-
1
-
-
11144298973
-
Exploring biology with small organic molecules
-
Stockwell, B. R. (2004) Exploring biology with small organic molecules Nature 432, 846-854
-
(2004)
Nature
, vol.432
, pp. 846-854
-
-
Stockwell, B.R.1
-
2
-
-
33644846857
-
Small molecules: The missing link in the central dogma
-
Schreiber, S. L. (2005) Small molecules: the missing link in the central dogma Nat. Chem. Biol. 1, 64-66
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 64-66
-
-
Schreiber, S.L.1
-
3
-
-
0037432765
-
From knowing to controlling: A path from genomics to drugs using small molecule probes
-
Strausberg, R. L. and Schreiber, S. L. (2003) From knowing to controlling: a path from genomics to drugs using small molecule probes Science 300, 294-295
-
(2003)
Science
, vol.300
, pp. 294-295
-
-
Strausberg, R.L.1
Schreiber, S.L.2
-
4
-
-
67650070045
-
Multi-parameter phenotypic profiling: Using cellular effects to characterize small-molecule compounds
-
Feng, Y., Mitchison, T. J., Bender, A., Young, D. W., and Tallarico, J. A. (2009) Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds Nat. Rev. Drug Discovery 8, 567-578
-
(2009)
Nat. Rev. Drug Discovery
, vol.8
, pp. 567-578
-
-
Feng, Y.1
Mitchison, T.J.2
Bender, A.3
Young, D.W.4
Tallarico, J.A.5
-
5
-
-
17044373269
-
Finding the target after screening the phenotype
-
Hart, C. P. (2005) Finding the target after screening the phenotype Drug Discovery Today 10, 513-519
-
(2005)
Drug Discovery Today
, vol.10
, pp. 513-519
-
-
Hart, C.P.1
-
6
-
-
50649112213
-
Activity-based protein profiling: From enzyme chemistry to proteomic chemistry
-
Cravatt, B. F., Wright, A. T., and Kozarich, J. W. (2008) Activity-based protein profiling: from enzyme chemistry to proteomic chemistry Annu. Rev. Biochem. 77, 383-414
-
(2008)
Annu. Rev. Biochem.
, vol.77
, pp. 383-414
-
-
Cravatt, B.F.1
Wright, A.T.2
Kozarich, J.W.3
-
7
-
-
43149105407
-
Activity-based protein profiling: New developments and directions in functional proteomics
-
Uttamchandani, M., Li, J., Sun, H., and Yao, S. Q. (2008) Activity-based protein profiling: new developments and directions in functional proteomics ChemBioChem 9, 667-675
-
(2008)
ChemBioChem
, vol.9
, pp. 667-675
-
-
Uttamchandani, M.1
Li, J.2
Sun, H.3
Yao, S.Q.4
-
8
-
-
33646462162
-
Proteomic profiling of metalloprotease activities with cocktails of active-site probes
-
Sieber, S. A., Niessen, S., Hoover, H. S., and Cravatt, B. F. (2006) Proteomic profiling of metalloprotease activities with cocktails of active-site probes Nat. Chem. Biol. 2, 274-281
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 274-281
-
-
Sieber, S.A.1
Niessen, S.2
Hoover, H.S.3
Cravatt, B.F.4
-
9
-
-
77955983759
-
Activity-based protein profiling for biochemical pathway discovery in cancer
-
Nomura, D. K., Dix, M. M., and Cravatt, B. F. (2010) Activity-based protein profiling for biochemical pathway discovery in cancer Nat. Rev. Cancer 10, 630-638
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 630-638
-
-
Nomura, D.K.1
Dix, M.M.2
Cravatt, B.F.3
-
10
-
-
33748595526
-
Mechanism-based profiling of enzyme families
-
Evans, M. J. and Cravatt, B. F. (2006) Mechanism-based profiling of enzyme families Chem. Rev. 106, 3279-3301
-
(2006)
Chem. Rev.
