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Volumn 52, Issue 1, 2013, Pages 145-156

Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts

Author keywords

BMP; Gene expression; Osteogenesis; Wnt catenin

Indexed keywords

BETA CATENIN; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; BONE MORPHOGENETIC PROTEIN 2; DICKKOPF 1 PROTEIN; F BOX PROTEIN; F BOX WD40 REPEAT PROTEIN 1; INHIBITOR OF BETA CATENIN AND TRANSCRIPTION FACTOR; INHIBITOR PROTEIN; MESSENGER RNA; SECRETED FRIZZLED RELATED PROTEIN 4; T CELL FACTOR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3A PROTEIN;

EID: 84870318883     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.09.029     Document Type: Article
Times cited : (260)

References (80)
  • 1
    • 0027946689 scopus 로고
    • Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage
    • Katagiri T., Yamaguchi A., Komaki M., Abe E., Takahashi N., Ikeda T., et al. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol 1994, 127:1755-1766.
    • (1994) J Cell Biol , vol.127 , pp. 1755-1766
    • Katagiri, T.1    Yamaguchi, A.2    Komaki, M.3    Abe, E.4    Takahashi, N.5    Ikeda, T.6
  • 2
    • 0031974284 scopus 로고    scopus 로고
    • Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair
    • Wozney J.M., Rosen V. Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin Orthop Relat Res 1998, 26-37.
    • (1998) Clin Orthop Relat Res , pp. 26-37
    • Wozney, J.M.1    Rosen, V.2
  • 4
    • 0031059353 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts
    • Chen D., Harris M.A., Rossini G., Dunstan C.R., Dallas S.L., Feng J.Q., et al. Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts. Calcif Tissue Int 1997, 60:283-290.
    • (1997) Calcif Tissue Int , vol.60 , pp. 283-290
    • Chen, D.1    Harris, M.A.2    Rossini, G.3    Dunstan, C.R.4    Dallas, S.L.5    Feng, J.Q.6
  • 5
    • 3142757397 scopus 로고    scopus 로고
    • Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of Dlx2 and Dlx5 transcription factors
    • Harris S.E., Guo D., Harris M.A., Krishnaswamy A., Lichtler A. Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of Dlx2 and Dlx5 transcription factors. Front Biosci 2003, 8:s1249-s1265.
    • (2003) Front Biosci , vol.8
    • Harris, S.E.1    Guo, D.2    Harris, M.A.3    Krishnaswamy, A.4    Lichtler, A.5
  • 6
    • 0037054548 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation
    • Zhao M., Harris S.E., Horn D., Geng Z., Nishimura R., Mundy G.R., et al. Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation. J Cell Biol 2002, 157:1049-1060.
    • (2002) J Cell Biol , vol.157 , pp. 1049-1060
    • Zhao, M.1    Harris, S.E.2    Horn, D.3    Geng, Z.4    Nishimura, R.5    Mundy, G.R.6
  • 8
    • 0028346631 scopus 로고
    • Expression of bone morphogenetic protein messenger RNA in prolonged cultures of fetal rat calvarial cells
    • Harris S.E., Sabatini M., Harris M.A., Feng J.Q., Wozney J., Mundy G.R. Expression of bone morphogenetic protein messenger RNA in prolonged cultures of fetal rat calvarial cells. J Bone Miner Res 1994, 9:389-394.
    • (1994) J Bone Miner Res , vol.9 , pp. 389-394
    • Harris, S.E.1    Sabatini, M.2    Harris, M.A.3    Feng, J.Q.4    Wozney, J.5    Mundy, G.R.6
  • 9
    • 3442884490 scopus 로고    scopus 로고
    • Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells
    • Arikawa T., Omura K., Morita I. Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells. J Cell Physiol 2004, 200:400-406.
    • (2004) J Cell Physiol , vol.200 , pp. 400-406
    • Arikawa, T.1    Omura, K.2    Morita, I.3
  • 10
    • 0043237419 scopus 로고    scopus 로고
    • NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro
    • Feng J.Q., Xing L., Zhang J.H., Zhao M., Horn D., Chan J., et al. NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro. J Biol Chem 2003, 278:29130-29135.
