The molecular and biochemical basis of nonshivering thermogenesis in an African endemic mammal, Elephantulus myurus

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 293, Issue 5, 2007, Pages

  Mzilikazi, Nomakwezi ^a   Jastroch, Martin ^b   Meyer, Carola W ^b   Klingenspor, Martin ^b  

^a NELSON MANDELA METROPOLITAN UNIVERSITY   (South Africa)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Basal metabolic rate; Brown adipose tissue; Proton leak kinetics; Uncoupling protein 1

Indexed keywords

COMPLEMENTARY DNA; CYTOCHROME C OXIDASE; MESSENGER RNA; NORADRENALIN; UNCOUPLING PROTEIN 1;

AFRICA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BROWN ADIPOSE TISSUE; COLD ACCLIMATIZATION; CONTROLLED STUDY; ELEPHANTULUS MYURUS; GENE SEQUENCE; LIVER MITOCHONDRION; MAMMAL; MITOCHONDRIAL MEMBRANE; MOLECULAR MODEL; NONHUMAN; NONSHIVERING THERMOGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTON TRANSPORT; SEASONAL VARIATION; SHREW;

ADAPTATION, PHYSIOLOGICAL; ADIPOSE TISSUE, BROWN; ANIMALS; BASAL METABOLISM; BODY WEIGHT; CLONING, MOLECULAR; COLD; ELECTRON TRANSPORT COMPLEX IV; GENE EXPRESSION REGULATION; HEAT; IMMUNOHISTOCHEMISTRY; ION CHANNELS; KINETICS; MEMBRANE POTENTIALS; MITOCHONDRIA; MITOCHONDRIA, LIVER; MITOCHONDRIAL PROTEINS; OXYGEN CONSUMPTION; PROTONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SHREWS; THERMOGENESIS;

EID: 36049046928     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00427.2007     Document Type: Article

References (36)

