotherian small mammal, the western rock elephant shrew (Elephantulus rupestris)
    • doi:10.1007/s00360-012-0647-x
    • Oelkrug, R., Meyer, C.W., Heldmaier, G., and Mzilikazi, N. 2012. Seasonal changes in thermogenesis of a free-ranging afrotherian small mammal, the western rock elephant shrew (Elephantulus rupestris). J. Comp. Physiol. B, 182(5): 715-727. doi:10.1007/s00360-012-0647-x.
    • (2012) J. Comp. Physiol. B , vol.182 , Issue.5 , pp. 715-727
    • Oelkrug, R.1    Meyer, C.W.2    Heldmaier, G.3    Mzilikazi, N.4
  • 90
    • 84858039282 scopus 로고    scopus 로고
    • PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
    • doi:10.1016/j.cmet.2012.01.019. PMID: 22405074
    • Ohno, H., Shinoda, K., Spiegelman, B.M., and Kajimura, S. 2012. PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 15(3): 395-404. doi:10.1016/j.cmet.2012.01.019. PMID: 22405074.
    • (2012) Cell Metab. , vol.15 , Issue.3 , pp. 395-404
    • Ohno, H.1    Shinoda, K.2    Spiegelman, B.M.3    Kajimura, S.4
  • 91
    • 0000996619 scopus 로고
    • Fat from Black-capped Chickadees: Avian brown adipose tissue?
    • doi:10.2307/ 1368340
    • Olson, J.M., Dawson, W.R., and Camilliere, J.J. 1988. Fat from Black-capped Chickadees: avian brown adipose tissue? Condor, 90(3): 529-537. doi:10.2307/ 1368340.
    • (1988) Condor , vol.90 , Issue.3 , pp. 529-537
    • Olson, J.M.1    Dawson, W.R.2    Camilliere, J.J.3
  • 92
    • 77950226740 scopus 로고    scopus 로고
    • Chronic peroxisome proliferator-activated receptor γ (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes
    • doi:10.1074/jbc.M109.053942. PMID:20028987
    • Petrovic, N., Walden, T.B., Shabalina, I.G., Timmons, J.A., Cannon, B., and Nedergaard, J. 2010. Chronic peroxisome proliferator-activated receptor γ (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J. Biol. Chem. 285(10): 7153-7164. doi:10.1074/jbc.M109.053942. PMID:20028987.
    • (2010) J. Biol. Chem. , vol.285 , Issue.10 , pp. 7153-7164
    • Petrovic, N.1    Walden, T.B.2    Shabalina, I.G.3    Timmons, J.A.4    Cannon, B.5    Nedergaard, J.6
  • 93
    • 81855224789 scopus 로고    scopus 로고
    • Phylogenetic differences of mammalian basal metabolic rate are not explained by mitochondrial basal proton leak
    • doi:10.1098/rspb.2011.0881. PMID:21632624
    • Polymeropoulos, E.T., Heldmaier, G., Frappell, P.B., McAllan, B.M., Withers, K.W., Klingenspor, M., White, C.R., and Jastroch, M. 2012a. Phylogenetic differences of mammalian basal metabolic rate are not explained by mitochondrial basal proton leak. Proc. R. Soc. B Biol. Sci. 279(1726): 185-193. doi:10.1098/rspb.2011.0881. PMID:21632624.
    • (2012) Proc. R. Soc. B Biol. Sci. , vol.279 , Issue.1726 , pp. 185-193
    • Polymeropoulos, E.T.1    Heldmaier, G.2    Frappell, P.B.3    McAllan, B.M.4    Withers, K.W.5    Klingenspor, M.6    White, C.R.7    Jastroch, M.8
  • 94
    • 84858721156 scopus 로고    scopus 로고
    • Absence of adaptive nonshivering thermogenesis in a marsupial, the fat-tailed dunnart (Sminthopsis crassicaudata)
    • doi:10.1007/s00360-011-0623-x
    • Polymeropoulos, E.T., Jastroch, M., and Frappell, P.B. 2012b. Absence of adaptive nonshivering thermogenesis in a marsupial, the fat-tailed dunnart (Sminthopsis crassicaudata). J. Comp. Physiol. B, 182(3): 393-401. doi:10.1007/s00360-011-0623-x.