, vol.106
, pp. 3279-3301
-
-
Evans, M.J.1
Cravatt, B.F.2
-
11
-
-
79951523274
-
A peptide aldehyde microarray for high-throughput profiling of cellular events
-
Wu, H., Ge, J., Yang, P. Y., Wang, J., Uttamchandani, M., and Yao, S. Q. (2011) A peptide aldehyde microarray for high-throughput profiling of cellular events J. Am. Chem. Soc. 133, 1946-1954
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 1946-1954
-
-
Wu, H.1
Ge, J.2
Yang, P.Y.3
Wang, J.4
Uttamchandani, M.5
Yao, S.Q.6
-
12
-
-
84863500157
-
Fully functionalized small-molecule probes for integrated phenotypic screening and target identification
-
Cisar, J. S. and Cravatt, B. F. (2012) Fully functionalized small-molecule probes for integrated phenotypic screening and target identification J. Am. Chem. Soc. 134, 10385-10388
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 10385-10388
-
-
Cisar, J.S.1
Cravatt, B.F.2
-
13
-
-
39549102872
-
Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes
-
Salisbury, C. M. and Cravatt, B. F. (2008) Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes J. Am. Chem. Soc. 130, 2184-2194
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 2184-2194
-
-
Salisbury, C.M.1
Cravatt, B.F.2
-
14
-
-
0024472603
-
A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase
-
Harding, M. W., Galat, A., Uehling, D. E., and Schreiber, S. L. (1989) A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase Nature 341, 758-760
-
(1989)
Nature
, vol.341
, pp. 758-760
-
-
Harding, M.W.1
Galat, A.2
Uehling, D.E.3
Schreiber, S.L.4
-
15
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
-
Brown, E. J., Albers, M. W., Shin, T. B., Ichikawa, K., Keith, C. T., Lane, W. S., and Schreiber, S. L. (1994) A mammalian protein targeted by G1-arresting rapamycin-receptor complex Nature 369, 756-758
-
(1994)
Nature
, vol.369
, pp. 756-758
-
-
Brown, E.J.1
Albers, M.W.2
Shin, T.B.3
Ichikawa, K.4
Keith, C.T.5
Lane, W.S.6
Schreiber, S.L.7
-
16
-
-
24744437350
-
Roscovitine targets, protein kinases and pyridoxal kinase
-
Bach, S., Knockaert, M., Reinhardt, J., Lozach, O., Schmitt, S., Baratte, B., Koken, M., Coburn, S. P., Tang, L., Jiang, T., Liang, D. C., Galons, H., Dierick, J. F., Pinna, L. A., Meggio, F., Totzke, F., Schachtele, C., Lerman, A. S., Carnero, A., Wan, Y., Gray, N., and Meijer, L. (2005) Roscovitine targets, protein kinases and pyridoxal kinase J. Biol. Chem. 280, 31208-31219
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31208-31219
-
-
Bach, S.1
Knockaert, M.2
Reinhardt, J.3
Lozach, O.4
Schmitt, S.5
Baratte, B.6
Koken, M.7
Coburn, S.P.8
Tang, L.9
Jiang, T.10
Liang, D.C.11
Galons, H.12
Dierick, J.F.13
Pinna, L.A.14
Meggio, F.15
Totzke, F.16
Schachtele, C.17
Lerman, A.S.18
Carnero, A.19
Wan, Y.20
Gray, N.21
Meijer, L.22
more..
-
17
-
-
77949350034
-
Identification of a primary target of thalidomide teratogenicity
-
Ito, T., Ando, H., Suzuki, T., Ogura, T., Hotta, K., Imamura, Y., Yamaguchi, Y., and Handa, H. (2010) Identification of a primary target of thalidomide teratogenicity Science 327, 1345-50
-
(2010)
Science
, vol.327
, pp. 1345-1350
-
-
Ito, T.1
Ando, H.2
Suzuki, T.3
Ogura, T.4
Hotta, K.5
Imamura, Y.6
Yamaguchi, Y.7
Handa, H.8
-
18
-
-
0028685470
-
A novel biotinylated heterobifunctional cross-linking reagent bearing an aromatic diazirine
-
Hatanaka, Y., Hashimoto, M., and Kanaoka, Y. (1994) A novel biotinylated heterobifunctional cross-linking reagent bearing an aromatic diazirine Bioorg. Med. Chem. 2, 1367-1373
-
(1994)
Bioorg. Med. Chem.