1. Brand MD. Measurement of the mitochondrial protonmotive force. In: Bioenergetics - A Practical Approach, edited by Brown GC. Oxford: IRL Press, 1995, p. 39-62.
2. Brand MD, Couture P, Else PL, Withers KW, Hulbert AJ. Evolution of energy and metabolism: Proton permeability of the inner membrane of liver mitochondria is greater in a mammal than in a reptile. Biochem J 275: 81-86, 1991.
3. Brand MD, Pakay JL, Ocloo A, Kokoszka J, Wallace DC, Brookes PS, Cornwall EJ. The basal proton conductance of mitochondria depends on adenine nucleotide translocase content. Biochem J 392: 353-362, 2005.
4. Brookes PS, Buckingham JA, Tenreiro AM, Hulbert AJ, Brand MD. The proton permeability of the inner membrane of liver mitochondria from ectothermic and endothermic vertebrates and from obese rats: correlations with standard metabolic rate and phospholipid fatty acid composition. Comp Biochem Physiol 119B: 325-334, 1998.
5. Cannon B, Nedergaard J. The biochemistry of an inefficient tissue: brown adipose tissue. Essays Biochem 20: 110-164, 1985.
6. Cannon B, Nedergaard J. Brown adipose tissue: Function and physiological significance. Physiol Rev 84: 277-359, 2004.
7. Chaffee RJ, Roberts JC. Temperature acclimation in birds and mammals. Annu Rev Physiol 33: 155-202, 1971.
8. Desautels M. Mitochondrial thermogenin content is unchanged during atrophy of BAT of fasting mice. Am J Physiol Endocrinol Metab 249: E99-E106, 1985.
9. Echtay KS, Esteves TC, Pakay JL, Jekabsons MB, Lambert AJ, Portero-Otín M, Pamplona R, Vidal-Puig AJ, Wang S, Roebuck SJ, Brand MD. A signalling role for 4-hydroxy-2nonenal in regulation of mitochondrial uncoupling. EMBO J 22: 4103-4110, 2003.
10. Heldmaier G, Klaus S, Wiesinger H, Friedrichs U, Wenzel M. Cold acclimation and thermogenesis. In: Living in the Cold II, edited by Malan A and Canguilhem B. Montrouge, France: John Libbey Eurotext, 1989, p. 347-358.
11. Heldmaier G, Ruf T. Body temperature and metabolic rate during natural hypothermia in endotherms. J Comp Physiol B 162: 696-706, 1992.
12. Heldmaier G, Klaus S, Wiesinger H. Seasonal adaptation of thermoregulatory heat production in small mammals. In: Thermoreception and Temperature Regulation, edited by Bligh J and Voigt K. Berlin: Springer-Verlag, 1990, p. 235-243.
13. Heldmaier G, Steinlechner S, Rafael J, Vsiansky P. Photoperiodic control and effects of melatonin on nonshivering thermogenesis and brown adipose tissue. Science 212: 917-919, 1981.
14. Hulbert AJ, Else PL, Manolis SC, Brand MD. Proton leak in hepatocytes and liver mitochondria from archosaurs (crocodiles) and allometric relationships for ectotherms. J Comp Physiol B 172: 387-397, 2002.
15. Jansky L. Non-shivering thermogenesis and its thermoregulatory significance. Biol Rev 48: 85-132, 1973.
16. Jastroch M, Withers K, Klingenspor M. Uncoupling protein 2 and 3 in marsupials: identification, phylogeny and gene expression in response to cold and fasting in Antechinus flavipes. Physiol Genomics 17: 130-139, 2004.
17. Jastroch M, Wuertz S, Kloas W, Klingenspor M. Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis. Physiol Genomics 22: 150-156, 2005.
18. Khailova LS, Prikhodko EA, Dedukhova VI, Mokhova EN, Popov VN, Skulachev VP. Participation of ATP/ADP antiporter in oleate and oleate-hydroperoxide-induced uncoupling suppresed by GDP and carboxyatractylate. Biochim Biophys Acta 1757: 1324-1329, 2006.
19. Klaus S, Heldmaier G, Ricquier D. Seasonal acclimation of bank voles and wood mice: nonshivering thermogenesis and thermogenic properties of brown adipose tissue mitochondria. J Comp Physiol B 158: 157-164, 1988.
20. Klingenspor M. Cold-induced recruitment of brown adipose tissue thermogenesis. Exp Physiol 88: 141-148, 2003.
21. Klingenspor M, Ivemeyer M, Wiesinger HK, Haas K, Heldmaier G, Wiesner RJ. Biogenesis of thermogenic mitochondria in brown adipose tissue of Djungarian hamsters during cold adaptation. Biochem J 316: 607-613, 1996.
22. Lovegrove BG. Seasonal thermoregulatory responses in mammals. J Comp Physiol B 175: 231-247, 2005.
23. Lovegrove BG, Raman J, Perrin MR. Heterothermy in elephant shrews (Elephantulus spp.): hibernation or daily torpor? J Comp Physiol B 171: 1-10, 2001.
24. Malan A. The origins of hibernation: a reappraisal. In: Adaptations to the Cold: Tenth International Hibernation Symposium, edited by Geiser F, Hulbert AJ, and Nicol SC. Armidale: University of New England Press, 1996, p. 1-6.
25. McKechnie AE, Chetty K, Lovegrove BG. Phenotypic flexibility in the basal metabolic rate of laughing doves: responses to short-term thermal acclimation. J Exp Biol 210: 97-106, 2007.
26. McKechnie AE, Wolf BO. Partitioning of evaporative water loss in white-winged doves: plasticity in response to short-term thermal acclimation. J Exp Biol 207: 203-210, 2004.
27. Mzilikazi N, Lovegrove BG. Daily torpor in free-ranging rock elephant shrews, Elephantulus myurus: A year-long study. Physiol Biochem Zool 77: 285-296, 2004.
28. Mzilikazi N, Lovegrove BG. Noradrenalin induces thermogenesis in a phylogenetically ancient eutherian mammal, the rock elephant shrew, Elephantulus myurus. J Comp Physiol B 176: 75-84, 2006.
29. Mzilikazi N, Lovegrove BG, Ribble DO. Exogenous passive heating during torpor arousal in free-ranging rock elephant shrews, Elephantulus myurus. Oecologia (Berl) 133: 307-314, 2002.
30. Mzilikazi N, Lovegrove B. Daily torpor during the active phase in free-ranging rock elephant shrews, Elephantulus myurus. J Zool Lond 267: 103-111, 2005.
31. Nespolo RF, Bacigalupe LD, Rezende EL, Bozinovic F. When nonshivering thermogenesis equals maximum metabolic rate: thermal acclimation and phenotypic plasticity of fossorial Spalacopus cyanus (Rodentia). Physiol Biochem Zool 74: 325-332, 2001.
32. Nicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiol Rev 64: 1-64, 1984.
33. 2 solubility in aqueous media determined by a kinetic method. Anal Biochem 145: 406-418, 1985.
34. Smith L, Camerino PW. Comparison of polarographic and spectrophotometric assays for cytochrome c oxidase activity. Biochemistry 2: 1428-1432, 1963.
35. Springer MS, Cleven GC, Madsen O, de Jong WW, Waddell VG, Amrine HM, Stanhope MJ. Endemic African mammals shake the phylogenetic tree. Nature 388: 61-64, 1997.
36. Wunder BA, Gettinger RD. Effects of body mass and temperature acclimation on the nonshivering thermogenic response of small mammals. In: Adaptations to the Cold: Tenth International Hibernation Symposium, edited by Geiser F, Hulbert AJ, and Nicol SC. Armidale: University of New England Press, 1996, p. 131-139.