메뉴 건너뛰기




Volumn 12, Issue 7, 2014, Pages 851-862

Molecular biology of calcific aortic valve disease: Towards new pharmacological therapies

Author keywords

aortic stenosis; bone morphogenetic protein; calcific aortic stenosis; calcific aortic valve disease; calcification; ectonucleotidase; lipid; Lp PLA2; notch; ox LDL; TGF ; Wnt

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; BONE MORPHOGENETIC PROTEIN 2; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 6; LIPID; MICRORNA; NOTCH RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PURINERGIC P2Y2 RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; LOW DENSITY LIPOPROTEIN;

EID: 84903159674     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/14779072.2014.923756     Document Type: Review
Times cited : (42)

References (100)
  • 1
    • 80054937214 scopus 로고    scopus 로고
    • Calcific aortic valve disease: Not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update
    • Rajamannan NM, Evans FJ, Aikawa E, et al. Calcific aortic valve disease: not simply a degenerative process: a review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: calcific aortic valve disease-2011 update. Circulation 2011; 124(16):1783-91
    • (2011) Circulation , vol.124 , Issue.16 , pp. 1783-1791
    • Rajamannan, N.M.1    Evans, F.J.2    Aikawa, E.3
  • 2
    • 0031051128 scopus 로고    scopus 로고
    • Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study
    • Stewart BF, Siscovick D, Lind BK, et al. Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study. J Am Coll Cardiol 1997;29(3):630-4
    • (1997) J Am Coll Cardiol , vol.29 , Issue.3 , pp. 630-634
    • Stewart, B.F.1    Siscovick, D.2    Lind, B.K.3
  • 3
    • 35448958501 scopus 로고    scopus 로고
    • The valvulo-metabolic' risk in calcific aortic valve disease
    • Mathieu P, Despres JP, Pibarot P. The valvulo-metabolic' risk in calcific aortic valve disease. Can J Cardiol 2007; 23(Suppl B):32B-9B
    • (2007) Can J Cardiol , vol.23 , Issue.SUPPL. B
    • Mathieu, P.1    Despres, J.P.2    Pibarot, P.3
  • 4
    • 77949883894 scopus 로고    scopus 로고
    • Refining molecular pathways leading to calcific aortic valve stenosis by studying gene expression profile of normal and calcified stenotic human aortic valves
    • Bosse Y, Miqdad A, Fournier D, et al. Refining molecular pathways leading to calcific aortic valve stenosis by studying gene expression profile of normal and calcified stenotic human aortic valves. Circ Cardiovasc Genet 2009;2(5):489-98
    • (2009) Circ Cardiovasc Genet , vol.2 , Issue.5 , pp. 489-498
    • Bosse, Y.1    Miqdad, A.2    Fournier, D.3
  • 5
    • 0032936072 scopus 로고    scopus 로고
    • Presence of oxidized low density lipoprotein in nonrheumatic stenotic aortic valves
    • Olsson M, Thyberg J, Nilsson J. Presence of oxidized low density lipoprotein in nonrheumatic stenotic aortic valves. Arterioscler Thromb Vasc Biol 1999;19(5): 1218-22
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , Issue.5 , pp. 1218-1222
    • Olsson, M.1    Thyberg, J.2    Nilsson, J.3
  • 6
    • 50249083965 scopus 로고    scopus 로고
    • Association between circulating oxidised low-density lipoprotein and fibrocalcific remodelling of the aortic valve in aortic stenosis
    • Cote C, Pibarot P, Despres JP, et al. Association between circulating oxidised low-density lipoprotein and fibrocalcific remodelling of the aortic valve in aortic stenosis. Heart 2008;94(9):1175-80
    • (2008) Heart , vol.94 , Issue.9 , pp. 1175-1180
    • Cote, C.1    Pibarot, P.2    Despres, J.P.3
  • 7
    • 33750703971 scopus 로고    scopus 로고
    • Calcific aortic valve stenosis in old hypercholesterolemic mice
    • Weiss RM, Ohashi M, Miller JD, et al. Calcific aortic valve stenosis in old hypercholesterolemic mice. Circulation 2006;114(19):2065-9
    • (2006) Circulation , vol.114 , Issue.19 , pp. 2065-2069
    • Weiss, R.M.1    Ohashi, M.2    Miller, J.D.3
  • 8
    • 65349154635 scopus 로고    scopus 로고
    • Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease
    • Aikawa E, Aikawa M, Libby P, et al. Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation 2009;119(13):1785-94
    • (2009) Circulation , vol.119 , Issue.13 , pp. 1785-1794
    • Aikawa, E.1    Aikawa, M.2    Libby, P.3
  • 9
    • 82155197192 scopus 로고    scopus 로고
    • Lipid lowering on progression of mild to moderate aortic stenosis: Meta-analysis of the randomized placebo-controlled clinical trials on 2344 patients
    • Teo KK, Corsi DJ, Tam JW, et al. Lipid lowering on progression of mild to moderate aortic stenosis: meta-analysis of the randomized placebo-controlled clinical trials on 2344 patients. Can J Cardiol 2011; 27(6):800-8
    • (2011) Can J Cardiol , vol.27 , Issue.6 , pp. 800-808
    • Teo, K.K.1    Corsi, D.J.2    Tam, J.W.3
  • 10
    • 78149452615 scopus 로고    scopus 로고
    • Impact of baseline severity of aortic valve stenosis on effect of intensive lipid lowering therapy (from the SEAS study)
    • Gerdts E, Rossebo AB, Pedersen TR, et al. Impact of baseline severity of aortic valve stenosis on effect of intensive lipid lowering therapy (from the SEAS study). Am J Cardiol 2010;106(11):1634-9
    • (2010) Am J Cardiol , vol.106 , Issue.11 , pp. 1634-1639
    • Gerdts, E.1    Rossebo, A.B.2    Pedersen, T.R.3
  • 11
    • 84867168145 scopus 로고    scopus 로고
    • A time course investigation of the statin paradox among valvular interstitial cell phenotypes