    • (2012) J. Comp. Physiol. B , vol.182 , Issue.3 , pp. 393-401
    • Polymeropoulos, E.T.1    Jastroch, M.2    Frappell, P.B.3
  • 96
    • 84864615516 scopus 로고    scopus 로고
    • Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ
    • doi:10.1016/j.cell.2012.06.027. PMID:22863012
    • Qiang, L., Wang, L., Kon, N., Zhao, W., Lee, S., Zhang, Y., Rosenbaum, M., Zhao, Y., Gu, W., Farmer, S.R., and Accili, D. 2012. Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell, 150(3): 620-632. doi:10.1016/j.cell.2012.06.027. PMID:22863012.
    • (2012) Cell , vol.150 , Issue.3 , pp. 620-632
    • Qiang, L.1    Wang, L.2    Kon, N.3    Zhao, W.4    Lee, S.5    Zhang, Y.6    Rosenbaum, M.7    Zhao, Y.8    Gu, W.9    Farmer, S.R.10    Accili, D.11
  • 97
    • 0030014594 scopus 로고    scopus 로고
    • A complex retinoic acid response element in the uncoupling protein gene defines a novel role for retinoids in thermogenesis
    • doi:10.1210/en. 137.8.3488. PMID:8754778
    • Rabelo, R., Reyes, C., Schifman, A., and Silva, J.E. 1996a. A complex retinoic acid response element in the uncoupling protein gene defines a novel role for retinoids in thermogenesis. Endocrinology, 137(8): 3488-3496. doi:10.1210/en. 137.8.3488. PMID:8754778.
    • (1996) Endocrinology , vol.137 , Issue.8 , pp. 3488-3496
    • Rabelo, R.1    Reyes, C.2    Schifman, A.3    Silva, J.E.4
  • 98
    • 0029927083 scopus 로고    scopus 로고
    • Interactions among receptors, thyroid hormone response elements, and ligands in the regulation of the rat uncoupling protein gene expression by thyroid hormone
    • doi:10.1210/en.137.8.3478. PMID:8754777
    • Rabelo, R., Reyes, C., Schifman, A., and Silva, J.E. 1996b. Interactions among receptors, thyroid hormone response elements, and ligands in the regulation of the rat uncoupling protein gene expression by thyroid hormone. Endocrinology, 137(8): 3478-3487. doi:10.1210/en.137.8.3478. PMID:8754777.
    • (1996) Endocrinology , vol.137 , Issue.8 , pp. 3478-3487
    • Rabelo, R.1    Reyes, C.2    Schifman, A.3    Silva, J.E.4
  • 99
    • 0030664523 scopus 로고    scopus 로고
    • 3′,5′-cyclic adenosine monophosphate-response sequences of the uncoupling protein gene are sequentially recruited during darglitazone-induced brown adipocyte differentiation
    • doi:10.1210/en.138.12.5325. PMID:9389517
    • Rabelo, R., Camirand, A., and Silva, J.E. 1997. 3′,5′-cyclic adenosine monophosphate-response sequences of the uncoupling protein gene are sequentially recruited during darglitazone-induced brown adipocyte differentiation. Endocrinology, 138(12): 5325-5332. doi:10.1210/en.138.12.5325. PMID:9389517.
    • (1997) Endocrinology , vol.138 , Issue.12 , pp. 5325-5332
    • Rabelo, R.1    Camirand, A.2    Silva, J.E.3
  • 101
    • 0034650763 scopus 로고    scopus 로고
    • The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
    • doi:10.1042/0264-6021:3450161
    • Ricquier, D., and Bouillaud, F. 2000. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem. J. 345: 161-179. doi:10.1042/0264-6021:3450161.
    • (2000) Biochem. J. , vol.345 , pp. 161-179
    • Ricquier, D.1    Bouillaud, F.2
  • 102
    • 0037072886 scopus 로고    scopus 로고
    • Regulatory motifs for CREB-binding protein and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling protein 1 gene
    • doi:10.1074/ jbc.M108866200. PMID:12084707
    • Rim, J.S., and Kozak, L.P. 2002. Regulatory motifs for CREB-binding protein and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling protein 1 gene. J. Biol. Chem. 277(37): 34589-34600. doi:10.1074/ jbc.M108866200. PMID:12084707.
