Fully functionalized small-molecule probes for integrated phenotypic screening and target identification

Journal of the American Chemical Society

Volumn 134, Issue 25, 2012, Pages 10385-10388

  Cisar, Justin S ^a   Cravatt, Benjamin F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE PROBE; BIOLOGICAL PROCESS; CHEMOPROTEOMICS; COMPLEX 1; COVALENT CROSSLINKING; CROSS-LINKED PROTEINS; FUNCTIONALIZED; FUNCTIONALIZED COMPOUNDS; IN-VITRO; INTEGRAL MEMBRANE; LIVING SYSTEMS; OXIDATIVE PHOSPHORYLATION; OXIDOREDUCTASES; PHARMACOLOGICAL ACTIVITY; PHENOTYPIC SCREENING; PROOF OF PRINCIPLES; PROTEIN TARGETS; SMALL MOLECULES; SMALL-MOLECULE LIBRARY; TARGET IDENTIFICATION;

ACETYLENE; CELL DEATH; CELL PROLIFERATION; GLUCOSE; MOLECULES; PHOSPHORYLATION;

PROBES;

ALKYNE; GLUCOSE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ARTICLE; CANCER CELL; CANCER INHIBITION; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; COVALENT BOND; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR LIBRARY; MOLECULAR PROBE; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PHOTOREACTIVITY; PROTEIN CROSS LINKING; PROTEIN TARGETING; PROTEOMICS; QUANTITATIVE ANALYSIS; SCREENING; ULTRAVIOLET RADIATION;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DELIVERY SYSTEMS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PHENOTYPE; PROTEIN BINDING; SMALL MOLECULE LIBRARIES;

EID: 84863500157     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja304213w     Document Type: Article

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