    • Monzack EL, Masters KS. A time course investigation of the statin paradox among valvular interstitial cell phenotypes. Am J Physiol Heart Circ Physiol 2012;303(7): H903-9
    • (2012) Am J Physiol Heart Circ Physiol , vol.303 , Issue.7
    • Monzack, E.L.1    Masters, K.S.2
  • 12
    • 36348976915 scopus 로고    scopus 로고
    • The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology
    • Liu AC, Joag VR, Gotlieb AI. The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology. Am J Pathol 2007;171(5): 1407-18
    • (2007) Am J Pathol , vol.171 , Issue.5 , pp. 1407-1418
    • Liu, A.C.1    Joag, V.R.2    Gotlieb, A.I.3
  • 14
    • 37549064021 scopus 로고    scopus 로고
    • Association between plasma LDL particle size, valvular accumulation of oxidized LDL, and inflammation in patients with aortic stenosis
    • Mohty D, Pibarot P, Despres JP, et al. Association between plasma LDL particle size, valvular accumulation of oxidized LDL, and inflammation in patients with aortic stenosis. Arterioscler Thromb Vasc Biol 2008;28(1): 187-93
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.1 , pp. 187-193
    • Mohty, D.1    Pibarot, P.2    Despres, J.P.3
  • 15
    • 84863646913 scopus 로고    scopus 로고
    • Impact of metabolic syndrome on progression of aortic stenosis: Influence of age and statin therapy
    • Capoulade R, Clavel MA, Dumesnil JG, et al. Impact of metabolic syndrome on progression of aortic stenosis: influence of age and statin therapy. J Am Coll Cardiol 2012;60(3):216-23
    • (2012) J Am Coll Cardiol , vol.60 , Issue.3 , pp. 216-223
    • Capoulade, R.1    Clavel, M.A.2    Dumesnil, J.G.3
  • 16
    • 84893258971 scopus 로고    scopus 로고
    • Elevated expression of lipoprotein-associated phospholipase A2 in calcific aortic valve disease: Implications for valve mineralization
    • Mahmut A, Boulanger MC, El HD, et al. Elevated expression of lipoprotein-associated phospholipase A2 in calcific aortic valve disease: implications for valve mineralization. J Am Coll Cardiol 2014; 63(5):460-9
    • (2014) J Am Coll Cardiol , vol.63 , Issue.5 , pp. 460-469
    • Mahmut, A.1    Boulanger, M.C.2    El, H.D.3
  • 17
    • 77953215987 scopus 로고    scopus 로고
    • Increased biglycan in aortic valve stenosis leads to the overexpression of phospholipid transfer protein via Toll-like receptor 2
    • Derbali H, Bosse Y, Cote N, et al. Increased biglycan in aortic valve stenosis leads to the overexpression of phospholipid transfer protein via Toll-like receptor 2. Am J Pathol 2010;176(6):2638-45
    • (2010) Am J Pathol , vol.176 , Issue.6 , pp. 2638-2645
    • Derbali, H.1    Bosse, Y.2    Cote, N.3
  • 18
    • 0041807631 scopus 로고    scopus 로고
    • Cell-associated and extracellular phospholipid transfer protein in human coronary atherosclerosis
    • O'Brien KD, Vuletic S, McDonald TO, et al. Cell-associated and extracellular phospholipid transfer protein in human coronary atherosclerosis. Circulation 2003; 108(3):270-4
    • (2003) Circulation , vol.108 , Issue.3 , pp. 270-274
    • O'Brien, K.D.1    Vuletic, S.2    McDonald, T.O.3
  • 19
    • 84871883037 scopus 로고    scopus 로고
    • Biglycan induces the expression of osteogenic factors in human aortic valve interstitial cells via Toll-like receptor-2
    • Song R, Zeng Q, Ao L, et al. Biglycan induces the expression of osteogenic factors in human aortic valve interstitial cells via Toll-like receptor-2. Arterioscler Thromb Vasc Biol 2012;32(11):2711-20
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , Issue.11 , pp. 2711-2720
    • Song, R.1    Zeng, Q.2    Ao, L.3
  • 20
    • 84873410033 scopus 로고    scopus 로고
    • Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans
    • Osman N, Grande-Allen KJ, Ballinger ML, et al. Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans. Cardiovasc Pathol 2013;22(2):146-55
    • (2013) Cardiovasc Pathol , vol.22 , Issue.2 , pp. 146-155
    • Osman, N.1    Grande-Allen, K.J.2    Ballinger, M.L.3
  • 21
    • 84877705895 scopus 로고    scopus 로고
    • Lipoprotein lipase in aortic valve stenosis is associated with lipid retention and remodelling
    • Mahmut A, Boulanger MC, Fournier D, et al. Lipoprotein lipase in aortic valve stenosis is associated with lipid retention and remodelling. Eur J Clin Invest 2013; 43(6):570-8
    • (2013) Eur J Clin Invest , vol.43 , Issue.6 , pp. 570-578
    • Mahmut, A.1    Boulanger, M.C.2    Fournier, D.3
  • 22
    • 0027232531 scopus 로고
    • Lipoprotein lipase enhances the interaction of low density lipoproteins with artery-derived extracellular matrix proteoglycans
    • Edwards IJ, Goldberg IJ, Parks JS, et al. Lipoprotein lipase enhances the interaction of low density lipoproteins with artery-derived extracellular matrix proteoglycans. J Lipid Res 1993;34(7): 1155-63
    • (1993) J Lipid Res , vol.34 , Issue.7 , pp. 1155-1163
    • Edwards, I.J.1    Goldberg, I.J.2    Parks, J.S.3
  • 23
    • 78449293027 scopus 로고    scopus 로고
    • 4-deoxy-4-fluoro-xyloside derivatives as inhibitors of glycosaminoglycan biosynthesis
    • Tsuzuki Y, Nguyen TK, Garud DR, et al. 4-deoxy-4-fluoro-xyloside derivatives as inhibitors of glycosaminoglycan biosynthesis. Bioorg Med Chem Lett 2010;20(24): 7269-73
    • (2010) Bioorg Med Chem Lett , vol.20 , Issue.24 , pp. 7269-7273
    • Tsuzuki, Y.1    Nguyen, T.K.2    Garud, D.R.3
  • 24