, vol.2
, pp. 1367-1373
-
-
Hatanaka, Y.1
Hashimoto, M.2
Kanaoka, Y.3
-
19
-
-
84865847867
-
Aptamer-based affinity labeling of proteins
-
Vinkenborg, J. L., Mayer, G., and Famulok, M. (2012) Aptamer-based affinity labeling of proteins Angew. Chem., Int. Ed. 51, 9176-9180
-
(2012)
Angew. Chem., Int. Ed.
, vol.51
, pp. 9176-9180
-
-
Vinkenborg, J.L.1
Mayer, G.2
Famulok, M.3
-
20
-
-
84861486811
-
Discovery and target identification of an antiproliferative agent in live cells using fluorescence difference in two-dimensional gel electrophoresis
-
Park, J., Oh, S., and Park, S. B. (2012) Discovery and target identification of an antiproliferative agent in live cells using fluorescence difference in two-dimensional gel electrophoresis Angew. Chem., Int. Ed. 51, 5447-5451
-
(2012)
Angew. Chem., Int. Ed.
, vol.51
, pp. 5447-5451
-
-
Park, J.1
Oh, S.2
Park, S.B.3
-
21
-
-
79961161118
-
Unraveling the protein targets of vancomycin in living S aureus and E faecalis cells
-
Eirich, J., Orth, R., and Sieber, S. A. (2011) Unraveling the protein targets of vancomycin in living S. aureus and E. faecalis cells J. Am. Chem. Soc. 133, 12144-12153
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 12144-12153
-
-
Eirich, J.1
Orth, R.2
Sieber, S.A.3
-
22
-
-
84860187002
-
Triple bioorthogonal ligation strategy for simultaneous labeling of multiple enzymatic activities
-
Willems, L. I., Li, N., Florea, B. I., Ruben, M., van der Marel, G. A., and Overkleeft, H. S. (2012) Triple bioorthogonal ligation strategy for simultaneous labeling of multiple enzymatic activities Angew. Chem., Int. Ed. 51, 4431-4434
-
(2012)
Angew. Chem., Int. Ed.
, vol.51
, pp. 4431-4434
-
-
Willems, L.I.1
Li, N.2
Florea, B.I.3
Ruben, M.4
Van Der Marel, G.A.5
Overkleeft, H.S.6
-
23
-
-
84872852493
-
Streamlining chemical probe discovery: Libraries of 'fully functionalized' small molecules for phenotypic screening
-
Oeljeklaus, J., Kaschani, F., and Kaiser, M. (2013) Streamlining chemical probe discovery: libraries of 'fully functionalized' small molecules for phenotypic screening Angew. Chem., Int. Ed. 52, 1368-1370
-
(2013)
Angew. Chem., Int. Ed.
, vol.52
, pp. 1368-1370
-
-
Oeljeklaus, J.1
Kaschani, F.2
Kaiser, M.3
-
24
-
-
84855428544
-
New approaches for dissecting protease functions to improve probe development and drug discovery
-
Deu, E., Verdoes, M., and Bogyo, M. (2012) New approaches for dissecting protease functions to improve probe development and drug discovery Nat. Struct. Mol. Biol. 19, 9-16
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 9-16
-
-
Deu, E.1
Verdoes, M.2
Bogyo, M.3
-
25
-
-
0036514084
-
Photoaffinity labeling in drug discovery and developments: Chemical gateway for entering proteomic frontier
-
Hatanaka, Y. and Sadakane, Y. (2002) Photoaffinity labeling in drug discovery and developments: chemical gateway for entering proteomic frontier Curr. Top. Med. Chem. 2, 271-288
-
(2002)
Curr. Top. Med. Chem.
