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Volumn 8, Issue 12, 2013, Pages

Defining the role of fluid shear stress in the expression of early signaling markers for calcific aortic valve disease

Author keywords

[No Author keywords available]

Indexed keywords

ANALYSIS OF VARIANCE; AORTIC VALVE; BIOMECHANICAL PHENOMENA; BONE MORPHOGENETIC PROTEIN 4; CALCINOSIS; CATHEPSIN L; CATHEPSINS; CELL ADHESION MOLECULES; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; HEART DEFECTS, CONGENITAL; HEART VALVE DISEASES; HEMODYNAMICS; HUMANS; IMMUNOBLOTTING; IMMUNOGLOBULINS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; SHEAR STRENGTH; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84893483278     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084433     Document Type: Article
Times cited : (69)

References (69)
  • 1
    • 84872091789 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2013 Update: A report from the American Heart Association
    • doi:10.1161/CIR.0b013e31828124ad
    • Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, et al. (2013) Heart disease and stroke statistics - 2013 update: a report from the American Heart Association. Circulation 127: e6-e245. doi:10.1161/CIR.0b013e31828124ad.
    • (2013) Circulation , vol.127
    • Go, A.S.1    Mozaffarian, D.2    Roger, V.L.3    Benjamin, E.J.4    Berry, J.D.5
  • 4
    • 0027991976 scopus 로고
    • Characterization of the early lesion of 'degenerative' valvular aortic stenosis: Histological and immunohistochemical studies
    • Otto CM, Kuusisto J, Reichenbach DD (1994) Characterization of the early lesion of "degenerative" valvular aortic stenosis. Histological and immunohistochemical studies. Circulation 90: 844-853. doi:10.1161/01.CIR.90.2. 844. (Pubitemid 24242754)
    • (1994) Circulation , vol.90 , Issue.2 , pp. 844-853
    • Otto, C.M.1    Kuusisto, J.2    Reichenbach, D.D.3    Gown, A.M.4    O'Brien, K.D.5
  • 5
    • 36348976915 scopus 로고    scopus 로고
    • The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology
    • DOI 10.2353/ajpath.2007.070251
    • Liu AC, Joag VR, Gotlieb AI (2007) The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology. Am J Pathol 171: 1407-1418. doi:10.2353/ajpath.2007.070251. (Pubitemid 350158303)
    • (2007) American Journal of Pathology , vol.171 , Issue.5 , pp. 1407-1418
    • Liu, A.C.1    Joag, V.R.2    Gotlieb, A.I.3
  • 6
    • 4043127381 scopus 로고    scopus 로고
    • Valvular myofibroblast activation by transforming growth factor-beta: Implications for pathological extracellular matrix remodeling in heart valve disease
    • DOI 10.1161/01.RES.0000136520.07995.aa
    • Walker GA, Masters KS, Shah DN, Anseth KS, Leinwand LA (2004) Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease. Circ Res 95: 253-260. doi:10.1161/01.RES.0000136520.07995.aa. (Pubitemid 39056285)
    • (2004) Circulation Research , vol.95 , Issue.3 , pp. 253-260
    • Walker, G.A.1    Masters, K.S.2    Shah, D.N.3    Anseth, K.S.4    Leinwand, L.A.5
  • 7
    • 0033735304 scopus 로고    scopus 로고
    • Matrix metalloproteinase expression in nonrheumatic aortic stenosis
    • doi:10.1016/S1054-8807(00)00043-0
    • Edep ME, Shirani J, Wolf P, Brown DL (2000) Matrix metalloproteinase expression in nonrheumatic aortic stenosis. Cardiovasc Pathol 9: 281-286. doi:10.1016/S1054-8807(00)00043-0.
    • (2000) Cardiovasc Pathol , vol.9 , pp. 281-286
    • Edep, M.E.1    Shirani, J.2    Wolf, P.3    Brown, D.L.4
  • 8
    • 33846429618 scopus 로고    scopus 로고
    • Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease
    • DOI 10.1161/CIRCULATIONAHA.106.654913, PII 0000301720070123000016
    • Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, et al. (2007) Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation 115: 377-386. doi:10.1161/ CIRCULATIONAHA.106.654913. (Pubitemid 46148512)
    • (2007) Circulation , vol.115 , Issue.3 , pp. 377-386
    • Aikawa, E.1    Nahrendorf, M.2    Sosnovik, D.3    Lok, V.M.4    Jaffer, F.A.5    Aikawa, M.6    Weissleder, R.7
  • 9
    • 79958148051 scopus 로고    scopus 로고
    • Differential proteoglycan and hyaluronan distribution in calcified aortic valves
    • n.d. doi:10.1016/j.carpath.2010.10.002
    • Stephens EH, Saltarrelli JG, Baggett LS, Nandi I, Kuo JJ, et al. (n.d.) Differential proteoglycan and hyaluronan distribution in calcified aortic valves. Cardiovasc Pathol 20: 334-342. doi:10.1016/j.carpath.2010.10.002.