    • (2003) J Biol Chem , vol.278 , pp. 29130-29135
    • Feng, J.Q.1    Xing, L.2    Zhang, J.H.3    Zhao, M.4    Horn, D.5    Chan, J.6
  • 11
    • 0038819051 scopus 로고    scopus 로고
    • Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro
    • Garrett I.R., Chen D., Gutierrez G., Zhao M., Escobedo A., Rossini G., et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest 2003, 111:1771-1782.
    • (2003) J Clin Invest , vol.111 , pp. 1771-1782
    • Garrett, I.R.1    Chen, D.2    Gutierrez, G.3    Zhao, M.4    Escobedo, A.5    Rossini, G.6
  • 12
    • 0028341364 scopus 로고
    • Effects of transforming growth factor beta on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts
    • Harris S.E., Bonewald L.F., Harris M.A., Sabatini M., Dallas S., Feng J.Q., et al. Effects of transforming growth factor beta on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts. J Bone Miner Res 1994, 9:855-863.
    • (1994) J Bone Miner Res , vol.9 , pp. 855-863
    • Harris, S.E.1    Bonewald, L.F.2    Harris, M.A.3    Sabatini, M.4    Dallas, S.5    Feng, J.Q.6
  • 13
    • 61749093281 scopus 로고    scopus 로고
    • Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2
    • Zhao M., Ko S.Y., Liu J.H., Chen D., Zhang J., Wang B., et al. Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Mol Cell Biol 2009, 29:1291-1305.
    • (2009) Mol Cell Biol , vol.29 , pp. 1291-1305
    • Zhao, M.1    Ko, S.Y.2    Liu, J.H.3    Chen, D.4    Zhang, J.5    Wang, B.6
  • 14
    • 33746987081 scopus 로고    scopus 로고
    • The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling
    • Zhao M., Qiao M., Harris S.E., Chen D., Oyajobi B.O., Mundy G.R. The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol Cell Biol 2006, 26:6197-6208.
    • (2006) Mol Cell Biol , vol.26 , pp. 6197-6208
    • Zhao, M.1    Qiao, M.2    Harris, S.E.3    Chen, D.4    Oyajobi, B.O.5    Mundy, G.R.6
  • 15
    • 0037249209 scopus 로고    scopus 로고
    • Estrogens activate bone morphogenetic protein-2 gene transcription in mouse mesenchymal stem cells
    • Zhou S., Turgeman G., Harris S.E., Leitman D.C., Komm B.S., Bodine P.V., et al. Estrogens activate bone morphogenetic protein-2 gene transcription in mouse mesenchymal stem cells. Mol Endocrinol 2003, 17:56-66.
    • (2003) Mol Endocrinol , vol.17 , pp. 56-66
    • Zhou, S.1    Turgeman, G.2    Harris, S.E.3    Leitman, D.C.4    Komm, B.S.5    Bodine, P.V.6
  • 16
    • 80052018275 scopus 로고    scopus 로고
    • Microtubule assembly affects bone mass by regulating both osteoblast and osteoclast functions: stathmin deficiency produces an osteopenic phenotype in mice
    • Liu H., Zhang R., Ko S.Y., Oyajobi B.O., Papasian C.J., Deng H.W., et al. Microtubule assembly affects bone mass by regulating both osteoblast and osteoclast functions: stathmin deficiency produces an osteopenic phenotype in mice. J Bone Miner Res 2011, 26:2052-2067.
    • (2011) J Bone Miner Res , vol.26 , pp. 2052-2067
    • Liu, H.1    Zhang, R.2    Ko, S.Y.3    Oyajobi, B.O.4    Papasian, C.J.5    Deng, H.W.6
  • 17
    • 79958249441 scopus 로고    scopus 로고
    • Transcriptional regulation of BMP2 expression by the PTH-CREB signaling pathway in osteoblasts
    • Zhang R., Edwards J.R., Ko S.Y., Dong S., Liu H., Oyajobi B.O., et al. Transcriptional regulation of BMP2 expression by the PTH-CREB signaling pathway in osteoblasts. PLoS One 2011, 6:e20780.
