메뉴 건너뛰기




Volumn 1777, Issue 7-8, 2008, Pages 637-641

An ancient look at UCP1

Author keywords

Brown adipose tissue; Mitochondria; Mitochondrial transporters; Nonshivering thermogenesis

Indexed keywords

MITOCHONDRIAL PROTEIN; UNCOUPLING PROTEIN 1;

EID: 46349111382     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbabio.2008.03.006     Document Type: Review
Times cited : (53)

References (46)
  • 1
    • 0017817970 scopus 로고
    • Brown-adipose-tissue mitochondria: photoaffinity labelling of the regulatory site of energy dissipation
    • Heaton G.M., Wagenvoord R.J., Kemp Jr. A., and Nicholls D.G. Brown-adipose-tissue mitochondria: photoaffinity labelling of the regulatory site of energy dissipation. Eur. J. Biochem. 82 (1978) 515-521
    • (1978) Eur. J. Biochem. , vol.82 , pp. 515-521
    • Heaton, G.M.1    Wagenvoord, R.J.2    Kemp Jr., A.3    Nicholls, D.G.4
  • 2
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: function and physiological significance
    • Cannon B., and Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84 (2004) 277-359
    • (2004) Physiol. Rev. , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 3
    • 0037251008 scopus 로고    scopus 로고
    • Cold-induced recruitment of brown adipose tissue thermogenesis
    • Klingenspor M. Cold-induced recruitment of brown adipose tissue thermogenesis. Exp. Physiol. 88 (2003) 141-148
    • (2003) Exp. Physiol. , vol.88 , pp. 141-148
    • Klingenspor, M.1
  • 6
    • 25144476923 scopus 로고    scopus 로고
    • Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3
    • Brand M.D., and Esteves T.C. Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell. Metab. 2 (2005) 85-93
    • (2005) Cell. Metab. , vol.2 , pp. 85-93
    • Brand, M.D.1    Esteves, T.C.2
  • 8
    • 33748954260 scopus 로고    scopus 로고
    • UCP2, UCP3, avUCP, what do they do when proton transport is not stimulated? Possible relevance to pyruvate and glutamine metabolism
    • Criscuolo F., Mozo J., Hurtaud C., Nubel T., and Bouillaud F. UCP2, UCP3, avUCP, what do they do when proton transport is not stimulated? Possible relevance to pyruvate and glutamine metabolism. Biochim. Biophys. Acta 1757 (2006) 1284-1291
    • (2006) Biochim. Biophys. Acta , vol.1757 , pp. 1284-1291
    • Criscuolo, F.1    Mozo, J.2    Hurtaud, C.3    Nubel, T.4    Bouillaud, F.5
  • 13
    • 0036182511 scopus 로고    scopus 로고
    • Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria
    • Harper J.A., Stuart J.A., Jekabsons M.B., Roussel D., Brindle K.M., Dickinson K., Jones R.B., and Brand M.D. Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria. Biochem. J. 361 (2002) 49-56
    • (2002) Biochem. J. , vol.361 , pp. 49-56
    • Harper, J.A.1    Stuart, J.A.2    Jekabsons, M.B.3    Roussel, D.4    Brindle, K.M.5    Dickinson, K.6    Jones, R.B.7    Brand, M.D.8
  • 14
    • 0035947694 scopus 로고    scopus 로고
    • Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria
    • Stuart J.A., Harper J.A., Brindle K.M., Jekabsons M.B., and Brand M.D. Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria. J. Biol. Chem. 276 (2001) 18633-18639
    • (2001) J. Biol. Chem. , vol.276 , pp. 18633-18639
    • Stuart, J.A.1    Harper, J.A.2    Brindle, K.M.3    Jekabsons, M.B.4    Brand, M.D.5
  • 15
  • 16
    • 25144489463 scopus 로고    scopus 로고
    • Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis
    • Jastroch M., Wuertz S., Kloas W., and Klingenspor M. Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis. Physiol. Genomics 22 (2005) 150-156
    • (2005) Physiol. Genomics , vol.22 , pp. 150-156
    • Jastroch, M.1    Wuertz, S.2    Kloas, W.3    Klingenspor, M.4
  • 17
    • 0018348872 scopus 로고
