Inflammatory cytokines promote mesenchymal transformation in embryonic and adult valve endothelial cells

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 33, Issue 1, 2013, Pages 121-130

  Mahler, Gretchen J ^a,b   Farrar, Emily J ^b   Butcher, Jonathan T ^b  

^a BINGHAMTON UNIVERSITY   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

calcification; invasion; smooth muscle actin; transforming growth factor ; tumor necrosis factor

Indexed keywords

ACTIVIN; ACTIVIN RECEPTOR LIKE KINASE 1; ACTIVIN RECEPTOR LIKE KINASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AORTA VALVE DISEASE; ARTICLE; CALCIFICATION; CELL ASSAY; CELL INVASION; CELL MATURATION; COLLAGEN GEL CULTURE ASSAY; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; EMBRYO; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; EPITHELIAL MESENCHYMAL TRANSITION; FETUS; GENE EXPRESSION; HEART MUSCLE; HUMAN; HUMAN CELL; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR ENDOTHELIUM;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; AORTIC VALVE; CALCINOSIS; CELL MOVEMENT; CELLS, CULTURED; CHICK EMBRYO; ENDOTHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; HEART VALVE DISEASES; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-6; NF-KAPPA B; PRIMARY CELL CULTURE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; QUAIL; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SWINE; TIME FACTORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84871737124     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.112.300504     Document Type: Article

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