    • (2011) PLoS One , vol.6
    • Zhang, R.1    Edwards, J.R.2    Ko, S.Y.3    Dong, S.4    Liu, H.5    Oyajobi, B.O.6
  • 18
    • 0031029768 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 transcripts in rapidly developing deer antler tissue contain an extended 5' non-coding region arising from a distal promoter
    • Feng J.Q., Chen D., Ghosh-Choudhury N., Esparza J., Mundy G.R., Harris S.E. Bone morphogenetic protein 2 transcripts in rapidly developing deer antler tissue contain an extended 5' non-coding region arising from a distal promoter. Biochim Biophys Acta 1997, 1350:47-52.
    • (1997) Biochim Biophys Acta , vol.1350 , pp. 47-52
    • Feng, J.Q.1    Chen, D.2    Ghosh-Choudhury, N.3    Esparza, J.4    Mundy, G.R.5    Harris, S.E.6
  • 19
    • 0037031854 scopus 로고    scopus 로고
    • Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription
    • Ghosh-Choudhury N., Abboud S.L., Nishimura R., Celeste A., Mahimainathan L., Choudhury G.G. Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription. J Biol Chem 2002, 277:33361-33368.
    • (2002) J Biol Chem , vol.277 , pp. 33361-33368
    • Ghosh-Choudhury, N.1    Abboud, S.L.2    Nishimura, R.3    Celeste, A.4    Mahimainathan, L.5    Choudhury, G.G.6
  • 21
    • 0037118285 scopus 로고    scopus 로고
    • High bone density due to a mutation in LDL-receptor-related protein 5
    • Boyden L.M., Mao J., Belsky J., Mitzner L., Farhi A., Mitnick M.A., et al. High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med 2002, 346:1513-1521.
    • (2002) N Engl J Med , vol.346 , pp. 1513-1521
    • Boyden, L.M.1    Mao, J.2    Belsky, J.3    Mitzner, L.4    Farhi, A.5    Mitnick, M.A.6
  • 22
    • 28444438846 scopus 로고    scopus 로고
    • Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice
    • Clement-Lacroix P., Ai M., Morvan F., Roman-Roman S., Vayssiere B., Belleville C., et al. Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc Natl Acad Sci U S A 2005, 102:17406-17411.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 17406-17411
    • Clement-Lacroix, P.1    Ai, M.2    Morvan, F.3    Roman-Roman, S.4    Vayssiere, B.5    Belleville, C.6
  • 23
    • 0036138175 scopus 로고    scopus 로고
    • A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    • Little R.D., Carulli J.P., Del Mastro R.G., Dupuis J., Osborne M., Folz C., et al. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet 2002, 70:11-19.
    • (2002) Am J Hum Genet , vol.70 , pp. 11-19
    • Little, R.D.1    Carulli, J.P.2    Del Mastro, R.G.3    Dupuis, J.4    Osborne, M.5    Folz, C.6
  • 24
    • 18044386744 scopus 로고    scopus 로고
    • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    • Gong Y., Slee R.B., Fukai N., Rawadi G., Roman-Roman S., Reginato A.M., et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 2001, 107:513-523.
    • (2001) Cell , vol.107 , pp. 513-523
    • Gong, Y.1    Slee, R.B.2    Fukai, N.3    Rawadi, G.4    Roman-Roman, S.5    Reginato, A.M.6
  • 25
    • 17844372752 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis
    • Day T.F., Guo X., Garrett-Beal L., Yang Y. Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 2005, 8:739-750.
    • (2005) Dev Cell , vol.8 , pp. 739-750
    • Day, T.F.1    Guo, X.2    Garrett-Beal, L.3    Yang, Y.4
  • 28
    • 47949085566 scopus 로고    scopus 로고
    • Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density
    • Ellwanger K., Saito H., Clement-Lacroix P., Maltry N., Niedermeyer J., Lee W.K., et al. Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Mol Cell Biol 2008, 28:4875-4882.
    • (2008) Mol Cell Biol , vol.28 , pp. 4875-4882
    • Ellwanger, K.1    Saito, H.2    Clement-Lacroix, P.3    Maltry, N.4    Niedermeyer, J.5    Lee, W.K.6
  • 29
    • 17844363974 scopus 로고    scopus 로고
    • Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes
    • Hill T.P., Spater D., Taketo M.M., Birchmeier W., Hartmann C. Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 2005, 8:727-738.