    • Tissue distribution of cold-induced thermogenesis in conscious warm- or cold-acclimated rats reevaluated from changes in tissue blood flow: the dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis
    • Foster D.O., and Frydman M.L. Tissue distribution of cold-induced thermogenesis in conscious warm- or cold-acclimated rats reevaluated from changes in tissue blood flow: the dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis. Can. J. Physiol. Pharmacol. 57 (1979) 257-270
    • (1979) Can. J. Physiol. Pharmacol. , vol.57 , pp. 257-270
    • Foster, D.O.1    Frydman, M.L.2
  • 18
    • 0022365783 scopus 로고
    • Sources of heat during nonshivering thermogenesis in Djungarian hamsters: a dominant role of brown adipose tissue during cold adaptation
    • Heldmaier G., and Buchberger A. Sources of heat during nonshivering thermogenesis in Djungarian hamsters: a dominant role of brown adipose tissue during cold adaptation. J. Comp. Physiol. [B] 156 (1985) 237-245
    • (1985) J. Comp. Physiol. [B] , vol.156 , pp. 237-245
    • Heldmaier, G.1    Buchberger, A.2
  • 19
    • 0023265606 scopus 로고
    • Organ blood flow and brown adipose tissue oxygen consumption during noradrenaline-induced nonshivering thermogenesis in the Djungarian hamster
    • Puchalski W., Bockler H., Heldmaier G., and Langefeld M. Organ blood flow and brown adipose tissue oxygen consumption during noradrenaline-induced nonshivering thermogenesis in the Djungarian hamster. J. Exp. Zool. 242 (1987) 263-271
    • (1987) J. Exp. Zool. , vol.242 , pp. 263-271
    • Puchalski, W.1    Bockler, H.2    Heldmaier, G.3    Langefeld, M.4
  • 20
    • 0035875366 scopus 로고    scopus 로고
    • A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast
    • Stuart J.A., Harper J.A., Brindle K.M., Jekabsons M.B., and Brand M.D. A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast. Biochem. J. 356 (2001) 779-789
    • (2001) Biochem. J. , vol.356 , pp. 779-789
    • Stuart, J.A.1    Harper, J.A.2    Brindle, K.M.3    Jekabsons, M.B.4    Brand, M.D.5
  • 22
    • 34548802573 scopus 로고    scopus 로고
    • Functional characterisation of UCP1 in the common carp: uncoupling activity in liver mitochondria and cold-induced expression in the brain
    • Jastroch M., Buckingham J.A., Helwig M., Klingenspor M., and Brand M.D. Functional characterisation of UCP1 in the common carp: uncoupling activity in liver mitochondria and cold-induced expression in the brain. J. Comp. Physiol. [B] 177 7 (2007) 743-752
    • (2007) J. Comp. Physiol. [B] , vol.177 , Issue.7 , pp. 743-752
    • Jastroch, M.1    Buckingham, J.A.2    Helwig, M.3    Klingenspor, M.4    Brand, M.D.5
  • 23
    • 36049046928 scopus 로고    scopus 로고
    • The molecular and biochemical basis of non-shivering thermogenesis in an African endemic mammal, Elephantulus myurus
    • Mzilikazi N., Jastroch M., Meyer C.W., and Klingenspor M. The molecular and biochemical basis of non-shivering thermogenesis in an African endemic mammal, Elephantulus myurus. Am. J. Physiol., Regul. Integr. Comp. Physiol. 293 5 (2007) R2120-R2127
    • (2007) Am. J. Physiol., Regul. Integr. Comp. Physiol. , vol.293 , Issue.5
    • Mzilikazi, N.1    Jastroch, M.2    Meyer, C.W.3    Klingenspor, M.4
  • 25
    • 37549064399 scopus 로고    scopus 로고
    • Adaptive evolution of the uncoupling protein 1 gene contributed to the acquisition of novel nonshivering thermogenesis in ancestral eutherian mammals
    • Saito S., Saito C.T., and Shingai R. Adaptive evolution of the uncoupling protein 1 gene contributed to the acquisition of novel nonshivering thermogenesis in ancestral eutherian mammals. Gene 408 (2008) 37-44
    • (2008) Gene , vol.408 , pp. 37-44
    • Saito, S.1    Saito, C.T.2    Shingai, R.3