    • 84873513160 scopus 로고    scopus 로고
    • Genetic associations with valvular calcification and aortic stenosis
    • Thanassoulis G, Campbell CY, Owens DS, et al. Genetic associations with valvular calcification and aortic stenosis. N Engl J Med 2013;368(6):503-12
    • (2013) N Engl J Med , vol.368 , Issue.6 , pp. 503-512
    • Thanassoulis, G.1    Campbell, C.Y.2    Owens, D.S.3
  • 25
    • 84903123480 scopus 로고    scopus 로고
    • Lipoprotein(a) levels, genotype and incident aortic valve stenosis: A prospective mendelian randomization study and replication in a case-control cohort
    • [Epub ahead of print]
    • Arsenault BJ, Boekholdt SM, Dube MP, et al. Lipoprotein(a) levels, genotype and incident aortic valve stenosis: a prospective mendelian randomization study and replication in a case-control cohort. Circ Cardiovasc Genet 2014. [Epub ahead of print]
    • (2014) Circ Cardiovasc Genet
    • Arsenault, B.J.1    Boekholdt, S.M.2    Dube, M.P.3
  • 26
    • 84893333521 scopus 로고    scopus 로고
    • Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population
    • Kamstrup PR, Tybjaerg-Hansen A, Nordestgaard BG. Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population. J Am Coll Cardiol 2014;63(5):470-7
    • (2014) J Am Coll Cardiol , vol.63 , Issue.5 , pp. 470-477
    • Kamstrup, P.R.1    Tybjaerg-Hansen, A.2    Nordestgaard, B.G.3
  • 27
    • 84892867500 scopus 로고    scopus 로고
    • Mechanical strain induces the production of spheroid mineralized microparticles in the aortic valve through a RhoA/ROCK-dependent mechanism
    • Bouchareb R, Boulanger MC, Fournier D, et al. Mechanical strain induces the production of spheroid mineralized microparticles in the aortic valve through a RhoA/ROCK-dependent mechanism. J Mol Cell Cardiol 2014;67:49-59
    • (2014) J Mol Cell Cardiol , vol.67 , pp. 49-59
    • Bouchareb, R.1    Boulanger, M.C.2    Fournier, D.3
  • 28
    • 84893324002 scopus 로고    scopus 로고
    • New Therapeutic Targets for Calcific Aortic Valve Stenosis: The Lipoprotein(a)-Lipoprotein-Associated Phospholipase A2-Oxidized Phospholipid Axis
    • Hung MY, Witztum JL, Tsimikas S. New Therapeutic Targets for Calcific Aortic Valve Stenosis: the Lipoprotein(a)-Lipoprotein-Associated Phospholipase A2-Oxidized Phospholipid Axis. J Am Coll Cardiol 2014;63(5):478-80
    • (2014) J Am Coll Cardiol , vol.63 , Issue.5 , pp. 478-480
    • Hung, M.Y.1    Witztum, J.L.2    Tsimikas, S.3
  • 29
    • 73349126414 scopus 로고    scopus 로고
    • Lipoprotein-associated phospholipase A2. and atherosclerosis
    • Wilensky RL, Macphee CH. Lipoprotein-associated phospholipase A2. and atherosclerosis. Curr Opin Lipidol 2009;20(5):415-20
    • (2009) Curr Opin Lipidol , vol.20 , Issue.5 , pp. 415-420
    • Wilensky, R.L.1    Macphee, C.H.2
  • 30
    • 84899718423 scopus 로고    scopus 로고
    • Darapladib for preventing ischemic events in stable coronary heart disease
    • White HD, Held C, Stewart R, et al. Darapladib for preventing ischemic events in stable coronary heart disease. N Engl J Med 2014;370:1702-11
    • (2014) N Engl J Med , vol.370 , pp. 1702-1711
    • White, H.D.1    Held, C.2    Stewart, R.3
  • 31
    • 79953699040 scopus 로고    scopus 로고
    • Antisense oligonucleotide lowers plasma levels of apolipoprotein (a) and lipoprotein (a) in transgenic mice
    • Merki E, Graham M, Taleb A, et al. Antisense oligonucleotide lowers plasma levels of apolipoprotein (a) and lipoprotein (a) in transgenic mice. J Am Coll Cardiol 2011;57(15):1611-21
    • (2011) J Am Coll Cardiol , vol.57 , Issue.15 , pp. 1611-1621
    • Merki, E.1    Graham, M.2    Taleb, A.3
  • 32
    • 84862219022 scopus 로고    scopus 로고
    • Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy
    • McKenney JM, Koren MJ, Kereiakes DJ, et al. Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy. J Am Coll Cardiol 2012;59(25):2344-53
    • (2012) J Am Coll Cardiol , vol.59 , Issue.25 , pp. 2344-2353
    • McKenney, J.M.1    Koren, M.J.2    Kereiakes, D.J.3
  • 33
    • 68949220302 scopus 로고    scopus 로고
    • HDL particle size and the risk of coronary heart disease in apparently healthy men and women: The EPIC-Norfolk prospective population study
    • Arsenault BJ, Lemieux I, Despres JP, et al. HDL particle size and the risk of coronary heart disease in apparently healthy men and women: the EPIC-Norfolk prospective population study. Atherosclerosis 2009; 206(1):276-81
    • (2009) Atherosclerosis , vol.206 , Issue.1 , pp. 276-281
    • Arsenault, B.J.1    Lemieux, I.2    Despres, J.P.3
  • 34
    • 84901931466 scopus 로고    scopus 로고
    • Mendelian randomization of blood lipids for coronary heart disease
    • [Epub ahead of print]
    • Holmes MV, Asselbergs FW, Palmer TM, et al. Mendelian randomization of blood lipids for coronary heart disease. Eur Heart J 2014. [Epub ahead of print]
    • (2014) Eur Heart J
    • Holmes, M.V.1    Asselbergs, F.W.2    Palmer, T.M.3
  • 35
    • 84898627368 scopus 로고    scopus 로고
    • Site-specific nitration of apolipoprotein A-I at tyrosine 166 is both abundant within human atherosclerotic plaque and dysfunctional
    • Didonato JA, Aulak K, Huang Y, et al. Site-specific nitration of apolipoprotein A-I at tyrosine 166 is both abundant within human atherosclerotic plaque and dysfunctional. J Biol Chem 2014;289(15): 10276-92
    • (2014) J Biol Chem , vol.289 , Issue.15 , pp. 10276-10292