, vol.2
, pp. 271-288
-
-
Hatanaka, Y.1
Sadakane, Y.2
-
26
-
-
43949112287
-
Photocrosslinkers illuminate interactions in living cells
-
Tanaka, Y., Bond, M. R., and Kohler, J. J. (2008) Photocrosslinkers illuminate interactions in living cells Mol. Biosyst. 4, 473-480
-
(2008)
Mol. Biosyst.
, vol.4
, pp. 473-480
-
-
Tanaka, Y.1
Bond, M.R.2
Kohler, J.J.3
-
27
-
-
78049296965
-
A small molecule accelerates neuronal differentiation in the adult rat
-
Wurdak, H., Zhu, S., Min, K. H., Aimone, L., Lairson, L. L., Watson, J., Chopiuk, G., Demas, J., Charette, B., Halder, R., Weerapana, E., Cravatt, B. F., Cline, H. T., Peters, E. C., Zhang, J., Walker, J. R., Wu, C., Chang, J., Tuntland, T., Cho, C. Y., and Schultz, P. G. (2010) A small molecule accelerates neuronal differentiation in the adult rat Proc. Nat. Acad. Sci. U.S.A. 107, 16542-16547
-
(2010)
Proc. Nat. Acad. Sci. U.S.A.
, vol.107
, pp. 16542-16547
-
-
Wurdak, H.1
Zhu, S.2
Min, K.H.3
Aimone, L.4
Lairson, L.L.5
Watson, J.6
Chopiuk, G.7
Demas, J.8
Charette, B.9
Halder, R.10
Weerapana, E.11
Cravatt, B.F.12
Cline, H.T.13
Peters, E.C.14
Zhang, J.15
Walker, J.R.16
Wu, C.17
Chang, J.18
Tuntland, T.19
Cho, C.Y.20
Schultz, P.G.21
more..
-
28
-
-
77951271075
-
A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor
-
Koteva, K., Hong, H. J., Wang, X. D., Nazi, I., Hughes, D., Naldrett, M. J., Buttner, M. J., and Wright, G. D. (2010) A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor Nat. Chem. Biol. 6, 327-329
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 327-329
-
-
Koteva, K.1
Hong, H.J.2
Wang, X.D.3
Nazi, I.4
Hughes, D.5
Naldrett, M.J.6
Buttner, M.J.7
Wright, G.D.8
-
29
-
-
0038344159
-
Reactivity of functional groups on the protein surface: Development of epoxide probes for protein labeling
-
Chen, G., Heim, A., Riether, D., Yee, D., Milgrom, Y., Gawinowicz, M. A., and Sames, D. (2003) Reactivity of functional groups on the protein surface: development of epoxide probes for protein labeling J. Am. Chem. Soc. 125, 8130-8133
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 8130-8133
-
-
Chen, G.1
Heim, A.2
Riether, D.3
Yee, D.4
Milgrom, Y.5
Gawinowicz, M.A.6
Sames, D.7
-
30
-
-
84856433232
-
Native FKBP12 engineering by ligand-directed tosyl chemistry: Labeling properties and application to photo-cross-linking of protein complexes in vitro and in living cells
-
Tamura, T., Tsukiji, S., and Hamachi, I. (2012) Native FKBP12 engineering by ligand-directed tosyl chemistry: labeling properties and application to photo-cross-linking of protein complexes in vitro and in living cells J. Am. Chem. Soc. 134, 2216-2226
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 2216-2226
-
-
Tamura, T.1
Tsukiji, S.2
Hamachi, I.3
-
31
-
-
65349110554
-
Ligand-directed tosyl chemistry for protein labeling in vivo
-
Tsukiji, S., Miyagawa, M., Takaoka, Y., Tamura, T., and Hamachi, I. (2009) Ligand-directed tosyl chemistry for protein labeling in vivo Nat. Chem. Biol. 5, 341-343
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 341-343
-
-
Tsukiji, S.1
Miyagawa, M.2
Takaoka, Y.3
Tamura, T.4
Hamachi, I.5
-
32
-
-
84883228365
-
Photoaffinity labeling of small-molecule-binding proteins by DNA-templated chemistry
-
Li, G., Liu, Y., Chen, L., Wu, S., and Li, X. (2013) Photoaffinity labeling of small-molecule-binding proteins by DNA-templated chemistry Angew. Chem., Int. Ed. 52, 9544-9549
-
(2013)
Angew. Chem., Int. Ed.