    • Cardiovasc Pathol , vol.20 , pp. 334-342
    • Stephens, E.H.1    Saltarrelli, J.G.2    Baggett, L.S.3    Nandi, I.4    Kuo, J.J.5
  • 10
    • 0038711036 scopus 로고    scopus 로고
    • Human aortic valve calcification is associated with an osteoblast phenotype
    • doi:10.1161/01.CIR.0000070591.21548.69 01.CIR.0000070591.21548.69 [pii]
    • Rajamannan NM, Subramaniam M, Rickard D, Stock SR, Donovan J, et al. (2003) Human aortic valve calcification is associated with an osteoblast phenotype. Circulation 107: 2181-2184. doi:10.1161/01.CIR.0000070591.21548.69 01.CIR.0000070591.21548.69 [pii].
    • (2003) Circulation , vol.107 , pp. 2181-2184
    • Rajamannan, N.M.1    Subramaniam, M.2    Rickard, D.3    Stock, S.R.4    Donovan, J.5
  • 11
    • 78650382469 scopus 로고    scopus 로고
    • Evidence for active regulation of pro-osteogenic signaling in advanced aortic valve disease
    • doi:10.1161/ATVBAHA.110.211029
    • Miller JD, Weiss RM, Serrano KM, Castaneda LE, Brooks RM, et al. (2010) Evidence for active regulation of pro-osteogenic signaling in advanced aortic valve disease. Arterioscler Thromb Vasc Biol 30: 2482-2486. doi:10.1161/ATVBAHA. 110.211029.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 2482-2486
    • Miller, J.D.1    Weiss, R.M.2    Serrano, K.M.3    Castaneda, L.E.4    Brooks, R.M.5
  • 12
    • 80052890196 scopus 로고    scopus 로고
    • Can valvular interstitial cells become true osteoblasts? A side-by-side comparison
    • Monzack EL, Masters KS (2011) Can valvular interstitial cells become true osteoblasts? A side-by-side comparison. J Heart Valve Dis 20: 449-463.
    • (2011) J Heart Valve Dis , vol.20 , pp. 449-463
    • Monzack, E.L.1    Masters, K.S.2
  • 14
    • 0037314647 scopus 로고    scopus 로고
    • Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis
    • doi:10.1016/S0003-4975(02)04312-6
    • Jian B, Narula N, Li QY, Mohler 3rd ER, Levy RJ (2003) Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis. Ann Thorac Surg 75: 456-457. doi:10.1016/S0003-4975(02)04312-6.
    • (2003) Ann Thorac Surg , vol.75 , pp. 456-457
    • Jian, B.1    Narula, N.2    Li, Q.Y.3    Mohler III, E.R.4    Levy, R.J.5
  • 15
    • 33644619491 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha promotes an osteoblast-like phenotype in human aortic valve myofibroblasts: A potential regulatory mechanism of valvular calcification
    • Kaden JJ, Kilic R, Sarikoc A, Hagl S, Lang S, et al. (2005) Tumor necrosis factor alpha promotes an osteoblast-like phenotype in human aortic valve myofibroblasts: a potential regulatory mechanism of valvular calcification. Int J Mol Med 16: 869-872.
    • (2005) Int J Mol Med , vol.16 , pp. 869-872
    • Kaden, J.J.1    Kilic, R.2    Sarikoc, A.3    Hagl, S.4    Lang, S.5
  • 16
    • 64049113676 scopus 로고    scopus 로고
    • Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix
    • doi:10.1161/ATVBAHA.108.182394
    • Yip CY, Chen JH, Zhao R, Simmons CA (2009) Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix. Arterioscler Thromb Vasc Biol 29: 936-942. doi:10.1161/ATVBAHA.108.182394.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 936-942
    • Yip, C.Y.1    Chen, J.H.2    Zhao, R.3    Simmons, C.A.4
  • 17
    • 0342748539 scopus 로고    scopus 로고
    • Expression of endothelial cell adhesion molecules on heart valves: Up- regulation in degeneration as well as acute endocarditis
    • DOI 10.1002/(SICI)1096-9896(200005)191:1<54::AID
    • Muller AM, Cronen C, Kupferwasser LI (2000) Expression of endothelial cell adhesion molecules on heart valves: up-regulation in defeneration as well as acute endocarditis. J Pathol 191: 54-60. doi:10.1002/(SICI)1096-9896(200005) 191:1〈54::AID-PATH568〉3.0.CO;2-Y. (Pubitemid 30235649)
    • (2000) Journal of Pathology , vol.191 , Issue.1 , pp. 54-60
    • Muller, A.M.1    Cronen, C.2    Kupferwasser, L.I.3    Oelert, H.4    Muller, K.-M.5    Kirkpatrick, C.J.6
  • 18
    • 7044260650 scopus 로고    scopus 로고
    • Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis
    • Kaden JJ, Bickelhaupt S, Grobholz R, Vahl CF, Hagl S, et al. (2004) Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis. J Heart Valve Dis 13: 560-566.