    • Didonato, J.A.1    Aulak, K.2    Huang, Y.3
  • 36
    • 84871923617 scopus 로고    scopus 로고
    • Amyloid substance within stenotic aortic valves promotes mineralization
    • Audet A, Cote N, Couture C, et al. Amyloid substance within stenotic aortic valves promotes mineralization. Histopathology 2012;61(4):610-19
    • (2012) Histopathology , vol.61 , Issue.4 , pp. 610-619
    • Audet, A.1    Cote, N.2    Couture, C.3
  • 37
    • 84895032730 scopus 로고    scopus 로고
    • Evaluation of links between high-density lipoprotein genetics functionality and aortic valve stenosis risk in humans
    • Arsenault BJ, Dube MP, Brodeur MR, et al. Evaluation of links between high-density lipoprotein genetics, functionality, and aortic valve stenosis risk in humans. Arterioscler Thromb Vasc Biol 2014;34(2):457-62
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , Issue.2 , pp. 457-462
    • Arsenault, B.J.1    Dube, M.P.2    Brodeur, M.R.3
  • 38
    • 84880270197 scopus 로고    scopus 로고
    • Improvement of aortic valve stenosis by ApoA-I mimetic therapy is associated with decreased aortic root and valve remodelling in mice
    • Trapeaux J, Busseuil D, Shi Y, et al. Improvement of aortic valve stenosis by ApoA-I mimetic therapy is associated with decreased aortic root and valve remodelling in mice. Br J Pharmacol 2013;169(7): 1587-99
    • (2013) Br J Pharmacol , vol.169 , Issue.7 , pp. 1587-1599
    • Trapeaux, J.1    Busseuil, D.2    Shi, Y.3
  • 39
    • 44949203465 scopus 로고    scopus 로고
    • Regression of aortic valve stenosis by ApoA-I mimetic peptide infusions in rabbits
    • Busseuil D, Shi Y, Mecteau M, et al. Regression of aortic valve stenosis by ApoA-I mimetic peptide infusions in rabbits. Br J Pharmacol 2008;154(4):765-73
    • (2008) Br J Pharmacol , vol.154 , Issue.4 , pp. 765-773
    • Busseuil, D.1    Shi, Y.2    Mecteau, M.3
  • 40
    • 77955960185 scopus 로고    scopus 로고
    • Recombinant apolipoprotein A-I Milano rapidly reverses aortic valve stenosis and decreases leaflet inflammation in an experimental rabbit model
    • Speidl WS, Cimmino G, Ibanez B, et al. Recombinant apolipoprotein A-I Milano rapidly reverses aortic valve stenosis and decreases leaflet inflammation in an experimental rabbit model. Eur Heart J 2010;31(16):2049-57
    • (2010) Eur Heart J , vol.31 , Issue.16 , pp. 2049-2057
    • Speidl, W.S.1    Cimmino, G.2    Ibanez, B.3
  • 41
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma
    • Nagy L, Tontonoz P, Alvarez JG, et al. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell 1998;93(2):229-40
    • (1998) Cell , vol.93 , Issue.2 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.3
  • 42
    • 84874388376 scopus 로고    scopus 로고
    • Pioglitazone attenuates valvular calcification induced by hypercholesterolemia
    • Chu Y, Lund DD, Weiss RM, et al. Pioglitazone attenuates valvular calcification induced by hypercholesterolemia. Arterioscler Thromb Vasc Biol 2013;33(3): 523-32
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , Issue.3 , pp. 523-532
    • Chu, Y.1    Lund, D.D.2    Weiss, R.M.3
  • 43
    • 66049138419 scopus 로고    scopus 로고
    • Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation
    • Festuccia WT, Laplante M, Brule S, et al. Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation. J Mol Cell Cardiol 2009;47(1):85-95
    • (2009) J Mol Cell Cardiol , vol.47 , Issue.1 , pp. 85-95
    • Festuccia, W.T.1    Laplante, M.2    Brule, S.3
  • 44
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007;356(24):2457-71
    • (2007) N Engl J Med , vol.356 , Issue.24 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 45
    • 49849089138 scopus 로고    scopus 로고
    • Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans
    • Miller JD, Chu Y, Brooks RM, et al. Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans. J Am Coll Cardiol 2008;52(10): 843-50
    • (2008) J Am Coll Cardiol , vol.52 , Issue.10 , pp. 843-850
    • Miller, J.D.1    Chu, Y.2    Brooks, R.M.3
  • 46
    • 84900547836 scopus 로고    scopus 로고
    • Aortic valve sclerosis in mice deficient in endothelial nitric oxide synthase
    • El Accaoui RN, Gould ST, Hajj GP, et al. Aortic valve sclerosis in mice deficient in endothelial nitric oxide synthase. Am J Physiol Heart Circ Physiol 2014;306: H1302-H13
    • (2014) Am J Physiol Heart Circ Physiol , vol.306
    • El Accaoui, R.N.1    Gould, S.T.2    Hajj, G.P.3
  • 47
    • 20044364836 scopus 로고    scopus 로고
    • Atorvastatin inhibits calcification and enhances nitric oxide synthase production in the hypercholesterolaemic aortic valve
    • Rajamannan NM, Subramaniam M, Stock SR, et al. Atorvastatin inhibits calcification and enhances nitric oxide synthase production in the hypercholesterolaemic aortic valve. Heart 2005;91(6):806-10
    • (2005) Heart , vol.91 , Issue.6 , pp. 806-810
    • Rajamannan, N.M.1    Subramaniam, M.2    Stock, S.R.3
  • 48
    • 84879411196 scopus 로고    scopus 로고
    • Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease
    • Li H, Forstermann U. Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease. Curr Opin Pharmacol 2013;13(2):161-7
    • (2013) Curr Opin Pharmacol , vol.13 , Issue.2 , pp. 161-167
    • Li, H.1    Forstermann, U.2
  • 49
    • 80051978810 scopus 로고    scopus 로고
    • Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling
    • Forstermann U, Li H. Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling. Br J Pharmacol 2011;164(2): 213-23