    • (2005) Dev Cell , vol.8 , pp. 727-738
    • Hill, T.P.1    Spater, D.2    Taketo, M.M.3    Birchmeier, W.4    Hartmann, C.5
  • 30
    • 0037474465 scopus 로고    scopus 로고
    • Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction
    • Bain G., Muller T., Wang X., Papkoff J. Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction. Biochem Biophys Res Commun 2003, 301:84-91.
    • (2003) Biochem Biophys Res Commun , vol.301 , pp. 84-91
    • Bain, G.1    Muller, T.2    Wang, X.3    Papkoff, J.4
  • 31
    • 20244373613 scopus 로고    scopus 로고
    • Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    • Glass D.A., Bialek P., Ahn J.D., Starbuck M., Patel M.S., Clevers H., et al. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 2005, 8:751-764.
    • (2005) Dev Cell , vol.8 , pp. 751-764
    • Glass, D.A.1    Bialek, P.2    Ahn, J.D.3    Starbuck, M.4    Patel, M.S.5    Clevers, H.6
  • 32
    • 0142241118 scopus 로고    scopus 로고
    • BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop
    • Rawadi G., Vayssiere B., Dunn F., Baron R., Roman-Roman S. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res 2003, 18:1842-1853.
    • (2003) J Bone Miner Res , vol.18 , pp. 1842-1853
    • Rawadi, G.1    Vayssiere, B.2    Dunn, F.3    Baron, R.4    Roman-Roman, S.5
  • 33
    • 77954145629 scopus 로고    scopus 로고
    • Canonical Wnts and BMPs cooperatively induce osteoblastic differentiation through a GSK3beta-dependent and beta-catenin-independent mechanism
    • Fukuda T., Kokabu S., Ohte S., Sasanuma H., Kanomata K., Yoneyama K., et al. Canonical Wnts and BMPs cooperatively induce osteoblastic differentiation through a GSK3beta-dependent and beta-catenin-independent mechanism. Differentiation 2010, 80:46-52.
    • (2010) Differentiation , vol.80 , pp. 46-52
    • Fukuda, T.1    Kokabu, S.2    Ohte, S.3    Sasanuma, H.4    Kanomata, K.5    Yoneyama, K.6
  • 34
    • 0038267120 scopus 로고    scopus 로고
    • Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity
    • Kusu N., Laurikkala J., Imanishi M., Usui H., Konishi M., Miyake A., et al. Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity. J Biol Chem 2003, 278:24113-24117.
    • (2003) J Biol Chem , vol.278 , pp. 24113-24117
    • Kusu, N.1    Laurikkala, J.2    Imanishi, M.3    Usui, H.4    Konishi, M.5    Miyake, A.6
  • 35
    • 21244480924 scopus 로고    scopus 로고
    • Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
    • Li X., Zhang Y., Kang H., Liu W., Liu P., Zhang J., et al. Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J Biol Chem 2005, 280:19883-19887.
    • (2005) J Biol Chem , vol.280 , pp. 19883-19887
    • Li, X.1    Zhang, Y.2    Kang, H.3    Liu, W.4    Liu, P.5    Zhang, J.6
  • 36
    • 13244298422 scopus 로고    scopus 로고
    • Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins
    • Winkler D.G., Sutherland M.S., Ojala E., Turcott E., Geoghegan J.C., Shpektor D., et al. Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins. J Biol Chem 2005, 280:2498-2502.
    • (2005) J Biol Chem , vol.280 , pp. 2498-2502
    • Winkler, D.G.1    Sutherland, M.S.2    Ojala, E.3    Turcott, E.4    Geoghegan, J.C.5    Shpektor, D.6
  • 37
    • 0036051343 scopus 로고    scopus 로고
    • Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta
    • Abreu J.G., Ketpura N.I., Reversade B., De Robertis E.M. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol 2002, 4:599-604.
    • (2002) Nat Cell Biol , vol.4 , pp. 599-604
    • Abreu, J.G.1    Ketpura, N.I.2    Reversade, B.3    De Robertis, E.M.4
  • 38
    • 2542631834 scopus 로고    scopus 로고
    • Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex
    • Mercurio S., Latinkic B., Itasaki N., Krumlauf R., Smith J.C. Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex. Development 2004, 131:2137-2147.
    • (2004) Development , vol.131 , pp. 2137-2147
    • Mercurio, S.1    Latinkic, B.2    Itasaki, N.3    Krumlauf, R.4    Smith, J.C.5
  • 39
    • 70450225232 scopus 로고    scopus 로고
    • A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling
    • Misra K., Matise M.P. A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev Biol 2010, 337:74-83.