    • (2004) J Heart Valve Dis , vol.13 , pp. 560-566
    • Kaden, J.J.1    Bickelhaupt, S.2    Grobholz, R.3    Vahl, C.F.4    Hagl, S.5
  • 19
    • 79551487609 scopus 로고    scopus 로고
    • Role of the Rho pathway in regulating valvular interstitial cell phenotype and nodule formation
    • doi:10.1152/ajpheart.01178.2009
    • Gu X, Masters KS (2011) Role of the Rho pathway in regulating valvular interstitial cell phenotype and nodule formation. Am J Physiol Heart Circ Physiol 300: H448-58. doi:10.1152/ajpheart.01178.2009.
    • (2011) Am J Physiol Heart Circ Physiol , vol.300
    • Gu, X.1    Masters, K.S.2
  • 20
    • 84873410033 scopus 로고    scopus 로고
    • Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans
    • n.d. doi:10.1016/j.carpath.2012.07.002
    • Osman N, Grande-Allen KJ, Ballinger ML, Getachew R, Marasco S, et al. (n.d.) Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans. Cardiovasc Pathol 22: 146-155. doi:10.1016/j.carpath.2012.07.002.
    • Cardiovasc Pathol , vol.22 , pp. 146-155
    • Osman, N.1    Grande-Allen, K.J.2    Ballinger, M.L.3    Getachew, R.4    Marasco, S.5
  • 22
    • 0035923477 scopus 로고    scopus 로고
    • Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves
    • Rabkin E, Aikawa M, Stone J, Fukumoto Y, Libby P, et al. (2000) Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves. Circulation 104: 2525-2532. doi:10.1161/hc4601.099489. (Pubitemid 33104788)
    • (2001) Circulation , vol.104 , Issue.21 , pp. 2525-2532
    • Rabkin, E.1    Aikawa, M.2    Stone, J.R.3    Fukumoto, Y.4    Libby, P.5    Schoen, F.J.6
  • 23
    • 0036857353 scopus 로고    scopus 로고
    • Profile and localization of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in human heart valves
    • discussion 880
    • Dreger SA, Taylor PM, Allen SP, Yacoub MH (2002) Profile and localization of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in human heart valves. J Heart Valve Dis 11: 875-80; discussion 880.
    • (2002) J Heart Valve Dis , vol.11 , pp. 875-880
    • Dreger, S.A.1    Taylor, P.M.2    Allen, S.P.3    Yacoub, M.H.4
  • 24
    • 0028823030 scopus 로고
    • Osteopontin is expressed in human aortic valvular lesions
    • doi:10.1161/01.CIR.92.8.216
    • O'Brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, et al. (1995) Osteopontin is expressed in human aortic valvular lesions. Circulation 92: 2163-2168. doi:10.1161/01.CIR.92.8.216.
    • (1995) Circulation , vol.92 , pp. 2163-2168
    • O'Brien, K.D.1    Kuusisto, J.2    Reichenbach, D.D.3    Ferguson, M.4    Giachelli, C.5
  • 26
    • 61849113386 scopus 로고    scopus 로고
    • Aortic stenosis
    • doi:10.1016/S0140-6736(09)60211-7
    • Carabello BA, Paulus WJ (2009) Aortic stenosis. Lancet 373: 956-966. doi:10.1016/S0140-6736(09)60211-7.
    • (2009) Lancet , vol.373 , pp. 956-966
    • Carabello, B.A.1    Paulus, W.J.2
  • 27
    • 58749105840 scopus 로고    scopus 로고
    • Cyclic strain regulates pro-inflammatory protein expression in porcine aortic valve endothelial cells
    • discussion 578
    • Metzler SA, Pregonero CA, Butcher JT, Burgess SC, Warnock JN (2008) Cyclic strain regulates pro-inflammatory protein expression in porcine aortic valve endothelial cells. J Heart Valve Dis 17: 571-7; discussion 578.
    • (2008) J Heart Valve Dis , vol.17 , pp. 571-577
    • Metzler, S.A.1    Pregonero, C.A.2    Butcher, J.T.3    Burgess, S.C.4    Warnock, J.N.5
  • 28
    • 84871762585 scopus 로고    scopus 로고
    • Calcific nodule morphogenesis by heart valve interstitial cells is strain dependent
    • doi:10.1007/s10237-012-0377-8
    • Fisher CI, Chen J, Merryman WD (2013) Calcific nodule morphogenesis by heart valve interstitial cells is strain dependent. Biomech Model Mechanobiol 12: 5-17. doi:10.1007/s10237-012-0377-8.