    • (2011) Br J Pharmacol , vol.164 , Issue.2 , pp. 213-223
    • Forstermann, U.1    Li, H.2
  • 50
    • 84877732914 scopus 로고    scopus 로고
    • Inflammation is associated with the remodeling of calcific aortic valve disease
    • Cote N, Mahmut A, Bosse Y, et al. Inflammation is associated with the remodeling of calcific aortic valve disease. Inflammation 2013;36(3):573-81
    • (2013) Inflammation , vol.36 , Issue.3 , pp. 573-581
    • Cote, N.1    Mahmut, A.2    Bosse, Y.3
  • 51
    • 33749529401 scopus 로고    scopus 로고
    • Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis
    • Yoshioka M, Yuasa S, Matsumura K, et al. Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. Nat Med 2006;12(10): 1151-9
    • (2006) Nat Med , vol.12 , Issue.10 , pp. 1151-1159
    • Yoshioka, M.1    Yuasa, S.2    Matsumura, K.3
  • 52
    • 20144377112 scopus 로고    scopus 로고
    • Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis
    • Kaden JJ, Dempfle CE, Grobholz R, et al. Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis. Cardiovasc Pathol 2005;14(2): 80-7
    • (2005) Cardiovasc Pathol , vol.14 , Issue.2 , pp. 80-87
    • Kaden, J.J.1    Dempfle, C.E.2    Grobholz, R.3
  • 53
    • 0033735304 scopus 로고    scopus 로고
    • Matrix metalloproteinase expression in nonrheumatic aortic stenosis
    • Edep ME, Shirani J, Wolf P, et al. Matrix metalloproteinase expression in nonrheumatic aortic stenosis. Cardiovasc Pathol 2000;9(5):281-6
    • (2000) Cardiovasc Pathol , vol.9 , Issue.5 , pp. 281-286
    • Edep, M.E.1    Shirani, J.2    Wolf, P.3
  • 54
    • 84893483278 scopus 로고    scopus 로고
    • Defining the role of fluid shear stress in the expression of early signaling markers for calcific aortic valve disease
    • Sun L, Rajamannan NM, Sucosky P. Defining the role of fluid shear stress in the expression of early signaling markers for calcific aortic valve disease. PLoS One 2013; 8(12):e84433
    • (2013) PLoS One , vol.8 , Issue.12
    • Sun, L.1    Rajamannan, N.M.2    Sucosky, P.3
  • 55
    • 84868283392 scopus 로고    scopus 로고
    • Ex vivo evidence for the contribution of hemodynamic shear stress abnormalities to the early pathogenesis of calcific bicuspid aortic valve disease
    • Sun L, Chandra S, Sucosky P. Ex vivo evidence for the contribution of hemodynamic shear stress abnormalities to the early pathogenesis of calcific bicuspid aortic valve disease. PLoS One 2012;7(10): e48843
    • (2012) PLoS One , vol.7 , Issue.10
    • Sun, L.1    Chandra, S.2    Sucosky, P.3
  • 56
    • 33750844857 scopus 로고    scopus 로고
    • Distribution of SPARC during neovascularisation of degenerative aortic stenosis
    • Charest A, Pepin A, Shetty R, et al. Distribution of SPARC during neovascularisation of degenerative aortic stenosis. Heart 2006;92(12):1844-9
    • (2006) Heart , vol.92 , Issue.12 , pp. 1844-1849
    • Charest, A.1    Pepin, A.2    Shetty, R.3
  • 57
    • 84887497888 scopus 로고    scopus 로고
    • Aortic valvular interstitial cells apoptosis and calcification are mediated by TNF-related apoptosis-inducing ligand
    • Galeone A, Brunetti G, Oranger A, et al. Aortic valvular interstitial cells apoptosis and calcification are mediated by TNF-related apoptosis-inducing ligand. Int J Cardiol 2013;169(4):296-304
    • (2013) Int J Cardiol , vol.169 , Issue.4 , pp. 296-304
    • Galeone, A.1    Brunetti, G.2    Oranger, A.3
  • 58
    • 77950889002 scopus 로고    scopus 로고
    • Deficiency of interleukin-1 receptor antagonist induces aortic valve disease in BALB/c mice
    • Isoda K, Matsuki T, Kondo H, et al. Deficiency of interleukin-1 receptor antagonist induces aortic valve disease in BALB/c mice. Arterioscler Thromb Vasc Biol 2010;30(4):708-15
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , Issue.4 , pp. 708-715
    • Isoda, K.1    Matsuki, T.2    Kondo, H.3
  • 59
    • 84871737124 scopus 로고    scopus 로고
    • Inflammatory cytokines promote mesenchymal transformation in embryonic and adult valve endothelial cells
    • Mahler GJ, Farrar EJ, Butcher JT. Inflammatory cytokines promote mesenchymal transformation in embryonic and adult valve endothelial cells. Arterioscler Thromb Vasc Biol 2013;33(1):121-30
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , Issue.1 , pp. 121-130
    • Mahler, G.J.1    Farrar, E.J.2    Butcher, J.T.3
  • 60
    • 84901234969 scopus 로고    scopus 로고
    • P2Y2 receptor represses IL-6 expression by valve interstitial cells through Akt: Implication for calcific aortic valve disease
    • El Husseini D, Boulanger MC, Mahmut A, et al. P2Y2 receptor represses IL-6 expression by valve interstitial cells through Akt: implication for calcific aortic valve disease. J Mol Cell Cardiol 2014;72:146-56
    • (2014) J Mol Cell Cardiol , vol.72 , pp. 146-156
    • El Husseini, D.1    Boulanger, M.C.2    Mahmut, A.3
  • 61
    • 78049445876 scopus 로고    scopus 로고
    • Tocilizumab for the treatment of rheumatoid arthritis
    • Tanaka T, Ogata A, Narazaki M. Tocilizumab for the treatment of rheumatoid arthritis. Expert Rev Clin Immunol 2010;6(6):843-54
    • (2010) Expert Rev Clin Immunol , vol.6 , Issue.6 , pp. 843-854
    • Tanaka, T.1    Ogata, A.2    Narazaki, M.3
  • 62
    • 80053918228 scopus 로고    scopus 로고
    • Angiotensin receptor blockers are associated with a lower remodelling score of stenotic aortic valves
