Stimulation of the extracellular signal-regulated kinase 1/2 pathway by human beta-3 adrenergic receptor: New pharmacological profile and mechanism of activation

Molecular Pharmacology

Volumn 55, Issue 2, 1999, Pages 255-262

  Gerhardt, C C ^a   Gros, J ^a   Strosberg, A D ^a   Issad, T ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; ADENYLATE CYCLASE; ADRENALIN; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; BUPRANOLOL; CARAZOLOL; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; INSULIN RECEPTOR; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; NORADRENALIN; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROPRANOLOL; PROTEIN KINASE B; WORTMANNIN;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0033017879     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.55.2.255     Document Type: Article

References (37)

1. Arch JR and Wilson S (1996) Prospects for beta 3-adrenoceptor agonists in the treatment of obesity and diabetes. Int J Obes Relat Metab Disord 20:191-199.
2. Bronnikov G, Houstek J and Nedergaard J (1992) Beta-adrenergic, cAMP-mediated stimulation of proliferation of brown fat cells in primary culture: Mediation via beta 1 but not via beta 3 adrenoceptors. J Biol Chem 267:2006-2013.
3. Burt AR, Carr IC, Mullaney I, Anderson NG and Milligan G (1996) Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse delta opioid receptor in Rat-1 fibroblasts: Effects of receptor expression levels and comparisons with G-protein activation. Biochem J 3:20:227-235.
4. Champigny O and Ricquier D (1996) Evidence from in vitro differentiating cells that adrenoceptor agonists can increase uncoupling protein mRNA level in adipocytes of adult humans: An RT-PCR study. J Lipid Res 37:1907-1914.
5. Champigny O, Ricquier D, Blondel O, Mayers RM, Briscoe MG and Holloway BR (1991) Beta 3-adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs. Proc Natl Acad Sci USA 88:10774-10777.
6. Chaudhry A, MacKenzie RG, Georgic LM and Granneman JG (1994) Differential interaction of beta 1- and beta 3-adrenergic receptors with Gi in rat adipocytes. Cell Signal 6:457-465.
7. Daaka Y, Luttrell LM and Lefkowitz RJ (1997) Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature (London) 390:88-91.
8. Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM and Lefkowitz RJ (1997) Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors: Convergence of Gi- and Gq-mediated pathways on calcium/ calmodulin, Pyk2, and Src kinase. J Biol Chem 272:19125-19132.
9. Dikic I, Tokiwa G, Lev S, Courtneidge SA and Schlessinger J (1996) A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature (London) 383:547-550.
10. Franke TF, Kaplan DR, Cantley LC and Toker A (1997) Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science (Wash DC) 275:665-668.
11. Etienne S, Adamson P, Greenwood J, Strosberg AD, Cazaubon S and Couraud PO (1998) ICAM-1 signalling pathways associated with Rho activation in microvascular brain endothelial cells. J Immunol, in press.
12. Gauthier C, Tavernier G, Charpentier F, Langin D and Le Marec H (1996) Functional beta3-adrenoceptor in the human heart. J Clin Invest 98:556-562.
13. Ghorbani M, Claus TH and Himms-Hagen J (1997) Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a beta(3)-adrenoceptor agonist. Biochem Pharmacol 54:121-131.
14. Gros J, Manning BS, Pietri-Rouxel F, Guillaume JL, Drumare MF and Strosberg AD (1998) Site-directed mutagenesis of the human beta3-adrenoceptor: Transmembrane residues involved in ligand binding and signal transduction. Eur J Biochem 251:590-596.
15. Gutkind JS (1998) The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J Biol Chem 273:1839-1842.
16. Hawes BE, Luttrell LM, van Biesen T and Lefkowitz RJ (1996) Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway. J Biol Chem 271:12133-12136.