    • (2013) Biomech Model Mechanobiol , vol.12 , pp. 5-17
    • Fisher, C.I.1    Chen, J.2    Merryman, W.D.3
  • 29
    • 17644380642 scopus 로고    scopus 로고
    • Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves
    • DOI 10.1161/01.RES.0000161998.92009.64
    • Simmons CA, Grant GR, Manduchi E, Davies PF (2005) Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves. Circ Res 96: 792-799. doi:10.1161/01.RES.0000161998.92009.64. (Pubitemid 40559519)
    • (2005) Circulation Research , vol.96 , Issue.7 , pp. 792-799
    • Simmons, C.A.1    Grant, G.R.2    Manduchi, E.3    Davies, P.F.4
  • 30
    • 84876562106 scopus 로고    scopus 로고
    • Side-specific endothelial-dependent regulation of aortic valve calcification: Interplay of hemodynamics and nitric oxide signaling
    • doi:10.1016/j.ajpath.2013.01.037
    • Richards J, El-Hamamsy I, Chen S, Sarang Z, Sarathchandra P, et al. (2013) Side-specific endothelial-dependent regulation of aortic valve calcification: interplay of hemodynamics and nitric oxide signaling. Am J Pathol 182: 1922-1931. doi:10.1016/j.ajpath.2013.01.037.
    • (2013) Am J Pathol , vol.182 , pp. 1922-1931
    • Richards, J.1    El-Hamamsy, I.2    Chen, S.3    Sarang, Z.4    Sarathchandra, P.5
  • 31
    • 33644831129 scopus 로고    scopus 로고
    • Transcriptional profiles of valvular and vascular endothelial cells reveal phenotypic differences: Influence of shear stress
    • DOI 10.1161/01.ATV.0000196624.70507.0d, PII 0004360520060100000013
    • Butcher JT, Tressel S, Johnson T, Turner D, Sorescu G, et al. (2006) Transcriptional profiles of valvular and vascular endothelial cells reveal phenotypic differences: influence of shear stress. Arterioscler Thromb Vasc Biol 26: 69-77. doi:10.1161/01.ATV.0000196624.70507.0d. (Pubitemid 43732230)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.1 , pp. 69-77
    • Butcher, J.T.1    Tressel, S.2    Johnson, T.3    Turner, D.4    Sorescu, G.5    Jo, H.6    Nerem, R.M.7
  • 32
    • 84865622433 scopus 로고    scopus 로고
    • Computational assessment of bicuspid aortic valve wall-shear stress: Implications for calcific aortic valve disease
    • doi:10.1007/s10237-012-0375-x
    • Chandra S, Rajamannan NM, Sucosky P (2012) Computational assessment of bicuspid aortic valve wall-shear stress: implications for calcific aortic valve disease. Biomech Model Mechanobiol 11: 1085-1096. doi:10.1007/s10237-012-0375-x.
    • (2012) Biomech Model Mechanobiol , vol.11 , pp. 1085-1096
    • Chandra, S.1    Rajamannan, N.M.2    Sucosky, P.3
  • 33
    • 84859889118 scopus 로고    scopus 로고
    • Experimental measurement of dynamic fluid shear stress on the ventricular surface of the aortic valve leaflet
    • doi:10.1007/s10237-011-0306-2
    • Yap CH, Saikrishnan N, Yoganathan AP (2011) Experimental measurement of dynamic fluid shear stress on the ventricular surface of the aortic valve leaflet. Biomech Model Mechanobiol 11: 231-244. doi:10.1007/s10237-011-0306-2.
    • (2011) Biomech Model Mechanobiol , vol.11 , pp. 231-244
    • Yap, C.H.1    Saikrishnan, N.2    Yoganathan, A.P.3
  • 34
    • 84859897858 scopus 로고    scopus 로고
    • Experimental measurement of dynamic fluid shear stress on the aortic surface of the aortic valve leaflet
    • doi:10.1007/s10237-011-0301-7
    • Yap CH, Saikrishnan N, Tamilselvan G, Yoganathan AP (2011) Experimental measurement of dynamic fluid shear stress on the aortic surface of the aortic valve leaflet. Biomech Model Mechanobiol 11: 171-182. doi:10.1007/s10237-011- 0301-7.
    • (2011) Biomech Model Mechanobiol , vol.11 , pp. 171-182
    • Yap, C.H.1    Saikrishnan, N.2    Tamilselvan, G.3    Yoganathan, A.P.4
  • 35
    • 39049176964 scopus 로고    scopus 로고
    • Cyclic pressure and shear stress regulate matrix metalloproteinases and cathepsin activity in porcine aortic valves
    • Platt MO, Xing Y, Jo H, Yoganathan AP (2006) Cyclic pressure and shear stress regulate matrix metalloproteinases and cathepsin activity in porcine aortic valves. J Heart Valve Dis 15: 622-629.