    • (2002) J. Biol. Chem. , vol.277 , Issue.37 , pp. 34589-34600
    • Rim, J.S.1    Kozak, L.P.2
  • 103
    • 78651160857 scopus 로고
    • Activation of an epinephrine-sensitive lipolytic activity from adipose tissue by adenosine 3′,5′-phosphate
    • PMID:14169136
    • Rizack, M.A. 1964. Activation of an epinephrine-sensitive lipolytic activity from adipose tissue by adenosine 3′,5′-phosphate. J. Biol. Chem. 239: 392-395. PMID:14169136.
    • (1964) J. Biol. Chem. , vol.239 , pp. 392-395
    • Rizack, M.A.1
  • 104
    • 20744441357 scopus 로고    scopus 로고
    • Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38α MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes
    • doi:10.1128/ MCB.25.13.5466-5479.2005. PMID:15964803
    • Robidoux, J., Cao, W., Quan, H., Daniel, K.W., Moukdar, F., Bai, X., Floering, L.M., and Collins, S. 2005. Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38α MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes. Mol. Cell. Biol. 25(13): 5466-5479. doi:10.1128/ MCB.25.13.5466-5479.2005. PMID:15964803.
    • (2005) Mol. Cell. Biol. , vol.25 , Issue.13 , pp. 5466-5479
    • Robidoux, J.1    Cao, W.2    Quan, H.3    Daniel, K.W.4    Moukdar, F.5    Bai, X.6    Floering, L.M.7    Collins, S.8
  • 105
    • 53549134683 scopus 로고    scopus 로고
    • Identification of white adipocyte progenitor cells in vivo
    • doi:10.1016/j.cell.2008. 09.036. PMID:18835024
    • Rodeheffer, M.S., Birsoy, K., and Friedman, J.M. 2008. Identification of white adipocyte progenitor cells in vivo. Cell,135(2):240-249. doi:10.1016/j.cell.2008. 09.036. PMID:18835024.
    • (2008) Cell , vol.135 , Issue.2 , pp. 240-249
    • Rodeheffer, M.S.1    Birsoy, K.2    Friedman, J.M.3
  • 106
    • 33845325476 scopus 로고    scopus 로고
    • Adipocyte differentiation from the inside out
    • doi:10.1038/nrm2066. PMID:17139329
    • Rosen, E.D., and MacDougald, O.A. 2006. Adipocyte differentiation from the inside out. Nat. Rev. Mol. Cell Biol. 7(12): 885-896. doi:10.1038/nrm2066. PMID:17139329.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , Issue.12 , pp. 885-896
    • Rosen, E.D.1    McDougald, O.A.2
  • 107
    • 84878525220 scopus 로고    scopus 로고
    • Bi-directional interconversion of brite and white adipocytes
    • doi:10.1038/ncb2740. PMID:23624403
    • Rosenwald, M., Perdikari, A., Rülicke, T., and Wolfrum, C. 2013. Bi-directional interconversion of brite and white adipocytes. Nat. Cell Biol. 15(6): 659-667. doi:10.1038/ncb2740. PMID:23624403.
    • (2013) Nat. Cell Biol. , vol.15 , Issue.6 , pp. 659-667
    • Rosenwald, M.1    Perdikari, A.2    Rülicke, T.3    Wolfrum, C.4
  • 109
    • 84865792944 scopus 로고    scopus 로고
    • PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors
    • doi:10.1016/j.cmet.2012.08.003
    • Sanchez-Gurmaches, J., Hung, C.-M., Sparks, C.A., Tang, Y., Li, H., and Guertin, D.A. 2012. PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors. Cell Metab. 16(3): 348-362. doi:10.1016/j.cmet.2012.08.003.
