Mechanical strain induces the production of spheroid mineralized microparticles in the aortic valve through a RhoA/ROCK-dependent mechanism

Journal of Molecular and Cellular Cardiology

Volumn 67, Issue , 2014, Pages 49-59

  Bouchareb, Rihab ^a   Boulanger, Marie Chloé ^a   Fournier, Dominique ^a   Pibarot, Philippe ^b   Messaddeq, Younès ^b   Mathieu, Patrick ^a  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

Calcific aortic valve disease; ENPP1; Mineralized microparticles; RhoA; Strain; Valve interstitial cells

Indexed keywords

CYTOKINE; ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; AORTA VALVE; APOPTOSIS; ARTICLE; BICUSPID AORTIC VALVE; CELL CULTURE; CELL ISOLATION; CELL MEMBRANE; CELL STRUCTURE; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MECHANICAL STRESS; MEMBRANE MICROPARTICLE; MINERALIZATION; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCANNING ELECTRON MICROSCOPE; SPHEROID CELL; VALVE INTERSTITIAL CELL; X RAY ANALYSIS;

CALCIFIC AORTIC VALVE DISEASE; ENPP1; MINERALIZED MICROPARTICLES; RHOA; STRAIN; VALVE INTERSTITIAL CELLS;

AORTIC VALVE; CALCINOSIS; CELL MEMBRANE; CELL-DERIVED MICROPARTICLES; CELLS, CULTURED; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; MINERALS; PHOSPHORIC DIESTER HYDROLASES; PYROPHOSPHATASES; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; STRESS, MECHANICAL;

EID: 84892867500     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2013.12.009     Document Type: Article

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