, vol.52
, pp. 9544-9549
-
-
Li, G.1
Liu, Y.2
Chen, L.3
Wu, S.4
Li, X.5
-
33
-
-
78649733298
-
Interaction-dependent PCR: Identification of ligand-target pairs from libraries of ligands and libraries of targets in a single solution-phase experiment
-
McGregor, L. M., Gorin, D. J., Dumelin, C. E., and Liu, D. R. (2010) Interaction-dependent PCR: identification of ligand-target pairs from libraries of ligands and libraries of targets in a single solution-phase experiment J. Am. Chem. Soc. 132, 15522-15524
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 15522-15524
-
-
McGregor, L.M.1
Gorin, D.J.2
Dumelin, C.E.3
Liu, D.R.4
-
34
-
-
84894628304
-
Identification of ligand-target pairs from combined libraries of small molecules and unpurified protein targets in cell lysates
-
McGregor, L. M., Jain, T., and Liu, D. R. (2014) Identification of ligand-target pairs from combined libraries of small molecules and unpurified protein targets in cell lysates J. Am. Chem. Soc. 136, 3264-3270
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 3264-3270
-
-
McGregor, L.M.1
Jain, T.2
Liu, D.R.3
-
35
-
-
80053469412
-
The real-time PCR for sensitive protein detection by target-induced intermolecular hybridization
-
Ma, C., Cao, L., Shi, C., and Ye, N. (2011) The real-time PCR for sensitive protein detection by target-induced intermolecular hybridization Chem. Commun. 47, 11303-11305
-
(2011)
Chem. Commun.
, vol.47
, pp. 11303-11305
-
-
Ma, C.1
Cao, L.2
Shi, C.3
Ye, N.4
-
36
-
-
29144483964
-
Practical conditions for photoaffinity labeling with 3-trifluoromethyl-3- phenyldiazirine photophore
-
Hashimoto, M. and Hatanaka, Y. (2006) Practical conditions for photoaffinity labeling with 3-trifluoromethyl-3-phenyldiazirine photophore Anal. Biochem. 348, 154-156
-
(2006)
Anal. Biochem.
, vol.348
, pp. 154-156
-
-
Hashimoto, M.1
Hatanaka, Y.2
-
37
-
-
84864632952
-
Covalent cross-linking within supramolecular peptide structures
-
Preston, G. W., Radford, S. E., Ashcroft, A. E., and Wilson, A. J. (2012) Covalent cross-linking within supramolecular peptide structures Anal. Chem. 84, 6790-6797
-
(2012)
Anal. Chem.
, vol.84
, pp. 6790-6797
-
-
Preston, G.W.1
Radford, S.E.2
Ashcroft, A.E.3
Wilson, A.J.4
-
38
-
-
84855816511
-
Diazirine based photoaffinity labeling
-
Dubinsky, L., Krom, B. P., and Meijler, M. M. (2012) Diazirine based photoaffinity labeling Bioorg. Med. Chem. 20, 554-570
-
(2012)
Bioorg. Med. Chem.