17. Himms-Hagen J (1990) Brown adipose tissue thermogenesis: interdisciplinary studies. FASEB J 4:2890-2898.
18. Hoffstedt J, Shimizu M, Sjostedt S and Lonnqvist F (1995) Determination of beta 3-adrenoceptor mediated lipolysis in human fat cells. Obes Res 3:447-457.
19. Jockers R, Issad T, Zilberfarb V, de Coppet P, Marullo S and Strosberg AD (1998) Desensitization of the beta-adrenergic response in human brown adipocytes. Endocrinology 138:2676-2684.
20. Kenakin T (1995) Agonist-receptor efficacy II. Agonist trafficking of receptor signals. Trends Pharmacol Sci 16:232-238.
21. Lonnqvist F, Krief S, Strosberg AD, Nyberg S, Emorine LJ and Arner P (1993) Evidence for a functional beta 3-adrenoceptor in man. Br J Pharmacol 110:929-936.
22. Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind JS and Wetzker R (1997) Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science (Wash DC) 275:394-397.
23. Marais R, Light Y, Mason C, Paterson H, Olson MF and Marshall J (1998) Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science (Wash DC) 28:109-112.
24. Moule SK, Welsh GI, Edgell NJ, Foulstone EJ, Proud CG and Denton RM (1997) Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells: Activation of protein kinase B by wortmannin-sengitive and -insensitive mechanisms. J Biol Chem 272:7713-7719.
25. Okamoto T, Murayama Y, Hayashi Y, Inagaki M, Ogata E and Nishimoto I (1991) Identification of a Gs activator region of the beta 2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation. Cell 67:723-730.
26. Pietri-Rouxel F, St John Manning B, Gros J and Strosberg AD (1997) The biochemical effect of the naturally occurring: Trp64→Arg mutation on human beta3-adrenoceptor activity. Eur J Biochem 247:1174-1179.
27. Rameh LE, Chen C-S and Cantley LC (1995) Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinaae association with tyrosine-phosphorylated proteins. Cell 83:821-830.
28. Rosenbaum M, Malbon CC, Hirsch J and Leibel RL (1993) Lack of beta 3-adrenergic effect on lipolysis in human subcutaneous adipose tissue. J Clin Endocrinol Metab 77:352-355.
29. Sable CL, Filippa N, Hemmings B and Van Obberghen E (1997) cAMP stimulates protein kinase B in a wortmannin-insensitive manner. FEBS Lett 409:253-257.
30. Sale EM Atkinson PG and Sale GJ (1995) Requirement of MAP kinase for differentiation of fibroblasts to adipocytes, for insulin activation of p90 S6 kinase and for insulin or serum stimulation of DNA synthesis. EMBO J 14:674-684.
31. Samama P, Cotecchia S, Costa T and Lefkowitz RJ (1993) A mutation-induced activated state of the beta 2-adrenergic receptor: Extending the ternary complex model. J Biol Chem 268:4625-4636.
32. Stoyanov B, Volinia S, Hanck T, Rubio I, Loubtchenkov M, Malek D, Soyanova S, Vanhaesebroeck B, Dhand R, Nürnberg B, Gierschik P, Seedorf K, Hsuan JJ, Waterfield MD and Wetzker R (1995) Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science (Wash DC) 269:690-693.
33. Strosberg AD (1997a) Association of β3-adrenoceptor polymorphism with obesity and diabetes: current status. Trends Pharmacol Sci 18:449-454.
34. Strosberg AD (1997b) Structure and function of the beta 3-adrenergic receptor. Annu Rev Pharmacol Toxicol 37:421-450.
35. Tavernier G, Barbe P, Galitzky J, Berlan M, Caput D, Lafontan M and Langin D (1996) Expression of beta3-adrenoceptors with low lipolytic action in human subcutaneous white adipocytes. J Lipid Res 37:87-97.
36. Tucek S (1997) Is the R and R dichotomy real? Trends Pharmacol Sci 18:414-416.
37. Zilberfarb V, Piétri-Rouxel F, Jockers R, Krief S, Delouis C, Issad T and Strosberg DA (1997) Human immortalized brown adipocytes express functional β3-adrenoceptor coupled to lipolysis. J Cell Sci 110:801-807.