    • (2006) J Heart Valve Dis , vol.15 , pp. 622-629
    • Platt, M.O.1    Xing, Y.2    Jo, H.3    Yoganathan, A.P.4
  • 36
    • 0034740596 scopus 로고    scopus 로고
    • Biosynthetic activity in heart valve leaflets in response to in vitro flow environments
    • DOI 10.1114/1.1397794
    • Weston MW, Yoganathan AP (2001) Biosynthetic activity in heart valve leaflets in response to in vitro flow environments. Ann Biomed Eng 29: 752-763. doi:10.1114/1.1397794. (Pubitemid 33013698)
    • (2001) Annals of Biomedical Engineering , vol.29 , Issue.9 , pp. 752-763
    • Weston, M.W.1    Yoganathan, A.P.2
  • 37
    • 3943101416 scopus 로고    scopus 로고
    • Unique morphology and focal adhesion development of valvular endothelial cells in static and fluid flow environments
    • DOI 10.1161/01.ATV.0000130462.50769.5a
    • Butcher JT, Penrod AM, Garcia AJ, Nerem RM (2004) Unique morphology and focal adhesion development of valvular endothelial cells in static and fluid flow environments. Arterioscler Thromb Vasc Biol 24: 1429-1434. doi:10.1161/01.ATV.0000130462.50769.5a. (Pubitemid 39050436)
    • (2004) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.24 , Issue.8 , pp. 1429-1434
    • Butcher, J.T.1    Penrod, A.M.2    Garcia, A.J.3    Nerem, R.M.4
  • 38
    • 85047679915 scopus 로고
    • Endothelial cell orientation on aortic valve leaflets
    • doi:10.1093/cvr/20.10.760
    • Deck JD (1986) Endothelial cell orientation on aortic valve leaflets. Cardiovasc Res 20: 760-767. doi:10.1093/cvr/20.10.760.
    • (1986) Cardiovasc Res , vol.20 , pp. 760-767
    • Deck, J.D.1
  • 39
    • 59449104824 scopus 로고    scopus 로고
    • Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-beta1-dependent pathway
    • doi:10.1161/ATVBAHA.108.176347
    • Sucosky P, Balachandran K, Elhammali A, Jo H, Yoganathan AP (2009) Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-beta1-dependent pathway. Arterioscler Thromb Vasc Biol 29: 254-260. doi:10.1161/ATVBAHA.108.176347.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 254-260
    • Sucosky, P.1    Balachandran, K.2    Elhammali, A.3    Jo, H.4    Yoganathan, A.P.5
  • 40
    • 79953168075 scopus 로고    scopus 로고
    • Role of Pathologic Shear Stress Alterations in Aortic Valve Endothelial Activation
    • doi:10.1007/s13239-010-0015-5
    • Hoehn D, Sun L, Sucosky P (2010) Role of Pathologic Shear Stress Alterations in Aortic Valve Endothelial Activation. Cardiovasc Eng Technol 1: 165-178. doi:10.1007/s13239-010-0015-5.
    • (2010) Cardiovasc Eng Technol , vol.1 , pp. 165-178
    • Hoehn, D.1    Sun, L.2    Sucosky, P.3
  • 41
    • 28244497030 scopus 로고    scopus 로고
    • The association of hypertension and aortic valve sclerosis
    • doi:10.1080/08037050500233320
    • Rabkin SW (2005) The association of hypertension and aortic valve sclerosis. Blood Press 14: 264-272. doi:10.1080/08037050500233320.
    • (2005) Blood Press , vol.14 , pp. 264-272
    • Rabkin, S.W.1
  • 42
    • 0027530386 scopus 로고
    • Rapidity of progression of aortic stenosis in patients with congenital bicuspid aortic valves
    • DOI 10.1016/0002-9149(93)90799-I
    • Beppu S, Suzuki S, Matsuda H, Ohmori F, Nagata S, et al. (1993) Rapidity of progression of aortic stenosis in patients with congenital bicuspid aortic valves. Am J Cardiol 71: 322-327. doi:10.1016/0002-9149(93)90799-I. (Pubitemid 23053442)
    • (1993) American Journal of Cardiology , vol.71 , Issue.4 , pp. 322-327
    • Beppu, S.1    Suzuki, S.2    Matsuda, H.3    Ohmori, F.4    Nagata, S.5    Miyatake, K.6
  • 43
    • 0032894771 scopus 로고    scopus 로고
    • Congenitally bicuspid aortic valves: A surgical pathology study of 542 cases (1991 through 1996) and a literature review of 2,715 additional cases
    • Sabet HY, Edwards WD, Tazelaar HD, Daly RC (1999) Congenitally bicuspid aortic valves: a surgical pathology study of 542 cases (1991 through 1996) and a literature review of 2,715 additional cases. Mayo Clin Proc 74: 14-26. doi:10.1016/S0025-6196(11)64554-0. (Pubitemid 29042671)
    • (1999) Mayo Clinic Proceedings , vol.74 , Issue.1 , pp. 14-26
    • Sabet, H.Y.1    Edwards, W.D.2    Tazelaar, H.D.3    Daly, R.C.4
  • 44
    • 84859057951 scopus 로고    scopus 로고
    • Oxidative-mechanical stress signals stem cell niche mediated Lrp5 osteogenesis in eNOS(-/-) null mice
    • doi:10.1002/jcb.24031
    • Rajamannan NM (2011) Oxidative-mechanical stress signals stem cell niche mediated Lrp5 osteogenesis in eNOS(-/-) null mice. J Cell Biochem 113: 1623-1634. doi:10.1002/jcb.24031.