  • 29
    • 33744548069 scopus 로고    scopus 로고
    • Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets
    • Zhang C.Y., Parton L.E., Ye C.P., Krauss S., Shen R., Lin C.T., Porco Jr. J.A., and Lowell B.B. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell. Metab. 3 (2006) 417-427
    • (2006) Cell. Metab. , vol.3 , pp. 417-427
    • Zhang, C.Y.1    Parton, L.E.2    Ye, C.P.3    Krauss, S.4    Shen, R.5    Lin, C.T.6    Porco Jr., J.A.7    Lowell, B.B.8
  • 30
    • 33846813359 scopus 로고    scopus 로고
    • Uncoupling protein-3: clues in an ongoing mitochondrial mystery
    • Bezaire V., Seifert E.L., and Harper M.E. Uncoupling protein-3: clues in an ongoing mitochondrial mystery. FASEB J. 21 (2007) 312-324
    • (2007) FASEB J. , vol.21 , pp. 312-324
    • Bezaire, V.1    Seifert, E.L.2    Harper, M.E.3
  • 31
    • 0035133171 scopus 로고    scopus 로고
    • Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis
    • Himms-Hagen J., and Harper M.E. Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis. Exp. Biol. Medicine (Maywood) 226 (2001) 78-84
    • (2001) Exp. Biol. Medicine (Maywood) , vol.226 , pp. 78-84
    • Himms-Hagen, J.1    Harper, M.E.2
  • 32
    • 2942737365 scopus 로고    scopus 로고
    • The role of uncoupling protein 3 in fatty acid metabolism: protection against lipotoxicity?
    • Schrauwen P., and Hesselink M.K. The role of uncoupling protein 3 in fatty acid metabolism: protection against lipotoxicity?. Proc. Nutr. Soc. 63 (2004) 287-292
    • (2004) Proc. Nutr. Soc. , vol.63 , pp. 287-292
    • Schrauwen, P.1    Hesselink, M.K.2
  • 33
    • 0042415622 scopus 로고    scopus 로고
    • A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet
    • Goglia F., and Skulachev V.P. A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet. FASEB J. 17 (2003) 1585-1591
    • (2003) FASEB J. , vol.17 , pp. 1585-1591
    • Goglia, F.1    Skulachev, V.P.2
  • 34
    • 38049120264 scopus 로고    scopus 로고
    • Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization
    • Pecqueur C., Bui T., Gelly C., Hauchard J., Barbot C., Bouillaud F., Ricquier D., Miroux B., and Thompson C.B. Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization. FASEB J. 22 (2008) 9-18
    • (2008) FASEB J. , vol.22 , pp. 9-18
    • Pecqueur, C.1    Bui, T.2    Gelly, C.3    Hauchard, J.4    Barbot, C.5    Bouillaud, F.6    Ricquier, D.7    Miroux, B.8    Thompson, C.B.9
  • 35
    • 43149088949 scopus 로고    scopus 로고
    • Brown adipose tissue specific lack of uncoupling protein 3 is associated with impaired cold tolerance and reduced transcript levels of metabolic genes
    • Nau K., Fromme T., Meyer C.W., von Praun C., Heldmaier G., and Klingenspor M. Brown adipose tissue specific lack of uncoupling protein 3 is associated with impaired cold tolerance and reduced transcript levels of metabolic genes,. J. Comp. Physiol. [B] 178 3 (2008) 269-277
    • (2008) J. Comp. Physiol. [B] , vol.178 , Issue.3 , pp. 269-277
    • Nau, K.1    Fromme, T.2    Meyer, C.W.3    von Praun, C.4    Heldmaier, G.5    Klingenspor, M.6
  • 37
    • 0032488633 scopus 로고    scopus 로고
    • H+ transport by uncoupling protein (UCP-1) is dependent on a histidine pair, absent in UCP-2 and UCP-3
    • Bienengraeber M., Echtay K.S., and Klingenberg M. H+ transport by uncoupling protein (UCP-1) is dependent on a histidine pair, absent in UCP-2 and UCP-3. Biochemistry 37 (1998) 3-8
    • (1998) Biochemistry , vol.37 , pp. 3-8
    • Bienengraeber, M.1    Echtay, K.S.2    Klingenberg, M.3
  • 38
    • 0030836775 scopus 로고    scopus 로고
    • Mutagenesis of the uncoupling protein of brown adipose tissue. Neutralization of E190 largely abolishes pH control of nucleotide binding