    • (2010) Dev Biol , vol.337 , pp. 74-83
    • Misra, K.1    Matise, M.P.2
  • 40
    • 0033602241 scopus 로고    scopus 로고
    • The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals
    • Piccolo S., Agius E., Leyns L., Bhattacharyya S., Grunz H., Bouwmeester T., et al. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature 1999, 397:707-710.
    • (1999) Nature , vol.397 , pp. 707-710
    • Piccolo, S.1    Agius, E.2    Leyns, L.3    Bhattacharyya, S.4    Grunz, H.5    Bouwmeester, T.6
  • 41
    • 13444310689 scopus 로고    scopus 로고
    • Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis
    • Edlund S., Lee S.Y., Grimsby S., Zhang S., Aspenstrom P., Heldin C.H., et al. Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis. Mol Cell Biol 2005, 25:1475-1488.
    • (2005) Mol Cell Biol , vol.25 , pp. 1475-1488
    • Edlund, S.1    Lee, S.Y.2    Grimsby, S.3    Zhang, S.4    Aspenstrom, P.5    Heldin, C.H.6
  • 42
    • 80054039657 scopus 로고    scopus 로고
    • Phosphorylation of Mad controls competition between wingless and BMP signaling
    • Eivers E., Demagny H., Choi R.H., De Robertis E.M. Phosphorylation of Mad controls competition between wingless and BMP signaling. Sci Signal 2011, 4:ra68.
    • (2011) Sci Signal , vol.4
    • Eivers, E.1    Demagny, H.2    Choi, R.H.3    De Robertis, E.M.4
  • 43
    • 70649099961 scopus 로고    scopus 로고
    • Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad
    • Eivers E., Demagny H., De Robertis E.M. Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad. Cytokine Growth Factor Rev 2009, 20:357-365.
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 357-365
    • Eivers, E.1    Demagny, H.2    De Robertis, E.M.3
  • 44
    • 36248995245 scopus 로고    scopus 로고
    • Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
    • Fuentealba L.C., Eivers E., Ikeda A., Hurtado C., Kuroda H., Pera E.M., et al. Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. Cell 2007, 131:980-993.
    • (2007) Cell , vol.131 , pp. 980-993
    • Fuentealba, L.C.1    Eivers, E.2    Ikeda, A.3    Hurtado, C.4    Kuroda, H.5    Pera, E.M.6
  • 45
    • 33745220304 scopus 로고    scopus 로고
    • A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells
    • Liu Z., Tang Y., Qiu T., Cao X., Clemens T.L. A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells. J Biol Chem 2006, 281:17156-17163.
    • (2006) J Biol Chem , vol.281 , pp. 17156-17163
    • Liu, Z.1    Tang, Y.2    Qiu, T.3    Cao, X.4    Clemens, T.L.5
  • 46
    • 53049085564 scopus 로고    scopus 로고
    • Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion
    • Tang Y., Liu Z., Zhao L., Clemens T.L., Cao X. Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion. J Biol Chem 2008, 283:23956-23963.
    • (2008) J Biol Chem , vol.283 , pp. 23956-23963
    • Tang, Y.1    Liu, Z.2    Zhao, L.3    Clemens, T.L.4    Cao, X.5
  • 47
    • 24344448238 scopus 로고    scopus 로고
    • Synergistic activation of the murine gastrin promoter by oncogenic Ras and beta-catenin involves SMAD recruitment
    • Chakladar A., Dubeykovskiy A., Wojtukiewicz L.J., Pratap J., Lei S., Wang T.C. Synergistic activation of the murine gastrin promoter by oncogenic Ras and beta-catenin involves SMAD recruitment. Biochem Biophys Res Commun 2005, 336:190-196.
    • (2005) Biochem Biophys Res Commun , vol.336 , pp. 190-196
    • Chakladar, A.1    Dubeykovskiy, A.2    Wojtukiewicz, L.J.3    Pratap, J.4    Lei, S.5    Wang, T.C.6
  • 48
    • 13444262316 scopus 로고    scopus 로고
    • Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription
    • Hu M.C., Rosenblum N.D. Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription. Development 2005, 132:215-225.