    • (2011) J Cell Biochem , vol.113 , pp. 1623-1634
    • Rajamannan, N.M.1
  • 45
    • 0029081007 scopus 로고
    • Age-dependent changes in the radial stretch of human aortic valve leaflets determined by biaxial testing
    • discussion S159. doi:10.1016/0003-4975(95)00219-B
    • Christie GW, Barratt-Boyes BG (1995) Age-dependent changes in the radial stretch of human aortic valve leaflets determined by biaxial testing. Ann Thorac Surg 60: S156-8; discussion S159. doi:10.1016/0003-4975(95)00219-B.
    • (1995) Ann Thorac Surg , vol.60
    • Christie, G.W.1    Barratt-Boyes, B.G.2
  • 46
    • 34347248775 scopus 로고    scopus 로고
    • Impact of blood pressure on the Doppler echocardiographic assessment of severity of aortic stenosis
    • DOI 10.1136/hrt.2006.098392
    • Little SH, Chan KL, Burwash IG (2007) Impact of blood pressure on the Doppler echocardiographic assessment of severity of aortic stenosis. Heart 93: 848-855. doi:10.1136/hrt.2006.098392. (Pubitemid 46998988)
    • (2007) Heart , vol.93 , Issue.7 , pp. 848-855
    • Little, S.H.1    Chan, K.-L.2    Burwash, I.G.3
  • 47
    • 67650105636 scopus 로고    scopus 로고
    • A computational model of aging and calcification in the aortic heart valve
    • doi:10.1371/journal.pone.0005960
    • Weinberg EJ, Schoen FJ, Mofrad MR (2009) A computational model of aging and calcification in the aortic heart valve. PLoS One 4: e5960. doi:10.1371/journal.pone.0005960.
    • (2009) PLoS One , vol.4
    • Weinberg, E.J.1    Schoen, F.J.2    Mofrad, M.R.3
  • 48
    • 80051552953 scopus 로고    scopus 로고
    • Design and validation of a novel bioreactor to subject aortic valve leaflets to side-specific shear stress
    • doi:10.1007/s10439-011-0305-6
    • Sun L, Rajamannan NM, Sucosky P (2011) Design and validation of a novel bioreactor to subject aortic valve leaflets to side-specific shear stress. Ann Biomed Eng 39: 2174-2185. doi:10.1007/s10439-011-0305-6.
    • (2011) Ann Biomed Eng , vol.39 , pp. 2174-2185
    • Sun, L.1    Rajamannan, N.M.2    Sucosky, P.3
  • 49
    • 84858786366 scopus 로고    scopus 로고
    • Hemodynamics and mechanobiology of aortic valve inflammation and calcification
    • doi:10.4061/2011/263870
    • Balachandran K, Sucosky P, Yoganathan AP (2011) Hemodynamics and mechanobiology of aortic valve inflammation and calcification. Int J Inflam 2011: 263870. doi:10.4061/2011/263870.
    • (2011) Int J Inflam , vol.2011 , pp. 263870
    • Balachandran, K.1    Sucosky, P.2    Yoganathan, A.P.3
  • 51
    • 84868283392 scopus 로고    scopus 로고
    • Ex vivo evidence for the contribution of hemodynamic shear stress abnormalities to the early pathogenesis of calcific bicuspid aortic valve disease
    • doi:10.1371/journal.pone.0048843
    • Sun L, Chandra S, Sucosky P (2012) Ex vivo evidence for the contribution of hemodynamic shear stress abnormalities to the early pathogenesis of calcific bicuspid aortic valve disease. PLoS One 7: e48843. doi:10.1371/journal.pone. 0048843.
    • (2012) PLoS One , vol.7
    • Sun, L.1    Chandra, S.2    Sucosky, P.3
  • 52
    • 84866359704 scopus 로고    scopus 로고
    • The congenital bicuspid aortic valve can experience high frequency unsteady shear stresses on its leaflet surface
    • doi:10.1152/ajpheart.00829.2011
    • Yap CH, Saikrishnan N, Tamilselvan G, Vasilyev N, Yoganathan AP, et al. (2012) The congenital bicuspid aortic valve can experience high frequency unsteady shear stresses on its leaflet surface. Am J Physiol Heart Circ Physiol 303: H721-31. doi:10.1152/ajpheart.00829.2011.