    • (2012) Cell Metab. , vol.16 , Issue.3 , pp. 348-362
    • Sanchez-Gurmaches, J.1    Hung, C.-M.2    Sparks, C.A.3    Tang, Y.4    Li, H.5    Guertin, D.A.6
  • 111
    • 49349118094 scopus 로고    scopus 로고
    • Hibernation and non-shivering thermogenesis in the Hottentot golden mole (Amblysomus hottentottus longiceps)
    • doi:10.1007/s00360-008-0277-5
    • Scantlebury, M., Lovegrove, B.G., Jackson, C.R., Bennett, N.C., and Lutermann, H. 2008. Hibernation and non-shivering thermogenesis in the Hottentot golden mole (Amblysomus hottentottus longiceps). J. Comp. Physiol. B, 178(7): 887-897. doi:10.1007/s00360-008-0277-5.
    • (2008) J. Comp. Physiol. B , vol.178 , Issue.7 , pp. 887-897
    • Scantlebury, M.1    Lovegrove, B.G.2    Jackson, C.R.3    Bennett, N.C.4    Lutermann, H.5
  • 114
  • 116
    • 80053928150 scopus 로고    scopus 로고
    • Orexin is required for brown adipose tissue development, differentiation, and function
    • doi:10.1016/j.cmet.2011.08.010. PMID:21982708
    • Sellayah, D., Bharaj, P., and Sikder, D. 2011. Orexin is required for brown adipose tissue development, differentiation, and function. Cell Metab. 14(4): 478-490. doi:10.1016/j.cmet.2011.08.010. PMID:21982708.
    • (2011) Cell Metab. , vol.14 , Issue.4 , pp. 478-490
    • Sellayah, D.1    Bharaj, P.2    Sikder, D.3
  • 118
    • 77952060999 scopus 로고    scopus 로고
    • Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue
    • doi:10. 1007/s00125-010-1701-4. PMID:20238096
    • Shore, A., Karamitri, A., Kemp, P., Speakman, J.R., and Lomax, M.A. 2010. Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue. Diabetologia, 53(6): 1164-1173. doi:10. 1007/s00125-010-1701-4. PMID:20238096.
    • (2010) Diabetologia , vol.53 , Issue.6 , pp. 1164-1173
    • Shore, A.1    Karamitri, A.2    Kemp, P.3    Speakman, J.R.4    Lomax, M.A.5
  • 119
    • 0014500234 scopus 로고
    • Brown fat and thermogenesis
    • PMID:4888392
    • Smith, R.E., and Horwitz, B.A. 1969. Brown fat and thermogenesis. Physiol. Rev. 49(2): 330-425. PMID:4888392.
    • (1969) Physiol. Rev. , vol.49 , Issue.2 , pp. 330-425
    • Smith, R.E.1    Horwitz, B.A.2
  • 121
    • 0032782532 scopus 로고    scopus 로고
    • Uncoupling protein 2 from carp and zebrafish, ectothermic vertebrates
    • doi:10.1016/S0005-2728(99)00081-X
    • Stuart, J.A., Harper, J.A., Brindle, K.M., and Brand, M.D. 1999. Uncoupling protein 2 from carp and zebrafish, ectothermic vertebrates. Biochim. Biophys. Acta, 1413(1): 50-54. doi:10.1016/S0005-2728(99)00081-X.
    • (1999) Biochim. Biophys. Acta , vol.1413 , Issue.1 , pp. 50-54
    • Stuart, J.A.1    Harper, J.A.2    Brindle, K.M.3    Brand, M.D.4
  • 122
    • 0242290249 scopus 로고    scopus 로고
    • Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytes
    • doi:10.1074/jbc. M301809200. PMID:12832420
    • Su, C.-L., Sztalryd, C., Contreras, J.A., Holm, C., Kimmel, A.R., and Londos, C. 2003. Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytes. J. Biol. Chem. 278(44): 43615-43619. doi:10.1074/jbc. M301809200. PMID:12832420.