    • (2005) Development , vol.132 , pp. 215-225
    • Hu, M.C.1    Rosenblum, N.D.2
  • 49
    • 1542569747 scopus 로고    scopus 로고
    • Smad4 and beta-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2
    • Hussein S.M., Duff E.K., Sirard C. Smad4 and beta-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2. J Biol Chem 2003, 278:48805-48814.
    • (2003) J Biol Chem , vol.278 , pp. 48805-48814
    • Hussein, S.M.1    Duff, E.K.2    Sirard, C.3
  • 50
    • 0034682515 scopus 로고    scopus 로고
    • Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways
    • Labbe E., Letamendia A., Attisano L. Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways. Proc Natl Acad Sci U S A 2000, 97:8358-8363.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 8358-8363
    • Labbe, E.1    Letamendia, A.2    Attisano, L.3
  • 51
    • 5644261271 scopus 로고    scopus 로고
    • The murine gastrin promoter is synergistically activated by transforming growth factor-beta/Smad and Wnt signaling pathways
    • Lei S., Dubeykovskiy A., Chakladar A., Wojtukiewicz L., Wang T.C. The murine gastrin promoter is synergistically activated by transforming growth factor-beta/Smad and Wnt signaling pathways. J Biol Chem 2004, 279:42492-42502.
    • (2004) J Biol Chem , vol.279 , pp. 42492-42502
    • Lei, S.1    Dubeykovskiy, A.2    Chakladar, A.3    Wojtukiewicz, L.4    Wang, T.C.5
  • 52
    • 27744550696 scopus 로고    scopus 로고
    • Regulation of Slug transcription in embryonic ectoderm by beta-catenin-Lef/Tcf and BMP-Smad signaling
    • Sakai D., Tanaka Y., Endo Y., Osumi N., Okamoto H., Wakamatsu Y. Regulation of Slug transcription in embryonic ectoderm by beta-catenin-Lef/Tcf and BMP-Smad signaling. Dev Growth Differ 2005, 47:471-482.
    • (2005) Dev Growth Differ , vol.47 , pp. 471-482
    • Sakai, D.1    Tanaka, Y.2    Endo, Y.3    Osumi, N.4    Okamoto, H.5    Wakamatsu, Y.6
  • 53
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • Morin P.J., Sparks A.B., Korinek V., Barker N., Clevers H., Vogelstein B., et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997, 275:1787-1790.
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6
  • 55
    • 0034661142 scopus 로고    scopus 로고
    • Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein
    • Tago K., Nakamura T., Nishita M., Hyodo J., Nagai S., Murata Y., et al. Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev 2000, 14:1741-1749.
    • (2000) Genes Dev , vol.14 , pp. 1741-1749
    • Tago, K.1    Nakamura, T.2    Nishita, M.3    Hyodo, J.4    Nagai, S.5    Murata, Y.6
  • 56
    • 0033522491 scopus 로고    scopus 로고
    • An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin
    • Kitagawa M., Hatakeyama S., Shirane M., Matsumoto M., Ishida N., Hattori K., et al. An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin. EMBO J 1999, 18:2401-2410.
    • (1999) EMBO J , vol.18 , pp. 2401-2410
    • Kitagawa, M.1    Hatakeyama, S.2    Shirane, M.3    Matsumoto, M.4    Ishida, N.5    Hattori, K.6
  • 57
    • 0041845297 scopus 로고    scopus 로고
    • E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation
    • Zhao M., Qiao M., Oyajobi B.O., Mundy G.R., Chen D. E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation. J Biol Chem 2003, 278:27939-27944.
    • (2003) J Biol Chem , vol.278 , pp. 27939-27944
    • Zhao, M.1    Qiao, M.2    Oyajobi, B.O.3    Mundy, G.R.4    Chen, D.5
  • 58
    • 73449086271 scopus 로고    scopus 로고
    • NEMO-binding domain peptide promotes osteoblast differentiation impaired by tumor necrosis factor alpha
    • Li W., Yu B., Li M., Sun D., Hu Y., Zhao M., et al. NEMO-binding domain peptide promotes osteoblast differentiation impaired by tumor necrosis factor alpha. Biochem Biophys Res Commun 2010, 391:1228-1233.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 1228-1233
    • Li, W.1    Yu, B.2    Li, M.3    Sun, D.4    Hu, Y.5    Zhao, M.6
  • 59
    • 0033521078 scopus 로고    scopus 로고
    • Stimulation of bone formation in vitro and in rodents by statins
    • Mundy G., Garrett R., Harris S., Chan J., Chen D., Rossini G., et al. Stimulation of bone formation in vitro and in rodents by statins. Science 1999, 286:1946-1949.