    • Cote N, Couture C, Pibarot P, et al. Angiotensin receptor blockers are associated with a lower remodelling score of stenotic aortic valves. Eur J Clin Invest 2011;41(11): 1172-9
    • (2011) Eur J Clin Invest , vol.41 , Issue.11 , pp. 1172-1179
    • Cote, N.1    Couture, C.2    Pibarot, P.3
  • 63
    • 78650010990 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein, angiotensin II and increased waist cirumference are associated with valve inflammation in prehypertensive patients with aortic stenosis
    • Cote N, Pibarot P, Pepin A, et al. Oxidized low-density lipoprotein, angiotensin II and increased waist cirumference are associated with valve inflammation in prehypertensive patients with aortic stenosis. Int J Cardiol 2010;145(3):444-9
    • (2010) Int J Cardiol , vol.145 , Issue.3 , pp. 444-449
    • Cote, N.1    Pibarot, P.2    Pepin, A.3
  • 64
    • 0031194295 scopus 로고    scopus 로고
    • Angiotensin II stimulated expression of transforming growth factor-beta1 in cardiac fibroblasts and myofibroblasts
    • Campbell SE, Katwa LC. Angiotensin II stimulated expression of transforming growth factor-beta1 in cardiac fibroblasts and myofibroblasts. J Mol Cell Cardiol 1997;29(7):1947-58
    • (1997) J Mol Cell Cardiol , vol.29 , Issue.7 , pp. 1947-1958
    • Campbell, S.E.1    Katwa, L.C.2
  • 65
    • 84873812335 scopus 로고    scopus 로고
    • Effects of probucol on angiotensin II-induced BMP-2 expression in human umbilical vein endothelial cells
    • Zhang M, Wang J, Liu JH, et al. Effects of probucol on angiotensin II-induced BMP-2 expression in human umbilical vein endothelial cells. Mol Med Rep 2013;7(1): 177-82
    • (2013) Mol Med Rep , vol.7 , Issue.1 , pp. 177-182
    • Zhang, M.1    Wang, J.2    Liu, J.H.3
  • 66
    • 17644373433 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors and change in aortic valve calcium
    • O'Brien KD, Probstfield JL, Caulfield MT, et al. Angiotensin-converting enzyme inhibitors and change in aortic valve calcium. Arch Intern Med 2005;165(8): 858-62
    • (2005) Arch Intern Med , vol.165 , Issue.8 , pp. 858-862
    • O'Brien, K.D.1    Probstfield, J.L.2    Caulfield, M.T.3
  • 67
    • 84888064712 scopus 로고    scopus 로고
    • Impact of hypertension and renin-angiotensin system inhibitors in aortic stenosis
    • Capoulade R, Clavel MA, Mathieu P, et al. Impact of hypertension and renin-angiotensin system inhibitors in aortic stenosis. Eur J Clin Invest 2013;43(12): 1262-72
    • (2013) Eur J Clin Invest , vol.43 , Issue.12 , pp. 1262-1272
    • Capoulade, R.1    Clavel, M.A.2    Mathieu, P.3
  • 68
    • 84884703844 scopus 로고    scopus 로고
    • Angiotensin receptor blockers are associated with reduced fibrosis and interleukin-6 expression in calcific aortic valve disease
    • Cote N, Mahmut A, Fournier D, et al. Angiotensin receptor blockers are associated with reduced fibrosis and interleukin-6 expression in calcific aortic valve disease. Pathobiology 2014;81(1):15-24
    • (2014) Pathobiology , vol.81 , Issue.1 , pp. 15-24
    • Cote, N.1    Mahmut, A.2    Fournier, D.3
  • 69
    • 84871385153 scopus 로고    scopus 로고
    • Angiotensin II promotes aortic valve thickening independent of elevated blood pressure in apolipoprotein-E deficient mice
    • Fujisaka T, Hoshiga M, Hotchi J, et al. Angiotensin II promotes aortic valve thickening independent of elevated blood pressure in apolipoprotein-E deficient mice. Atherosclerosis 2013;226(1): 82-7
    • (2013) Atherosclerosis , vol.226 , Issue.1 , pp. 82-87
    • Fujisaka, T.1    Hoshiga, M.2    Hotchi, J.3
  • 70
    • 7044237097 scopus 로고    scopus 로고
    • Induction of local angiotensin II-producing systems in stenotic aortic valves
    • Helske S, Lindstedt KA, Laine M, et al. Induction of local angiotensin II-producing systems in stenotic aortic valves. J Am Coll Cardiol 2004;44(9):1859-66
    • (2004) J Am Coll Cardiol , vol.44 , Issue.9 , pp. 1859-1866
    • Helske, S.1    Lindstedt, K.A.2    Laine, M.3
  • 71
    • 33947579076 scopus 로고    scopus 로고
    • Angiotensin receptor-1 blocker inhibits atherosclerotic changes and endothelial disruption of the aortic valve in hypercholesterolemic rabbits
    • Arishiro K, Hoshiga M, Negoro N, et al. Angiotensin receptor-1 blocker inhibits atherosclerotic changes and endothelial disruption of the aortic valve in hypercholesterolemic rabbits. J Am Coll Cardiol 2007;49(13):1482-9
    • (2007) J Am Coll Cardiol , vol.49 , Issue.13 , pp. 1482-1489
    • Arishiro, K.1    Hoshiga, M.2    Negoro, N.3
  • 72
    • 3042844216 scopus 로고    scopus 로고
    • Hemodynamic effects of the angiotensin-converting enzyme inhibitor, ramipril, in patients with mild to moderate aortic stenosis and preserved left ventricular function
    • O'Brien KD, Zhao XQ, Shavelle DM, et al. Hemodynamic effects of the angiotensin-converting enzyme inhibitor, ramipril, in patients with mild to moderate aortic stenosis and preserved left ventricular function. J Investig Med 2004;52(3): 185-91
    • (2004) J Investig Med , vol.52 , Issue.3 , pp. 185-191
    • O'Brien, K.D.1    Zhao, X.Q.2    Shavelle, D.M.3
  • 73
    • 24644467759 scopus 로고    scopus 로고
    • Mutations in NOTCH1 cause aortic valve disease
    • Garg V, Muth AN, Ransom JF, et al. Mutations in NOTCH1 cause aortic valve disease. Nature 2005;437(7056):270-4
    • (2005) Nature , vol.437 , Issue.7056 , pp. 270-274