, vol.20
, pp. 554-570
-
-
Dubinsky, L.1
Krom, B.P.2
Meijler, M.M.3
-
39
-
-
43949136114
-
Influence of solvent on carbene intersystem crossing rates
-
Wang, J., Kubicki, J., Peng, H., and Platz, M. S. (2008) Influence of solvent on carbene intersystem crossing rates J. Am. Chem. Soc. 130, 6604-6609
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 6604-6609
-
-
Wang, J.1
Kubicki, J.2
Peng, H.3
Platz, M.S.4
-
40
-
-
84883326082
-
Photo-induced covalent cross-linking for the analysis of biomolecular interactions
-
Preston, G. W. and Wilson, A. J. (2013) Photo-induced covalent cross-linking for the analysis of biomolecular interactions Chem. Soc. Rev. 42, 3289-3301
-
(2013)
Chem. Soc. Rev.
, vol.42
, pp. 3289-3301
-
-
Preston, G.W.1
Wilson, A.J.2
-
41
-
-
0027203297
-
New photolabeling and crosslinking methods
-
Brunner, J. (1993) New photolabeling and crosslinking methods Annu. Rev. Biochem. 62, 483-514
-
(1993)
Annu. Rev. Biochem.
, vol.62
, pp. 483-514
-
-
Brunner, J.1
-
42
-
-
0032520692
-
Survey of four different photoreactive moieties for DNA photoaffinity labeling of yeast RNA polymerase III transcription complexes
-
Tate, J. J., Persinger, J., and Bartholomew, B. (1998) Survey of four different photoreactive moieties for DNA photoaffinity labeling of yeast RNA polymerase III transcription complexes Nucleic Acids Res. 26, 1421-1426
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 1421-1426
-
-
Tate, J.J.1
Persinger, J.2
Bartholomew, B.3
-
43
-
-
0030979415
-
Photocross-linking of nucleic acids to associated proteins
-
Meisenheimer, K. M. and Koch, T. H. (1997) Photocross-linking of nucleic acids to associated proteins Crit. Rev. Biochem. Mol. Biol. 32, 101-140
-
(1997)
Crit. Rev. Biochem. Mol. Biol.
, vol.32
, pp. 101-140
-
-
Meisenheimer, K.M.1
Koch, T.H.2
-
44
-
-
33748817772
-
Recent trends in photoaffinity labeling
-
Kotzyba-ibert, F., Kapfer, I., and Goeldner, M. (1995) Recent trends in photoaffinity labeling Angew. Chem., Int. Ed. 34, 1296-1312
-
(1995)
Angew. Chem., Int. Ed.
, vol.34
, pp. 1296-1312
-
-
Kotzyba-Ibert, F.1
Kapfer, I.2
Goeldner, M.3
-
45
-
-
38249033072
-
Identifying subunits of ATP synthase TFo.F1 in contact with phospholipid head groups
-
Gao, Z. and Bauerlein, E. (1987) Identifying subunits of ATP synthase TFo.F1 in contact with phospholipid head groups FEBS Lett. 223, 366-370
-
(1987)
FEBS Lett.
, vol.223
, pp. 366-370
-
-
Gao, Z.1
Bauerlein, E.2
-
46
-
-
0027572579
-
Exploratory photochemistry of fluorinated aryl azides. Implications for the design of photoaffinity labeling reagents
-
Schnapp, K. A., Poe, R., Leyva, E., Soundararajan, N., and Platz, M. S. (1993) Exploratory photochemistry of fluorinated aryl azides. Implications for the design of photoaffinity labeling reagents Bioconjugate Chem. 4, 172-177
-
(1993)
Bioconjugate Chem.