    • (1999) Science , vol.286 , pp. 1946-1949
    • Mundy, G.1    Garrett, R.2    Harris, S.3    Chan, J.4    Chen, D.5    Rossini, G.6
  • 60
    • 84934434613 scopus 로고    scopus 로고
    • Assessing new bone formation in neonatal calvarial organ cultures
    • Mohammad K.S., Chirgwin J.M., Guise T.A. Assessing new bone formation in neonatal calvarial organ cultures. Methods Mol Biol 2008, 455:37-50.
    • (2008) Methods Mol Biol , vol.455 , pp. 37-50
    • Mohammad, K.S.1    Chirgwin, J.M.2    Guise, T.A.3
  • 62
    • 33646130168 scopus 로고    scopus 로고
    • Multiple roles of mesenchymal beta-catenin during murine limb patterning
    • Hill T.P., Taketo M.M., Birchmeier W., Hartmann C. Multiple roles of mesenchymal beta-catenin during murine limb patterning. Development 2006, 133:1219-1229.
    • (2006) Development , vol.133 , pp. 1219-1229
    • Hill, T.P.1    Taketo, M.M.2    Birchmeier, W.3    Hartmann, C.4
  • 63
    • 0037093072 scopus 로고    scopus 로고
    • Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells
    • Kim J.S., Crooks H., Dracheva T., Nishanian T.G., Singh B., Jen J., et al. Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells. Cancer Res 2002, 62:2744-2748.
    • (2002) Cancer Res , vol.62 , pp. 2744-2748
    • Kim, J.S.1    Crooks, H.2    Dracheva, T.3    Nishanian, T.G.4    Singh, B.5    Jen, J.6
  • 64
  • 65
    • 84155184243 scopus 로고    scopus 로고
    • Functional redundancy of type II BMP receptor and type IIB activin receptor in BMP2-induced osteoblast differentiation
    • Liu H., Zhang R., Chen D., Oyajobi B.O., Zhao M. Functional redundancy of type II BMP receptor and type IIB activin receptor in BMP2-induced osteoblast differentiation. J Cell Physiol 2011, 227:952-963.
    • (2011) J Cell Physiol , vol.227 , pp. 952-963
    • Liu, H.1    Zhang, R.2    Chen, D.3    Oyajobi, B.O.4    Zhao, M.5
  • 66
    • 13444267284 scopus 로고    scopus 로고
    • Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells
    • He B., Lee A.Y., Dadfarmay S., You L., Xu Z., Reguart N., et al. Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. Cancer Res 2005, 65:743-748.
    • (2005) Cancer Res , vol.65 , pp. 743-748
    • He, B.1    Lee, A.Y.2    Dadfarmay, S.3    You, L.4    Xu, Z.5    Reguart, N.6
  • 68
    • 2142707976 scopus 로고    scopus 로고
    • Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions
    • Gottardi C.J., Gumbiner B.M. Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions. Am J Physiol Cell Physiol 2004, 286:C747-C756.
    • (2004) Am J Physiol Cell Physiol , vol.286
    • Gottardi, C.J.1    Gumbiner, B.M.2
  • 69
    • 56949083398 scopus 로고    scopus 로고
    • ICAT participates in proliferation and osteogenic differentiation of human adipose tissue-derived mesenchymal stem cell
    • Kim Y.J., Kim J.T., Bae Y.C., Suh K.T., Jung J.S. ICAT participates in proliferation and osteogenic differentiation of human adipose tissue-derived mesenchymal stem cell. Life Sci 2008, 83:851-858.
    • (2008) Life Sci , vol.83 , pp. 851-858
    • Kim, Y.J.1    Kim, J.T.2    Bae, Y.C.3    Suh, K.T.4    Jung, J.S.5
  • 70
    • 0035825119 scopus 로고    scopus 로고
    • Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription
    • Chen S., Guttridge D.C., You Z., Zhang Z., Fribley A., Mayo M.W., et al. Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription. J Cell Biol 2001, 152:87-96.