    • (2012) Am J Physiol Heart Circ Physiol , vol.303
    • Yap, C.H.1    Saikrishnan, N.2    Tamilselvan, G.3    Vasilyev, N.4    Yoganathan, A.P.5
  • 53
    • 33750703971 scopus 로고    scopus 로고
    • Calcific aortic valve stenosis in old hypercholesterolemic mice
    • DOI 10.1161/CIRCULATIONAHA.106.634139, PII 0000301720061107000013
    • Weiss RM, Ohashi M, Miller JD, Young SG, Heistad DD (2006) Calcific aortic valve stenosis in old hypercholesterolemic mice. Circulation 114: 2065-2069. doi:10.1161/CIRCULATIONAHA.106.634139. (Pubitemid 44706883)
    • (2006) Circulation , vol.114 , Issue.19 , pp. 2065-2069
    • Weiss, R.M.1    Ohashi, M.2    Miller, J.D.3    Young, S.G.4    Heistad, D.D.5
  • 55
    • 24644510707 scopus 로고    scopus 로고
    • Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway
    • DOI 10.1161/01.CIRCULATIONAHA.104.524306
    • Rajamannan NM, Subramaniam M, Caira F, Stock SR, Spelsberg TC (2005) Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway. Circulation 112: I229-34. doi:10.1161/01.CIRCULATIONAHA.104.524306. (Pubitemid 41266679)
    • (2005) Circulation , vol.112 , Issue.9 SUPPL.
    • Rajamannan, N.M.1    Subramaniam, M.2    Caira, F.3    Stock, S.R.4    Spelsberg, T.C.5
  • 57
    • 73549103784 scopus 로고    scopus 로고
    • Mechanisms of aortic valve calcification: The LDL-density-radius theory: A translation from cell signaling to physiology
    • doi:10.1152/ajpheart.00824.2009
    • Rajamannan NM (2010) Mechanisms of aortic valve calcification: the LDL-density-radius theory: a translation from cell signaling to physiology. Am J Physiol Cell Physiol 298: 5-15. doi:10.1152/ajpheart.00824.2009.
    • (2010) Am J Physiol Cell Physiol , vol.298 , pp. 5-15
    • Rajamannan, N.M.1
  • 58
    • 84860390043 scopus 로고    scopus 로고
    • The role of Lrp5/6 in cardiac valve disease: LDL-density-pressure theory
    • doi:10.1002/jcb.23182
    • Rajamannan NM (2011) The role of Lrp5/6 in cardiac valve disease: LDL-density-pressure theory. J Cell Biochem 112: 2222-2229. doi:10.1002/jcb. 23182.
    • (2011) J Cell Biochem , vol.112 , pp. 2222-2229
    • Rajamannan, N.M.1
  • 59
    • 84879411845 scopus 로고    scopus 로고
    • Gene Profiling of Aortic Valve Interstitial Cells under Elevated Pressure Conditions: Modulation of Inflammatory Gene Networks
    • doi:10.4061/2011/176412
    • Warnock JN, Nanduri B, Pregonero Gamez CA, Tang J, Koback D, et al. (2011) Gene Profiling of Aortic Valve Interstitial Cells under Elevated Pressure Conditions: Modulation of Inflammatory Gene Networks. Int J Inflam 2011: 176412. doi:10.4061/2011/176412.
    • (2011) Int J Inflam , vol.2011 , pp. 176412
    • Warnock, J.N.1    Nanduri, B.2    Pregonero Gamez, C.A.3    Tang, J.4    Koback, D.5
  • 60
    • 77954568359 scopus 로고    scopus 로고
    • Elevated Cyclic Stretch Induces Aortic Valve Calcification in a Bone Morphogenic Protein-Dependent Manner
    • doi:10.2353/ajpath.2010.090631
    • Balachandran K, Sucosky P, Jo H, Yoganathan AP (2010) Elevated Cyclic Stretch Induces Aortic Valve Calcification in a Bone Morphogenic Protein-Dependent Manner. Am J Pathol 177: 49-57. doi:10.2353/ajpath.2010. 090631.
    • (2010) Am J Pathol , vol.177 , pp. 49-57
    • Balachandran, K.1    Sucosky, P.2    Jo, H.3    Yoganathan, A.P.4
  • 61
    • 79958818345 scopus 로고    scopus 로고
    • Preferential activation of SMAD1/5/8 on the fibrosa endothelium in calcified human aortic valves-association with low BMP antagonists and SMAD6
    • doi:10.1371/journal.pone.0020969
    • Ankeny RF, Thourani VH, Weiss D, Vega JD, Taylor WR, et al. (2011) Preferential activation of SMAD1/5/8 on the fibrosa endothelium in calcified human aortic valves-association with low BMP antagonists and SMAD6. PLoS One 6: e20969. doi:10.1371/journal.pone.0020969.
    • (2011) PLoS One , vol.6
    • Ankeny, R.F.1    Thourani, V.H.2    Weiss, D.3    Vega, J.D.4    Taylor, W.R.5
  • 62
    • 79551611520 scopus 로고    scopus 로고
    • Differential expression of cartilage and bone-related proteins in pediatric and adult diseased aortic valves
    • doi:10.1016/j.yjmcc.2010.12.005
    • Wirrig EE, Hinton RB, Yutzey KE (2011) Differential expression of cartilage and bone-related proteins in pediatric and adult diseased aortic valves. J Mol Cell Cardiol 50: 561-569. doi:10.1016/j.yjmcc.2010.12.005.