, vol.4
, pp. 172-177
-
-
Schnapp, K.A.1
Poe, R.2
Leyva, E.3
Soundararajan, N.4
Platz, M.S.5
-
47
-
-
0019332445
-
3-Trifluoromethyl-3-phenyldiazirine. A new carbene generating group for photolabeling reagents
-
Brunner, J., Senn, H., and Richards, F. M. (1980) 3-Trifluoromethyl-3- phenyldiazirine. A new carbene generating group for photolabeling reagents J. Biol. Chem. 255, 3313-3318
-
(1980)
J. Biol. Chem.
, vol.255
, pp. 3313-3318
-
-
Brunner, J.1
Senn, H.2
Richards, F.M.3
-
48
-
-
44949229448
-
Thermodynamic analysis of protein stability and ligand binding using a chemical modification- and mass spectrometry-based strategy
-
West, G. M., Tang, L., and Fitzgerald, M. C. (2008) Thermodynamic analysis of protein stability and ligand binding using a chemical modification- and mass spectrometry-based strategy Anal. Chem. 80, 4175-4185
-
(2008)
Anal. Chem.
, vol.80
, pp. 4175-4185
-
-
West, G.M.1
Tang, L.2
Fitzgerald, M.C.3
-
49
-
-
79961136807
-
Chemical cell-surface receptor engineering using affinity-guided, multivalent organocatalysts
-
Wang, H., Koshi, Y., Minato, D., Nonaka, H., Kiyonaka, S., Mori, Y., Tsukiji, S., and Hamachi, I. (2011) Chemical cell-surface receptor engineering using affinity-guided, multivalent organocatalysts J. Am. Chem. Soc. 133, 12220-12228
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 12220-12228
-
-
Wang, H.1
Koshi, Y.2
Minato, D.3
Nonaka, H.4
Kiyonaka, S.5
Mori, Y.6
Tsukiji, S.7
Hamachi, I.8
-
50
-
-
0032476812
-
Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors
-
Mammen, M., Choi, S.-K., and Whitesides, G. M. (1998) Polyvalent interactions in biological systems: implications for design and use of multivalent ligands and inhibitors Angew. Chem., Int. Ed. 37, 2754-2794
-
(1998)
Angew. Chem., Int. Ed.
, vol.37
, pp. 2754-2794
-
-
Mammen, M.1
Choi, S.-K.2
Whitesides, G.M.3
-
51
-
-
33746296180
-
Synthetic multivalent ligands as probes of signal transduction
-
Kiessling, L. L., Gestwicki, J. E., and Strong, L. E. (2006) Synthetic multivalent ligands as probes of signal transduction Angew. Chem., Int. Ed. 45, 2348-2368
-
(2006)
Angew. Chem., Int. Ed.
, vol.45
, pp. 2348-2368
-
-
Kiessling, L.L.1
Gestwicki, J.E.2
Strong, L.E.3
-
52
-
-
63849172494
-
Identifying the proteins to which small-molecule probes and drugs bind in cells
-
Ong, S. E., Schenone, M., Margolin, A. A., Li, X., Do, K., Doud, M. K., Mani, D. R., Kuai, L., Wang, X., Wood, J. L., Tolliday, N. J., Koehler, A. N., Marcaurelle, L. A., Golub, T. R., Gould, R. J., Schreiber, S. L., and Carr, S. A. (2009) Identifying the proteins to which small-molecule probes and drugs bind in cells Proc. Nat. Acad. Sci. U.S.A. 106, 4617-4622
-
(2009)
Proc. Nat. Acad. Sci. U.S.A.
, vol.106
, pp. 4617-4622
-
-
Ong, S.E.1
Schenone, M.2
Margolin, A.A.3
Li, X.4
Do, K.5
Doud, M.K.6
Mani, D.R.7
Kuai, L.8
Wang, X.9
Wood, J.L.10
Tolliday, N.J.11
Koehler, A.N.12
Marcaurelle, L.A.13
Golub, T.R.14
Gould, R.J.15
Schreiber, S.L.16
Carr, S.A.17
-
53
-
-
0343433408
-
Cysteine proteases and their inhibitors
-
Otto, H. H. and Schirmeister, T. (1997) Cysteine proteases and their inhibitors Chem. Rev. 97, 133-172
-
(1997)
Chem. Rev.
, vol.97
, pp. 133-172
-
-
Otto, H.H.1
Schirmeister, T.2
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