    • (2001) J Cell Biol , vol.152 , pp. 87-96
    • Chen, S.1    Guttridge, D.C.2    You, Z.3    Zhang, Z.4    Fribley, A.5    Mayo, M.W.6
  • 71
    • 0033602227 scopus 로고    scopus 로고
    • The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell
    • Hart M., Concordet J.P., Lassot I., Albert I., del los Santos R., Durand H., et al. The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Curr Biol 1999, 9:207-210.
    • (1999) Curr Biol , vol.9 , pp. 207-210
    • Hart, M.1    Concordet, J.P.2    Lassot, I.3    Albert, I.4    del los Santos, R.5    Durand, H.6
  • 72
    • 0032576777 scopus 로고    scopus 로고
    • Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
    • Jiang J., Struhl G. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 1998, 391:493-496.
    • (1998) Nature , vol.391 , pp. 493-496
    • Jiang, J.1    Struhl, G.2
  • 73
    • 0033611567 scopus 로고    scopus 로고
    • The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin
    • Latres E., Chiaur D.S., Pagano M. The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. Oncogene 1999, 18:849-854.
    • (1999) Oncogene , vol.18 , pp. 849-854
    • Latres, E.1    Chiaur, D.S.2    Pagano, M.3
  • 74
    • 0033034120 scopus 로고    scopus 로고
    • Beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation
    • Liu C., Kato Y., Zhang Z., Do V.M., Yankner B.A., He X. beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc Natl Acad Sci U S A 1999, 96:6273-6278.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 6273-6278
    • Liu, C.1    Kato, Y.2    Zhang, Z.3    Do, V.M.4    Yankner, B.A.5    He, X.6
  • 75
    • 0032170327 scopus 로고    scopus 로고
    • Beta-TrCP is a negative regulator of Wnt/beta-catenin signaling pathway and dorsal axis formation in Xenopus embryos
    • Marikawa Y., Elinson R.P. beta-TrCP is a negative regulator of Wnt/beta-catenin signaling pathway and dorsal axis formation in Xenopus embryos. Mech Dev 1998, 77:75-80.
    • (1998) Mech Dev , vol.77 , pp. 75-80
    • Marikawa, Y.1    Elinson, R.P.2
  • 76
    • 0030975671 scopus 로고    scopus 로고
    • Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    • Korinek V., Barker N., Morin P.J., van Wichen D., de Weger R., Kinzler K.W., et al. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 1997, 275:1784-1787.
    • (1997) Science , vol.275 , pp. 1784-1787
    • Korinek, V.1    Barker, N.2    Morin, P.J.3    van Wichen, D.4    de Weger, R.5    Kinzler, K.W.6
  • 77
    • 0033119801 scopus 로고    scopus 로고
    • Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • Tetsu O., McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999, 398:422-426.
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 78
    • 0036149985 scopus 로고    scopus 로고
    • Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors
    • Lustig B., Jerchow B., Sachs M., Weiler S., Pietsch T., Karsten U., et al. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol 2002, 22:1184-1193.
    • (2002) Mol Cell Biol , vol.22 , pp. 1184-1193
    • Lustig, B.1    Jerchow, B.2    Sachs, M.3    Weiler, S.4    Pietsch, T.5    Karsten, U.6
  • 79
    • 0001990330 scopus 로고    scopus 로고
    • Transcriptional regulation by Smads: crosstalk between the TGF-beta and Wnt pathways
    • Letamendia A., Labbe E., Attisano L. Transcriptional regulation by Smads: crosstalk between the TGF-beta and Wnt pathways. J Bone Joint Surg Am 2001, 83-A(Suppl. 1):S31-S39.
    • (2001) J Bone Joint Surg Am , Issue.SUPPL. 1
    • Letamendia, A.1    Labbe, E.2    Attisano, L.3
  • 80
    • 0036333793 scopus 로고    scopus 로고
    • Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon
    • Theil T., Aydin S., Koch S., Grotewold L., Ruther U. Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon. Development 2002, 129:3045-3054.
    • (2002) Development , vol.129 , pp. 3045-3054
    • Theil, T.1    Aydin, S.2    Koch, S.3    Grotewold, L.4    Ruther, U.5


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