    • Garg, V.1    Muth, A.N.2    Ransom, J.F.3
  • 74
    • 84865241459 scopus 로고    scopus 로고
    • The Notch signalling system: Recent insights into the complexity of a conserved pathway
    • Guruharsha KG, Kankel MW, Artavanis-Tsakonas S. The Notch signalling system: recent insights into the complexity of a conserved pathway. Nat Rev Genet 2012; 13(9):654-66
    • (2012) Nat Rev Genet , vol.13 , Issue.9 , pp. 654-666
    • Guruharsha, K.G.1    Kankel, M.W.2    Artavanis-Tsakonas, S.3
  • 75
    • 70350580660 scopus 로고    scopus 로고
    • Notch1 represses osteogenic pathways in aortic valve cells
    • Nigam V, Srivastava D. Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol 2009;47(6):828-34
    • (2009) J Mol Cell Cardiol , vol.47 , Issue.6 , pp. 828-834
    • Nigam, V.1    Srivastava, D.2
  • 76
    • 79959714407 scopus 로고    scopus 로고
    • Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL
    • Nus M, MacGrogan D, Martinez-Poveda B, et al. Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL. Arterioscler Thromb Vasc Biol 2011;31(7):1580-8
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , Issue.7 , pp. 1580-1588
    • Nus, M.1    Macgrogan, D.2    Martinez-Poveda, B.3
  • 77
    • 84880575212 scopus 로고    scopus 로고
    • NOTCH1 genetic variants in patients with tricuspid calcific aortic valve stenosis
    • Ducharme V, Guauque-Olarte S, Gaudreault N, et al. NOTCH1 genetic variants in patients with tricuspid calcific aortic valve stenosis. J Heart Valve Dis 2013;22(2): 142-9
    • (2013) J Heart Valve Dis , vol.22 , Issue.2 , pp. 142-149
    • Ducharme, V.1    Guauque-Olarte, S.2    Gaudreault, N.3
  • 78
    • 0038711036 scopus 로고    scopus 로고
    • Human aortic valve calcification is associated with an osteoblast phenotype
    • Rajamannan NM, Subramaniam M, Rickard D, et al. Human aortic valve calcification is associated with an osteoblast phenotype. Circulation 2003;107(17): 2181-4
    • (2003) Circulation , vol.107 , Issue.17 , pp. 2181-2184
    • Rajamannan, N.M.1    Subramaniam, M.2    Rickard, D.3
  • 79
    • 24644510707 scopus 로고    scopus 로고
    • Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway
    • Rajamannan NM, Subramaniam M, Caira F, et al. Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway. Circulation 2005;112(9 Suppl): I229-34
    • (2005) Circulation , vol.112 , Issue.9 SUPPL.
    • Rajamannan, N.M.1    Subramaniam, M.2    Caira, F.3
  • 80
    • 45849117967 scopus 로고    scopus 로고
    • Wnt signal transduction pathways
    • Komiya Y, Habas R. Wnt signal transduction pathways. Organogenesis 2008; 4(2):68-75
    • (2008) Organogenesis , vol.4 , Issue.2 , pp. 68-75
    • Komiya, Y.1    Habas, R.2
  • 81
    • 33646466212 scopus 로고    scopus 로고
    • Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation
    • Caira FC, Stock SR, Gleason TG, et al. Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation. J Am Coll Cardiol 2006;47(8):1707-12
    • (2006) J Am Coll Cardiol , vol.47 , Issue.8 , pp. 1707-1712
    • Caira, F.C.1    Stock, S.R.2    Gleason, T.G.3
  • 82
    • 84870318883 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts
    • Zhang R, Oyajobi BO, Harris SE, et al. Wnt/beta-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts. Bone 2013;52(1):145-56
    • (2013) Bone , vol.52 , Issue.1 , pp. 145-156
    • Zhang, R.1    Oyajobi, B.O.2    Harris, S.E.3
  • 83
    • 80053213765 scopus 로고    scopus 로고
    • The role of Lrp5/6 in cardiac valve disease: Experimental hypercholesterolemia in the ApoE-/-/Lrp5-/-mice
    • Rajamannan NM. The role of Lrp5/6 in cardiac valve disease: experimental hypercholesterolemia in the ApoE-/-/Lrp5-/-mice. J Cell Biochem 2011;112(10): 2987-91
    • (2011) J Cell Biochem , vol.112 , Issue.10 , pp. 2987-2991
    • Rajamannan, N.M.1
  • 84
    • 33646550902 scopus 로고    scopus 로고
    • Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling
    • Deregowski V, Gazzerro E, Priest L, et al. Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling. J Biol Chem 2006;281(10): 6203-10
    • (2006) J Biol Chem , vol.281 , Issue.10 , pp. 6203-6210
    • Deregowski, V.1    Gazzerro, E.2    Priest, L.3
  • 85
    • 84894077407 scopus 로고    scopus 로고
    • MicroRNA-30b is a multifunctional regulator of aortic valve interstitial cells
    • Zhang M, Liu X, Zhang X, et al. MicroRNA-30b is a multifunctional regulator of aortic valve interstitial cells. J Thorac Cardiovasc Surg 2014;147(3): 1073-80
    • (2014) J Thorac Cardiovasc Surg , vol.147 , Issue.3 , pp. 1073-1080
    • Zhang, M.1    Liu, X.2    Zhang, X.3
  • 86
    • 84862629212 scopus 로고    scopus 로고
    • MiRNA-141 is a novel regulator of BMP-2-mediated calcification in aortic stenosis
    • Yanagawa B, Lovren F, Pan Y, et al. miRNA-141 is a novel regulator of BMP-2-mediated calcification in aortic stenosis. J Thorac Cardiovasc Surg 2012; 144(1):256-62
    • (2012) J Thorac Cardiovasc Surg , vol.144 , Issue.1 , pp. 256-262
    • Yanagawa, B.1    Lovren, F.2    Pan, Y.3
  • 87
    • 84892837923 scopus 로고    scopus 로고
    • MicroRNA miR-378 promotes BMP2-induced osteogenic differentiation of mesenchymal progenitor cells
    • Hupkes M, Sotoca AM, Hendriks JM, et al. MicroRNA miR-378 promotes BMP2-induced osteogenic differentiation of mesenchymal progenitor cells. BMC Mol Biol 2014;15:1-15
    • (2014) BMC Mol Biol , vol.15 , pp. 1-15
    • Hupkes, M.1    Sotoca, A.M.2    Hendriks, J.M.3