    • Echtay K.S., Bienengraeber M., and Klingenberg M. Mutagenesis of the uncoupling protein of brown adipose tissue. Neutralization of E190 largely abolishes pH control of nucleotide binding. Biochemistry 36 (1997) 8253-8260
    • (1997) Biochemistry , vol.36 , pp. 8253-8260
    • Echtay, K.S.1    Bienengraeber, M.2    Klingenberg, M.3
  • 39
    • 0034724170 scopus 로고    scopus 로고
    • Site-directed mutagenesis identifies residues in uncoupling protein (UCP1) involved in three different functions
    • Echtay K.S., Winkler E., Bienengraeber M., and Klingenberg M. Site-directed mutagenesis identifies residues in uncoupling protein (UCP1) involved in three different functions. Biochemistry 39 (2000) 3311-3317
    • (2000) Biochemistry , vol.39 , pp. 3311-3317
    • Echtay, K.S.1    Winkler, E.2    Bienengraeber, M.3    Klingenberg, M.4
  • 40
    • 0035340729 scopus 로고    scopus 로고
    • Role of intrahelical arginine residues in functional properties of uncoupling protein (UCP1)
    • Echtay K.S., Bienengraeber M., and Klingenberg M. Role of intrahelical arginine residues in functional properties of uncoupling protein (UCP1). Biochemistry 40 (2001) 5243-5248
    • (2001) Biochemistry , vol.40 , pp. 5243-5248
    • Echtay, K.S.1    Bienengraeber, M.2    Klingenberg, M.3
  • 42
    • 0342602044 scopus 로고    scopus 로고
    • Deletion of amino acids 261-269 in the brown fat uncoupling protein converts the carrier into a pore
    • Gonzalez-Barroso M.M., Fleury C., Levi-Meyrueis C., Zaragoza P., Bouillaud F., and Rial E. Deletion of amino acids 261-269 in the brown fat uncoupling protein converts the carrier into a pore. Biochemistry 36 (1997) 10930-10935
    • (1997) Biochemistry , vol.36 , pp. 10930-10935
    • Gonzalez-Barroso, M.M.1    Fleury, C.2    Levi-Meyrueis, C.3    Zaragoza, P.4    Bouillaud, F.5    Rial, E.6
  • 43
    • 0030881775 scopus 로고    scopus 로고
    • Identification by site-directed mutagenesis of three arginines in uncoupling protein that are essential for nucleotide binding and inhibition
    • Modriansky M., Murdza-Inglis D.L., Patel H.V., Freeman K.B., and Garlid K.D. Identification by site-directed mutagenesis of three arginines in uncoupling protein that are essential for nucleotide binding and inhibition. J. Biol. Chem. 272 (1997) 24759-24762
    • (1997) J. Biol. Chem. , vol.272 , pp. 24759-24762
    • Modriansky, M.1    Murdza-Inglis, D.L.2    Patel, H.V.3    Freeman, K.B.4    Garlid, K.D.5
  • 44
    • 0037290649 scopus 로고    scopus 로고
    • Substitutional mutations in the uncoupling protein-specific sequences of mitochondrial uncoupling protein UCP1 lead to the reduction of fatty acid-induced H+ uniport
    • Urbankova E., Hanak P., Skobisova E., Ruzicka M., and Jezek P. Substitutional mutations in the uncoupling protein-specific sequences of mitochondrial uncoupling protein UCP1 lead to the reduction of fatty acid-induced H+ uniport. Int. J. Biochem. Cell Biol. 35 (2003) 212-220
    • (2003) Int. J. Biochem. Cell Biol. , vol.35 , pp. 212-220
    • Urbankova, E.1    Hanak, P.2    Skobisova, E.3    Ruzicka, M.4    Jezek, P.5
  • 45
  • 46
    • 33748954833 scopus 로고    scopus 로고
    • Fatty acid activation of the uncoupling proteins requires the presence of the central matrix loop from UCP1
    • Jimenez-Jimenez J., Ledesma A., Zaragoza P., Gonzalez-Barroso M.M., and Rial E. Fatty acid activation of the uncoupling proteins requires the presence of the central matrix loop from UCP1. Biochim. Biophys. Acta 1757 (2006) 1292-1296
    • (2006) Biochim. Biophys. Acta , vol.1757 , pp. 1292-1296
    • Jimenez-Jimenez, J.1    Ledesma, A.2    Zaragoza, P.3    Gonzalez-Barroso, M.M.4    Rial, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.