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 561-569
    • Wirrig, E.E.1    Hinton, R.B.2    Yutzey, K.E.3
  • 63
    • 20544460601 scopus 로고    scopus 로고
    • Comparison of surgically removed cardiac valves of patients with ESRD with those of the general population
    • DOI 10.1053/j.ajkd.2005.03.020, PII S0272638605005561
    • Kajbaf S, Veinot JP, Ha A, Zimmerman D (2005) Comparison of surgically removed cardiac valves of patients with ESRD with those of the general population. Am J Kidney Dis 46: 86-93. doi:10.1053/j.ajkd.2005.03.020. (Pubitemid 40848436)
    • (2005) American Journal of Kidney Diseases , vol.46 , Issue.1 , pp. 86-93
    • Kajbaf, S.1    Veinot, J.P.2    Ha, A.3    Zimmerman, D.4
  • 64
    • 31844454880 scopus 로고    scopus 로고
    • Differential immediate-early gene responses to elevated pressure in porcine aortic valve interstitial cells
    • discussion 42
    • Warnock JN, Burgess SC, Shack A, Yoganathan AP (2006) Differential immediate-early gene responses to elevated pressure in porcine aortic valve interstitial cells. J Heart Valve Dis 15: 34-41; discussion 42.
    • (2006) J Heart Valve Dis , vol.15 , pp. 34-41
    • Warnock, J.N.1    Burgess, S.C.2    Shack, A.3    Yoganathan, A.P.4
  • 65
    • 64049108554 scopus 로고    scopus 로고
    • Elevated Cyclic Stretch Alters Matrix Remodeling in Aortic Valve Cusps - Implications for Degenerative Aortic Valve Disease?
    • doi:10.1152/ajpheart.00900.2008
    • Balachandran K, Sucosky P, Jo H, Yoganathan AP (2009) Elevated Cyclic Stretch Alters Matrix Remodeling in Aortic Valve Cusps - Implications for Degenerative Aortic Valve Disease? Am J Physiol Circ Physiol 296: H756-64. doi:10.1152/ajpheart.00900.2008.
    • (2009) Am J Physiol Circ Physiol , vol.296
    • Balachandran, K.1    Sucosky, P.2    Jo, H.3    Yoganathan, A.P.4
  • 66
    • 79958851205 scopus 로고    scopus 로고
    • The Effects of Combined Cyclic Stretch and Pressure on the Aortic Valve Interstitial Cell Phenotype
    • doi:10.1007/s10439-011-0273-x
    • Thayer P, Balachandran K, Rathan S, Yap CH, Arjunon S, et al. (2011) The Effects of Combined Cyclic Stretch and Pressure on the Aortic Valve Interstitial Cell Phenotype. Ann Biomed Eng 39: 1654-1667. doi:10.1007/s10439-011-0273-x.
    • (2011) Ann Biomed Eng , vol.39 , pp. 1654-1667
    • Thayer, P.1    Balachandran, K.2    Rathan, S.3    Yap, C.H.4    Arjunon, S.5
  • 67
    • 11044223619 scopus 로고    scopus 로고
    • Cyclic pressure affects the biological properties of porcine aortic valve leaflets in a magnitude and frequency dependent manner
    • DOI 10.1114/B:ABME.0000049031.07512.11
    • Xing Y, Warnock JN, He Z, Hilbert SL, Yoganathan AP (2004) Cyclic pressure affects the biological properties of porcine aortic valve leaflets in a magnitude and frequency dependent manner. Ann Biomed Eng 32: 1461-1470. doi:10.1114/B:ABME.0000049031.07512.11. (Pubitemid 40044493)
    • (2004) Annals of Biomedical Engineering , vol.32 , Issue.11 , pp. 1461-1470
    • Xing, Y.1    Warnock, J.N.2    Zhaoming, H.3    Hilbert, S.L.4    Yoganathan, A.P.5
  • 68
    • 33750736339 scopus 로고    scopus 로고
    • An ex vivo study of the biological properties of porcine aortic valves in response to circumferential cyclic stretch
    • DOI 10.1007/s10439-006-9167-8
    • Balachandran K, Konduri S, Sucosky P, Jo H, Yoganathan AP (2006) An ex vivo study of the biological properties of porcine aortic valves in response to circumferential cyclic stretch. Ann Biomed Eng 34: 1655-1665. doi:10.1007/s10439-006-9167-8. (Pubitemid 44704821)
    • (2006) Annals of Biomedical Engineering , vol.34 , Issue.11 , pp. 1655-1665
    • Balachandran, K.1    Konduri, S.2    Sucosky, P.3    Jo, H.4    Yoganathan, A.P.5


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