  • 88
    • 0037314647 scopus 로고    scopus 로고
    • Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis
    • Jian B, Narula N, Li QY, et al. Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis. Ann Thorac Surg 2003;75(2):457-65
    • (2003) Ann Thorac Surg , vol.75 , Issue.2 , pp. 457-465
    • Jian, B.1    Narula, N.2    Li, Q.Y.3
  • 89
    • 79958818345 scopus 로고    scopus 로고
    • Preferential activation of SMAD1/5/8 on the fibrosa endothelium in calcified human aortic valves-association with low BMP antagonists and SMAD6
    • Ankeny RF, Thourani VH, Weiss D, et al. Preferential activation of SMAD1/5/8 on the fibrosa endothelium in calcified human aortic valves-association with low BMP antagonists and SMAD6. PLoS One 2011; 6(6):e20969
    • (2011) PLoS One , vol.6 , Issue.6
    • Ankeny, R.F.1    Thourani, V.H.2    Weiss, D.3
  • 90
    • 84871778802 scopus 로고    scopus 로고
    • Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts
    • Hutcheson JD, Chen J, Sewell-Loftin MK, et al. Cadherin-11 regulates cell-cell tension necessary for calcific nodule formation by valvular myofibroblasts. Arterioscler Thromb Vasc Biol 2013;33(1):114-20
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , Issue.1 , pp. 114-120
    • Hutcheson, J.D.1    Chen, J.2    Sewell-Loftin, M.K.3
  • 91
    • 79952134815 scopus 로고    scopus 로고
    • Beta-catenin mediates mechanically regulated transforming growth factor-beta1-induced myofibroblast differentiation of aortic valve interstitial cells
    • Chen JH, Chen WL, Sider KL, et al. beta-catenin mediates mechanically regulated, transforming growth factor-beta1-induced myofibroblast differentiation of aortic valve interstitial cells. Arterioscler Thromb Vasc Biol 2011; 31(3):590-7
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , Issue.3 , pp. 590-597
    • Chen, J.H.1    Chen, W.L.2    Sider, K.L.3
  • 92
    • 84867398372 scopus 로고    scopus 로고
    • 5-HT(2B) antagonism arrests non-canonical TGF-beta1-induced valvular myofibroblast differentiation
    • Hutcheson JD, Ryzhova LM, Setola V, et al. 5-HT(2B) antagonism arrests non-canonical TGF-beta1-induced valvular myofibroblast differentiation. J Mol Cell Cardiol 2012;53(5):707-14
    • (2012) J Mol Cell Cardiol , vol.53 , Issue.5 , pp. 707-714
    • Hutcheson, J.D.1    Ryzhova, L.M.2    Setola, V.3
  • 94
    • 84896291778 scopus 로고    scopus 로고
    • Serum phosphate is associated with aortic valve calcification in the Multi-ethnic Study of Atherosclerosis (MESA)
    • Linefsky JP, O'Brien KD, Sachs M, et al. Serum phosphate is associated with aortic valve calcification in the Multi-ethnic Study of Atherosclerosis (MESA). Atherosclerosis 2014;233(2):331-7
    • (2014) Atherosclerosis , vol.233 , Issue.2 , pp. 331-337
    • Linefsky, J.P.1    O'Brien, K.D.2    Sachs, M.3
  • 95
    • 84869085338 scopus 로고    scopus 로고
    • Pharmacology of ectonucleotidases: Relevance for the treatment of cardiovascular disorders
    • Mathieu P. Pharmacology of ectonucleotidases: relevance for the treatment of cardiovascular disorders. Eur J Pharmacol 2012;696(1-3):1-4
    • (2012) Eur J Pharmacol , vol.696 , Issue.1-3 , pp. 1-4
    • Mathieu, P.1
  • 96
    • 24344435113 scopus 로고    scopus 로고
    • Calcification of human valve interstitial cells is dependent on alkaline phosphatase activity
    • Mathieu P, Voisine P, Pepin A, et al. Calcification of human valve interstitial cells is dependent on alkaline phosphatase activity. J Heart Valve Dis 2005;14(3): 353-7
    • (2005) J Heart Valve Dis , vol.14 , Issue.3 , pp. 353-357
    • Mathieu, P.1    Voisine, P.2    Pepin, A.3
  • 97
    • 84859652051 scopus 로고    scopus 로고
    • ATP acts as a survival signal and prevents the mineralization of aortic valve
    • Cote N, El HD, Pepin A, et al. ATP acts as a survival signal and prevents the mineralization of aortic valve. J Mol Cell Cardiol 2012;52(5):1191-202
    • (2012) J Mol Cell Cardiol , vol.52 , Issue.5 , pp. 1191-1202
    • Cote, N.1    El, H.D.2    Pepin, A.3
  • 98
    • 0031859977 scopus 로고    scopus 로고
    • Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine
    • Okawa A, Nakamura I, Goto S, et al. Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet 1998; 19(3):271-3
    • (1998) Nat Genet , vol.19 , Issue.3 , pp. 271-273
    • Okawa, A.1    Nakamura, I.2    Goto, S.3
  • 99
    • 84871897290 scopus 로고    scopus 로고
    • High expression of the Pi-transporter SLC20A1/Pit1 in calcific aortic valve disease promotes mineralization through regulation of Akt-1
    • El Husseini D, Boulanger MC, Fournier D, et al. High expression of the Pi-transporter SLC20A1/Pit1 in calcific aortic valve disease promotes mineralization through regulation of Akt-1. PLoS One 2013;8(1):e53393
    • (2013) PLoS One , vol.8 , Issue.1
    • El Husseini, D.1    Boulanger, M.C.2    Fournier, D.3
  • 100
    • 84864284460 scopus 로고    scopus 로고
    • Inhibition of ectonucleotidase with ARL67156 prevents the development of calcific aortic valve disease in warfarin-treated rats
    • Cote N, El Husseini D, Pepin A, et al. Inhibition of ectonucleotidase with ARL67156 prevents the development of calcific aortic valve disease in warfarin-treated rats. Eur J Pharmacol 2012; 689(1-3):139-46
    • (2012) Eur J Pharmacol , vol.689 , Issue.1-3 , pp. 139-146
    • Cote, N.1    El Husseini, D.2    Pepin, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.