    • (2003) J. Biol. Chem. , vol.278 , Issue.44 , pp. 43615-43619
    • Su, C.-L.1    Sztalryd, C.2    Contreras, J.A.3    Holm, C.4    Kimmel, A.R.5    Londos, C.6
  • 123
    • 0037093338 scopus 로고    scopus 로고
    • A novel pathway for adrenergic stimulation of cAMP-response-element-binding protein (CREB) phosphorylation: Mediation via α1-adrenoceptors and protein kinase C activation
    • PMID:11988078
    • Thonberg, H., Fredriksson, J.M., Nedergaard, J., and Cannon, B. 2002. A novel pathway for adrenergic stimulation of cAMP-response-element-binding protein (CREB) phosphorylation: mediation via α1-adrenoceptors and protein kinase C activation. Biochem. J. 364: 73-79. PMID:11988078.
    • (2002) Biochem. J. , vol.364 , pp. 73-79
    • Thonberg, H.1    Fredriksson, J.M.2    Nedergaard, J.3    Cannon, B.4
  • 124
    • 0027431063 scopus 로고
    • Postnatal development of uncoupling protein, uncoupling protein mRNA, and GLUT4 in adipose tissues of goats
    • PMID:8214163
    • Trayhurn, P., Thomas, M.E., and Keith, J.S. 1993. Postnatal development of uncoupling protein, uncoupling protein mRNA, and GLUT4 in adipose tissues of goats. Am. J. Physiol. 265: R676-R682. PMID:8214163.
    • (1993) Am. J. Physiol. , vol.265
    • Trayhurn, P.1    Thomas, M.E.2    Keith, J.S.3
  • 126
    • 77953169046 scopus 로고    scopus 로고
    • Cellular bioenergetics as a target for obesity therapy
    • doi:10.1038/nrd3138. PMID:20514071
    • Tseng, Y.-H., Cypess, A.M., and Kahn, C.R. 2010. Cellular bioenergetics as a target for obesity therapy. Nat. Rev. Drug Discov. 9(6): 465-482. doi:10.1038/nrd3138. PMID:20514071.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , Issue.6 , pp. 465-482
    • Tseng, Y.-H.1    Cypess, A.M.2    Kahn, C.R.3
  • 127
    • 75949130333 scopus 로고    scopus 로고
    • Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle
    • doi:10.1038/ ncb2014. PMID:20081842
    • Uezumi, A., Fukada, S., Yamamoto, N., Takeda, S., and Tsuchida, K. 2010. Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle. Nat. Cell. Biol. 12(2): 143-152. doi:10.1038/ ncb2014. PMID:20081842.
    • (2010) Nat. Cell. Biol. , vol.12 , Issue.2 , pp. 143-152
    • Uezumi, A.1    Fukada, S.2    Yamamoto, N.3    Takeda, S.4    Tsuchida, K.5
  • 128
    • 33845969892 scopus 로고    scopus 로고
    • UCP1-independent thermogenesis in white adipose tissue of cold-acclimated Ucp1-/-mice
    • doi:10.1074/jbc.M606114200. PMID:16914547
    • Ukropec, J., Anunciado, R.P., Ravussin, Y., Hulver, M.W., and Kozak, L.P. 2006. UCP1-independent thermogenesis in white adipose tissue of cold-acclimated Ucp1-/-mice. J. Biol. Chem. 281(42): 31894-31908. doi:10.1074/jbc.M606114200. PMID:16914547.
    • (2006) J. Biol. Chem. , vol.281 , Issue.42 , pp. 31894-31908
    • Ukropec, J.1    Anunciado, R.P.2    Ravussin, Y.3    Hulver, M.W.4    Kozak, L.P.5
  • 134
    • 13544268363 scopus 로고    scopus 로고
    • Mutational analysis of the "regulatory module" of hormone-sensitive lipase
    • doi:10.1021/bi049206t. PMID:15697220
    • Wang, J., Shen, W.-J., Patel, S., Harada, K., and Kraemer, F.B. 2005. Mutational analysis of the "regulatory module" of hormone-sensitive lipase. Biochemistry, 44(6): 1953-1959. doi:10.1021/bi049206t. PMID:15697220.
    • (2005) Biochemistry , vol.44 , Issue.6 , pp. 1953-1959
    • Wang, J.1    Shen, W.-J.2    Patel, S.3    Harada, K.4    Kraemer, F.B.5
  • 136
    • 0028971225 scopus 로고
    • Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis
    • doi:10.1101/gad.9.19.2350. PMID: 7557387
    • Wu, Z., Xie, Y., Bucher, N.L., and Farmer, S.R. 1995. Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. Genes Dev. 9(19): 2350-2363. doi:10.1101/gad.9.19.2350. PMID: 7557387.
    • (1995) Genes Dev. , vol.9 , Issue.19 , pp. 2350-2363
    • Wu, Z.1    Xie, Y.2    Bucher, N.L.3    Farmer, S.R.4
  • 137
    • 33845977987 scopus 로고    scopus 로고
    • Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat
    • doi:10.1194/jlr. M600287-JLR200. PMID:17041251
    • Xue, B., Rim, J.-S., Hogan, J.C., Coulter, A.A., Koza, R.A., and Kozak, L.P. 2007. Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. J. Lipid Res. 48(1): 41-51. doi:10.1194/jlr. M600287-JLR200. PMID:17041251.
    • (2007) J. Lipid Res. , vol.48 , Issue.1 , pp. 41-51
    • Xue, B.1    Rim, J.-S.2    Hogan, J.C.3    Coulter, A.A.4    Koza, R.A.5    Kozak, L.P.6
  • 138
    • 0021319695 scopus 로고
    • Brown adipose tissue in the parametrial fat pad of the mouse
    • doi:10.1016/0014-5793(84) 80822-4. PMID:6698197
    • Young, P., Arch, J.R.S., and Ashwell, M. 1984. Brown adipose tissue in the parametrial fat pad of the mouse. FEBS Lett. 167(1): 10-14. doi:10.1016/0014-5793(84) 80822-4. PMID:6698197.
    • (1984) FEBS Lett. , vol.167 , Issue.1 , pp. 10-14
    • Young, P.1    Arch, J.R.S.2    Ashwell, M.3
  • 139
    • 84856725443 scopus 로고    scopus 로고
    • Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice
    • doi:10.1007/ s00125-011-2304-4. PMID:21927895
    • Zhang, C., McFarlane, C., Lokireddy, S., Masuda, S., Ge, X., Gluckman, P.D., Sharma, M., and Kambadur, R. 2012. Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice. Diabetologia, 55(1): 183-193. doi:10.1007/ s00125-011-2304-4. PMID:21927895.
    • (2012) Diabetologia , vol.55 , Issue.1 , pp. 183-193
    • Zhang, C.1    McFarlane, C.2    Lokireddy, S.3    Masuda, S.4    Ge, X.5    Gluckman, P.D.6    Sharma, M.7    Kambadur, R.8
  • 140
    • 0041353552 scopus 로고    scopus 로고
    • Cidea-deficient mice have lean phenotype and are resistant to obesity
    • doi:10.1038/ng1225. PMID:12910269
    • Zhou, Z., Yon Toh, S., Chen, Z., Guo, K., Ng, C.P., Ponniah, S., Lin, S.-C., Hong, W., and Li, P. 2003. Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat. Genet. 35(1): 49-56. doi:10.1038/ng1225. PMID:12910269.
    • (2003) Nat. Genet. , vol.35 , Issue.1 , pp. 49-56
    • Zhou, Z.1    Yon Toh, S.2    Chen, Z.3    Guo, K.4    Ng, C.P.5    Ponniah, S.6    Lin, S.-C.7    Hong, W.8    Li, P.9
  • 141
    • 78650888657 scopus 로고    scopus 로고
    • Regulation of thermogenesis in plants: The interaction of alternative oxidase and plant uncoupling mitochondrial protein
    • doi:10.1111/j.1744-7909. 2010.01004.x. PMID:21205176
    • Zhu, Y., Lu, J., Wang, J., Chen, F., Leng, F., and Li, H. 2011. Regulation of thermogenesis in plants: the interaction of alternative oxidase and plant uncoupling mitochondrial protein. J. Integr. Plant Biol. 53(1): 7-13. doi:10.1111/j.1744-7909. 2010.01004.x. PMID:21205176.
    • (2011) J. Integr. Plant Biol. , vol.53 , Issue.1 , pp. 7-13
    • Zhu, Y.1    Lu, J.2    Wang, J.3    Chen, F.4    Leng, F.5    Li, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.